The oral LD50 is 230 mg/kg in rats and 75 mg/kg in mice. The subcutaneous LD50 is 90 mg/kg in rats and 53 mg/kg in mice. The intraperitoneal LD50 is 43 mg/kg in rats.L31608
Xylometazoline poisoning is documented in three pediatric patients who were exposed to a drug concentration 40 times above the adequate dosage for children due to a compounding error: these patients experienced bradypnea and sinus bradycardia with supraventricular extrasystoles and were managed with fluid management.A228528
Xylometazoline is an imidazoline derivative A228523 with sympathomimetic and nasal decongestant activity. Xylometazoline works by binding to alpha (?)-adrenergic receptors to cause vasoconstriction of nasal blood vessels.A228508
Xylometazoline is available in over-the-counter (OTC) nasal sprays or drops to temporarily relieve nasal congestion due to cold, hay fever or other respiratory allergies. In some countries, it is available as combination products with ipratropium, domiphen, or dexpanthenol.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Valsartan | Xylometazoline may decrease the antihypertensive activities of Valsartan. |
| Ramipril | Xylometazoline may decrease the antihypertensive activities of Ramipril. |
| Reserpine | Xylometazoline may decrease the antihypertensive activities of Reserpine. |
| Remikiren | Xylometazoline may decrease the antihypertensive activities of Remikiren. |
| Torasemide | Xylometazoline may decrease the antihypertensive activities of Torasemide. |
| Olmesartan | Xylometazoline may decrease the antihypertensive activities of Olmesartan. |
| Chlorthalidone | Xylometazoline may decrease the antihypertensive activities of Chlorthalidone. |
| Minoxidil | Xylometazoline may decrease the antihypertensive activities of Minoxidil. |
| Treprostinil | Xylometazoline may decrease the antihypertensive activities of Treprostinil. |
| Bendroflumethiazide | Xylometazoline may decrease the antihypertensive activities of Bendroflumethiazide. |
| Fosinopril | Xylometazoline may decrease the antihypertensive activities of Fosinopril. |
| Trandolapril | Xylometazoline may decrease the antihypertensive activities of Trandolapril. |
| Metolazone | Xylometazoline may decrease the antihypertensive activities of Metolazone. |
| Benazepril | Xylometazoline may decrease the antihypertensive activities of Benazepril. |
| Bosentan | Xylometazoline may decrease the antihypertensive activities of Bosentan. |
| Enalapril | Xylometazoline may decrease the antihypertensive activities of Enalapril. |
| Cyclothiazide | Xylometazoline may decrease the antihypertensive activities of Cyclothiazide. |
| Candoxatril | Xylometazoline may decrease the antihypertensive activities of Candoxatril. |
| Mecamylamine | Xylometazoline may decrease the antihypertensive activities of Mecamylamine. |
| Moexipril | Xylometazoline may decrease the antihypertensive activities of Moexipril. |
| Eplerenone | Xylometazoline may decrease the antihypertensive activities of Eplerenone. |
| Lisinopril | Xylometazoline may decrease the antihypertensive activities of Lisinopril. |
| Nitroglycerin | Xylometazoline may decrease the antihypertensive activities of Nitroglycerin. |
| Metyrosine | Xylometazoline may decrease the antihypertensive activities of Metyrosine. |
| Hydroflumethiazide | Xylometazoline may decrease the antihypertensive activities of Hydroflumethiazide. |
| Cryptenamine | Xylometazoline may decrease the antihypertensive activities of Cryptenamine. |
| Perindopril | Xylometazoline may decrease the antihypertensive activities of Perindopril. |
| Candesartan cilexetil | Xylometazoline may decrease the antihypertensive activities of Candesartan cilexetil. |
| Fenoldopam | Xylometazoline may decrease the antihypertensive activities of Fenoldopam. |
| Indapamide | Xylometazoline may decrease the antihypertensive activities of Indapamide. |
| Tadalafil | Xylometazoline may decrease the antihypertensive activities of Tadalafil. |
| Eprosartan | Xylometazoline may decrease the antihypertensive activities of Eprosartan. |
| Chlorothiazide | Xylometazoline may decrease the antihypertensive activities of Chlorothiazide. |
| Quinapril | Xylometazoline may decrease the antihypertensive activities of Quinapril. |
| Telmisartan | Xylometazoline may decrease the antihypertensive activities of Telmisartan. |
| Methyldopa | Xylometazoline may decrease the antihypertensive activities of Methyldopa. |
| Hydrochlorothiazide | Xylometazoline may decrease the antihypertensive activities of Hydrochlorothiazide. |
| Trichlormethiazide | Xylometazoline may decrease the antihypertensive activities of Trichlormethiazide. |
| Irbesartan | Xylometazoline may decrease the antihypertensive activities of Irbesartan. |
| Deserpidine | Xylometazoline may decrease the antihypertensive activities of Deserpidine. |
| Pentolinium | Xylometazoline may decrease the antihypertensive activities of Pentolinium. |
| Trimethaphan | Xylometazoline may decrease the antihypertensive activities of Trimethaphan. |
| Diazoxide | Xylometazoline may decrease the antihypertensive activities of Diazoxide. |
| Captopril | Xylometazoline may decrease the antihypertensive activities of Captopril. |
| Epoprostenol | Xylometazoline may decrease the antihypertensive activities of Epoprostenol. |
| Hydralazine | Xylometazoline may decrease the antihypertensive activities of Hydralazine. |
| Polythiazide | Xylometazoline may decrease the antihypertensive activities of Polythiazide. |
| Cilazapril | Xylometazoline may decrease the antihypertensive activities of Cilazapril. |
| Saprisartan | Xylometazoline may decrease the antihypertensive activities of Saprisartan. |
| Spirapril | Xylometazoline may decrease the antihypertensive activities of Spirapril. |
| Tienilic acid | Xylometazoline may decrease the antihypertensive activities of Tienilic acid. |
| Debrisoquine | Xylometazoline may decrease the antihypertensive activities of Debrisoquine. |
| Sitaxentan | Xylometazoline may decrease the antihypertensive activities of Sitaxentan. |
| Ambrisentan | Xylometazoline may decrease the antihypertensive activities of Ambrisentan. |
| Diethylnorspermine | Xylometazoline may decrease the antihypertensive activities of Diethylnorspermine. |
| Pinacidil | Xylometazoline may decrease the antihypertensive activities of Pinacidil. |
| Temocapril | Xylometazoline may decrease the antihypertensive activities of Temocapril. |
| Riociguat | Xylometazoline may decrease the antihypertensive activities of Riociguat. |
| Macitentan | Xylometazoline may decrease the antihypertensive activities of Macitentan. |
| Hexamethonium | Xylometazoline may decrease the antihypertensive activities of Hexamethonium. |
| Aliskiren | Xylometazoline may decrease the antihypertensive activities of Aliskiren. |
| Rauwolfia serpentina root | Xylometazoline may decrease the antihypertensive activities of Rauwolfia serpentina root. |
| Enalaprilat | Xylometazoline may decrease the antihypertensive activities of Enalaprilat. |
| Selexipag | Xylometazoline may decrease the antihypertensive activities of Selexipag. |
| Angiotensin 1-7 | Xylometazoline may decrease the antihypertensive activities of Angiotensin 1-7. |
| Imidapril | Xylometazoline may decrease the antihypertensive activities of Imidapril. |
| BQ-123 | Xylometazoline may decrease the antihypertensive activities of BQ-123. |
| Dihydralazine | Xylometazoline may decrease the antihypertensive activities of Dihydralazine. |
| Zofenopril | Xylometazoline may decrease the antihypertensive activities of Zofenopril. |
| Guanoxan | Xylometazoline may decrease the antihypertensive activities of Guanoxan. |
| Delapril | Xylometazoline may decrease the antihypertensive activities of Delapril. |
| Vincamine | Xylometazoline may decrease the antihypertensive activities of Vincamine. |
| Linsidomine | Xylometazoline may decrease the antihypertensive activities of Linsidomine. |
| Guanoxabenz | Xylometazoline may decrease the antihypertensive activities of Guanoxabenz. |
| Tolonidine | Xylometazoline may decrease the antihypertensive activities of Tolonidine. |
| Endralazine | Xylometazoline may decrease the antihypertensive activities of Endralazine. |
| Cadralazine | Xylometazoline may decrease the antihypertensive activities of Cadralazine. |
| Cyclopenthiazide | Xylometazoline may decrease the antihypertensive activities of Cyclopenthiazide. |
| Bietaserpine | Xylometazoline may decrease the antihypertensive activities of Bietaserpine. |
| Guanazodine | Xylometazoline may decrease the antihypertensive activities of Guanazodine. |
| Methoserpidine | Xylometazoline may decrease the antihypertensive activities of Methoserpidine. |
| Guanoclor | Xylometazoline may decrease the antihypertensive activities of Guanoclor. |
| Muzolimine | Xylometazoline may decrease the antihypertensive activities of Muzolimine. |
| Xipamide | Xylometazoline may decrease the antihypertensive activities of Xipamide. |
| Candesartan | Xylometazoline may decrease the antihypertensive activities of Candesartan. |
| Tocopherylquinone | Xylometazoline may decrease the antihypertensive activities of Tocopherylquinone. |
| Benazeprilat | Xylometazoline may decrease the antihypertensive activities of Benazeprilat. |
| Ramiprilat | Xylometazoline may decrease the antihypertensive activities of Ramiprilat. |
| Perindoprilat | Xylometazoline may decrease the antihypertensive activities of Perindoprilat. |
| Quinaprilat | Xylometazoline may decrease the antihypertensive activities of Quinaprilat. |
| Furosemide | Xylometazoline may decrease the antihypertensive activities of Furosemide. |
| Levamlodipine | Xylometazoline may decrease the antihypertensive activities of Levamlodipine. |
| Buthiazide | Xylometazoline may decrease the antihypertensive activities of Buthiazide. |
| Azilsartan medoxomil | Xylometazoline may decrease the antihypertensive activities of Azilsartan medoxomil. |
| Benzylpenicilloyl polylysine | Xylometazoline may decrease effectiveness of Benzylpenicilloyl polylysine as a diagnostic agent. |
| Desmopressin | The risk or severity of hypertension can be increased when Desmopressin is combined with Xylometazoline. |
| Cyclosporine | The risk or severity of hypertension can be increased when Cyclosporine is combined with Xylometazoline. |
| Icosapent | The risk or severity of hypertension can be increased when Icosapent is combined with Xylometazoline. |
| Phentermine | The risk or severity of hypertension can be increased when Phentermine is combined with Xylometazoline. |
| Midodrine | The risk or severity of hypertension can be increased when Midodrine is combined with Xylometazoline. |