Fluorodopa (18F)

DB13848

small molecule approved experimental

Deskripsi

Fluorodopa F 18 is a fluorinated analog of levodopa used as a diagnostic agent for positron emission tomography (PET) in the evaluation of Parkinsonian syndromes.^L12849 Fluorodopa F 18 PET is used adjunctly with other diagnostic investigations and serves primarily to visualize dopaminergic nerve terminals in the striatum.^L12849

Struktur Molekul 2D

Berat 214.183

Wujud solid

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) The plasma half-life following intravenous administration is approximately 1-3 hours.[L12849]

Volume Distribusi -

Klirens (Clearance) The agent is cleared from blood and tissue within 24 hours following administration.[L12849]

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Fluorodopa F 18 is decarboxylated by aromatic amino acid decarboxylase (AADC) in the striatum to fluorodopamine F 18. Fluorodopamine F 18 is then further metabolized by monoamine oxidase (MAO) to yield 18F 6-fluoro-3,4-dihydroxyphenylacetic acid, then subsequently by COMT to yield 18F6-fluorohomovanillic acid.^L12849

Rute Eliminasi

Approximately 80% of the administered radioactivity is eliminated in the urine.^L12849

Interaksi Makanan

1 Data

1. Take on an empty stomach. Before fluorodopa F18 administration do not eat or drink anything, except for water, for at least 4 hours.

Interaksi Obat

3 Data

Carbidopa	The bioavailability of Fluorodopa (18F) can be increased when combined with Carbidopa.
Methyldopa	The bioavailability of Fluorodopa (18F) can be increased when combined with Methyldopa.
Benserazide	The bioavailability of Fluorodopa (18F) can be increased when combined with Benserazide.

Referensi & Sumber

Link

FDA Approved Drug Products: Fluorodopa F18 injection for intravenous use

Contoh Produk & Brand

Produk: 2 • International brands: 0

Produk

Fluorodopa F18

Injection • 8.33 mCi/1mL • Intravenous • US • Approved
Fluorodopa F18

Injection • 40 mCi/1mL • Intravenous • US • Approved

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.