Peringatan Keamanan

Oral LD50 value in rats is 636 mg/kg.A19261 For more information, refer to ibuprofen.

Dexibuprofen

DB09213

small molecule approved investigational

Deskripsi

Dexibuprofen, S(+)-ibuprofen, is a non-steroidal anti-inflammatory drug (NSAID). It is a pharmacologically effective enantiomer of racemic ibuprofen that differs in physicochemical properties. It is proposed to be more pharmacologically active and tolerable with a better safety profile than ibuprofen due to higher concentration of active S enantiomer. Dexibuprofen has a slower dissolution rate in the simulated gastric and enteric juices compared with the racemic ibuprofen and displays improved oral bioavilability A19259. For Metabolism, Enzymes, Carriers, Transporters Sections, refer to Ibuprofen.

Struktur Molekul 2D

Berat 206.2808
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Oral tablets containing 300mg of dexibuprofen results in 2.2-4.7 hours [A19254]. For more information, refer to [ibuprofen].
Volume Distribusi For more information, refer to [ibuprofen].
Klirens (Clearance) For more information, refer to [ibuprofen].

Absorpsi

The time it take to reach peak plasma concentration is 2.25-5 hours post-administration of oral tablets containing 300mg of dexibuprofen.A19254 For more information, refer to ibuprofen.

Metabolisme

For more information, refer to ibuprofen.

Rute Eliminasi

Mainly renal excretion. For more information, refer to ibuprofen.

Interaksi Obat

1599 Data
Amlodipine The metabolism of Dexibuprofen can be decreased when combined with Amlodipine.
Phentermine The risk or severity of hypertension can be increased when Phentermine is combined with Dexibuprofen.
Midodrine The risk or severity of hypertension can be increased when Midodrine is combined with Dexibuprofen.
Eletriptan The risk or severity of hypertension can be increased when Eletriptan is combined with Dexibuprofen.
Isoetharine The risk or severity of hypertension can be increased when Isoetharine is combined with Dexibuprofen.
Ziprasidone The risk or severity of hypertension can be increased when Ziprasidone is combined with Dexibuprofen.
Methysergide The risk or severity of hypertension can be increased when Methysergide is combined with Dexibuprofen.
Cabergoline The risk or severity of hypertension can be increased when Cabergoline is combined with Dexibuprofen.
Zolmitriptan The risk or severity of hypertension can be increased when Zolmitriptan is combined with Dexibuprofen.
Dihydroergotamine The risk or severity of hypertension can be increased when Dihydroergotamine is combined with Dexibuprofen.
Methylergometrine The risk or severity of hypertension can be increased when Methylergometrine is combined with Dexibuprofen.
Norepinephrine The risk or severity of hypertension can be increased when Norepinephrine is combined with Dexibuprofen.
Mirtazapine The risk or severity of hypertension can be increased when Mirtazapine is combined with Dexibuprofen.
Phenylpropanolamine The risk or severity of hypertension can be increased when Phenylpropanolamine is combined with Dexibuprofen.
Promazine The risk or severity of hypertension can be increased when Promazine is combined with Dexibuprofen.
Droperidol The risk or severity of hypertension can be increased when Droperidol is combined with Dexibuprofen.
Doxapram The risk or severity of hypertension can be increased when Doxapram is combined with Dexibuprofen.
Atropine The risk or severity of hypertension can be increased when Atropine is combined with Dexibuprofen.
Lisuride The risk or severity of hypertension can be increased when Lisuride is combined with Dexibuprofen.
Linezolid The risk or severity of hypertension can be increased when Linezolid is combined with Dexibuprofen.
Metaraminol The risk or severity of hypertension can be increased when Metaraminol is combined with Dexibuprofen.
Furazolidone The risk or severity of hypertension can be increased when Furazolidone is combined with Dexibuprofen.
Thioridazine The risk or severity of hypertension can be increased when Thioridazine is combined with Dexibuprofen.
Ergotamine The risk or severity of hypertension can be increased when Ergotamine is combined with Dexibuprofen.
Nicergoline The risk or severity of hypertension can be increased when Nicergoline is combined with Dexibuprofen.
Sufentanil The risk or severity of hypertension can be increased when Sufentanil is combined with Dexibuprofen.
Methoxamine The risk or severity of hypertension can be increased when Methoxamine is combined with Dexibuprofen.
Risperidone The risk or severity of hypertension can be increased when Risperidone is combined with Dexibuprofen.
Isoflurane The risk or severity of hypertension can be increased when Isoflurane is combined with Dexibuprofen.
Propiomazine The risk or severity of hypertension can be increased when Propiomazine is combined with Dexibuprofen.
Alfentanil The risk or severity of hypertension can be increased when Alfentanil is combined with Dexibuprofen.
Minaprine The risk or severity of hypertension can be increased when Minaprine is combined with Dexibuprofen.
Orciprenaline The risk or severity of hypertension can be increased when Orciprenaline is combined with Dexibuprofen.
Phenmetrazine The risk or severity of hypertension can be increased when Phenmetrazine is combined with Dexibuprofen.
Trifluoperazine The risk or severity of hypertension can be increased when Trifluoperazine is combined with Dexibuprofen.
Pseudoephedrine The risk or severity of hypertension can be increased when Pseudoephedrine is combined with Dexibuprofen.
Benzphetamine The risk or severity of hypertension can be increased when Benzphetamine is combined with Dexibuprofen.
Ritodrine The risk or severity of hypertension can be increased when Ritodrine is combined with Dexibuprofen.
Flupentixol The risk or severity of hypertension can be increased when Flupentixol is combined with Dexibuprofen.
Remifentanil The risk or severity of hypertension can be increased when Remifentanil is combined with Dexibuprofen.
Bitolterol The risk or severity of hypertension can be increased when Bitolterol is combined with Dexibuprofen.
Oxymetazoline The risk or severity of hypertension can be increased when Oxymetazoline is combined with Dexibuprofen.
Diethylpropion The risk or severity of hypertension can be increased when Diethylpropion is combined with Dexibuprofen.
Naratriptan The risk or severity of hypertension can be increased when Naratriptan is combined with Dexibuprofen.
Formoterol The risk or severity of hypertension can be increased when Formoterol is combined with Dexibuprofen.
Frovatriptan The risk or severity of hypertension can be increased when Frovatriptan is combined with Dexibuprofen.
Methoxyflurane The risk or severity of hypertension can be increased when Methoxyflurane is combined with Dexibuprofen.
Ergoloid mesylate The risk or severity of hypertension can be increased when Ergoloid mesylate is combined with Dexibuprofen.
Isoprenaline The risk or severity of hypertension can be increased when Isoprenaline is combined with Dexibuprofen.
Arbutamine The risk or severity of hypertension can be increased when Arbutamine is combined with Dexibuprofen.
Dutasteride The risk or severity of hypertension can be increased when Dutasteride is combined with Dexibuprofen.
Halothane The risk or severity of hypertension can be increased when Halothane is combined with Dexibuprofen.
Moclobemide The risk or severity of hypertension can be increased when Moclobemide is combined with Dexibuprofen.
Pergolide The risk or severity of hypertension can be increased when Pergolide is combined with Dexibuprofen.
Desflurane The risk or severity of hypertension can be increased when Desflurane is combined with Dexibuprofen.
Bromocriptine The risk or severity of hypertension can be increased when Bromocriptine is combined with Dexibuprofen.
Finasteride The risk or severity of hypertension can be increased when Finasteride is combined with Dexibuprofen.
Aripiprazole The risk or severity of hypertension can be increased when Aripiprazole is combined with Dexibuprofen.
Isocarboxazid The risk or severity of hypertension can be increased when Isocarboxazid is combined with Dexibuprofen.
Ergometrine The risk or severity of hypertension can be increased when Ergometrine is combined with Dexibuprofen.
Lisdexamfetamine The risk or severity of hypertension can be increased when Lisdexamfetamine is combined with Dexibuprofen.
Fenoterol The risk or severity of hypertension can be increased when Fenoterol is combined with Dexibuprofen.
Pirbuterol The risk or severity of hypertension can be increased when Pirbuterol is combined with Dexibuprofen.
Ephedra sinica root The risk or severity of hypertension can be increased when Ephedra sinica root is combined with Dexibuprofen.
Ephedrine The risk or severity of hypertension can be increased when Ephedrine is combined with Dexibuprofen.
Mephentermine The risk or severity of hypertension can be increased when Mephentermine is combined with Dexibuprofen.
Procaterol The risk or severity of hypertension can be increased when Procaterol is combined with Dexibuprofen.
Yohimbine The risk or severity of hypertension can be increased when Yohimbine is combined with Dexibuprofen.
Methotrimeprazine The risk or severity of hypertension can be increased when Methotrimeprazine is combined with Dexibuprofen.
Clenbuterol The risk or severity of hypertension can be increased when Clenbuterol is combined with Dexibuprofen.
Bambuterol The risk or severity of hypertension can be increased when Bambuterol is combined with Dexibuprofen.
MMDA The risk or severity of hypertension can be increased when MMDA is combined with Dexibuprofen.
Midomafetamine The risk or severity of hypertension can be increased when Midomafetamine is combined with Dexibuprofen.
2,5-Dimethoxy-4-ethylamphetamine The risk or severity of hypertension can be increased when 2,5-Dimethoxy-4-ethylamphetamine is combined with Dexibuprofen.
4-Methoxyamphetamine The risk or severity of hypertension can be increased when 4-Methoxyamphetamine is combined with Dexibuprofen.
4-Bromo-2,5-dimethoxyamphetamine The risk or severity of hypertension can be increased when 4-Bromo-2,5-dimethoxyamphetamine is combined with Dexibuprofen.
Tenamfetamine The risk or severity of hypertension can be increased when Tenamfetamine is combined with Dexibuprofen.
Chlorphentermine The risk or severity of hypertension can be increased when Chlorphentermine is combined with Dexibuprofen.
Dextroamphetamine The risk or severity of hypertension can be increased when Dextroamphetamine is combined with Dexibuprofen.
Phendimetrazine The risk or severity of hypertension can be increased when Phendimetrazine is combined with Dexibuprofen.
Solifenacin The risk or severity of hypertension can be increased when Solifenacin is combined with Dexibuprofen.
Periciazine The risk or severity of hypertension can be increased when Periciazine is combined with Dexibuprofen.
Acepromazine The risk or severity of hypertension can be increased when Acepromazine is combined with Dexibuprofen.
Thioproperazine The risk or severity of hypertension can be increased when Thioproperazine is combined with Dexibuprofen.
Zuclopenthixol The risk or severity of hypertension can be increased when Zuclopenthixol is combined with Dexibuprofen.
Epicaptopril The risk or severity of hypertension can be increased when Epicaptopril is combined with Dexibuprofen.
Clorgiline The risk or severity of hypertension can be increased when Clorgiline is combined with Dexibuprofen.
1-benzylimidazole The risk or severity of hypertension can be increased when 1-benzylimidazole is combined with Dexibuprofen.
Nialamide The risk or severity of hypertension can be increased when Nialamide is combined with Dexibuprofen.
Lysergic acid diethylamide The risk or severity of hypertension can be increased when Lysergic acid diethylamide is combined with Dexibuprofen.
Dronedarone The risk or severity of hypertension can be increased when Dronedarone is combined with Dexibuprofen.
Flibanserin The risk or severity of hypertension can be increased when Flibanserin is combined with Dexibuprofen.
Iloperidone The risk or severity of hypertension can be increased when Iloperidone is combined with Dexibuprofen.
Indacaterol The risk or severity of hypertension can be increased when Indacaterol is combined with Dexibuprofen.
Rotigotine The risk or severity of hypertension can be increased when Rotigotine is combined with Dexibuprofen.
Amibegron The risk or severity of hypertension can be increased when Amibegron is combined with Dexibuprofen.
Naluzotan The risk or severity of hypertension can be increased when Naluzotan is combined with Dexibuprofen.
Cariprazine The risk or severity of hypertension can be increased when Cariprazine is combined with Dexibuprofen.
Mianserin The risk or severity of hypertension can be increased when Mianserin is combined with Dexibuprofen.
Pizotifen The risk or severity of hypertension can be increased when Pizotifen is combined with Dexibuprofen.

Target Protein

Prostaglandin G/H synthase 2 PTGS2
Prostaglandin G/H synthase 1 PTGS1
Apoptosis regulator Bcl-2 BCL2
Thrombomodulin THBD
Tissue-type plasminogen activator PLAT
Fatty acid-binding protein, intestinal FABP2
Peroxisome proliferator-activated receptor gamma PPARG
Cystic fibrosis transmembrane conductance regulator CFTR
Solute carrier family 15 member 1 SLC15A1
Peroxisome proliferator-activated receptor alpha PPARA
Platelet glycoprotein Ib alpha chain GP1BA
Protein S100-A7 S100A7

Referensi & Sumber

Artikel (PubMed)
  • PMID: 19552094
    Hardikar MS: Chiral non-steroidal anti-inflammatory drugs--a review. J Indian Med Assoc. 2008 Sep;106(9):615-8, 622, 624.
  • PMID: 19032727
    Yoon JS, Jeong DC, Oh JW, Lee KY, Lee HS, Koh YY, Kim JT, Kang JH, Lee JS: The effects and safety of dexibuprofen compared with ibuprofen in febrile children caused by upper respiratory tract infection. Br J Clin Pharmacol. 2008 Dec;66(6):854-60. doi: 10.1111/j.1365-2125.2008.03271.x.
  • PMID: 23316393
    Muralidharan S: Pharmacokinetic-pharmacodynamic model of newly developed dexibuprofen sustained release formulations. ISRN Pharm. 2012;2012:451481. doi: 10.5402/2012/451481. Epub 2012 Dec 6.
  • PMID: 8582471
    Gabard B, Nirnberger G, Schiel H, Mascher H, Kikuta C, Mayer JM: Comparison of the bioavailability of dexibuprofen administered alone or as part of racemic ibuprofen. Eur J Clin Pharmacol. 1995;48(6):505-11.
  • PMID: 24151035
    Derry S, Best J, Moore RA: Single dose oral dexibuprofen S(+)-ibuprofen for acute postoperative pain in adults. Cochrane Database Syst Rev. 2013 Oct 23;(10):CD007550. doi: 10.1002/14651858.CD007550.pub3.
  • PMID: 17264714
    Gonzalez-Correa JA, Arrebola MM, Martin-Salido E, Munoz-Marin J, de la Cuesta FS, De La Cruz JP: Effects of dexibuprofen on platelet function in humans: comparison with low-dose aspirin. Anesthesiology. 2007 Feb;106(2):218-25.
Textbook
  • ISBN: 978-0-7020-3471-8
    26. (2012). In Rang and Dale's Pharmacology (7th ed., pp. 318-323). Edinburgh: Elsevier/Churchill Livingstone.

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