Peringatan Keamanan

In clinical trials, there are reports of pulmonary hemorrhage when colfosceril palmitate is administered in infants with a weight of fewer than 700 grams at birth. Another potential risk of the use of colfosceril palmitate is the formation of mucus plugging in the endotracheal tube which can be prevented by performing suction prior to dosing.L1109

Colfosceril palmitate

DB09114

small molecule approved investigational withdrawn

Deskripsi

Colfosceril palmitate is a synthetic pulmonary surfactant administered in infants with respiratory distress syndrome.A31510 It was part of the first generation of commercially available artificial surfactants.T70 It was developed by Burroughs Wellcome and it was FDA approved on August 6, 1990.L1109 Nowadays colfosceril palmitate is under the state of canceled post-marketing.

Struktur Molekul 2D

Berat 734.0389
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) The half-life of colfosceril palmitate is registered to be in the range of 20-36 hours.[L1112]
Volume Distribusi Colfosceril palmitate is distributed uniformly to all lobes of the lung, distal airways and alveolar spaces.[L1112] It will not enter the systemic circulation in healthy lungs, however when the integrity of the tissue is distrupted colfosceril can reach systemic circulation.[A31515] Even 5 days after administration, there are traces of colfosceril palmitate retained in the body that represented 72% of the administered dose which by then have entered pathways of lipid metabolism to become tissue associated.[A31523]
Klirens (Clearance) After 5 days of drug administration, the lung and liver would contain 10% of the administered dose and the elimination via renal excretion accounts only for 8% of the administered dose. This proved a very small renal clearance and confirmed that the major elimination route is by expired air.[A31523]

Absorpsi

The absorption is done directly in the alveolus into the lung tissue.L1110 As the lung surfactant is distributed in the bronchi, bronchioles and alveoli, its highest concentration is at the alveolar air-fluid interface where it remains as a monolayer.A31515

Metabolisme

Colfosceril palmitate is catabolized and reutilized for further synthesis and secretion in lung tissues.L1110

Rute Eliminasi

After 5 days, most of the administered dose (56%) is distributed throughout the body with renal and fecal excretion being the minor elimination pathway representing the 4 and 2% of the eliminated dose respectively. The major route of elimination is by expelled air which accounts for 28% of the administered dose.A31523

Interaksi Obat

0 Data
Tidak ada data.

Referensi & Sumber

Artikel (PubMed)
  • PMID: 10155285
    Bryson HM, Whittington R: Colfosceril palmitate. A pharmacoeconomic evaluation of a synthetic surfactant preparation (Exosurf Neonatal) in infants with respiratory distress syndrome. Pharmacoeconomics. 1994 Dec;6(6):563-77.
  • PMID: 2670398
    Reynolds MS, Wallander KA: Use of surfactant in the prevention and treatment of neonatal respiratory distress syndrome. Clin Pharm. 1989 Aug;8(8):559-76.
  • PMID: 8131363
    DeAngelis RL, Findlay JW: Metabolism of synthetic surfactants. Clin Perinatol. 1993 Dec;20(4):697-710.
Textbook
  • Jackson, J.C. (2012). Avery's diseases of the newborn (9th ed., pp. 633-646). Elsevier.
  • Sweet D. and Speer C. (2012). The newborn lung: neonatology questions and controversies (2nd ed., pp. 283-299). Elsevier.
  • 1. (2010). In Ashcraft's pediatric surgery (5th ed., pp. 3-18). Elsevier.
  • 52. (2011). In Pediatric Critical Care (4th ed., pp. 706-716). Mosby.

Contoh Produk & Brand

Produk: 3 • International brands: 0
Produk
  • Exosurf Neonatal
    Powder, for suspension • 108 mg / vial • Endotracheal • Canada • Approved
  • Exosurf Neonatal
    Kit; Powder, for suspension • 108 mg / vial • Endotracheal • Canada • Approved
  • Surfaxin
    Suspension • - • Endotracheal • US • Approved

Sekuens Gen/Protein (FASTA)

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