Peringatan Keamanan

Routes of Entry: Inhalation. Ingestion.

Toxicity to Animals:
Lowest Published Lethal Dose:
LDL [Rat - Route: oral; Dose: 7500 mg/kg
LDL Rabbit - Route: Oral; Dose: 5000 mg/kg
LDL Dog - Rout: Oral; Dose: 5000 mg/kg
Lethal Dose/Conc 50% kill:
LD50 Mouse - Route: Intravenous; Dose: 485 mg/kgL50221

Other Toxic Effects on Humans:
Acute Potential Health Effects:
Skin: Causes skin irritation
Eyes: Causes eye irritation
Inhalation: Causes respiratory tract irritation
Ingestion: Causes gastrointestinal tract irritation with nausea, vomiting and diarrhea. May affect kidneys (kidney
damage), blood, and behavior (convulsions, somnolence), and respiration.
Chronic Potential Health Effects:
Ingestion: Repeated or prolonged ingestion may cause lesions of the mouth, gastric ulcers, gastrointestinal
hyperacidity, and symptoms similar to those of metal fume fever - flu-like condition with fever, chills, sweats,
nausea, vomiting, muscle aches, pains, and weakness.
Skin: Repeated or prolonged skin contact may cause skin ulcerations or lesions.

L-tartaric acid

DB09459

small molecule experimental

Deskripsi

Tartaric acid is a white crystalline organic acid that occurs naturally in many plants, most notably in grapes.Tartaric is an alpha-hydroxy-carboxylic acid, is diprotic and aldaric in acid characteristics, and is a dihydroxyl derivative of succinic acid.

Struktur Molekul 2D

Berat 150.0868
Wujud -

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Oral or parenteral doses of monosodium 14C-L(+)-tartrate (400 mg/kg) are rapidly excreted by rats and a proportion completely metabolized to CO2. The oral dose was well-absorbed.

Metabolisme

Most tartarate that is consumed by humans is metabolized by bacteria in the gastrointestinal tract , primarily in the large instestine.

Rute Eliminasi

Only about 15-20% of consumed tartaric acid is secreted in the urine unchanged.

Interaksi Obat

39 Data
Technetium Tc-99m oxidronate L-tartaric acid may decrease effectiveness of Technetium Tc-99m oxidronate as a diagnostic agent.
Amphetamine The excretion of Amphetamine can be decreased when combined with L-tartaric acid.
Phentermine The excretion of Phentermine can be decreased when combined with L-tartaric acid.
Pseudoephedrine The excretion of Pseudoephedrine can be decreased when combined with L-tartaric acid.
Benzphetamine The excretion of Benzphetamine can be decreased when combined with L-tartaric acid.
Diethylpropion The excretion of Diethylpropion can be decreased when combined with L-tartaric acid.
Lisdexamfetamine The serum concentration of Lisdexamfetamine can be increased when it is combined with L-tartaric acid.
Mephentermine The excretion of Mephentermine can be decreased when combined with L-tartaric acid.
MMDA The excretion of MMDA can be decreased when combined with L-tartaric acid.
Midomafetamine The excretion of Midomafetamine can be decreased when combined with L-tartaric acid.
2,5-Dimethoxy-4-ethylamphetamine The excretion of 2,5-Dimethoxy-4-ethylamphetamine can be decreased when combined with L-tartaric acid.
4-Bromo-2,5-dimethoxyamphetamine The excretion of 4-Bromo-2,5-dimethoxyamphetamine can be decreased when combined with L-tartaric acid.
Tenamfetamine The excretion of Tenamfetamine can be decreased when combined with L-tartaric acid.
Chlorphentermine The excretion of Chlorphentermine can be decreased when combined with L-tartaric acid.
Methylenedioxyethamphetamine The excretion of Methylenedioxyethamphetamine can be decreased when combined with L-tartaric acid.
Dextroamphetamine The excretion of Dextroamphetamine can be decreased when combined with L-tartaric acid.
Metamfetamine The excretion of Metamfetamine can be decreased when combined with L-tartaric acid.
Iofetamine I-123 The excretion of Iofetamine I-123 can be decreased when combined with L-tartaric acid.
Ritobegron The excretion of Ritobegron can be decreased when combined with L-tartaric acid.
Mephedrone The excretion of Mephedrone can be decreased when combined with L-tartaric acid.
Methoxyphenamine The excretion of Methoxyphenamine can be decreased when combined with L-tartaric acid.
Gepefrine The excretion of Gepefrine can be decreased when combined with L-tartaric acid.
2,5-Dimethoxy-4-ethylthioamphetamine The excretion of 2,5-Dimethoxy-4-ethylthioamphetamine can be decreased when combined with L-tartaric acid.
Phendimetrazine The excretion of Phendimetrazine can be decreased when combined with L-tartaric acid.
Doxycycline The therapeutic efficacy of Doxycycline can be decreased when used in combination with L-tartaric acid.
Lymecycline The therapeutic efficacy of Lymecycline can be decreased when used in combination with L-tartaric acid.
Clomocycline The therapeutic efficacy of Clomocycline can be decreased when used in combination with L-tartaric acid.
Tigecycline The therapeutic efficacy of Tigecycline can be decreased when used in combination with L-tartaric acid.
Oxytetracycline The therapeutic efficacy of Oxytetracycline can be decreased when used in combination with L-tartaric acid.
Demeclocycline The therapeutic efficacy of Demeclocycline can be decreased when used in combination with L-tartaric acid.
Tetracycline The therapeutic efficacy of Tetracycline can be decreased when used in combination with L-tartaric acid.
Metacycline The therapeutic efficacy of Metacycline can be decreased when used in combination with L-tartaric acid.
Minocycline The therapeutic efficacy of Minocycline can be decreased when used in combination with L-tartaric acid.
Rolitetracycline The therapeutic efficacy of Rolitetracycline can be decreased when used in combination with L-tartaric acid.
Sarecycline The therapeutic efficacy of Sarecycline can be decreased when used in combination with L-tartaric acid.
Eravacycline The therapeutic efficacy of Eravacycline can be decreased when used in combination with L-tartaric acid.
Omadacycline The therapeutic efficacy of Omadacycline can be decreased when used in combination with L-tartaric acid.
Penimepicycline The therapeutic efficacy of Penimepicycline can be decreased when used in combination with L-tartaric acid.
Memantine The excretion of Memantine can be decreased when combined with L-tartaric acid.

Referensi & Sumber

Artikel (PubMed)
  • PMID: 891842
    Chasseaud LF, Down WH, Kirkpatrick D: Absorption and biotransformation of L(+)-tartaric acid in rats. Experientia. 1977 Aug 15;33(8):998-9.

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