Peringatan Keamanan

Acute oral toxicity (LD50): 4500 mg/kg Mouse.

Sulfathiazole

DB06147

small molecule approved vet_approved withdrawn

Deskripsi

Sulfathiazole is a short-acting sulfa drug. It used to be a common oral and topical antimicrobial until less toxic alternatives were discovered. It is still occasionally used, sometimes in combination with sulfabenzamide and sulfacetamide.

Except for those formulated for vaginal use, the FDA withdrew its approval for the use of all drug products containing sulfathiazole.L43942

Struktur Molekul 2D

Berat 255.317
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Metabolism of sulfonamide drugs in animals includes conjugation at the N4-position (acetyl, sulfate, glucuronic acid, and glucose), conjugation at the N1-position (sulfate and glucuronic acid), removal of the p-amino group (formation of the desamino metabolite), ring hydroxylation, and conjugation of the ring hydroxylation products. Dietary nitrite enhances the production of the desamino metabolite of sulfathiazole. The intermediate leading to the desamino metabolite of sulfamethazine is weakly mutagenic in the Ames test (Nelson et al., 1987; Paulson et al., 1987).

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

17 Data
Magnesium The serum concentration of Magnesium can be decreased when it is combined with Sulfathiazole.
Benzylpenicillin Sulfathiazole may decrease the excretion rate of Benzylpenicillin which could result in a higher serum level.
Insulin human The risk or severity of hypoglycemia can be increased when Sulfathiazole is combined with Insulin human.
Insulin lispro The risk or severity of hypoglycemia can be increased when Sulfathiazole is combined with Insulin lispro.
Insulin glargine The risk or severity of hypoglycemia can be increased when Sulfathiazole is combined with Insulin glargine.
Insulin pork The risk or severity of hypoglycemia can be increased when Sulfathiazole is combined with Insulin pork.
Insulin aspart The risk or severity of hypoglycemia can be increased when Sulfathiazole is combined with Insulin aspart.
Insulin detemir The risk or severity of hypoglycemia can be increased when Sulfathiazole is combined with Insulin detemir.
Insulin glulisine The risk or severity of hypoglycemia can be increased when Sulfathiazole is combined with Insulin glulisine.
NN344 The risk or severity of hypoglycemia can be increased when Sulfathiazole is combined with NN344.
Insulin beef The risk or severity of hypoglycemia can be increased when Sulfathiazole is combined with Insulin beef.
Insulin degludec The risk or severity of hypoglycemia can be increased when Sulfathiazole is combined with Insulin degludec.
Insulin argine The risk or severity of hypoglycemia can be increased when Sulfathiazole is combined with Insulin argine.
Insulin peglispro The risk or severity of hypoglycemia can be increased when Sulfathiazole is combined with Insulin peglispro.
Insulin tregopil The risk or severity of hypoglycemia can be increased when Sulfathiazole is combined with Insulin tregopil.
Chloroprocaine The therapeutic efficacy of Sulfathiazole can be decreased when used in combination with Chloroprocaine.
Insulin icodec The risk or severity of hypoglycemia can be increased when Sulfathiazole is combined with Insulin icodec.

Target Protein

Dihydropteroate synthetase

Referensi & Sumber

Contoh Produk & Brand

Produk: 2 • International brands: 2
Produk
  • Gyne-Sulf
    Cream • - • Vaginal • US • Generic • Approved
  • Triple Sulfa
    Cream • - • Vaginal • US • Generic • Approved
International Brands
  • Norsulfazolum — Galen
  • Sulfatiazol — Fecofar

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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