Imetelstat is a first-in-class 18-amino acid oligonucleotide that directly and competitively inhibits human telomerase.A263973 It is used to treat anemia in patients with myelodysplastic syndromes (MDS), a group of hematologic disorders characterized by ineffective hematopoiesis, peripheral cytopenia, abnormal marrow cell morphology and a risk for transformation to acute myeloid leukemia.A187838 Standard therapy for anemia in patients with MDS involves the use of erythropoiesis-stimulating agents (e.g. erythropoietin), but primary resistance to these agents is frequent - the median response duration is 18 to 24 months, with most responders (70%) relapsing due to loss of sensitivity of erythroid progenitors to ESAs.A187838
Imetelstat received FDA approval in June 2024 for use in certain patients with MDS who have transfusion-dependent anemia and are unable to use ESAs.L50883,L50888
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Darbepoetin alfa | The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Imetelstat. |
| Erythropoietin | The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Imetelstat. |
| Peginesatide | The risk or severity of Thrombosis can be increased when Peginesatide is combined with Imetelstat. |
| Methoxy polyethylene glycol-epoetin beta | The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Imetelstat. |
| Lidocaine | The risk or severity of methemoglobinemia can be increased when Imetelstat is combined with Lidocaine. |
| Ropivacaine | The risk or severity of methemoglobinemia can be increased when Imetelstat is combined with Ropivacaine. |
| Bupivacaine | The risk or severity of methemoglobinemia can be increased when Imetelstat is combined with Bupivacaine. |
| Cinchocaine | The risk or severity of methemoglobinemia can be increased when Imetelstat is combined with Cinchocaine. |
| Dyclonine | The risk or severity of methemoglobinemia can be increased when Imetelstat is combined with Dyclonine. |
| Procaine | The risk or severity of methemoglobinemia can be increased when Imetelstat is combined with Procaine. |
| Prilocaine | The risk or severity of methemoglobinemia can be increased when Imetelstat is combined with Prilocaine. |
| Proparacaine | The risk or severity of methemoglobinemia can be increased when Imetelstat is combined with Proparacaine. |
| Meloxicam | The risk or severity of methemoglobinemia can be increased when Imetelstat is combined with Meloxicam. |
| Oxybuprocaine | The risk or severity of methemoglobinemia can be increased when Imetelstat is combined with Oxybuprocaine. |
| Cocaine | The risk or severity of methemoglobinemia can be increased when Imetelstat is combined with Cocaine. |
| Mepivacaine | The risk or severity of methemoglobinemia can be increased when Imetelstat is combined with Mepivacaine. |
| Levobupivacaine | The risk or severity of methemoglobinemia can be increased when Imetelstat is combined with Levobupivacaine. |
| Diphenhydramine | The risk or severity of methemoglobinemia can be increased when Imetelstat is combined with Diphenhydramine. |
| Benzocaine | The risk or severity of methemoglobinemia can be increased when Imetelstat is combined with Benzocaine. |
| Chloroprocaine | The risk or severity of methemoglobinemia can be increased when Imetelstat is combined with Chloroprocaine. |
| Phenol | The risk or severity of methemoglobinemia can be increased when Imetelstat is combined with Phenol. |
| Tetrodotoxin | The risk or severity of methemoglobinemia can be increased when Imetelstat is combined with Tetrodotoxin. |
| Ambroxol | The risk or severity of methemoglobinemia can be increased when Imetelstat is combined with Ambroxol. |
| Benzyl alcohol | The risk or severity of methemoglobinemia can be increased when Imetelstat is combined with Benzyl alcohol. |
| Capsaicin | The risk or severity of methemoglobinemia can be increased when Imetelstat is combined with Capsaicin. |
| Etidocaine | The risk or severity of methemoglobinemia can be increased when Imetelstat is combined with Etidocaine. |
| Articaine | The risk or severity of methemoglobinemia can be increased when Imetelstat is combined with Articaine. |
| Tetracaine | The risk or severity of methemoglobinemia can be increased when Imetelstat is combined with Tetracaine. |
| Propoxycaine | The risk or severity of methemoglobinemia can be increased when Imetelstat is combined with Propoxycaine. |
| Pramocaine | The risk or severity of methemoglobinemia can be increased when Imetelstat is combined with Pramocaine. |
| Butamben | The risk or severity of methemoglobinemia can be increased when Imetelstat is combined with Butamben. |
| Butacaine | The risk or severity of methemoglobinemia can be increased when Imetelstat is combined with Butacaine. |
| Oxetacaine | The risk or severity of methemoglobinemia can be increased when Imetelstat is combined with Oxetacaine. |
| Ethyl chloride | The risk or severity of methemoglobinemia can be increased when Imetelstat is combined with Ethyl chloride. |
| Butanilicaine | The risk or severity of methemoglobinemia can be increased when Imetelstat is combined with Butanilicaine. |
| Metabutethamine | The risk or severity of methemoglobinemia can be increased when Imetelstat is combined with Metabutethamine. |
| Quinisocaine | The risk or severity of methemoglobinemia can be increased when Imetelstat is combined with Quinisocaine. |
| Etrasimod | The risk or severity of immunosuppression can be increased when Imetelstat is combined with Etrasimod. |
| Eluxadoline | The serum concentration of Eluxadoline can be increased when it is combined with Imetelstat. |
| Pravastatin | The serum concentration of Pravastatin can be increased when it is combined with Imetelstat. |
| Valsartan | The serum concentration of Valsartan can be increased when it is combined with Imetelstat. |
| Erythromycin | The serum concentration of Erythromycin can be increased when it is combined with Imetelstat. |
| Torasemide | The serum concentration of Torasemide can be increased when it is combined with Imetelstat. |
| Mesalazine | The serum concentration of Mesalazine can be increased when it is combined with Imetelstat. |
| Liothyronine | The serum concentration of Liothyronine can be increased when it is combined with Imetelstat. |
| Conjugated estrogens | The serum concentration of Conjugated estrogens can be increased when it is combined with Imetelstat. |
| Digoxin | The serum concentration of Digoxin can be increased when it is combined with Imetelstat. |
| Cerivastatin | The serum concentration of Cerivastatin can be increased when it is combined with Imetelstat. |
| Raloxifene | The serum concentration of Raloxifene can be increased when it is combined with Imetelstat. |
| Caspofungin | The serum concentration of Caspofungin can be increased when it is combined with Imetelstat. |
| Bosentan | The serum concentration of Bosentan can be increased when it is combined with Imetelstat. |
| Methotrexate | The serum concentration of Methotrexate can be increased when it is combined with Imetelstat. |
| Enalapril | The serum concentration of Enalapril can be increased when it is combined with Imetelstat. |
| Simvastatin | The serum concentration of Simvastatin can be increased when it is combined with Imetelstat. |
| Sumatriptan | The serum concentration of Sumatriptan can be increased when it is combined with Imetelstat. |
| Mycophenolate mofetil | The serum concentration of Mycophenolate mofetil can be increased when it is combined with Imetelstat. |
| Penicillamine | The serum concentration of Penicillamine can be increased when it is combined with Imetelstat. |
| Repaglinide | The serum concentration of Repaglinide can be increased when it is combined with Imetelstat. |
| Dinoprostone | The serum concentration of Dinoprostone can be increased when it is combined with Imetelstat. |
| Fexofenadine | The serum concentration of Fexofenadine can be increased when it is combined with Imetelstat. |
| Ezetimibe | The serum concentration of Ezetimibe can be increased when it is combined with Imetelstat. |
| Benzylpenicillin | The serum concentration of Benzylpenicillin can be increased when it is combined with Imetelstat. |
| Atorvastatin | The serum concentration of Atorvastatin can be increased when it is combined with Imetelstat. |
| Ouabain | The serum concentration of Ouabain can be increased when it is combined with Imetelstat. |
| Fluvastatin | The serum concentration of Fluvastatin can be increased when it is combined with Imetelstat. |
| Rosuvastatin | The serum concentration of Rosuvastatin can be increased when it is combined with Imetelstat. |
| Liotrix | The serum concentration of Liotrix can be increased when it is combined with Imetelstat. |
| Cholic Acid | The serum concentration of Cholic Acid can be increased when it is combined with Imetelstat. |
| Taurocholic acid | The serum concentration of Taurocholic acid can be increased when it is combined with Imetelstat. |
| Atrasentan | The serum concentration of Atrasentan can be increased when it is combined with Imetelstat. |
| Simeprevir | The serum concentration of Simeprevir can be increased when it is combined with Imetelstat. |
| Ambrisentan | The serum concentration of Ambrisentan can be increased when it is combined with Imetelstat. |
| Axitinib | The serum concentration of Axitinib can be increased when it is combined with Imetelstat. |
| Gimatecan | The serum concentration of Gimatecan can be increased when it is combined with Imetelstat. |
| Temocapril | The serum concentration of Temocapril can be increased when it is combined with Imetelstat. |
| Cholecystokinin | The serum concentration of Cholecystokinin can be increased when it is combined with Imetelstat. |
| Gadoxetic acid | The serum concentration of Gadoxetic acid can be increased when it is combined with Imetelstat. |
| Technetium Tc-99m mebrofenin | The serum concentration of Technetium Tc-99m mebrofenin can be increased when it is combined with Imetelstat. |
| Fimasartan | The serum concentration of Fimasartan can be increased when it is combined with Imetelstat. |
| Paritaprevir | The serum concentration of Paritaprevir can be increased when it is combined with Imetelstat. |
| Tenofovir alafenamide | The serum concentration of Tenofovir alafenamide can be increased when it is combined with Imetelstat. |
| Selexipag | The serum concentration of Selexipag can be increased when it is combined with Imetelstat. |
| Grazoprevir | The serum concentration of Grazoprevir can be increased when it is combined with Imetelstat. |
| Asunaprevir | The serum concentration of Asunaprevir can be increased when it is combined with Imetelstat. |
| Tezacaftor | The serum concentration of Tezacaftor can be increased when it is combined with Imetelstat. |
| Momelotinib | The serum concentration of Momelotinib can be increased when it is combined with Imetelstat. |
| Revefenacin | Imetelstat may decrease the excretion rate of Revefenacin which could result in a higher serum level. |
| Elagolix | The serum concentration of Elagolix can be increased when it is combined with Imetelstat. |
| Voxilaprevir | The serum concentration of Voxilaprevir can be increased when it is combined with Imetelstat. |
| Letermovir | The serum concentration of Letermovir can be increased when it is combined with Imetelstat. |
| Brincidofovir | The serum concentration of Brincidofovir can be increased when it is combined with Imetelstat. |
| Resmetirom | The serum concentration of Resmetirom can be increased when it is combined with Imetelstat. |
| Levosalbutamol | The serum concentration of Levosalbutamol can be increased when it is combined with Imetelstat. |
| Glecaprevir | The serum concentration of Glecaprevir can be increased when it is combined with Imetelstat. |
| Belantamab mafodotin | The serum concentration of Belantamab mafodotin can be increased when it is combined with Imetelstat. |
| Atogepant | The serum concentration of Atogepant can be increased when it is combined with Imetelstat. |
| Testosterone | The serum concentration of Testosterone can be increased when it is combined with Imetelstat. |
| Paclitaxel | The serum concentration of Paclitaxel can be increased when it is combined with Imetelstat. |
| Docetaxel | The serum concentration of Docetaxel can be increased when it is combined with Imetelstat. |
| Sincalide | The serum concentration of Sincalide can be increased when it is combined with Imetelstat. |