Peringatan Keamanan

There are no data available regarding overdosage with levacetylleucine.

L-Acetylleucine

DB16956

small molecule approved investigational

Deskripsi

Levacetylleucine (L-acetylleucine) is a modified acetylated derivative of the amino acid leucine. The racemic (i.e. DL-) form has been available in France since 1957 for the treatment of vertigo.^A264439

Observational studies in patients with Niemann-Pick disease type C (NPC) suggested a beneficial symptomatic as well as neuroprotective disease-modifying effect of the DL-form of N-acetylleucine, after which animal studies showed that the L-enantiomer (i.e. levacetylleucine) has potential clinical benefits compared to the racemic mixture.^A264439 In September 2024, the FDA approved levacetylleucine for the treatment of select patients with NPC.^L51444

Struktur Molekul 2D

Berat 173.212

Wujud solid

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) The half-life of levacetylleucine is approximately 1 hour.[L51439]

Volume Distribusi The apparent volume of distribution following oral administration of levacetylleucine is 253 liters.[L51439]

Klirens (Clearance) The apparent oral clearance of levacetylleucine is 139 L/h.[L51439]

Absorpsi

The C_maxand AUC^0-24h of levacetylleucine following oral administration were 8.3 ?g/mL and 33.2 h*?g/mL, respectively.^L51439 The time to maximum concentration (T_max) is approximately 1 hour.^L51439

Metabolisme

Levacetylleucine is metabolized into acetate and L-leucine by ubiquitously expressed enzymes.^L51439

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

1 Data

1. Take with or without food.

Interaksi Obat

162 Data

Acetylleucine	The therapeutic efficacy of L-Acetylleucine can be decreased when used in combination with Acetylleucine.
DS-1211	The therapeutic efficacy of L-Acetylleucine can be decreased when used in combination with DS-1211.
Daptomycin	The serum concentration of Daptomycin can be increased when it is combined with L-Acetylleucine.
Cyclosporine	The serum concentration of Cyclosporine can be increased when it is combined with L-Acetylleucine.
Pravastatin	The serum concentration of Pravastatin can be increased when it is combined with L-Acetylleucine.
Bortezomib	The serum concentration of Bortezomib can be increased when it is combined with L-Acetylleucine.
Sildenafil	The serum concentration of Sildenafil can be increased when it is combined with L-Acetylleucine.
Ranolazine	The serum concentration of Ranolazine can be increased when it is combined with L-Acetylleucine.
Morphine	The serum concentration of Morphine can be increased when it is combined with L-Acetylleucine.
Tenofovir disoproxil	The serum concentration of Tenofovir disoproxil can be increased when it is combined with L-Acetylleucine.
Clobazam	The serum concentration of Clobazam can be increased when it is combined with L-Acetylleucine.
Mefloquine	The serum concentration of Mefloquine can be increased when it is combined with L-Acetylleucine.
Digoxin	The serum concentration of Digoxin can be increased when it is combined with L-Acetylleucine.
Gemcitabine	The serum concentration of Gemcitabine can be increased when it is combined with L-Acetylleucine.
Quinine	The serum concentration of Quinine can be increased when it is combined with L-Acetylleucine.
Toremifene	The serum concentration of Toremifene can be increased when it is combined with L-Acetylleucine.
Vincristine	The serum concentration of Vincristine can be increased when it is combined with L-Acetylleucine.
Vinblastine	The serum concentration of Vinblastine can be increased when it is combined with L-Acetylleucine.
Bisoprolol	The serum concentration of Bisoprolol can be increased when it is combined with L-Acetylleucine.
Simvastatin	The serum concentration of Simvastatin can be increased when it is combined with L-Acetylleucine.
Verapamil	The serum concentration of Verapamil can be increased when it is combined with L-Acetylleucine.
Midazolam	The serum concentration of Midazolam can be increased when it is combined with L-Acetylleucine.
Mannitol	The serum concentration of Mannitol can be increased when it is combined with L-Acetylleucine.
Etoposide	The serum concentration of Etoposide can be increased when it is combined with L-Acetylleucine.
Loperamide	The excretion of Loperamide can be decreased when combined with L-Acetylleucine.
Vardenafil	The serum concentration of Vardenafil can be increased when it is combined with L-Acetylleucine.
Sirolimus	The serum concentration of Sirolimus can be increased when it is combined with L-Acetylleucine.
Clomifene	The serum concentration of Clomifene can be increased when it is combined with L-Acetylleucine.
Quinidine	The serum concentration of Quinidine can be increased when it is combined with L-Acetylleucine.
Tipranavir	The serum concentration of Tipranavir can be increased when it is combined with L-Acetylleucine.
Fexofenadine	The serum concentration of Fexofenadine can be increased when it is combined with L-Acetylleucine.
Dactinomycin	The serum concentration of Dactinomycin can be increased when it is combined with L-Acetylleucine.
Tegaserod	The serum concentration of Tegaserod can be increased when it is combined with L-Acetylleucine.
Saquinavir	The serum concentration of Saquinavir can be increased when it is combined with L-Acetylleucine.
Dasatinib	The serum concentration of Dasatinib can be increased when it is combined with L-Acetylleucine.
Sitagliptin	The serum concentration of Sitagliptin can be increased when it is combined with L-Acetylleucine.
Posaconazole	The serum concentration of Posaconazole can be increased when it is combined with L-Acetylleucine.
Darunavir	The serum concentration of Darunavir can be increased when it is combined with L-Acetylleucine.
Paliperidone	The serum concentration of Paliperidone can be increased when it is combined with L-Acetylleucine.
Mibefradil	The serum concentration of Mibefradil can be increased when it is combined with L-Acetylleucine.
Colchicine	The serum concentration of Colchicine can be increased when it is combined with L-Acetylleucine.
Digitoxin	The serum concentration of Digitoxin can be increased when it is combined with L-Acetylleucine.
Everolimus	The serum concentration of Everolimus can be increased when it is combined with L-Acetylleucine.
Belinostat	The serum concentration of Belinostat can be increased when it is combined with L-Acetylleucine.
Indacaterol	The serum concentration of Indacaterol can be increased when it is combined with L-Acetylleucine.
Cobimetinib	The serum concentration of Cobimetinib can be increased when it is combined with L-Acetylleucine.
Mavorixafor	The excretion of Mavorixafor can be decreased when combined with L-Acetylleucine.
Telaprevir	The serum concentration of Telaprevir can be increased when it is combined with L-Acetylleucine.
Trastuzumab emtansine	The serum concentration of Trastuzumab emtansine can be increased when it is combined with L-Acetylleucine.
Romidepsin	The serum concentration of Romidepsin can be increased when it is combined with L-Acetylleucine.
Silodosin	The excretion of Silodosin can be decreased when combined with L-Acetylleucine.
Tolvaptan	The serum concentration of Tolvaptan can be increased when it is combined with L-Acetylleucine.
Rivaroxaban	The serum concentration of Rivaroxaban can be increased when it is combined with L-Acetylleucine.
Avanafil	The serum concentration of Avanafil can be increased when it is combined with L-Acetylleucine.
Temsirolimus	The serum concentration of Temsirolimus can be increased when it is combined with L-Acetylleucine.
Simeprevir	The serum concentration of Simeprevir can be increased when it is combined with L-Acetylleucine.
Ambrisentan	The serum concentration of Ambrisentan can be increased when it is combined with L-Acetylleucine.
Cethromycin	The serum concentration of Cethromycin can be increased when it is combined with L-Acetylleucine.
Pazopanib	The serum concentration of Pazopanib can be increased when it is combined with L-Acetylleucine.
Panobinostat	The serum concentration of Panobinostat can be increased when it is combined with L-Acetylleucine.
Apixaban	The serum concentration of Apixaban can be increased when it is combined with L-Acetylleucine.
Odanacatib	The serum concentration of Odanacatib can be increased when it is combined with L-Acetylleucine.
Dabigatran etexilate	The serum concentration of Dabigatran etexilate can be increased when it is combined with L-Acetylleucine.
Ticagrelor	The serum concentration of Ticagrelor can be increased when it is combined with L-Acetylleucine.
Crizotinib	The serum concentration of Crizotinib can be increased when it is combined with L-Acetylleucine.
Vemurafenib	The serum concentration of Vemurafenib can be increased when it is combined with L-Acetylleucine.
Linagliptin	The serum concentration of Linagliptin can be increased when it is combined with L-Acetylleucine.
Mirabegron	The serum concentration of Mirabegron can be increased when it is combined with L-Acetylleucine.
Canagliflozin	The serum concentration of Canagliflozin can be increased when it is combined with L-Acetylleucine.
Pomalidomide	The serum concentration of Pomalidomide can be increased when it is combined with L-Acetylleucine.
Dabrafenib	The serum concentration of Dabrafenib can be increased when it is combined with L-Acetylleucine.
Afatinib	The serum concentration of Afatinib can be increased when it is combined with L-Acetylleucine.
Dolutegravir	The serum concentration of Dolutegravir can be increased when it is combined with L-Acetylleucine.
Riociguat	The serum concentration of Riociguat can be increased when it is combined with L-Acetylleucine.
Sofosbuvir	The serum concentration of Sofosbuvir can be increased when it is combined with L-Acetylleucine.
Ledipasvir	The serum concentration of Ledipasvir can be increased when it is combined with L-Acetylleucine.
Idelalisib	The serum concentration of Idelalisib can be increased when it is combined with L-Acetylleucine.
Ceritinib	The serum concentration of Ceritinib can be increased when it is combined with L-Acetylleucine.
Edoxaban	The serum concentration of Edoxaban can be increased when it is combined with L-Acetylleucine.
Umeclidinium	The serum concentration of Umeclidinium can be increased when it is combined with L-Acetylleucine.
Lenvatinib	The serum concentration of Lenvatinib can be increased when it is combined with L-Acetylleucine.
Nintedanib	The serum concentration of Nintedanib can be increased when it is combined with L-Acetylleucine.
Technetium Tc-99m sestamibi	The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with L-Acetylleucine.
Dasabuvir	The serum concentration of Dasabuvir can be increased when it is combined with L-Acetylleucine.
Methylene blue	The serum concentration of Methylene blue can be increased when it is combined with L-Acetylleucine.
Ombitasvir	The serum concentration of Ombitasvir can be increased when it is combined with L-Acetylleucine.
Paritaprevir	The serum concentration of Paritaprevir can be increased when it is combined with L-Acetylleucine.
Osimertinib	The serum concentration of Osimertinib can be increased when it is combined with L-Acetylleucine.
Selexipag	The serum concentration of Selexipag can be increased when it is combined with L-Acetylleucine.
Elbasvir	The serum concentration of Elbasvir can be increased when it is combined with L-Acetylleucine.
Grazoprevir	The serum concentration of Grazoprevir can be increased when it is combined with L-Acetylleucine.
Venetoclax	The serum concentration of Venetoclax can be increased when it is combined with L-Acetylleucine.
Velpatasvir	The serum concentration of Velpatasvir can be increased when it is combined with L-Acetylleucine.
Vinflunine	The serum concentration of Vinflunine can be increased when it is combined with L-Acetylleucine.
Tucatinib	The serum concentration of Tucatinib can be increased when it is combined with L-Acetylleucine.
Selumetinib	The serum concentration of Selumetinib can be increased when it is combined with L-Acetylleucine.
Voclosporin	The serum concentration of Voclosporin can be increased when it is combined with L-Acetylleucine.
Tezacaftor	The serum concentration of Tezacaftor can be increased when it is combined with L-Acetylleucine.
Encorafenib	The serum concentration of Encorafenib can be increased when it is combined with L-Acetylleucine.
Lasmiditan	The serum concentration of Lasmiditan can be increased when it is combined with L-Acetylleucine.

Referensi & Sumber

Synthesis reference: H. D. DeWitt and A. W. Ingersoll. The Preparation of Pure N-Acetyl-L-leucine and L-Leucine. Journal of the American Chemical Society 1951 73 (7), 3359-3360. DOI: 10.1021/ja01151a108

Artikel (PubMed)

PMID: 38294974
Bremova-Ertl T, Ramaswami U, Brands M, Foltan T, Gautschi M, Gissen P, Gowing F, Hahn A, Jones S, Kay R, Kolnikova M, Arash-Kaps L, Marquardt T, Mengel E, Park JH, Reichmannova S, Schneider SA, Sivananthan S, Walterfang M, Wibawa P, Strupp M, Martakis K: Trial of N-Acetyl-l-Leucine in Niemann-Pick Disease Type C. N Engl J Med. 2024 Feb 1;390(5):421-431. doi: 10.1056/NEJMoa2310151.
PMID: 37248494
Fields T, M Bremova T, Billington I, Churchill GC, Evans W, Fields C, Galione A, Kay R, Mathieson T, Martakis K, Patterson M, Platt F, Factor M, Strupp M: N-acetyl-L-leucine for Niemann-Pick type C: a multinational double-blind randomized placebo-controlled crossover study. Trials. 2023 May 29;24(1):361. doi: 10.1186/s13063-023-07399-6.

Link

Contoh Produk & Brand

Produk: 2 • International brands: 0

Produk

Aqneursa

Granule, for suspension • 1000 mg/1 • Oral • US • Approved
Brand name

Granule, for solution • 1000 mg/1 • Oral • US

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.