Peringatan Keamanan

Signs and symptoms in human : When undiluted, it whitens & cauterizes the skin & mucous membranes. 4-chlorophenol was shown to permeate the skin. It produces damage at a threshold concentration of 0.75% (w/v).

Routes of Entry: Absorbed through skin. Eye contact.
Toxicity to Animals:
Acute oral toxicity (LD50): 500 mg/kg Rat. Acute dermal toxicity (LD50): 1500 mg/kg Rat.
Chronic Effects on Humans:
CARCINOGENIC EFFECTS: Classified 2B (Possible for human.) by IARC. DEVELOPMENTAL TOXICITY: Classified
Reproductive system/toxin/male, Development toxin POSSIBLE. May cause damage to the following organs: liver, brain,
gastrointestinal tract, upper respiratory tract, central nervous system (CNS).
Other Toxic Effects on Humans: Very hazardous in case of skin contact (irritant).

Parachlorophenol

DB13154

small molecule approved

Deskripsi

P-chlorophenol is a white crystals with a strong phenol odor. Slightly soluble to soluble in water, depending on the isomer, and denser than water. Noncombustible.

Struktur Molekul 2D

Berat 128.556

Wujud solid

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) -

Volume Distribusi -

Klirens (Clearance) -

Absorpsi

absorbed from gastrointestinal tract.

Metabolisme

P-Chlorophenol yields p-chloroanisole in guinea pigs. P-Chlorophenol yields 4-chlorocatechol p-chloro phenyl-beta-D-glucuronide & p-chlorphenyl sulfate in rabbits. P-Chlorophenol yields p-chlorophenyl sulfate in rats.

Rute Eliminasi

87% of 4-chlorophenol was excreted in urine of dogs as sulfate and glucuronide.

Interaksi Obat

8 Data

Tenofovir alafenamide	The serum concentration of Tenofovir alafenamide can be increased when it is combined with Parachlorophenol.
Pretomanid	The serum concentration of Parachlorophenol can be increased when it is combined with Pretomanid.
Trofinetide	The serum concentration of Parachlorophenol can be increased when it is combined with Trofinetide.
Leniolisib	The excretion of Parachlorophenol can be decreased when combined with Leniolisib.
Elexacaftor	The serum concentration of Parachlorophenol can be increased when it is combined with Elexacaftor.
Encorafenib	The serum concentration of Parachlorophenol can be increased when it is combined with Encorafenib.
Ceftobiprole medocaril	The serum concentration of Parachlorophenol can be increased when it is combined with Ceftobiprole medocaril.
Imetelstat	The serum concentration of Parachlorophenol can be increased when it is combined with Imetelstat.

Target Protein

Sodium channel protein type 4 subunit alpha SCN4A

Referensi & Sumber

Link

Contoh Produk & Brand

Produk: 2 • International brands: 0

Produk

Camphorated Para Chlorophenol Liq

Liquid • - • Dental • Canada • Approved
Cresophene Liq

Liquid • - • Dental • Canada • Approved

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.