Norgestrel

DB09389

small molecule approved

Deskripsi

Norgestrel is synthetic steroidal progestin that is used in combination with ethinyl estradiol for oral contraception. Norgestrel is composed of a racemic mixture of two stereoisomers, dextronorgestrel and levonorgestrel. However, only the levorotary enantiomer (levonorgestrel) is biologically active.

Struktur Molekul 2D

Berat 312.453
Wujud -

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

3 Data
  • 1. Avoid grapefruit products. Grapefruit inhibits CYP3A metabolism, which may increase the serum concentration of norgestrel.
  • 2. Avoid St. John's Wort. This herb induces CYP3A metabolism and may reduce serum levels of norgestrel.
  • 3. Take at the same time every day.

Interaksi Obat

537 Data
Acitretin The therapeutic efficacy of Norgestrel can be decreased when used in combination with Acitretin.
Aprepitant The serum concentration of Norgestrel can be decreased when it is combined with Aprepitant.
Atazanavir The serum concentration of Norgestrel can be increased when it is combined with Atazanavir.
Boceprevir The serum concentration of Norgestrel can be increased when it is combined with Boceprevir.
Prucalopride The serum concentration of Norgestrel can be decreased when it is combined with Prucalopride.
Sugammadex The serum concentration of Norgestrel can be decreased when it is combined with Sugammadex.
Thalidomide Norgestrel may increase the thrombogenic activities of Thalidomide.
Ulipristal The therapeutic efficacy of Norgestrel can be decreased when used in combination with Ulipristal.
Ursodeoxycholic acid The therapeutic efficacy of Ursodeoxycholic acid can be decreased when used in combination with Norgestrel.
Glycochenodeoxycholic Acid The therapeutic efficacy of Glycochenodeoxycholic Acid can be decreased when used in combination with Norgestrel.
Cholic Acid The therapeutic efficacy of Cholic Acid can be decreased when used in combination with Norgestrel.
Glycocholic acid The therapeutic efficacy of Glycocholic acid can be decreased when used in combination with Norgestrel.
Deoxycholic acid The therapeutic efficacy of Deoxycholic acid can be decreased when used in combination with Norgestrel.
Taurocholic acid The therapeutic efficacy of Taurocholic acid can be decreased when used in combination with Norgestrel.
Obeticholic acid The therapeutic efficacy of Obeticholic acid can be decreased when used in combination with Norgestrel.
Tauroursodeoxycholic acid The therapeutic efficacy of Tauroursodeoxycholic acid can be decreased when used in combination with Norgestrel.
Bamet-UD2 The therapeutic efficacy of Bamet-UD2 can be decreased when used in combination with Norgestrel.
cis-Diamminechlorocholylglycinateplatinum(II) The therapeutic efficacy of cis-Diamminechlorocholylglycinateplatinum(II) can be decreased when used in combination with Norgestrel.
Dehydrocholic acid The therapeutic efficacy of Dehydrocholic acid can be decreased when used in combination with Norgestrel.
Hyodeoxycholic Acid The therapeutic efficacy of Hyodeoxycholic Acid can be decreased when used in combination with Norgestrel.
Aramchol The therapeutic efficacy of Aramchol can be decreased when used in combination with Norgestrel.
Ox bile extract The therapeutic efficacy of Ox bile extract can be decreased when used in combination with Norgestrel.
Chenodeoxycholic acid The therapeutic efficacy of Chenodeoxycholic acid can be decreased when used in combination with Norgestrel.
Taurochenodeoxycholic acid The therapeutic efficacy of Taurochenodeoxycholic acid can be decreased when used in combination with Norgestrel.
Tranexamic acid Norgestrel may increase the thrombogenic activities of Tranexamic acid.
Clobazam The serum concentration of Norgestrel can be decreased when it is combined with Clobazam.
Colestipol Colestipol can cause a decrease in the absorption of Norgestrel resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sevelamer Sevelamer can cause a decrease in the absorption of Norgestrel resulting in a reduced serum concentration and potentially a decrease in efficacy.
Colesevelam Colesevelam can cause a decrease in the absorption of Norgestrel resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cholestyramine Cholestyramine can cause a decrease in the absorption of Norgestrel resulting in a reduced serum concentration and potentially a decrease in efficacy.
Griseofulvin The metabolism of Norgestrel can be increased when combined with Griseofulvin.
Tixocortol The serum concentration of Tixocortol can be increased when it is combined with Norgestrel.
Fluocortin The serum concentration of Fluocortin can be increased when it is combined with Norgestrel.
Fluperolone The serum concentration of Fluperolone can be increased when it is combined with Norgestrel.
Fluclorolone The serum concentration of Fluclorolone can be increased when it is combined with Norgestrel.
Flunisolide The serum concentration of Flunisolide can be increased when it is combined with Norgestrel.
Beclomethasone dipropionate The serum concentration of Beclomethasone dipropionate can be increased when it is combined with Norgestrel.
Betamethasone The serum concentration of Betamethasone can be increased when it is combined with Norgestrel.
Fluocinolone acetonide The serum concentration of Fluocinolone acetonide can be increased when it is combined with Norgestrel.
Triamcinolone The serum concentration of Triamcinolone can be increased when it is combined with Norgestrel.
Prednisone The serum concentration of Prednisone can be increased when it is combined with Norgestrel.
Hydrocortisone The serum concentration of Hydrocortisone can be increased when it is combined with Norgestrel.
Prednisolone The serum concentration of Prednisolone can be increased when it is combined with Norgestrel.
Methylprednisolone The serum concentration of Methylprednisolone can be increased when it is combined with Norgestrel.
Corticotropin The serum concentration of Corticotropin can be increased when it is combined with Norgestrel.
Cortisone acetate The serum concentration of Cortisone acetate can be increased when it is combined with Norgestrel.
Fluprednidene The serum concentration of Fluprednidene can be increased when it is combined with Norgestrel.
Meprednisone The serum concentration of Meprednisone can be increased when it is combined with Norgestrel.
Dexamethasone isonicotinate The serum concentration of Dexamethasone isonicotinate can be increased when it is combined with Norgestrel.
Deflazacort The serum concentration of Deflazacort can be increased when it is combined with Norgestrel.
Cortivazol The serum concentration of Cortivazol can be increased when it is combined with Norgestrel.
Prednylidene The serum concentration of Prednylidene can be increased when it is combined with Norgestrel.
Cloprednol The serum concentration of Cloprednol can be increased when it is combined with Norgestrel.
Mometasone furoate The serum concentration of Mometasone furoate can be increased when it is combined with Norgestrel.
Hydrocortisone acetate The serum concentration of Hydrocortisone acetate can be increased when it is combined with Norgestrel.
Hydrocortisone succinate The serum concentration of Hydrocortisone succinate can be increased when it is combined with Norgestrel.
Prednisolone phosphate The serum concentration of Prednisolone phosphate can be increased when it is combined with Norgestrel.
Prednisolone hemisuccinate The serum concentration of Prednisolone hemisuccinate can be increased when it is combined with Norgestrel.
Methylprednisolone hemisuccinate The serum concentration of Methylprednisolone hemisuccinate can be increased when it is combined with Norgestrel.
Prednisone acetate The serum concentration of Prednisone acetate can be increased when it is combined with Norgestrel.
Clocortolone acetate The serum concentration of Clocortolone acetate can be increased when it is combined with Norgestrel.
Melengestrol acetate The serum concentration of Melengestrol acetate can be increased when it is combined with Norgestrel.
Betamethasone phosphate The serum concentration of Betamethasone phosphate can be increased when it is combined with Norgestrel.
Cortisone The serum concentration of Cortisone can be increased when it is combined with Norgestrel.
Fluticasone propionate The serum concentration of Fluticasone propionate can be increased when it is combined with Norgestrel.
Fludrocortisone The serum concentration of Fludrocortisone can be increased when it is combined with Norgestrel.
Trilostane The serum concentration of Trilostane can be increased when it is combined with Norgestrel.
Budesonide The serum concentration of Budesonide can be increased when it is combined with Norgestrel.
Dexamethasone The serum concentration of Dexamethasone can be increased when it is combined with Norgestrel.
Paramethasone The serum concentration of Paramethasone can be increased when it is combined with Norgestrel.
Ciclesonide The serum concentration of Ciclesonide can be increased when it is combined with Norgestrel.
Aldosterone The serum concentration of Aldosterone can be increased when it is combined with Norgestrel.
Fluticasone furoate The serum concentration of Fluticasone furoate can be increased when it is combined with Norgestrel.
Fluprednisolone The serum concentration of Fluprednisolone can be increased when it is combined with Norgestrel.
Melengestrol The serum concentration of Melengestrol can be increased when it is combined with Norgestrel.
Fluticasone The serum concentration of Fluticasone can be increased when it is combined with Norgestrel.
Hydrocortisone cypionate The serum concentration of Hydrocortisone cypionate can be increased when it is combined with Norgestrel.
Clobetasol propionate The serum concentration of Clobetasol propionate can be increased when it is combined with Norgestrel.
Fluocinonide The serum concentration of Fluocinonide can be increased when it is combined with Norgestrel.
Hydrocortisone butyrate The serum concentration of Hydrocortisone butyrate can be increased when it is combined with Norgestrel.
Desoximetasone The serum concentration of Desoximetasone can be increased when it is combined with Norgestrel.
Mometasone The serum concentration of Mometasone can be increased when it is combined with Norgestrel.
Fluocortolone The serum concentration of Fluocortolone can be increased when it is combined with Norgestrel.
Prednisolone acetate The serum concentration of Prednisolone acetate can be increased when it is combined with Norgestrel.
Fluorometholone The serum concentration of Fluorometholone can be increased when it is combined with Norgestrel.
Difluocortolone The serum concentration of Difluocortolone can be increased when it is combined with Norgestrel.
Flumethasone The serum concentration of Flumethasone can be increased when it is combined with Norgestrel.
Methylprednisolone aceponate The serum concentration of Methylprednisolone aceponate can be increased when it is combined with Norgestrel.
Vitamin A The therapeutic efficacy of Norgestrel can be decreased when used in combination with Vitamin A.
Bexarotene The therapeutic efficacy of Norgestrel can be decreased when used in combination with Bexarotene.
Alitretinoin The therapeutic efficacy of Norgestrel can be decreased when used in combination with Alitretinoin.
Tretinoin The therapeutic efficacy of Norgestrel can be decreased when used in combination with Tretinoin.
Tazarotene The therapeutic efficacy of Norgestrel can be decreased when used in combination with Tazarotene.
Etretinate The therapeutic efficacy of Norgestrel can be decreased when used in combination with Etretinate.
Isotretinoin The therapeutic efficacy of Norgestrel can be decreased when used in combination with Isotretinoin.
4-Oxoretinol The therapeutic efficacy of Norgestrel can be decreased when used in combination with 4-Oxoretinol.
Fenretinide The therapeutic efficacy of Norgestrel can be decreased when used in combination with Fenretinide.
Ro 12-7310 The therapeutic efficacy of Norgestrel can be decreased when used in combination with Ro 12-7310.
Zuretinol acetate The therapeutic efficacy of Norgestrel can be decreased when used in combination with Zuretinol acetate.
Motretinide The therapeutic efficacy of Norgestrel can be decreased when used in combination with Motretinide.

Target Protein

Progesterone receptor PGR
3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1
Androgen receptor AR

Contoh Produk & Brand

Produk: 28 • International brands: 0
Produk
  • Cryselle
    Kit • - • Oral • US • Generic • Approved
  • Cryselle
    Kit • - • Oral • US • Generic • Approved
  • Cryselle
    Kit; Tablet, film coated • - • Oral • US • Generic • Approved
  • Cryselle
    Kit; Tablet, film coated • - • Oral • US • Generic • Approved
  • Cryselle
    Kit; Tablet, film coated • - • Oral • US • Generic • Approved
  • Cryselle
    Kit; Tablet, film coated • - • Oral • US • Generic • Approved
  • Cryselle
    Kit; Tablet, film coated • - • Oral • US • Generic • Approved
  • Elinest
    Kit; Tablet • - • Oral • US • Generic • Approved
Menampilkan 8 dari 28 produk.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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