The oral LD50 of umbralisib in rats is 3320 mg/kg.L31898 Overdose information is not readily available on prescribing information L31878 or the literature. In any overdose, supportive and symptomatic treatment should be provided as required.
Marginal zone lymphoma is a rare, slowly progressing type of non-Hodgkin lymphoma initially treated with rituximab (an anti-CD20 drug), either alone or in combination with chemotherapy. Unfortunately, many patients experience a relapse or develop resistance to these drugs. Treatment options then become limited, and alternate treatments for the lymphoma are required to control disease progression.A229363 Follicular lymphoma is also treated with rituximab and other chemotherapeutic agents, but may show similar progression.A229668
On February 5, 2021, the Food and Drug Administration granted accelerated approval to umbralisib, a kinase inhibitor for PI3K-delta and casein kinase CK1-epsilon, based on promising results from clinical trials. It was marketed as Ukoniq by TG Therapeutics and has been approved for the treatment of relapsing and refractory marginal cell lymphoma and follicular lymphoma in adults.L31863 Umbralisib inhibits casein kinase, a primary regulator of protein translation, kinase-1?, distinguishing it from other lymphoma treatments. While it initially offered a promising therapy for patients experiencing relapsing or refractory disease,A229363 umbralisib was withdrawn from the market due to safety concerns as the drug was associated with a possible increased risk of death outweighing the benefits.L41930
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Afatinib | The serum concentration of Afatinib can be increased when it is combined with Umbralisib. |
| Bosutinib | The serum concentration of Bosutinib can be increased when it is combined with Umbralisib. |
| Brentuximab vedotin | The serum concentration of Brentuximab vedotin can be increased when it is combined with Umbralisib. |
| Colchicine | The serum concentration of Colchicine can be increased when it is combined with Umbralisib. |
| Edoxaban | The serum concentration of Edoxaban can be increased when it is combined with Umbralisib. |
| Ledipasvir | The serum concentration of Ledipasvir can be increased when it is combined with Umbralisib. |
| Naloxegol | The serum concentration of Naloxegol can be increased when it is combined with Umbralisib. |
| Pazopanib | The serum concentration of Pazopanib can be increased when it is combined with Umbralisib. |
| Prucalopride | The serum concentration of Prucalopride can be increased when it is combined with Umbralisib. |
| Ranolazine | The serum concentration of Ranolazine can be increased when it is combined with Umbralisib. |
| Silodosin | The excretion of Silodosin can be decreased when combined with Umbralisib. |
| Topotecan | The serum concentration of Topotecan can be increased when it is combined with Umbralisib. |
| Everolimus | The serum concentration of Everolimus can be increased when it is combined with Umbralisib. |
| Rifaximin | The serum concentration of Rifaximin can be increased when it is combined with Umbralisib. |
| Vincristine | The excretion of Vincristine can be decreased when combined with Umbralisib. |
| Doxorubicin | The serum concentration of Doxorubicin can be increased when it is combined with Umbralisib. |
| Betrixaban | The serum concentration of Betrixaban can be increased when it is combined with Umbralisib. |
| Pravastatin | The serum concentration of Pravastatin can be increased when it is combined with Umbralisib. |
| Sildenafil | The serum concentration of Sildenafil can be increased when it is combined with Umbralisib. |
| Morphine | The serum concentration of Morphine can be increased when it is combined with Umbralisib. |
| Tenofovir disoproxil | The serum concentration of Tenofovir disoproxil can be increased when it is combined with Umbralisib. |
| Clobazam | The serum concentration of Clobazam can be increased when it is combined with Umbralisib. |
| Mefloquine | The serum concentration of Mefloquine can be increased when it is combined with Umbralisib. |
| Quinine | The serum concentration of Quinine can be increased when it is combined with Umbralisib. |
| Toremifene | The serum concentration of Toremifene can be increased when it is combined with Umbralisib. |
| Bisoprolol | The serum concentration of Bisoprolol can be increased when it is combined with Umbralisib. |
| Simvastatin | The serum concentration of Simvastatin can be increased when it is combined with Umbralisib. |
| Mannitol | The serum concentration of Mannitol can be increased when it is combined with Umbralisib. |
| Loperamide | The excretion of Loperamide can be decreased when combined with Umbralisib. |
| Vardenafil | The serum concentration of Vardenafil can be increased when it is combined with Umbralisib. |
| Clomifene | The serum concentration of Clomifene can be increased when it is combined with Umbralisib. |
| Tipranavir | The serum concentration of Tipranavir can be increased when it is combined with Umbralisib. |
| Fexofenadine | The serum concentration of Fexofenadine can be increased when it is combined with Umbralisib. |
| Tegaserod | The serum concentration of Tegaserod can be increased when it is combined with Umbralisib. |
| Saquinavir | The serum concentration of Saquinavir can be increased when it is combined with Umbralisib. |
| Sitagliptin | The serum concentration of Sitagliptin can be increased when it is combined with Umbralisib. |
| Posaconazole | The serum concentration of Posaconazole can be increased when it is combined with Umbralisib. |
| Darunavir | The serum concentration of Darunavir can be increased when it is combined with Umbralisib. |
| Paliperidone | The serum concentration of Paliperidone can be increased when it is combined with Umbralisib. |
| Mibefradil | The serum concentration of Mibefradil can be increased when it is combined with Umbralisib. |
| Belinostat | The serum concentration of Belinostat can be increased when it is combined with Umbralisib. |
| Indacaterol | The serum concentration of Indacaterol can be increased when it is combined with Umbralisib. |
| Telaprevir | The serum concentration of Telaprevir can be increased when it is combined with Umbralisib. |
| Rivaroxaban | The serum concentration of Rivaroxaban can be increased when it is combined with Umbralisib. |
| Simeprevir | The serum concentration of Simeprevir can be increased when it is combined with Umbralisib. |
| Ambrisentan | The serum concentration of Ambrisentan can be increased when it is combined with Umbralisib. |
| Cethromycin | The serum concentration of Cethromycin can be increased when it is combined with Umbralisib. |
| Apixaban | The serum concentration of Apixaban can be increased when it is combined with Umbralisib. |
| Odanacatib | The serum concentration of Odanacatib can be increased when it is combined with Umbralisib. |
| Ticagrelor | The serum concentration of Ticagrelor can be increased when it is combined with Umbralisib. |
| Linagliptin | The serum concentration of Linagliptin can be increased when it is combined with Umbralisib. |
| Mirabegron | The serum concentration of Mirabegron can be increased when it is combined with Umbralisib. |
| Canagliflozin | The serum concentration of Canagliflozin can be increased when it is combined with Umbralisib. |
| Dolutegravir | The serum concentration of Dolutegravir can be increased when it is combined with Umbralisib. |
| Sofosbuvir | The serum concentration of Sofosbuvir can be increased when it is combined with Umbralisib. |
| Idelalisib | The serum concentration of Idelalisib can be increased when it is combined with Umbralisib. |
| Umeclidinium | The serum concentration of Umeclidinium can be increased when it is combined with Umbralisib. |
| Lenvatinib | The serum concentration of Lenvatinib can be increased when it is combined with Umbralisib. |
| Nintedanib | The serum concentration of Nintedanib can be increased when it is combined with Umbralisib. |
| Technetium Tc-99m sestamibi | The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Umbralisib. |
| Dasabuvir | The serum concentration of Dasabuvir can be increased when it is combined with Umbralisib. |
| Methylene blue | The serum concentration of Methylene blue can be increased when it is combined with Umbralisib. |
| Ombitasvir | The serum concentration of Ombitasvir can be increased when it is combined with Umbralisib. |
| Paritaprevir | The serum concentration of Paritaprevir can be increased when it is combined with Umbralisib. |
| Selexipag | The serum concentration of Selexipag can be increased when it is combined with Umbralisib. |
| Elbasvir | The serum concentration of Elbasvir can be increased when it is combined with Umbralisib. |
| Grazoprevir | The serum concentration of Grazoprevir can be increased when it is combined with Umbralisib. |
| Velpatasvir | The serum concentration of Velpatasvir can be increased when it is combined with Umbralisib. |
| Tucatinib | The serum concentration of Tucatinib can be increased when it is combined with Umbralisib. |
| Selumetinib | The serum concentration of Selumetinib can be increased when it is combined with Umbralisib. |
| Voclosporin | The serum concentration of Voclosporin can be increased when it is combined with Umbralisib. |
| Tezacaftor | The serum concentration of Tezacaftor can be increased when it is combined with Umbralisib. |
| Lasmiditan | The serum concentration of Lasmiditan can be increased when it is combined with Umbralisib. |
| Talinolol | The serum concentration of Talinolol can be increased when it is combined with Umbralisib. |
| Fostemsavir | The serum concentration of Fostemsavir can be increased when it is combined with Umbralisib. |
| Revefenacin | The serum concentration of Revefenacin can be increased when it is combined with Umbralisib. |
| Valspodar | The serum concentration of Valspodar can be increased when it is combined with Umbralisib. |
| Lemborexant | The serum concentration of Lemborexant can be increased when it is combined with Umbralisib. |
| Duvelisib | The serum concentration of Duvelisib can be increased when it is combined with Umbralisib. |
| Glasdegib | The serum concentration of Glasdegib can be increased when it is combined with Umbralisib. |
| Elagolix | The serum concentration of Elagolix can be increased when it is combined with Umbralisib. |
| Voxilaprevir | The serum concentration of Voxilaprevir can be increased when it is combined with Umbralisib. |
| Gilteritinib | The serum concentration of Gilteritinib can be increased when it is combined with Umbralisib. |
| Omadacycline | The serum concentration of Omadacycline can be increased when it is combined with Umbralisib. |
| Fedratinib | The serum concentration of Fedratinib can be increased when it is combined with Umbralisib. |
| Grapiprant | The serum concentration of Grapiprant can be increased when it is combined with Umbralisib. |
| Tazemetostat | The serum concentration of Tazemetostat can be increased when it is combined with Umbralisib. |
| Darolutamide | The serum concentration of Darolutamide can be increased when it is combined with Umbralisib. |
| Enfortumab vedotin | The serum concentration of Enfortumab vedotin can be increased when it is combined with Umbralisib. |
| Lusutrombopag | The serum concentration of Lusutrombopag can be increased when it is combined with Umbralisib. |
| Pibrentasvir | The serum concentration of Pibrentasvir can be increased when it is combined with Umbralisib. |
| Glecaprevir | The serum concentration of Glecaprevir can be increased when it is combined with Umbralisib. |
| Tenofovir | The serum concentration of Tenofovir can be increased when it is combined with Umbralisib. |
| Prednisolone phosphate | The serum concentration of Prednisolone phosphate can be increased when it is combined with Umbralisib. |
| Ripretinib | The serum concentration of Ripretinib can be increased when it is combined with Umbralisib. |
| Belantamab mafodotin | The serum concentration of Belantamab mafodotin can be increased when it is combined with Umbralisib. |
| Trilaciclib | The serum concentration of Trilaciclib can be increased when it is combined with Umbralisib. |
| Daptomycin | The serum concentration of Daptomycin can be increased when it is combined with Umbralisib. |
| Avanafil | The serum concentration of Avanafil can be increased when it is combined with Umbralisib. |
| Tivozanib | The serum concentration of Tivozanib can be increased when it is combined with Umbralisib. |