Peringatan Keamanan

Overdoses of Fludeoxyglucose F 18 Injection have not been reported.

Fludeoxyglucose (18F)

DB09502

small molecule approved investigational

Deskripsi

Fludeoxyglucose F 18 Injection is a positron emitting radiopharmaceutical containing no-carrier added radioactive 2-deoxy-2-18Ffluoro-D-g1ucose, which is used for diagnostic purposes in conjunction with Positron Emission Tomography (PET). It is administered by intravenous injection.

Struktur Molekul 2D

Berat 181.15
Wujud -

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 10-13 minutes
Volume Distribusi Fludeoxyglucose F 18 Injection is rapidly distributed to all organs of the body after intravenous administration.
Klirens (Clearance) Fludeoxyglucose F 18 and related compounds are cleared from non-cardiac tissues within 3 to 24 hours after administration. Clearance from the cardiac tissue may require more than 96 hours

Absorpsi

Fludeoxyglucose F 18 Injection is rapidly distributed to all organs of the body after intravenous administration.

Metabolisme

Fludeoxyglucose F 18 is transported into cells and phosphorylated to 18F-FDG-6-phosphate at a rate proportional to the rate of glucose utilization within that tissue. 18F-FDG-6-phosphate presumably is metabolized to 2-deoxy-2-18F fluoro-6-phospho-Dmannose (18FFDM-6-phosphate). Fludeoxyglucose F 18 Injection may contain several impurities (e.g., 2-deoxy-2-chloro-D-glucose (ClDG)). Biodistribution and metabolism of C1DG are presumed to be similar to Fludeoxyglucose F 18 and would be expected to result in intracellular formation of 2-deoxy-2-chloro-6-phospho-D-glucose (C1DG-6-phosphate) and 2-deoxy-2-chloro-6-phospho-D-mannose (ClDM-6-phosphate). The phosphorylated deoxyglucose compounds are dephosphorylated and the resulting compounds (FDG, FDM, C1DG, and ClDM) presumably leave cells by passive diffusion.

Rute Eliminasi

Fludeoxyglucose F 18 is cleared from most tissues within 24 hours and can be eliminated from the body unchanged in the urine.

Interaksi Makanan

2 Data
  • 1. Take on an empty stomach. When using Fludeoxyglucose (18F) in oncology or neurology, avoid eating for 4-6 hours before Fludeoxyglucose (18F) administration.
  • 2. Take with food. Consuming food or beverages containing 50-75 grams of glucose just before the administration of Fludeoxyglucose (18F) may be beneficial in the setting of cardiology imaging.

Interaksi Obat

727 Data
Cyclosporine Cyclosporine may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Icosapent Icosapent may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Cefotiam Cefotiam may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Mesalazine Mesalazine may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Cefmenoxime Cefmenoxime may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Cefmetazole Cefmetazole may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Pamidronic acid Pamidronic acid may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Tenofovir disoproxil Tenofovir disoproxil may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Indomethacin Indomethacin may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Cidofovir Cidofovir may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Cefpiramide Cefpiramide may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Ceftazidime Ceftazidime may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Loracarbef Loracarbef may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Cefalotin Cefalotin may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Nabumetone Nabumetone may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Ketorolac Ketorolac may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Tenoxicam Tenoxicam may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Celecoxib Celecoxib may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Cefotaxime Cefotaxime may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Tolmetin Tolmetin may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Foscarnet Foscarnet may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Rofecoxib Rofecoxib may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Piroxicam Piroxicam may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Methotrexate Methotrexate may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Cephalexin Cephalexin may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Fenoprofen Fenoprofen may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Valaciclovir Valaciclovir may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Valdecoxib Valdecoxib may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Diclofenac Diclofenac may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Sulindac Sulindac may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Bacitracin Bacitracin may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Amphotericin B Amphotericin B may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Cephaloglycin Cephaloglycin may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Flurbiprofen Flurbiprofen may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Adefovir dipivoxil Adefovir dipivoxil may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Pentamidine Pentamidine may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Etodolac Etodolac may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Mefenamic acid Mefenamic acid may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Acyclovir Acyclovir may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Naproxen Naproxen may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Sulfasalazine Sulfasalazine may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Phenylbutazone Phenylbutazone may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Meloxicam Meloxicam may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Carprofen Carprofen may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Cefaclor Cefaclor may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Diflunisal Diflunisal may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Tacrolimus Tacrolimus may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Ceforanide Ceforanide may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Salicylic acid Salicylic acid may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Meclofenamic acid Meclofenamic acid may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Acetylsalicylic acid Acetylsalicylic acid may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Carboplatin Carboplatin may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Oxaprozin Oxaprozin may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Ketoprofen Ketoprofen may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Balsalazide Balsalazide may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Ibuprofen Ibuprofen may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Cefditoren Cefditoren may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Atazanavir Atazanavir may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Colistimethate Colistimethate may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Cefuroxime Cefuroxime may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Cefapirin Cefapirin may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Cefadroxil Cefadroxil may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Cefprozil Cefprozil may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Ceftriaxone Ceftriaxone may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Olsalazine Olsalazine may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Lumiracoxib Lumiracoxib may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Cefamandole Cefamandole may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Cefazolin Cefazolin may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Cefonicid Cefonicid may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Cefoperazone Cefoperazone may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Cefotetan Cefotetan may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Cefoxitin Cefoxitin may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Ceftizoxime Ceftizoxime may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Cefradine Cefradine may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Magnesium salicylate Magnesium salicylate may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Salsalate Salsalate may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Choline magnesium trisalicylate Choline magnesium trisalicylate may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Cefepime Cefepime may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Cefacetrile Cefacetrile may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Ceftibuten Ceftibuten may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Cefpodoxime Cefpodoxime may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Antrafenine Antrafenine may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Aminophenazone Aminophenazone may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Antipyrine Antipyrine may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Tiaprofenic acid Tiaprofenic acid may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Lopinavir Lopinavir may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Etoricoxib Etoricoxib may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Hydrolyzed Cephalothin Hydrolyzed Cephalothin may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Cephalothin Group Cephalothin Group may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Oxyphenbutazone Oxyphenbutazone may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Latamoxef Latamoxef may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Nimesulide Nimesulide may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Benoxaprofen Benoxaprofen may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Metamizole Metamizole may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Zomepirac Zomepirac may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Ceftobiprole Ceftobiprole may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Cimicoxib Cimicoxib may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Ceftaroline fosamil Ceftaroline fosamil may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Lornoxicam Lornoxicam may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Aceclofenac Aceclofenac may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.

Referensi & Sumber

Artikel (PubMed)
  • PMID: 26159590
    Tragardh M, Moller N, Sorensen M: Methodologic Considerations for Quantitative 18F-FDG PET/CT Studies of Hepatic Glucose Metabolism in Healthy Subjects. J Nucl Med. 2015 Sep;56(9):1366-71. doi: 10.2967/jnumed.115.154211. Epub 2015 Jul 9.
  • PMID: 15883258
    Mega MS, Dinov ID, Porter V, Chow G, Reback E, Davoodi P, O'Connor SM, Carter MF, Amezcua H, Cummings JL: Metabolic patterns associated with the clinical response to galantamine therapy: a fludeoxyglucose f 18 positron emission tomographic study. Arch Neurol. 2005 May;62(5):721-8.
  • PMID: 7848128
    Perani D, Bressi S, Testa D, Grassi F, Cortelli P, Gentrini S, Savoiardo M, Caraceni T, Fazio F: Clinical/metabolic correlations in multiple system atrophy. A fludeoxyglucose F 18 positron emission tomographic study. Arch Neurol. 1995 Feb;52(2):179-85.
Link

Contoh Produk & Brand

Produk: 48 • International brands: 0
Produk
  • Fludeoxyglucose F 18
    Injection • 40 mCi/1mL • Intravenous • US • Generic • Approved
  • Fludeoxyglucose F 18
    Injection • 500 mCi/1mL • Intravenous • US • Generic • Approved
  • Fludeoxyglucose F 18
    Injection • 300 mCi/1mL • Intravenous • US • Generic • Approved
  • Fludeoxyglucose F 18
    Injection • 240 mCi/1mL • Intravenous • US • Generic • Approved
  • Fludeoxyglucose F 18
    Injection, solution • 475 mCi/1mL • Intravenous • US
  • Fludeoxyglucose F 18
    Injection • 40 mCi/1mL • Intravenous • US • Generic • Approved
  • Fludeoxyglucose F 18
    Injection • 300 mCi/1mL • Intravenous • US • Generic • Approved
  • Fludeoxyglucose F 18
    Injection, solution • 100 mCi/1mL • Intravenous • US • Generic • Approved
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