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8

Total database: 17430
Struktur (SMILES)
5 (62.5%)
Target
6 (75.0%)
Genomik
1 (12.5%)
Referensi
8 (100.0%)

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Hasil Pencarian (8)

Albumin human Approved DB00062
biotech | CAS: 9048-46-8

Human serum albumin is the primary protein present in human blood plasma. The main function of albumin is to maintain the oncotic pressure of blood [A33706]. It binds to water, cations (such as Ca2+, Na+ and K+), fatty acids, hormones, bilirubin, thyroxine (T…

Kategori:
AlbuminsAmino Acids, Peptides, and ProteinsBlood and Blood Forming Organs +13
Target Protein:
Nitric oxide
Waktu Paruh-
Vol. DistribusiAlbumin is distribu…
Klirens-
Genetik -
Calcium DB01373
small molecule | CAS: 7440-70-2

Calcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal transduction pathways. The skeleton acts as a major mineral storage site for the element and releases Ca2+ ions into the bloodstream un…

Kategori:
Alimentary Tract and MetabolismAntacids and AdsorbentsBiological Factors +13
Target Protein:
Voltage-dependent L-type calcium channel subunit alpha-1CCalcium-transporting ATPase type 2C member 1Troponin C, skeletal muscle +17
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Calcium lactate Approved DB13231
small molecule | CAS: 814-80-2

Calcium lactate is a salt that consists of two lactate anions for each calcium cation (Ca2+). It is prepared commercially by the neutralization of lactic acid with calcium carbonate or calcium hydroxide. Approved by the FDA as a direct food substance affirmed…

Kategori:
Alimentary Tract and MetabolismCalcium SaltsHydroxy Acids +1
Waktu ParuhNo pharmacokinetic …
Vol. DistribusiThe majority of cal…
KlirensNo pharmacokinetic …
Genetik -
Cannabidiol Approved DB09061
small molecule | CAS: 13956-29-1

Cannabidiol, or CBD, is one of at least 85 active cannabinoids identified within the Cannabis plant. It is a major phytocannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological targets of the endocan…

Kategori:
Agents producing tachycardiaAgents that produce hypertensionAnticonvulsants +56
Target Protein:
Cannabinoid receptor 1Cannabinoid receptor 2G-protein coupled receptor 12 +36
Waktu ParuhThe CBD component o…
Vol. DistribusiCannabinoids are di…
Klirens-
Genetik -
Gliquidone Approved DB01251
small molecule | CAS: 33342-05-1

Gliquidone is a sulfonylurea drug used to treat diabetes mellitus type 2. It is an ATP-dependent K+ (KATP) channel blocker. This block causes a depolarization which leads to activation of voltage-dependent Ca channels and Ca2+ influx, and eventually increases…

Kategori:
Alimentary Tract and MetabolismAmidesBlood Glucose Lowering Agents +8
Target Protein:
ATP-binding cassette sub-family C member 8ATP-sensitive inward rectifier potassium channel 10ATP-sensitive inward rectifier potassium channel 8
Waktu ParuhThe mean terminal h…
Vol. Distribusi-
Klirens-
Genetik -
Infliximab Approved DB00065
biotech | CAS: 170277-31-3

Infliximab is a tumor necrosis factor (TNF-alpha or TNF-?) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions [A31469]. Infliximab is produced by a recombinant cell line cultured by continuous pe…

Kategori:
Agents Causing Muscle ToxicityAgents reducing cytokine levelsAmino Acids, Peptides, and Proteins +21
Target Protein:
Tumor necrosis factor
Gen Terkait:
FCGR3A
Waktu ParuhThe median terminal…
Vol. DistribusiBased on a pharmaco…
KlirensIn patients with Cr…
Genetik 1 Varian
biotech

The use of the plant species _Cannabis sativa_ and _Cannabis indica_, popularly known as marijuana, has gained popularity in recent years for the management of a wide variety of medical conditions as a wave of legalization in North America has changed public …

Kategori:
Agents producing tachycardiaBCRP/ABCG2 InhibitorsCytochrome P-450 CYP1A2 Inducers +51
Target Protein:
Cannabinoid receptor 1Cannabinoid receptor 2G-protein coupled receptor 12 +38
Waktu ParuhThe half life of TH…
Vol. DistribusiAs a very lipophili…
KlirensOne study reported …
Genetik -
Saruparib DB18982
small molecule | CAS: 2589531-76-8

Saruparib is under investigation in clinical trial NCT06380751 (Saruparib (AZD5305) Plus Camizestrant Compared With CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant in Hr-positive, Her2-negative (IHC 0, 1+, 2+/ ISH Non-amplified), BRCA1, BRCA2, or…

Kategori:
Heterocyclic Compounds, Fused-Ring
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -