Povidone-iodine

DB06812

small molecule approved

Deskripsi

Povidone-iodine is a stable chemical complex of polyvinylpyrrolidone (povidone, PVP) and elemental iodine. It contains from 9.0% to 12.0% available iodine, calculated on a dry basis. This unique complex was discovered in 1955 at the Industrial Toxicology Laboratories in Philadelphia by H. A. Shelanski and M. V. Shelanski. During in vitro testing to demonstrate anti-bacterial activity it was found that the complex was less toxic in mice than tincture of iodine. Human clinical trials showed the product to be superior to other iodine formulations. Povidone-iodine was immediately marketed, and has since become the universally preferred iodine antiseptic.

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) Povidone-Iodine is intended for topical application and is not eliminated.

Volume Distribusi Povidone-Iodine is intended for topical application and has no volume of distribution.

Klirens (Clearance) Povidone-Iodine is intended for topical application and is not eliminated.

Absorpsi

Povidone-Iodine is intended for topical application and is not absorbed.

Metabolisme

Povidone-Iodine is not absorbed or metabolized.

Rute Eliminasi

Povidone-Iodine is intended for topical application and is not eliminated.

Interaksi Obat

0 Data

Tidak ada data.

Referensi & Sumber

Artikel (PubMed)

PMID: 28648795
Bigliardi PL, Alsagoff SAL, El-Kafrawi HY, Pyon JK, Wa CTC, Villa MA: Povidone iodine in wound healing: A review of current concepts and practices. Int J Surg. 2017 Aug;44:260-268. doi: 10.1016/j.ijsu.2017.06.073. Epub 2017 Jun 23.

Link

Contoh Produk & Brand

Produk: 757 • International brands: 0

Produk

3-in-1 First Aid Povidone-Iodine Swab

Liquid • 10 mg/1mL • Topical • US • OTC
3-Step First Aid Kit

Kit • - • Topical • US • OTC
3M Skin and Nasal Antiseptic

Solution • 5 mg/1mL • Topical • US • OTC
4042 First Aid Kit

Kit • - • Topical • US • OTC
4044 First Aid Kit

Kit • - • Topical • US • OTC
4045 First Aid Kit

Kit • - • Topical • US • OTC
4046 First Aid Kit

Kit • 10 mg/1mL • Topical • US • OTC
4050 First Aid Kit

Kit • - • Topical • US • OTC

Menampilkan 8 dari 757 produk.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.

Peringatan Keamanan