Peringatan Keamanan

Acute oral toxicity (LD50): 866 mg/kg Mouse.

Phenacetin

DB03783

small molecule withdrawn

Deskripsi

Phenacetin was withdrawn from the Canadian market in June 1973 due to concerns regarding nephropathy (damage to or disease of the kidney).

Struktur Molekul 2D

Berat 179.2157
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Metabolised in the body to paracetamol.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

799 Data
Deferasirox The serum concentration of Phenacetin can be increased when it is combined with Deferasirox.
Peginterferon alfa-2b The serum concentration of Phenacetin can be increased when it is combined with Peginterferon alfa-2b.
Leflunomide The serum concentration of Phenacetin can be decreased when it is combined with Leflunomide.
Teriflunomide The serum concentration of Phenacetin can be decreased when it is combined with Teriflunomide.
Mirabegron The serum concentration of Phenacetin can be increased when it is combined with Mirabegron.
Abiraterone The serum concentration of Phenacetin can be increased when it is combined with Abiraterone.
Cyproterone acetate The metabolism of Phenacetin can be increased when combined with Cyproterone acetate.
Albendazole The metabolism of Phenacetin can be increased when combined with Albendazole.
Carbamazepine The metabolism of Phenacetin can be increased when combined with Carbamazepine.
Primidone The metabolism of Phenacetin can be increased when combined with Primidone.
Rifampin The metabolism of Phenacetin can be increased when combined with Rifampicin.
Caffeine The metabolism of Phenacetin can be decreased when combined with Caffeine.
Moxifloxacin The metabolism of Phenacetin can be decreased when combined with Moxifloxacin.
Lidocaine The metabolism of Phenacetin can be decreased when combined with Lidocaine.
Mexiletine The metabolism of Phenacetin can be decreased when combined with Mexiletine.
Alosetron The metabolism of Phenacetin can be decreased when combined with Alosetron.
Gatifloxacin The metabolism of Phenacetin can be decreased when combined with Gatifloxacin.
Simeprevir The metabolism of Phenacetin can be decreased when combined with Simeprevir.
Lobeglitazone The metabolism of Phenacetin can be decreased when combined with Lobeglitazone.
Pazufloxacin The metabolism of Phenacetin can be decreased when combined with Pazufloxacin.
Osilodrostat The metabolism of Phenacetin can be decreased when combined with Osilodrostat.
Tranylcypromine The metabolism of Phenacetin can be decreased when combined with Tranylcypromine.
Nicardipine The metabolism of Phenacetin can be decreased when combined with Nicardipine.
Sulfaphenazole The metabolism of Phenacetin can be decreased when combined with Sulfaphenazole.
Cimetidine The metabolism of Phenacetin can be decreased when combined with Cimetidine.
Manidipine The metabolism of Phenacetin can be decreased when combined with Manidipine.
Clobazam The serum concentration of Phenacetin can be increased when it is combined with Clobazam.
Fusidic acid The metabolism of Phenacetin can be decreased when combined with Fusidic acid.
Cholecalciferol The metabolism of Phenacetin can be decreased when combined with Cholecalciferol.
Metoprolol The metabolism of Phenacetin can be decreased when combined with Metoprolol.
Venlafaxine The metabolism of Phenacetin can be decreased when combined with Venlafaxine.
Celecoxib The metabolism of Phenacetin can be decreased when combined with Celecoxib.
Chloroquine The metabolism of Phenacetin can be decreased when combined with Chloroquine.
Perhexiline The metabolism of Phenacetin can be decreased when combined with Perhexiline.
Panobinostat The metabolism of Phenacetin can be decreased when combined with Panobinostat.
Vilazodone The metabolism of Phenacetin can be decreased when combined with Vilazodone.
Phenylbutyric acid The metabolism of Phenacetin can be decreased when combined with Phenylbutyric acid.
Rolapitant The metabolism of Phenacetin can be decreased when combined with Rolapitant.
Asunaprevir The metabolism of Phenacetin can be decreased when combined with Asunaprevir.
Ritanserin The metabolism of Phenacetin can be decreased when combined with Ritanserin.
Clozapine The serum concentration of Phenacetin can be increased when it is combined with Clozapine.
Quinine The metabolism of Phenacetin can be decreased when combined with Quinine.
Terbinafine The metabolism of Phenacetin can be decreased when combined with Terbinafine.
Lumefantrine The metabolism of Phenacetin can be decreased when combined with Lumefantrine.
Cyclosporine The metabolism of Phenacetin can be decreased when combined with Cyclosporine.
Imipramine The metabolism of Phenacetin can be decreased when combined with Imipramine.
Darifenacin The metabolism of Phenacetin can be decreased when combined with Darifenacin.
Desipramine The metabolism of Phenacetin can be decreased when combined with Desipramine.
Dosulepin The metabolism of Phenacetin can be decreased when combined with Dosulepin.
Tegaserod The metabolism of Phenacetin can be decreased when combined with Tegaserod.
Primaquine The metabolism of Phenacetin can be decreased when combined with Primaquine.
Rhein The metabolism of Phenacetin can be decreased when combined with Rhein.
Duloxetine The metabolism of Phenacetin can be decreased when combined with Duloxetine.
Chlorpromazine The metabolism of Phenacetin can be decreased when combined with Chlorpromazine.
Rucaparib The metabolism of Phenacetin can be decreased when combined with Rucaparib.
Fluvoxamine The metabolism of Phenacetin can be decreased when combined with Fluvoxamine.
Lorcaserin The metabolism of Phenacetin can be decreased when combined with Lorcaserin.
Berotralstat The metabolism of Phenacetin can be decreased when combined with Berotralstat.
Thioridazine The metabolism of Phenacetin can be decreased when combined with Thioridazine.
Paroxetine The metabolism of Phenacetin can be decreased when combined with Paroxetine.
Cinacalcet The metabolism of Phenacetin can be decreased when combined with Cinacalcet.
Bupropion The metabolism of Phenacetin can be decreased when combined with Bupropion.
Orphenadrine The metabolism of Phenacetin can be decreased when combined with Orphenadrine.
Propafenone The metabolism of Phenacetin can be decreased when combined with Propafenone.
Halofantrine The metabolism of Phenacetin can be decreased when combined with Halofantrine.
Methotrimeprazine The metabolism of Phenacetin can be decreased when combined with Methotrimeprazine.
Glycerol phenylbutyrate The metabolism of Phenacetin can be decreased when combined with Glycerol phenylbutyrate.
Cisapride The metabolism of Phenacetin can be decreased when combined with Cisapride.
Quinidine The metabolism of Phenacetin can be decreased when combined with Quinidine.
Troglitazone The metabolism of Phenacetin can be decreased when combined with Troglitazone.
Nabilone The metabolism of Phenacetin can be decreased when combined with Nabilone.
Imatinib The serum concentration of Phenacetin can be increased when it is combined with Imatinib.
Mifepristone The metabolism of Phenacetin can be decreased when combined with Mifepristone.
Felbamate The metabolism of Phenacetin can be decreased when combined with Felbamate.
Sulfinpyrazone The metabolism of Phenacetin can be decreased when combined with Sulfinpyrazone.
Iproniazid The metabolism of Phenacetin can be decreased when combined with Iproniazid.
Medical Cannabis The metabolism of Phenacetin can be decreased when combined with Medical Cannabis.
Valproic acid The metabolism of Phenacetin can be decreased when combined with Valproic acid.
Dabrafenib The serum concentration of Phenacetin can be decreased when it is combined with Dabrafenib.
Fluconazole The metabolism of Phenacetin can be decreased when combined with Fluconazole.
Floxuridine The metabolism of Phenacetin can be decreased when combined with Floxuridine.
Sorafenib The metabolism of Phenacetin can be decreased when combined with Sorafenib.
Miconazole The metabolism of Phenacetin can be decreased when combined with Miconazole.
Gemfibrozil The metabolism of Phenacetin can be decreased when combined with Gemfibrozil.
Pentobarbital The metabolism of Phenacetin can be increased when combined with Pentobarbital.
Letrozole The metabolism of Phenacetin can be decreased when combined with Letrozole.
Osimertinib The serum concentration of Phenacetin can be decreased when it is combined with Osimertinib.
Vemurafenib The serum concentration of Phenacetin can be increased when it is combined with Vemurafenib.
Pitolisant The serum concentration of Phenacetin can be decreased when it is combined with Pitolisant.
Metreleptin The metabolism of Phenacetin can be increased when combined with Metreleptin.
Citrulline The excretion of Citrulline can be decreased when combined with Phenacetin.
Cefotiam The excretion of Cefotiam can be decreased when combined with Phenacetin.
Tenofovir disoproxil The excretion of Tenofovir disoproxil can be decreased when combined with Phenacetin.
Indomethacin The excretion of Indomethacin can be decreased when combined with Phenacetin.
Aminohippuric acid The excretion of Aminohippuric acid can be decreased when combined with Phenacetin.
Cidofovir The excretion of Cidofovir can be decreased when combined with Phenacetin.
Trifluridine The excretion of Trifluridine can be decreased when combined with Phenacetin.
Cefdinir The excretion of Cefdinir can be decreased when combined with Phenacetin.
Stavudine The excretion of Stavudine can be decreased when combined with Phenacetin.
Fluorescein The excretion of Fluorescein can be decreased when combined with Phenacetin.

Target Protein

Prostaglandin G/H synthase 1 PTGS1
Inosine-5'-monophosphate dehydrogenase 1 IMPDH1

Referensi & Sumber

Synthesis reference: Ernst Bocker, Wolfgang Kracht, Roland Rupp, Erhard Schellmann, Viktor Trescher, Martin Ullrich, "Preparation of melt-sprayed spherical phenacetin granules." U.S. Patent US4086346, issued October, 1972.
Artikel (PubMed)
  • PMID: 1984193
    Dubach UC, Rosner B, Sturmer T: An epidemiologic study of abuse of analgesic drugs. Effects of phenacetin and salicylate on mortality and cardiovascular morbidity (1968 to 1987) N Engl J Med. 1991 Jan 17;324(3):155-60.
  • PMID: 6036245
    Cochran AJ, Lawson DH, Linton AL: Renal papillary necrosis following phenacetin excess. Scott Med J. 1967 Jul;12(7):246-50.
  • PMID: 14180501
    TAN GH, RABBINO MD, HOPPER J Jr: IS PHENACETIN A NEPHROTOXIN?A REPORT ON TWENTY-THREE USERS OF THE DRUG. Calif Med. 1964 Aug;101:73-7.
  • PMID: 12512867
    Brix AE: Renal papillary necrosis. Toxicol Pathol. 2002 Nov-Dec;30(6):672-4.

Contoh Produk & Brand

Produk: 0 • International brands: 5
International Brands
  • Achrocidin
  • Codempiral
  • Commotional
  • Contradol
  • Contradouleur

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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