Bifonazole

DB04794

small molecule approved investigational

Deskripsi

Bifonazole is an azole antifungal drug.

Struktur Molekul 2D

Berat 310.3917
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 1-2 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Very low absorption following topical administration (0.6% of an applied dose). In cases of skin lesions absorption is increased (2.5%).

Metabolisme

Hepatic.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

309 Data
Lomitapide The metabolism of Lomitapide can be decreased when combined with Bifonazole.
Amphotericin B The therapeutic efficacy of Amphotericin B can be decreased when used in combination with Bifonazole.
Didanosine Didanosine can cause a decrease in the absorption of Bifonazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Eliglustat The metabolism of Eliglustat can be decreased when combined with Bifonazole.
Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Bifonazole.
Sildenafil The serum concentration of Sildenafil can be increased when it is combined with Bifonazole.
Cilostazol The metabolism of Cilostazol can be decreased when combined with Bifonazole.
Colchicine The metabolism of Colchicine can be decreased when combined with Bifonazole.
Iloperidone The metabolism of Iloperidone can be decreased when combined with Bifonazole.
Retapamulin The metabolism of Retapamulin can be decreased when combined with Bifonazole.
Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Bifonazole.
Vardenafil The metabolism of Vardenafil can be decreased when combined with Bifonazole.
Eszopiclone The metabolism of Eszopiclone can be decreased when combined with Bifonazole.
Zopiclone The metabolism of Zopiclone can be decreased when combined with Bifonazole.
Lovastatin The metabolism of Lovastatin can be decreased when combined with Bifonazole.
Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Bifonazole.
Alprazolam The metabolism of Alprazolam can be decreased when combined with Bifonazole.
Sucralfate Sucralfate can cause a decrease in the absorption of Bifonazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Warfarin The serum concentration of Warfarin can be increased when it is combined with Bifonazole.
Acenocoumarol The serum concentration of Acenocoumarol can be increased when it is combined with Bifonazole.
(R)-warfarin The serum concentration of (R)-warfarin can be increased when it is combined with Bifonazole.
R,S-Warfarin alcohol The serum concentration of R,S-Warfarin alcohol can be increased when it is combined with Bifonazole.
S,R-Warfarin alcohol The serum concentration of S,R-Warfarin alcohol can be increased when it is combined with Bifonazole.
(S)-Warfarin The serum concentration of (S)-Warfarin can be increased when it is combined with Bifonazole.
Midazolam The serum concentration of Midazolam can be increased when it is combined with Bifonazole.
Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Bifonazole.
Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Bifonazole.
Isradipine The therapeutic efficacy of Bifonazole can be increased when used in combination with Isradipine.
Diltiazem The therapeutic efficacy of Bifonazole can be increased when used in combination with Diltiazem.
Amlodipine The therapeutic efficacy of Bifonazole can be increased when used in combination with Amlodipine.
Nimodipine The therapeutic efficacy of Bifonazole can be increased when used in combination with Nimodipine.
Nisoldipine The therapeutic efficacy of Bifonazole can be increased when used in combination with Nisoldipine.
Lercanidipine The therapeutic efficacy of Bifonazole can be increased when used in combination with Lercanidipine.
Cinnarizine The therapeutic efficacy of Bifonazole can be increased when used in combination with Cinnarizine.
Nicardipine The therapeutic efficacy of Bifonazole can be increased when used in combination with Nicardipine.
Magnesium sulfate The therapeutic efficacy of Bifonazole can be increased when used in combination with Magnesium sulfate.
Verapamil The therapeutic efficacy of Bifonazole can be increased when used in combination with Verapamil.
Zonisamide The therapeutic efficacy of Bifonazole can be increased when used in combination with Zonisamide.
Felodipine The therapeutic efficacy of Bifonazole can be increased when used in combination with Felodipine.
Nitrendipine The therapeutic efficacy of Bifonazole can be increased when used in combination with Nitrendipine.
Perhexiline The therapeutic efficacy of Bifonazole can be increased when used in combination with Perhexiline.
Nifedipine The therapeutic efficacy of Bifonazole can be increased when used in combination with Nifedipine.
Bepridil The therapeutic efficacy of Bifonazole can be increased when used in combination with Bepridil.
Mibefradil The therapeutic efficacy of Bifonazole can be increased when used in combination with Mibefradil.
Nimesulide The therapeutic efficacy of Bifonazole can be increased when used in combination with Nimesulide.
Prenylamine The therapeutic efficacy of Bifonazole can be increased when used in combination with Prenylamine.
Cyclandelate The therapeutic efficacy of Bifonazole can be increased when used in combination with Cyclandelate.
Flunarizine The therapeutic efficacy of Bifonazole can be increased when used in combination with Flunarizine.
Fluspirilene The therapeutic efficacy of Bifonazole can be increased when used in combination with Fluspirilene.
Clevidipine The therapeutic efficacy of Bifonazole can be increased when used in combination with Clevidipine.
Methsuximide The therapeutic efficacy of Bifonazole can be increased when used in combination with Methsuximide.
Seletracetam The therapeutic efficacy of Bifonazole can be increased when used in combination with Seletracetam.
Nylidrin The therapeutic efficacy of Bifonazole can be increased when used in combination with Nylidrin.
Ziconotide The therapeutic efficacy of Bifonazole can be increased when used in combination with Ziconotide.
Dotarizine The therapeutic efficacy of Bifonazole can be increased when used in combination with Dotarizine.
Xylometazoline The therapeutic efficacy of Bifonazole can be increased when used in combination with Xylometazoline.
Tranilast The therapeutic efficacy of Bifonazole can be increased when used in combination with Tranilast.
Fasudil The therapeutic efficacy of Bifonazole can be increased when used in combination with Fasudil.
Agmatine The therapeutic efficacy of Bifonazole can be increased when used in combination with Agmatine.
Fendiline The therapeutic efficacy of Bifonazole can be increased when used in combination with Fendiline.
Eperisone The therapeutic efficacy of Bifonazole can be increased when used in combination with Eperisone.
Trimebutine The therapeutic efficacy of Bifonazole can be increased when used in combination with Trimebutine.
Pinaverium The therapeutic efficacy of Bifonazole can be increased when used in combination with Pinaverium.
Barnidipine The therapeutic efficacy of Bifonazole can be increased when used in combination with Barnidipine.
Aranidipine The therapeutic efficacy of Bifonazole can be increased when used in combination with Aranidipine.
Azelnidipine The therapeutic efficacy of Bifonazole can be increased when used in combination with Azelnidipine.
Benidipine The therapeutic efficacy of Bifonazole can be increased when used in combination with Benidipine.
Cilnidipine The therapeutic efficacy of Bifonazole can be increased when used in combination with Cilnidipine.
Darodipine The therapeutic efficacy of Bifonazole can be increased when used in combination with Darodipine.
Efonidipine The therapeutic efficacy of Bifonazole can be increased when used in combination with Efonidipine.
Lacidipine The therapeutic efficacy of Bifonazole can be increased when used in combination with Lacidipine.
Manidipine The therapeutic efficacy of Bifonazole can be increased when used in combination with Manidipine.
Niguldipine The therapeutic efficacy of Bifonazole can be increased when used in combination with Niguldipine.
Niludipine The therapeutic efficacy of Bifonazole can be increased when used in combination with Niludipine.
Carboxyamidotriazole The therapeutic efficacy of Bifonazole can be increased when used in combination with Carboxyamidotriazole.
Naftopidil The therapeutic efficacy of Bifonazole can be increased when used in combination with Naftopidil.
Tetrahydropalmatine The therapeutic efficacy of Bifonazole can be increased when used in combination with Tetrahydropalmatine.
Vinpocetine The therapeutic efficacy of Bifonazole can be increased when used in combination with Vinpocetine.
Gallopamil The therapeutic efficacy of Bifonazole can be increased when used in combination with Gallopamil.
Bencyclane The therapeutic efficacy of Bifonazole can be increased when used in combination with Bencyclane.
Otilonium The therapeutic efficacy of Bifonazole can be increased when used in combination with Otilonium.
Terodiline The therapeutic efficacy of Bifonazole can be increased when used in combination with Terodiline.
Lidoflazine The therapeutic efficacy of Bifonazole can be increased when used in combination with Lidoflazine.
Penfluridol The therapeutic efficacy of Bifonazole can be increased when used in combination with Penfluridol.
Caroverine The therapeutic efficacy of Bifonazole can be increased when used in combination with Caroverine.
WIN 55212-2 The therapeutic efficacy of Bifonazole can be increased when used in combination with WIN 55212-2.
Dexverapamil The therapeutic efficacy of Bifonazole can be increased when used in combination with Dexverapamil.
Emopamil The therapeutic efficacy of Bifonazole can be increased when used in combination with Emopamil.
Lomerizine The therapeutic efficacy of Bifonazole can be increased when used in combination with Lomerizine.
Tetrandrine The therapeutic efficacy of Bifonazole can be increased when used in combination with Tetrandrine.
Dexniguldipine The therapeutic efficacy of Bifonazole can be increased when used in combination with Dexniguldipine.
Aripiprazole The metabolism of Aripiprazole can be decreased when combined with Bifonazole.
Aripiprazole lauroxil The metabolism of Aripiprazole lauroxil can be decreased when combined with Bifonazole.
Azithromycin The metabolism of Azithromycin can be decreased when combined with Bifonazole.
Ziprasidone The metabolism of Ziprasidone can be decreased when combined with Bifonazole.
Methysergide The metabolism of Methysergide can be decreased when combined with Bifonazole.
Meperidine The metabolism of Meperidine can be decreased when combined with Bifonazole.
Chlorpromazine The metabolism of Chlorpromazine can be decreased when combined with Bifonazole.
Albendazole The metabolism of Albendazole can be decreased when combined with Bifonazole.
Cephalexin The metabolism of Cephalexin can be decreased when combined with Bifonazole.

Target Protein

Lanosterol 14-alpha demethylase ERG11
Cytochrome P450 2B6 CYP2B6

Referensi & Sumber

Synthesis reference: Regal, E., Draber, W., Buchel, K.H.and Plempel, M.; U.S. Patent 4,118,487; October 3,1978; assigned to Bayer A.G.
Artikel (PubMed)
  • PMID: 16681817
    Watanabe S, Takahashi H, Nishikawa T, Takiuchi I, Higashi N, Nishimoto K, Kagawa S, Yamaguchi H, Ogawa H: A comparative clinical study between 2 weeks of luliconazole 1% cream treatment and 4 weeks of bifonazole 1% cream treatment for tinea pedis. Mycoses. 2006 May;49(3):236-41.
  • PMID: 11767287
    Cho KJ, Su W, Chen WC, Law YP, Fang HC, Liu CP, Cheng JS, Lee KC, Lo YK, Chang HT, Huang JK, Jan CR: Mechanism of bifonazole-induced Ca2+i increases in MDCK renal tubular cells. Chin J Physiol. 2001 Sep 30;44(3):97-101.
  • PMID: 10907343
    Tanuma H, Doi M, Sato N, Nishiyama S, Abe M, Kume H, Katsuoka K: Bifonazole (Mycospor cream) in the treatment of moccasin-type tinea pedis. Comparison between combination therapy of bifonazole cream + 10% urea ointment (Urepearl) and occlusive dressing therapy with the same agents. Mycoses. 2000;43(3-4):129-37.
  • PMID: 6372801
    Berg D, Regel E, Harenberg HE, Plempel M: Bifonazole and clotrimazole. Their mode of action and the possible reason for the fungicidal behaviour of bifonazole. Arzneimittelforschung. 1984;34(2):139-46.

Contoh Produk & Brand

Produk: 0 • International brands: 7
International Brands
  • Amycor — Merck
  • Azolmen — Menarini
  • Bayclear Plus — Bayer
  • Bifonol — Mayado Seiyaku
  • Canespor — Bayer
  • Canesten — Bayer
  • Mycospor — Bayer

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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