Commonly known as decadron, dexamethasone acetate is a glucocorticosteroid previously marketed in the USA for the treatment of inflammatory respiratory, allergic, autoimmune, and other conditions.T797,L10695,L14348 Developed in 1957, dexamethasone is structurally similar to other corticosteroids such as hydrocortisone and prednisolone.A188724 Dexamethasone acetate has largely been replaced by dexamethasone phosphate and continues to be administered for a large variety of inflammatory conditions.L10701
Recently, dexamethasone has been a drug of interest in the treatment of COVID-19. In a June 16 2020 press release highlighting early results of a clinical trial, Randomized Evaluation of COVID-19 Therapy (RECOVERY), it was reported that dexamethasone reduced COVID-19 deaths by approximately one-fifth and one-third in patients on oxygen therapy and mechanical ventilation, respectively. Dexamethasone was therefore recommended as a life-saving treatment for COVID-19 patients experiencing severe respiratory symptoms.L14318
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Aripiprazole | The metabolism of Aripiprazole can be increased when combined with Dexamethasone acetate. |
| Aripiprazole lauroxil | The metabolism of Aripiprazole lauroxil can be increased when combined with Dexamethasone acetate. |
| Afatinib | The serum concentration of Afatinib can be decreased when it is combined with Dexamethasone acetate. |
| Brentuximab vedotin | The serum concentration of Brentuximab vedotin can be decreased when it is combined with Dexamethasone acetate. |
| Dabigatran etexilate | The serum concentration of Dabigatran etexilate can be decreased when it is combined with Dexamethasone acetate. |
| Linagliptin | The serum concentration of Linagliptin can be decreased when it is combined with Dexamethasone acetate. |
| Paliperidone | The serum concentration of Paliperidone can be decreased when it is combined with Dexamethasone acetate. |
| Sofosbuvir | The serum concentration of Sofosbuvir can be decreased when it is combined with Dexamethasone acetate. |
| Daclatasvir | The metabolism of Daclatasvir can be increased when combined with Dexamethasone acetate. |
| Aspartame | The excretion of Dexamethasone acetate can be decreased when combined with Aspartame. |
| Pravastatin | The excretion of Dexamethasone acetate can be decreased when combined with Pravastatin. |
| Pantoprazole | The excretion of Dexamethasone acetate can be decreased when combined with Pantoprazole. |
| Cefotiam | The excretion of Dexamethasone acetate can be decreased when combined with Cefotiam. |
| Liothyronine | The excretion of Dexamethasone acetate can be decreased when combined with Liothyronine. |
| Conjugated estrogens | The excretion of Dexamethasone acetate can be decreased when combined with Conjugated estrogens. |
| Valproic acid | The excretion of Dexamethasone acetate can be decreased when combined with Valproic acid. |
| Indomethacin | The risk or severity of gastrointestinal irritation can be increased when Dexamethasone acetate is combined with Indomethacin. |
| Aminohippuric acid | The excretion of Dexamethasone acetate can be decreased when combined with Aminohippuric acid. |
| Lansoprazole | The excretion of Dexamethasone acetate can be decreased when combined with Lansoprazole. |
| Cefalotin | The excretion of Dexamethasone acetate can be decreased when combined with Cefalotin. |
| Tenoxicam | The risk or severity of gastrointestinal irritation can be increased when Dexamethasone acetate is combined with Tenoxicam. |
| Cefotaxime | The excretion of Dexamethasone acetate can be decreased when combined with Cefotaxime. |
| Zidovudine | The excretion of Dexamethasone acetate can be decreased when combined with Zidovudine. |
| Cimetidine | The excretion of Dexamethasone acetate can be decreased when combined with Cimetidine. |
| Guanidine | The excretion of Dexamethasone acetate can be decreased when combined with Guanidine. |
| Piroxicam | The risk or severity of gastrointestinal irritation can be increased when Dexamethasone acetate is combined with Piroxicam. |
| Cephalexin | The excretion of Dexamethasone acetate can be decreased when combined with Cephalexin. |
| Enalapril | The excretion of Dexamethasone acetate can be decreased when combined with Enalapril. |
| Diclofenac | The risk or severity of gastrointestinal irritation can be increased when Dexamethasone acetate is combined with Diclofenac. |
| Oxytetracycline | The excretion of Dexamethasone acetate can be decreased when combined with Oxytetracycline. |
| Leucovorin | The excretion of Dexamethasone acetate can be decreased when combined with Leucovorin. |
| Furosemide | The excretion of Dexamethasone acetate can be decreased when combined with Furosemide. |
| Esomeprazole | The excretion of Dexamethasone acetate can be decreased when combined with Esomeprazole. |
| Tetracycline | The excretion of Dexamethasone acetate can be decreased when combined with Tetracycline. |
| Acyclovir | The excretion of Dexamethasone acetate can be decreased when combined with Acyclovir. |
| Phenylbutazone | The risk or severity of gastrointestinal irritation can be increased when Dexamethasone acetate is combined with Phenylbutazone. |
| Cefaclor | The excretion of Dexamethasone acetate can be decreased when combined with Cefaclor. |
| Bumetanide | The excretion of Dexamethasone acetate can be decreased when combined with Bumetanide. |
| Dinoprostone | The excretion of Dexamethasone acetate can be decreased when combined with Dinoprostone. |
| Famotidine | The excretion of Dexamethasone acetate can be decreased when combined with Famotidine. |
| Salicylic acid | The risk or severity of gastrointestinal irritation can be increased when Dexamethasone acetate is combined with Salicylic acid. |
| Acetylsalicylic acid | The risk or severity of gastrointestinal irritation can be increased when Dexamethasone acetate is combined with Acetylsalicylic acid. |
| Ganciclovir | The excretion of Dexamethasone acetate can be decreased when combined with Ganciclovir. |
| Ketoprofen | The risk or severity of gastrointestinal irritation can be increased when Dexamethasone acetate is combined with Ketoprofen. |
| Minocycline | The excretion of Dexamethasone acetate can be decreased when combined with Minocycline. |
| Probenecid | The excretion of Dexamethasone acetate can be decreased when combined with Probenecid. |
| Mercaptopurine | The excretion of Dexamethasone acetate can be decreased when combined with Mercaptopurine. |
| Ibuprofen | The risk or severity of gastrointestinal irritation can be increased when Dexamethasone acetate is combined with Ibuprofen. |
| Novobiocin | The excretion of Dexamethasone acetate can be decreased when combined with Novobiocin. |
| Benzylpenicillin | The excretion of Dexamethasone acetate can be decreased when combined with Benzylpenicillin. |
| Melatonin | The excretion of Dexamethasone acetate can be decreased when combined with Melatonin. |
| Ouabain | The excretion of Dexamethasone acetate can be decreased when combined with Ouabain. |
| Rosuvastatin | The excretion of Dexamethasone acetate can be decreased when combined with Rosuvastatin. |
| Cefadroxil | The excretion of Dexamethasone acetate can be decreased when combined with Cefadroxil. |
| Ceftriaxone | The excretion of Dexamethasone acetate can be decreased when combined with Ceftriaxone. |
| Gemfibrozil | The excretion of Dexamethasone acetate can be decreased when combined with Gemfibrozil. |
| Cefamandole | The excretion of Dexamethasone acetate can be decreased when combined with Cefamandole. |
| Cefazolin | The excretion of Dexamethasone acetate can be decreased when combined with Cefazolin. |
| Cefoperazone | The excretion of Dexamethasone acetate can be decreased when combined with Cefoperazone. |
| Ceftizoxime | The excretion of Dexamethasone acetate can be decreased when combined with Ceftizoxime. |
| Cefacetrile | The excretion of Dexamethasone acetate can be decreased when combined with Cefacetrile. |
| Ceftibuten | The excretion of Dexamethasone acetate can be decreased when combined with Ceftibuten. |
| Liotrix | The excretion of Dexamethasone acetate can be decreased when combined with Liotrix. |
| Cilastatin | The excretion of Dexamethasone acetate can be decreased when combined with Cilastatin. |
| Tazobactam | The excretion of Dexamethasone acetate can be decreased when combined with Tazobactam. |
| trans-2-hydroxycinnamic acid | The excretion of Dexamethasone acetate can be decreased when combined with trans-2-hydroxycinnamic acid. |
| Topiroxostat | The excretion of Dexamethasone acetate can be decreased when combined with Topiroxostat. |
| Cholic Acid | The excretion of Dexamethasone acetate can be decreased when combined with Cholic Acid. |
| Glutaric Acid | The excretion of Dexamethasone acetate can be decreased when combined with Glutaric Acid. |
| Benzoic acid | The therapeutic efficacy of Benzoic acid can be decreased when used in combination with Dexamethasone acetate. |
| Taurocholic acid | The excretion of Dexamethasone acetate can be decreased when combined with Taurocholic acid. |
| Caprylic acid | The excretion of Dexamethasone acetate can be decreased when combined with Caprylic acid. |
| Ataluren | The excretion of Dexamethasone acetate can be decreased when combined with Ataluren. |
| Teriflunomide | The excretion of Dexamethasone acetate can be decreased when combined with Teriflunomide. |
| Dolutegravir | The excretion of Dexamethasone acetate can be decreased when combined with Dolutegravir. |
| Cefaloridine | The excretion of Dexamethasone acetate can be decreased when combined with Cefaloridine. |
| Lenvatinib | The excretion of Dexamethasone acetate can be decreased when combined with Lenvatinib. |
| Tafamidis | The excretion of Dexamethasone acetate can be decreased when combined with Tafamidis. |
| Cabotegravir | The excretion of Dexamethasone acetate can be decreased when combined with Cabotegravir. |
| Letermovir | The metabolism of Dexamethasone acetate can be decreased when combined with Letermovir. |
| Rucaparib | Dexamethasone acetate may decrease the excretion rate of Rucaparib which could result in a higher serum level. |
| Favipiravir | The excretion of Dexamethasone acetate can be decreased when combined with Favipiravir. |
| Pradigastat | The excretion of Dexamethasone acetate can be decreased when combined with Pradigastat. |
| Linezolid | The excretion of Dexamethasone acetate can be decreased when combined with Linezolid. |
| Ifosfamide | The metabolism of Ifosfamide can be increased when combined with Dexamethasone acetate. |
| Ledipasvir | The serum concentration of Ledipasvir can be decreased when it is combined with Dexamethasone acetate. |
| Perampanel | The metabolism of Perampanel can be increased when combined with Dexamethasone acetate. |
| Warfarin | Dexamethasone acetate may increase the anticoagulant activities of Warfarin. |
| Acenocoumarol | Dexamethasone acetate may increase the anticoagulant activities of Acenocoumarol. |
| (R)-warfarin | Dexamethasone acetate may increase the anticoagulant activities of (R)-warfarin. |
| R,S-Warfarin alcohol | The metabolism of R,S-Warfarin alcohol can be increased when combined with Dexamethasone acetate. |
| S,R-Warfarin alcohol | The metabolism of S,R-Warfarin alcohol can be increased when combined with Dexamethasone acetate. |
| (S)-Warfarin | Dexamethasone acetate may increase the anticoagulant activities of (S)-Warfarin. |
| Doxorubicin | The serum concentration of Doxorubicin can be decreased when it is combined with Dexamethasone acetate. |
| Vincristine | The serum concentration of Vincristine can be decreased when it is combined with Dexamethasone acetate. |
| Rolapitant | The metabolism of Rolapitant can be increased when combined with Dexamethasone acetate. |
| Erlotinib | The serum concentration of Erlotinib can be decreased when it is combined with Dexamethasone acetate. |
| Diethylstilbestrol | The serum concentration of Dexamethasone acetate can be increased when it is combined with Diethylstilbestrol. |
| Etonogestrel | The serum concentration of Dexamethasone acetate can be increased when it is combined with Etonogestrel. |
| Desogestrel | The serum concentration of Dexamethasone acetate can be increased when it is combined with Desogestrel. |