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Total database: 17430
Struktur (SMILES)
50 (75.8%)
Target
39 (59.1%)
Genomik
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Referensi
66 (100.0%)

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Hasil Pencarian (66)

Halaman 1 / 2
small molecule

Deskripsi belum tersedia.

Target Protein:
Peptidyl-prolyl cis-trans isomerase FKBP1A
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small molecule

Deskripsi belum tersedia.

Target Protein:
Polyubiquitin-B
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small molecule

Deskripsi belum tersedia.

Target Protein:
Amidophosphoribosyltransferase
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small molecule | CAS: 157-03-9

6-diazo-5-oxo-L-norleucine is a broad-acting glutamine antagonist.

Kategori:
Amino AcidsAmino Acids, Peptides, and ProteinsAminocaproates +7
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small molecule

Deskripsi belum tersedia.

Target Protein:
L-asparaginase
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small molecule | CAS: 6033-32-5

Deskripsi belum tersedia.

Kategori:
Amino AcidsAmino Acids, Peptides, and ProteinsAminocaproates
Target Protein:
L-asparaginase
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small molecule | CAS: 143205-42-9

9-(N-methyl-L-isoleucine)-cyclosporin A (NIM811) has been used in trials studying the treatment of Chronic Hepatitis C Genotype-1 Relapse.

Kategori:
Amino Acids, Peptides, and ProteinsCyclosporinsImmunosuppressive Agents +2
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A-16L DB18270
biotech | CAS: 410527-75-2

Deskripsi belum tersedia.

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Acetylleucine DB13226
small molecule | CAS: 99-15-0

Used for treating vestibular-related imbalance and vertigo.

Kategori:
Amino AcidsAmino Acids, Branched-ChainAmino Acids, Peptides, and Proteins +2
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small molecule | CAS: 110044-82-1

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsCysteine Proteinase InhibitorsEnzyme Inhibitors +4
Target Protein:
Proteasome subunit alpha type-7
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Aclerastide DB12631
small molecule | CAS: 227803-63-6

Aclerastide has been investigated for the treatment of Diabetic Foot, Diabetic Foot Ulcers, and Foot Ulcer, Diabetic.

Kategori:
Amino Acids, Peptides, and ProteinsAngiotensinsAutacoids +10
Target Protein:
Proto-oncogene Mas
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Adegramotide DB17248
small molecule | CAS: 1252802-98-4

Deskripsi belum tersedia.

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Allysine DB02571
small molecule | CAS: 6665-12-9

Deskripsi belum tersedia.

Kategori:
Acids, AcyclicAdipatesAmino Acids +3
Target Protein:
Glutaminase-asparaginase
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small molecule | CAS: 24809-08-3

Deskripsi belum tersedia.

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small molecule | CAS: 816-66-0

Deskripsi belum tersedia.

Kategori:
Caproates
Target Protein:
Deacetoxycephalosporin C synthaseD-2-hydroxyisocaproate dehydrogenase
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small molecule | CAS: 105743-53-1

Deskripsi belum tersedia.

Target Protein:
Branched-chain-amino-acid aminotransferase
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Angiotensin II Approved DB11842
biotech | CAS: 4474-91-3

Angiotensin II is under investigation for the treatment of Sepsis, Septic Shock, Diabetes Mellitus, and Acute Renal Failure. Angiotensin II has been investigated for the treatment, basic science, and diagnostic of Hypertension, Renin Angiotensin System, and I…

Kategori:
Amino Acids, Peptides, and ProteinsAngiotensin II, antagonists & inhibitorsAngiotensins +16
Target Protein:
Type-2 angiotensin II receptorType-1 angiotensin II receptor
Waktu ParuhThe plasma half-lif…
Vol. DistribusiThe official prescr…
KlirensThe official prescr…
Genetik -
Beludavimab DB18952
biotech | CAS: 2423016-74-2

Beludavimab is under investigation in clinical trial NCT04746183 (AGILE (Early Phase Platform Trial for COVID-19)).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesBlood Proteins +5
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small molecule

Deskripsi belum tersedia.

Kategori:
Amino AcidsAmino Acids, Branched-ChainAmino Acids, Peptides, and Proteins
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BQ-788 DB17984
small molecule | CAS: 156161-89-6

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsAntihypertensive AgentsCardiovascular Agents +3
Target Protein:
Endothelin receptor type B
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CDX-6210 DB17610
biotech

CDX-6210 is a modified version of a leucine decarboxylase enzyme from _Planctomycetaceae bacterium_.

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CDX-6512 DB17841
biotech

CDX-6512 is a modified, gastrointestinal-stable bacterial leucine decarboxylase. Developed by Codexis, it is being investigated for the treatment of homocystinuria And Maple Syrup Urine Disease.[L46651, L46656]

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Cycloleucine DB04620
small molecule | CAS: 52-52-8

Cycloleucine is non-metabolisable amino acid formed by cyclization of leucine. It is also a specific and reversible inhibitor of nucleic acid methylation and widely used in biochemical experiments.

Kategori:
Amino AcidsAmino Acids, CyclicAmino Acids, Peptides, and Proteins +2
Target Protein:
Glutamate receptor ionotropic, NMDA 1
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D-Leucine DB01746
small molecule | CAS: 328-38-1

An essential branched-chain amino acid important for hemoglobin formation. [PubChem]

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D-norleucine DB04419
small molecule | CAS: 327-56-0

An unnatural amino acid that is used experimentally to study protein structure and function. It is structurally similar to METHIONINE, however it does not contain SULFUR.

Target Protein:
Phenylalanine-4-hydroxylaseParathyroid hormoneHepatocyte nuclear factor 1-alpha
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DADLE DB08856
small molecule | CAS: 63631-40-3

A delta-selective opioid (ANALGESICS, OPIOID). It can cause transient depression of mean arterial blood pressure and heart rate.

Kategori:
Amino Acids, Peptides, and ProteinsEnkephalin, LeucineEnkephalins +5
Target Protein:
Delta-type opioid receptorMu-type opioid receptor
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Genetik -
biotech | CAS: 2061938-98-3

Deskripsi belum tersedia.

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Dihydro-alpha-ergocryptine Approved DB11274
small molecule | CAS: 25447-66-9

Alpha-dihydroergocryptine is usually referred to the mixture of the alpha and beta dihydroergocryptine. These two compounds are differentiated in the position of a methyl group. This structural difference is due to a proteinogenic amino acid replacement from …

Kategori:
Cytochrome P-450 CYP3A SubstratesCytochrome P-450 CYP3A4 SubstratesCytochrome P-450 Substrates
Target Protein:
5-hydroxytryptamine receptor 75-hydroxytryptamine receptor 2BD(2) dopamine receptor +2
Waktu ParuhAlpha-dihydroergocr…
Vol. DistribusiIn preclinical stud…
KlirensIn preclinical stud…
Genetik -
DS-1211 DB17837
small molecule | CAS: 19764-30-8

DS-1211 is a potent and selective novel small molecule tissue-nonspecific alkaline phosphatase (TNAP) inhibitor.[A259786]

Target Protein:
Alkaline phosphatase, tissue-nonspecific isozyme
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Fluciclovine (18F) Approved DB13146
small molecule | CAS: 222727-39-1

Fluciclovine is a [18F]-tagged synthetic analog of the amino acid L-leucine. It presents excellent diagnostic properties to be used in positron emission tomography (PET) imaging.[A31384] The structure of fluciclovine allows it to be uptaken by the tumoral cel…

Kategori:
CycloparaffinsDiagnostic RadiopharmaceuticalsPositron Emitting Activity +2
Target Protein:
Neutral amino acid transporter B(0)Y+L amino acid transporter 1Cationic amino acid transporter 3 +5
Waktu ParuhFluciclovine is a c…
Vol. DistribusiThe compartmental v…
KlirensFluciclovine renal …
Genetik -
Furoyl-Leucine DB02215
small molecule

Deskripsi belum tersedia.

Target Protein:
Disintegrin and metalloproteinase domain-containing protein 28
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Isoleucine DB00167
small molecule | CAS: 73-32-5

An essential branched-chain aliphatic amino acid found in many proteins. It is an isomer of leucine. It is important in hemoglobin synthesis and regulation of blood sugar and energy levels.

Kategori:
Amino AcidsAmino Acids, Branched-ChainAmino Acids, Essential +4
Target Protein:
Short/branched chain specific acyl-CoA dehydrogenase, mitochondrialBranched-chain-amino-acid aminotransferase, cytosolicBranched-chain-amino-acid aminotransferase, mitochondrial +2
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L-Acetylleucine Approved DB16956
small molecule | CAS: 1188-21-2

Levacetylleucine (L-acetylleucine) is a modified acetylated derivative of the amino acid [leucine]. The racemic (i.e. DL-) form has been available in France since 1957 for the treatment of vertigo.[A264439] Observational studies in patients with Niemann-Pi…

Kategori:
Amino AcidsAmino Acids, Branched-ChainAmino Acids, Essential +7
Waktu ParuhThe half-life of le…
Vol. DistribusiThe apparent volume…
KlirensThe apparent oral c…
Genetik -
small molecule | CAS: 1509-34-8

Deskripsi belum tersedia.

Kategori:
Amino AcidsAmino Acids, Branched-ChainAmino Acids, Peptides, and Proteins
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Lepirudin Approved DB00001
biotech | CAS: 138068-37-8

Lepirudin is a recombinant hirudin formed by 65 amino acids that acts as a highly specific and direct thrombin inhibitor.[L41539,L41569] Natural hirudin is an endogenous anticoagulant found in _Hirudo medicinalis_ leeches.[L41539] Lepirudin is produced in yea…

Kategori:
Amino Acids, Peptides, and ProteinsAnticoagulantsAntithrombin Proteins +12
Target Protein:
Prothrombin
Waktu ParuhLepirudin has an in…
Vol. DistribusiThe volume of distr…
KlirensThe clearance of le…
Genetik -
Leucine DB00149
small molecule | CAS: 61-90-5

An essential branched-chain amino acid important for hemoglobin formation.

Kategori:
Amino AcidsAmino Acids, Branched-ChainAmino Acids, Essential +4
Target Protein:
Leucine--tRNA ligase, mitochondrialtRNA wybutosine-synthesizing protein 4Leucine carboxyl methyltransferase 1 +3
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small molecule

Deskripsi belum tersedia.

Target Protein:
Serine protease inhibitor Kazal-type 6
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small molecule

Deskripsi belum tersedia.

Kategori:
Amino AcidsAmino Acids, Branched-ChainAmino Acids, Peptides, and Proteins +1
Target Protein:
Bacterial leucyl aminopeptidaseCytosol aminopeptidase
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LM-030 DB18283
small molecule | CAS: 1122484-55-2

Deskripsi belum tersedia.

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Lucinactant Approved DB04897
biotech | CAS: 825600-90-6

Lucinactant is a new synthetic peptide-containing surfactant for intratracheal use. It contains sinapultide, a novel, hydrophobic, 21-amino acid peptide (leucine and lysine repeating units, KL4 peptide) designed to mimic human surfactant protein-B (SB-P). Mor…

Kategori:
AlcoholsAmino Acids, Peptides, and ProteinsBiological Factors +11
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Lysine Approved DB00123
small molecule | CAS: 56-87-1

Lysine (abbreviated as Lys or K) is an ?-amino acid with the chemical formula HO2CCH(NH2)(CH2)4NH2. This amino acid is an essential amino acid, which means that humans cannot synthesize it. Its codons are AAA and AAG. Lysine is a base, as are arginine and his…

Kategori:
Amino AcidsAmino Acids, BasicAmino Acids, Diamino +10
Target Protein:
High affinity cationic amino acid transporter 1Cationic amino acid transporter 4Cationic amino acid transporter 3 +2
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Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Proteasome subunit betaProteasome subunit alpha
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small molecule

Deskripsi belum tersedia.

Target Protein:
Macrophage metalloelastase
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small molecule

Deskripsi belum tersedia.

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N-Methylleucine DB04487
small molecule | CAS: 31321-74-1

Deskripsi belum tersedia.

Target Protein:
C-X-C motif chemokine 10
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small molecule

Deskripsi belum tersedia.

Target Protein:
Bifunctional cytochrome P450/NADPH--P450 reductase
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Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Branched-chain-amino-acid aminotransferase, mitochondrial
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small molecule

Deskripsi belum tersedia.

Target Protein:
Cathepsin B
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small molecule

Deskripsi belum tersedia.

Target Protein:
Cathepsin B
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