Peringatan Keamanan

Acute oral toxicity (LD50): 620 mg/kg Mouse. Symptoms of overdose include elevated liver enzymes, headaches, hair loss, low levels of white blood cells (neutropenia), fever, and itching.

Mebendazole

DB00643

small molecule approved vet_approved

Deskripsi

A benzimidazole that acts by interfering with carbohydrate metabolism and inhibiting polymerization of microtubules. PubChem

Struktur Molekul 2D

Berat 295.2927
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 2.5 to 5.5 hours (range 2.5 to 9 hours) in patients with normal hepatic function. Approximately 35 hours in patients with impaired hepatic function (cholestasis).
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Poorly absorbed (approximately 5 to 10%) from gastrointestinal tract. Fatty food increases absorption.

Metabolisme

Primarily hepatic. Primary metabolite is 2-amino-5-benzoylbenzimidazole, but also metabolized to inactive hydroxy and hydroxyamino metabolites. All metabolites are devoid of anthelmintic activity.

Rute Eliminasi

In man, approximately 2% of administered mebendazole is excreted in urine and the remainder in the feces as unchanged drug or a primary metabolite.

Interaksi Makanan

1 Data
  • 1. Take with or without food.

Interaksi Obat

5 Data
Phenytoin The serum concentration of Mebendazole can be decreased when it is combined with Phenytoin.
Fosphenytoin The serum concentration of Mebendazole can be decreased when it is combined with Fosphenytoin.
Cimetidine The serum concentration of Mebendazole can be increased when it is combined with Cimetidine.
Metronidazole The risk or severity of adverse effects can be increased when Mebendazole is combined with Metronidazole.
Methotrexate The excretion of Methotrexate can be decreased when combined with Mebendazole.

Target Protein

Tubulin alpha-1A chain TUBA1A
Tubulin beta-4B chain TUBB4B

Referensi & Sumber

Synthesis reference: U.S. Patent 3,657,267.

Contoh Produk & Brand

Produk: 8 • International brands: 19
Produk
  • Emverm
    Tablet, chewable • 100 mg/1 • Oral • US • Generic • Approved
  • Emverm
    Tablet, chewable • 100 mg/1 • Oral • US • Generic • Approved
  • Mebendazole
    Tablet, chewable • 100 mg/1 • Oral • US • Generic • Approved
  • Mebendazole
    Tablet, chewable • 100 mg/1 • Oral • US • Generic • Approved
  • Mebendazole
    Tablet, chewable • 100 mg/1 • Oral • US • Generic • Approved
  • Vermox
    Tablet, chewable • 100 mg/1 • Oral • US • Approved
  • Vermox
    Tablet, chewable • 500 mg/1 • Oral • US • Approved
  • Vermox
    Tablet • 100 mg • Oral • Canada • Approved
International Brands
  • Lomper — Esteve
  • Meberix — Aversi
  • Mebex — Cipla
  • Mebezol — Johnson
  • Mebfil — Fourrts Laboratories
  • Mebutar — Andromaco
  • Mebzol — Julphar
  • Mendazole — GlaxoSmithKline
  • Mezole — Yuan Chou
  • Minyoozole — Emil

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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