Peringatan Keamanan

Patients experiencing an overdose may present with hematuria, oliguria, abdominal pain, acute renal failure, vomiting, diarrhea, rash, hyperactivity, and drowsiness.A190660,L11650 Treat overdose with symptomatic and supportive treatment, which may include emesis or hemodialysis.L11650

Amoxicillin

DB01060

small molecule approved vet_approved

Deskripsi

Amoxicillin, or BRL-2333, is a penicillin G derivative first described in the literature in 1972.A190648 Amoxicillin has similar activity to penicillin and ampicillin, but leads to higher serum concentrations than ampicillin.A190648

Amoxicillin was granted FDA approval on 18 January 1974.L11644

Struktur Molekul 2D

Berat 365.404
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) The half life of amoxicillin is 61.3 minutes.[A190675]
Volume Distribusi The central volume of distribution of amoxicillin is 27.7L.[A190630]
Klirens (Clearance) The mean clearance of amoxicillin is 21.3L/h.[A190630]

Absorpsi

Amoxicillin is approximately 60% bioavailable.A190675 A 250mg dose of oral amoxicillin reaches a Cmax 3.93±1.13mg/L with a Tmax 1.31±0.33h and an AUC of 27.29±4.72mg\*h/L.A190630 A 875mg dose of oral amoxicillin reaches a Cmax 11.21±3.42mg/L with a Tmax 1.52±0.40h and an AUC of 55.04±12.68mg\*h/L.A190630

Metabolisme

Incubation with human liver microsomes has lead to the detection of 7 metabolites.A190618 The M1 metabolite has undergone hydroxylation, M2 has undergone oxidative deamination, M3 to M5 have undergone oxidation of the aliphatic chain, M6 has undergone decarboxylation, and M7 has undergone glucuronidation.A190618

Rute Eliminasi

125mg to 1g doses of amoxicillin are 70-78% eliminated in the urine after 6 hours.A190648

Interaksi Makanan

1 Data
  • 1. Take with food.

Interaksi Obat

881 Data
Methotrexate The excretion of Methotrexate can be decreased when combined with Amoxicillin.
Probenecid The excretion of Amoxicillin can be decreased when combined with Probenecid.
Doxycycline The therapeutic efficacy of Amoxicillin can be decreased when used in combination with Doxycycline.
Lymecycline The therapeutic efficacy of Amoxicillin can be decreased when used in combination with Lymecycline.
Clomocycline The therapeutic efficacy of Amoxicillin can be decreased when used in combination with Clomocycline.
Tigecycline The therapeutic efficacy of Amoxicillin can be decreased when used in combination with Tigecycline.
Oxytetracycline The therapeutic efficacy of Amoxicillin can be decreased when used in combination with Oxytetracycline.
Demeclocycline The therapeutic efficacy of Amoxicillin can be decreased when used in combination with Demeclocycline.
Tetracycline The therapeutic efficacy of Amoxicillin can be decreased when used in combination with Tetracycline.
Metacycline The therapeutic efficacy of Amoxicillin can be decreased when used in combination with Metacycline.
Minocycline The therapeutic efficacy of Amoxicillin can be decreased when used in combination with Minocycline.
Rolitetracycline The therapeutic efficacy of Amoxicillin can be decreased when used in combination with Rolitetracycline.
Sarecycline The therapeutic efficacy of Amoxicillin can be decreased when used in combination with Sarecycline.
Eravacycline The therapeutic efficacy of Amoxicillin can be decreased when used in combination with Eravacycline.
Omadacycline The therapeutic efficacy of Amoxicillin can be decreased when used in combination with Omadacycline.
Penimepicycline The therapeutic efficacy of Amoxicillin can be decreased when used in combination with Penimepicycline.
Allopurinol The risk of a hypersensitivity reaction to Amoxicillin is increased when it is combined with Allopurinol.
Picosulfuric acid The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Amoxicillin.
Dicoumarol Amoxicillin may increase the anticoagulant activities of Dicoumarol.
Phenindione Amoxicillin may increase the anticoagulant activities of Phenindione.
Phenprocoumon Amoxicillin may increase the anticoagulant activities of Phenprocoumon.
Acenocoumarol Amoxicillin may increase the anticoagulant activities of Acenocoumarol.
4-hydroxycoumarin Amoxicillin may increase the anticoagulant activities of 4-hydroxycoumarin.
Coumarin Amoxicillin may increase the anticoagulant activities of Coumarin.
(R)-warfarin Amoxicillin may increase the anticoagulant activities of (R)-warfarin.
Ethyl biscoumacetate Amoxicillin may increase the anticoagulant activities of Ethyl biscoumacetate.
Fluindione Amoxicillin may increase the anticoagulant activities of Fluindione.
Clorindione Amoxicillin may increase the anticoagulant activities of Clorindione.
Diphenadione Amoxicillin may increase the anticoagulant activities of Diphenadione.
Tioclomarol Amoxicillin may increase the anticoagulant activities of Tioclomarol.
(S)-Warfarin Amoxicillin may increase the anticoagulant activities of (S)-Warfarin.
Diethylstilbestrol The therapeutic efficacy of Diethylstilbestrol can be decreased when used in combination with Amoxicillin.
Desogestrel The therapeutic efficacy of Desogestrel can be decreased when used in combination with Amoxicillin.
Levonorgestrel The therapeutic efficacy of Levonorgestrel can be decreased when used in combination with Amoxicillin.
Progesterone The therapeutic efficacy of Progesterone can be decreased when used in combination with Amoxicillin.
Norethisterone The therapeutic efficacy of Norethisterone can be decreased when used in combination with Amoxicillin.
Ethynodiol diacetate The therapeutic efficacy of Ethynodiol diacetate can be decreased when used in combination with Amoxicillin.
Mifepristone The therapeutic efficacy of Mifepristone can be decreased when used in combination with Amoxicillin.
Norgestimate The therapeutic efficacy of Norgestimate can be decreased when used in combination with Amoxicillin.
Ethinylestradiol The therapeutic efficacy of Ethinylestradiol can be decreased when used in combination with Amoxicillin.
Mestranol The therapeutic efficacy of Mestranol can be decreased when used in combination with Amoxicillin.
Octylphenoxy polyethoxyethanol The therapeutic efficacy of Octylphenoxy polyethoxyethanol can be decreased when used in combination with Amoxicillin.
Cyproterone acetate The therapeutic efficacy of Cyproterone acetate can be decreased when used in combination with Amoxicillin.
Trestolone The therapeutic efficacy of Trestolone can be decreased when used in combination with Amoxicillin.
Norelgestromin The therapeutic efficacy of Norelgestromin can be decreased when used in combination with Amoxicillin.
Gestodene The therapeutic efficacy of Gestodene can be decreased when used in combination with Amoxicillin.
Hydroxyprogesterone caproate The therapeutic efficacy of Hydroxyprogesterone caproate can be decreased when used in combination with Amoxicillin.
Ulipristal The therapeutic efficacy of Ulipristal can be decreased when used in combination with Amoxicillin.
Norethynodrel The therapeutic efficacy of Norethynodrel can be decreased when used in combination with Amoxicillin.
Norgestrel The therapeutic efficacy of Norgestrel can be decreased when used in combination with Amoxicillin.
Cloprostenol The therapeutic efficacy of Cloprostenol can be decreased when used in combination with Amoxicillin.
Gestrinone The therapeutic efficacy of Gestrinone can be decreased when used in combination with Amoxicillin.
Nomegestrol The therapeutic efficacy of Nomegestrol can be decreased when used in combination with Amoxicillin.
Lynestrenol The therapeutic efficacy of Lynestrenol can be decreased when used in combination with Amoxicillin.
Gossypol The therapeutic efficacy of Gossypol can be decreased when used in combination with Amoxicillin.
Ormeloxifene The therapeutic efficacy of Ormeloxifene can be decreased when used in combination with Amoxicillin.
Chlormadinone The therapeutic efficacy of Chlormadinone can be decreased when used in combination with Amoxicillin.
Norgestrienone The therapeutic efficacy of Norgestrienone can be decreased when used in combination with Amoxicillin.
Quingestanol The therapeutic efficacy of Quingestanol can be decreased when used in combination with Amoxicillin.
Demegestone The therapeutic efficacy of Demegestone can be decreased when used in combination with Amoxicillin.
Etynodiol The therapeutic efficacy of Etynodiol can be decreased when used in combination with Amoxicillin.
Estradiol benzoate The therapeutic efficacy of Estradiol benzoate can be decreased when used in combination with Amoxicillin.
Nomegestrol acetate The therapeutic efficacy of Nomegestrol acetate can be decreased when used in combination with Amoxicillin.
Norethindrone enanthate The therapeutic efficacy of Norethindrone enanthate can be decreased when used in combination with Amoxicillin.
Framycetin The serum concentration of Framycetin can be decreased when it is combined with Amoxicillin.
Paromomycin The serum concentration of Paromomycin can be decreased when it is combined with Amoxicillin.
Geneticin The serum concentration of Geneticin can be decreased when it is combined with Amoxicillin.
Apramycin The serum concentration of Apramycin can be decreased when it is combined with Amoxicillin.
Neamine The serum concentration of Neamine can be decreased when it is combined with Amoxicillin.
Puromycin The serum concentration of Puromycin can be decreased when it is combined with Amoxicillin.
Dihydrostreptomycin The serum concentration of Dihydrostreptomycin can be decreased when it is combined with Amoxicillin.
Hygromycin B The serum concentration of Hygromycin B can be decreased when it is combined with Amoxicillin.
BCG vaccine The therapeutic efficacy of BCG vaccine can be decreased when used in combination with Amoxicillin.
Typhoid vaccine The therapeutic efficacy of Typhoid vaccine can be decreased when used in combination with Amoxicillin.
Acemetacin Acemetacin may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Cyclosporine Cyclosporine may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Icosapent Icosapent may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Cefotiam Cefotiam may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Mesalazine Mesalazine may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Cefmenoxime Cefmenoxime may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Cefmetazole Cefmetazole may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Pamidronic acid Pamidronic acid may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Tenofovir disoproxil Tenofovir disoproxil may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Indomethacin Indomethacin may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Cidofovir Cidofovir may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Cefpiramide Cefpiramide may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Ceftazidime Ceftazidime may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Loracarbef Loracarbef may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Cefalotin Cefalotin may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Nabumetone Nabumetone may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Ketorolac Ketorolac may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Tenoxicam Tenoxicam may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Celecoxib Celecoxib may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Cefotaxime Cefotaxime may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Tolmetin Tolmetin may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Foscarnet Foscarnet may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Rofecoxib Rofecoxib may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Piroxicam Piroxicam may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Cephalexin Cephalexin may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Fenoprofen Fenoprofen may decrease the excretion rate of Amoxicillin which could result in a higher serum level.

Target Protein

Penicillin binding protein PBP1

Referensi & Sumber

Synthesis reference: Joan Cabre, Jose Diago, Asuncion Esteve, Johannes Ludescher, "Production of a crystalline salt of amoxicillin." U.S. Patent US6103897, issued April, 1971.
Artikel (PubMed)
  • PMID: 25089048
    Szultka M, Krzeminski R, Jackowski M, Buszewski B: Identification of In Vitro Metabolites of Amoxicillin in Human Liver Microsomes by LC-ESI/MS. Chromatographia. 2014;77:1027-1035. doi: 10.1007/s10337-014-2648-2. Epub 2014 Mar 22.
  • PMID: 16434549
    Li M, Anderson GD, Phillips BR, Kong W, Shen DD, Wang J: Interactions of amoxicillin and cefaclor with human renal organic anion and peptide transporters. Drug Metab Dispos. 2006 Apr;34(4):547-55. Epub 2006 Jan 24.
  • PMID: 23800901
    Carlier M, Noe M, De Waele JJ, Stove V, Verstraete AG, Lipman J, Roberts JA: Population pharmacokinetics and dosing simulations of amoxicillin/clavulanic acid in critically ill patients. J Antimicrob Chemother. 2013 Nov;68(11):2600-8. doi: 10.1093/jac/dkt240. Epub 2013 Jun 25.
  • PMID: 27330071
    de Velde F, de Winter BC, Koch BC, van Gelder T, Mouton JW: Non-linear absorption pharmacokinetics of amoxicillin: consequences for dosing regimens and clinical breakpoints. J Antimicrob Chemother. 2016 Oct;71(10):2909-17. doi: 10.1093/jac/dkw226. Epub 2016 Jun 20.
  • PMID: 29489203
    Akhavan BJ, Vijhani P: Amoxicillin .
  • PMID: 4598841
    Bodey GP, Nance J: Amoxicillin: in vitro and pharmacological studies. Antimicrob Agents Chemother. 1972 Apr;1(4):358-62. doi: 10.1128/aac.1.4.358.
  • PMID: 8584329
    Belko J, Urueta G, Emre U: Amoxicillin overdose manifested by hematuria and acute renal failure. Pediatr Infect Dis J. 1995 Oct;14(10):917-9.
  • PMID: 4680813
    Gordon C, Regamey C, Kirby WM: Comparative clinical pharmacology of amoxicillin and ampicillin administered orally. Antimicrob Agents Chemother. 1972 Jun;1(6):504-7. doi: 10.1128/aac.1.6.504.
Menampilkan 8 dari 10 artikel.

Contoh Produk & Brand

Produk: 1356 • International brands: 22
Produk
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Menampilkan 8 dari 1356 produk.
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Sekuens Gen/Protein (FASTA)

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