Peringatan Keamanan

Menthol, DL: ORAL (LD50): Acute: 2900 mg/kg Rat, 3100 mg/kg Mouse. DERMAL (LD50): Acute: 5001 mg/kg Rabbit.

Levomenthol

DB00825

small molecule approved

Deskripsi

Menthol is a covalent organic compound made synthetically or obtained from peppermint or other mint oils. Forming clear or white waxy, crystalline substance, menthol is typically solid at room temperature. (-)-Menthol is the naturally-occurring and main form of menthol, and is assigned the (1R,2S,5R) configuration. Menthol mediates anesthetic properties and anti-irritating properties locally, thus it is widely used to relieve minor throat irritations.

Struktur Molekul 2D

Berat 156.2652
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

717 Data
Ceritinib Levomenthol may increase the bradycardic activities of Ceritinib.
Ivabradine Levomenthol may increase the bradycardic activities of Ivabradine.
Ruxolitinib Ruxolitinib may increase the bradycardic activities of Levomenthol.
Hyoscyamine Hyoscyamine may increase the arrhythmogenic activities of Levomenthol.
Carteolol Levomenthol may increase the arrhythmogenic activities of Carteolol.
Tocainide Levomenthol may increase the arrhythmogenic activities of Tocainide.
Metipranolol Levomenthol may increase the arrhythmogenic activities of Metipranolol.
Aprindine Levomenthol may increase the arrhythmogenic activities of Aprindine.
Xylometazoline Levomenthol may increase the arrhythmogenic activities of Xylometazoline.
Sparteine Levomenthol may increase the arrhythmogenic activities of Sparteine.
Fasudil Levomenthol may increase the arrhythmogenic activities of Fasudil.
Tropisetron Levomenthol may increase the arrhythmogenic activities of Tropisetron.
Spiradoline Levomenthol may increase the arrhythmogenic activities of Spiradoline.
Tiracizine Levomenthol may increase the arrhythmogenic activities of Tiracizine.
Ethacizine Levomenthol may increase the arrhythmogenic activities of Ethacizine.
Hydroquinine Levomenthol may increase the arrhythmogenic activities of Hydroquinine.
Bioallethrin Levomenthol may increase the arrhythmogenic activities of Bioallethrin.
Fosfructose Levomenthol may increase the arrhythmogenic activities of Fosfructose.
Hydroquinidine Levomenthol may increase the arrhythmogenic activities of Hydroquinidine.
SOR-C13 Levomenthol may increase the arrhythmogenic activities of SOR-C13.
Betaxolol Betaxolol may increase the arrhythmogenic activities of Levomenthol.
Diltiazem Diltiazem may increase the arrhythmogenic activities of Levomenthol.
Nimodipine Nimodipine may increase the arrhythmogenic activities of Levomenthol.
Cinnarizine Cinnarizine may increase the arrhythmogenic activities of Levomenthol.
Propranolol Propranolol may increase the arrhythmogenic activities of Levomenthol.
Atropine Atropine may increase the arrhythmogenic activities of Levomenthol.
Adenosine Adenosine may increase the arrhythmogenic activities of Levomenthol.
Levosimendan Levomenthol may increase the arrhythmogenic activities of Levosimendan.
Nifedipine Levomenthol may increase the arrhythmogenic activities of Nifedipine.
Propafenone Levomenthol may increase the arrhythmogenic activities of Propafenone.
Acebutolol Levomenthol may increase the arrhythmogenic activities of Acebutolol.
Flecainide Levomenthol may increase the arrhythmogenic activities of Flecainide.
Oxprenolol Levomenthol may increase the arrhythmogenic activities of Oxprenolol.
Prenylamine Levomenthol may increase the arrhythmogenic activities of Prenylamine.
Fluspirilene Levomenthol may increase the arrhythmogenic activities of Fluspirilene.
Azimilide Levomenthol may increase the arrhythmogenic activities of Azimilide.
Tedisamil Levomenthol may increase the arrhythmogenic activities of Tedisamil.
Nilvadipine Levomenthol may increase the arrhythmogenic activities of Nilvadipine.
Indenolol Levomenthol may increase the arrhythmogenic activities of Indenolol.
Fendiline Levomenthol may increase the arrhythmogenic activities of Fendiline.
Eperisone Levomenthol may increase the arrhythmogenic activities of Eperisone.
Melperone Levomenthol may increase the arrhythmogenic activities of Melperone.
Benidipine Levomenthol may increase the arrhythmogenic activities of Benidipine.
Simendan Levomenthol may increase the arrhythmogenic activities of Simendan.
Otilonium Levomenthol may increase the arrhythmogenic activities of Otilonium.
Nizofenone Levomenthol may increase the arrhythmogenic activities of Nizofenone.
Bunaftine Levomenthol may increase the arrhythmogenic activities of Bunaftine.
Lorcainide Levomenthol may increase the arrhythmogenic activities of Lorcainide.
Penfluridol Levomenthol may increase the arrhythmogenic activities of Penfluridol.
Dexverapamil Levomenthol may increase the arrhythmogenic activities of Dexverapamil.
Disopyramide Disopyramide may increase the arrhythmogenic activities of Levomenthol.
Ibutilide Ibutilide may increase the arrhythmogenic activities of Levomenthol.
Sotalol Sotalol may increase the arrhythmogenic activities of Levomenthol.
Procainamide Levomenthol may increase the arrhythmogenic activities of Procainamide.
Bepridil Levomenthol may increase the arrhythmogenic activities of Bepridil.
Terodiline Levomenthol may increase the arrhythmogenic activities of Terodiline.
Isradipine Isradipine may increase the arrhythmogenic activities of Levomenthol.
Trimethadione Trimethadione may increase the arrhythmogenic activities of Levomenthol.
Amlodipine Amlodipine may increase the arrhythmogenic activities of Levomenthol.
Lercanidipine Lercanidipine may increase the arrhythmogenic activities of Levomenthol.
Lamotrigine Lamotrigine may increase the arrhythmogenic activities of Levomenthol.
Nicardipine Nicardipine may increase the arrhythmogenic activities of Levomenthol.
Verapamil Verapamil may increase the arrhythmogenic activities of Levomenthol.
Losartan Losartan may increase the arrhythmogenic activities of Levomenthol.
Zonisamide Levomenthol may increase the arrhythmogenic activities of Zonisamide.
Nitrendipine Levomenthol may increase the arrhythmogenic activities of Nitrendipine.
Perhexiline Levomenthol may increase the arrhythmogenic activities of Perhexiline.
Nimesulide Levomenthol may increase the arrhythmogenic activities of Nimesulide.
Cyclandelate Levomenthol may increase the arrhythmogenic activities of Cyclandelate.
Flunarizine Levomenthol may increase the arrhythmogenic activities of Flunarizine.
Clevidipine Levomenthol may increase the arrhythmogenic activities of Clevidipine.
Methsuximide Levomenthol may increase the arrhythmogenic activities of Methsuximide.
Seletracetam Levomenthol may increase the arrhythmogenic activities of Seletracetam.
Nylidrin Levomenthol may increase the arrhythmogenic activities of Nylidrin.
Ziconotide Levomenthol may increase the arrhythmogenic activities of Ziconotide.
Dotarizine Levomenthol may increase the arrhythmogenic activities of Dotarizine.
Tranilast Levomenthol may increase the arrhythmogenic activities of Tranilast.
Agmatine Levomenthol may increase the arrhythmogenic activities of Agmatine.
Trimebutine Levomenthol may increase the arrhythmogenic activities of Trimebutine.
Pinaverium Levomenthol may increase the arrhythmogenic activities of Pinaverium.
Nicorandil Levomenthol may increase the arrhythmogenic activities of Nicorandil.
Barnidipine Levomenthol may increase the arrhythmogenic activities of Barnidipine.
Aranidipine Levomenthol may increase the arrhythmogenic activities of Aranidipine.
Azelnidipine Levomenthol may increase the arrhythmogenic activities of Azelnidipine.
Cilnidipine Levomenthol may increase the arrhythmogenic activities of Cilnidipine.
Darodipine Levomenthol may increase the arrhythmogenic activities of Darodipine.
Efonidipine Levomenthol may increase the arrhythmogenic activities of Efonidipine.
Lacidipine Levomenthol may increase the arrhythmogenic activities of Lacidipine.
Manidipine Levomenthol may increase the arrhythmogenic activities of Manidipine.
Niludipine Levomenthol may increase the arrhythmogenic activities of Niludipine.
Carboxyamidotriazole Levomenthol may increase the arrhythmogenic activities of Carboxyamidotriazole.
Naftopidil Levomenthol may increase the arrhythmogenic activities of Naftopidil.
Tetrahydropalmatine Levomenthol may increase the arrhythmogenic activities of Tetrahydropalmatine.
Vinpocetine Levomenthol may increase the arrhythmogenic activities of Vinpocetine.
Gallopamil Levomenthol may increase the arrhythmogenic activities of Gallopamil.
Bencyclane Levomenthol may increase the arrhythmogenic activities of Bencyclane.
Lidoflazine Levomenthol may increase the arrhythmogenic activities of Lidoflazine.
Caroverine Levomenthol may increase the arrhythmogenic activities of Caroverine.
WIN 55212-2 Levomenthol may increase the arrhythmogenic activities of WIN 55212-2.
Fish oil Levomenthol may increase the arrhythmogenic activities of Fish oil.

Target Protein

Transient receptor potential cation channel subfamily M member 8 TRPM8
Transient receptor potential cation channel subfamily A member 1 TRPA1
Transient receptor potential cation channel subfamily V member 3 TRPV3
Voltage-dependent L-type calcium channel CACNA1C
Kappa-type opioid receptor OPRK1

Referensi & Sumber

Synthesis reference: Tatsuo Higashiyama, Isao Sakata, "Menthol glycoside, process for preparing the same and method for releasing menthol therefrom." U.S. Patent US4038270, issued December, 1972.

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Sekuens Gen/Protein (FASTA)

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