Peringatan Keamanan

The oral LD50 of lymecycline in rats is 3200 mg/kg.L13913 Overdoses with lymecycline are rare. In the case of an overdose, gastric lavage should be performed immediately. Provide supportive treatment and maintain fluid balance.L13883

Lymecycline

DB00256

small molecule approved investigational

Deskripsi

Lymecycline is a broad-spectrum second-generation tetracycline antibiotic used for the treatment of acne and other susceptible bacterial infections.L13880,L13883 It has been proven a cost-effective alternative to treatment with minocycline with comparable safety and efficacy.A203255 Lymecycline was initially discovered in 1961. It is marketed by Galderma and used in the UK as well as New Zealand in addition to other countries. Lymecycline is not marketed in the USA, however, equivalent drugs are available, such as minocycline and tetracycline.A19429,L13880

Struktur Molekul 2D

Berat 602.6328
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) The half-life of lymecycline is approximately 8 hours.[A1424]
Volume Distribusi Lymecycline is lipophilic and easily crosses the cell membrane and passively diffuses through bacterial porin channels.[A1424,A19429] As a second-generation tetracycline, the concentration in the bile ranges from 10 to 25 times higher than plasma concentration.[A1424,A203366] In general, the volume of distribution of tetracyclines ranges from 1.3–1.7 L/kg or 100–130 L.[A1424]
Klirens (Clearance) Lymecycline is partially cleared by the kidneys, like other tetracyclines.[A203366]

Absorpsi

Lymecycline is 77-88% absorbed after oral administration with a relative bioavailability of 70%.A203258 The Cmax of lymecycline is 2.1 mg/L and is achieved about 3 hours after administration.A1424 The AUC is 21.9 ± 4.3 mg·h/L.A1424

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Lymecycline is 25% eliminated in the urine.A1424 Based on being a member of the tetracycline drug class, fecal elimination is likely another route of elimination.A203366

Interaksi Makanan

1 Data
  • 1. Take with or without food.

Interaksi Obat

365 Data
Succinylcholine The therapeutic efficacy of Succinylcholine can be increased when used in combination with Lymecycline.
Metocurine iodide The therapeutic efficacy of Metocurine iodide can be increased when used in combination with Lymecycline.
Gallamine triethiodide The therapeutic efficacy of Gallamine triethiodide can be increased when used in combination with Lymecycline.
Cisatracurium Lymecycline may increase the neuromuscular blocking activities of Cisatracurium.
Rocuronium The therapeutic efficacy of Rocuronium can be increased when used in combination with Lymecycline.
Atracurium besylate The therapeutic efficacy of Atracurium besylate can be increased when used in combination with Lymecycline.
Doxacurium The therapeutic efficacy of Doxacurium can be increased when used in combination with Lymecycline.
Mivacurium The therapeutic efficacy of Mivacurium can be increased when used in combination with Lymecycline.
Decamethonium The therapeutic efficacy of Decamethonium can be increased when used in combination with Lymecycline.
Metocurine The therapeutic efficacy of Metocurine can be increased when used in combination with Lymecycline.
Pancuronium The therapeutic efficacy of Pancuronium can be increased when used in combination with Lymecycline.
Pipecuronium The therapeutic efficacy of Pipecuronium can be increased when used in combination with Lymecycline.
Vecuronium The therapeutic efficacy of Vecuronium can be increased when used in combination with Lymecycline.
Rapacuronium The therapeutic efficacy of Rapacuronium can be increased when used in combination with Lymecycline.
Pyrantel The therapeutic efficacy of Pyrantel can be increased when used in combination with Lymecycline.
Neosaxitoxin The therapeutic efficacy of Neosaxitoxin can be increased when used in combination with Lymecycline.
Atracurium The therapeutic efficacy of Atracurium can be increased when used in combination with Lymecycline.
Gallamine The therapeutic efficacy of Gallamine can be increased when used in combination with Lymecycline.
Alcuronium The therapeutic efficacy of Alcuronium can be increased when used in combination with Lymecycline.
Tubocurarine The therapeutic efficacy of Tubocurarine can be increased when used in combination with Lymecycline.
Bismuth subsalicylate The serum concentration of Lymecycline can be decreased when it is combined with Bismuth subsalicylate.
Mecamylamine Lymecycline may increase the neuromuscular blocking activities of Mecamylamine.
Mipomersen Lymecycline may increase the hepatotoxic activities of Mipomersen.
Quinapril Quinapril can cause a decrease in the absorption of Lymecycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sucralfate Sucralfate can cause a decrease in the absorption of Lymecycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Iron sucrose The serum concentration of Lymecycline can be decreased when it is combined with Iron sucrose.
Flucloxacillin The therapeutic efficacy of Flucloxacillin can be decreased when used in combination with Lymecycline.
Piperacillin The therapeutic efficacy of Piperacillin can be decreased when used in combination with Lymecycline.
Ampicillin The therapeutic efficacy of Ampicillin can be decreased when used in combination with Lymecycline.
Phenoxymethylpenicillin The therapeutic efficacy of Phenoxymethylpenicillin can be decreased when used in combination with Lymecycline.
Dicloxacillin The therapeutic efficacy of Dicloxacillin can be decreased when used in combination with Lymecycline.
Carbenicillin The therapeutic efficacy of Carbenicillin can be decreased when used in combination with Lymecycline.
Nafcillin The therapeutic efficacy of Nafcillin can be decreased when used in combination with Lymecycline.
Oxacillin The therapeutic efficacy of Oxacillin can be decreased when used in combination with Lymecycline.
Hetacillin The therapeutic efficacy of Hetacillin can be decreased when used in combination with Lymecycline.
Benzylpenicilloyl polylysine The therapeutic efficacy of Benzylpenicilloyl polylysine can be decreased when used in combination with Lymecycline.
Mezlocillin The therapeutic efficacy of Mezlocillin can be decreased when used in combination with Lymecycline.
Cyclacillin The therapeutic efficacy of Cyclacillin can be decreased when used in combination with Lymecycline.
Benzylpenicillin The therapeutic efficacy of Benzylpenicillin can be decreased when used in combination with Lymecycline.
Amoxicillin The therapeutic efficacy of Amoxicillin can be decreased when used in combination with Lymecycline.
Azlocillin The therapeutic efficacy of Azlocillin can be decreased when used in combination with Lymecycline.
Cloxacillin The therapeutic efficacy of Cloxacillin can be decreased when used in combination with Lymecycline.
Amdinocillin The therapeutic efficacy of Amdinocillin can be decreased when used in combination with Lymecycline.
Bacampicillin The therapeutic efficacy of Bacampicillin can be decreased when used in combination with Lymecycline.
Meticillin The therapeutic efficacy of Meticillin can be decreased when used in combination with Lymecycline.
Pivampicillin The therapeutic efficacy of Pivampicillin can be decreased when used in combination with Lymecycline.
Pivmecillinam The therapeutic efficacy of Pivmecillinam can be decreased when used in combination with Lymecycline.
Ticarcillin The therapeutic efficacy of Ticarcillin can be decreased when used in combination with Lymecycline.
Azidocillin The therapeutic efficacy of Azidocillin can be decreased when used in combination with Lymecycline.
Carindacillin The therapeutic efficacy of Carindacillin can be decreased when used in combination with Lymecycline.
Procaine benzylpenicillin The therapeutic efficacy of Procaine benzylpenicillin can be decreased when used in combination with Lymecycline.
Sultamicillin The therapeutic efficacy of Sultamicillin can be decreased when used in combination with Lymecycline.
Temocillin The therapeutic efficacy of Temocillin can be decreased when used in combination with Lymecycline.
Epicillin The therapeutic efficacy of Epicillin can be decreased when used in combination with Lymecycline.
Pheneticillin The therapeutic efficacy of Pheneticillin can be decreased when used in combination with Lymecycline.
Carfecillin The therapeutic efficacy of Carfecillin can be decreased when used in combination with Lymecycline.
Propicillin The therapeutic efficacy of Propicillin can be decreased when used in combination with Lymecycline.
Clometocillin The therapeutic efficacy of Clometocillin can be decreased when used in combination with Lymecycline.
Sulbenicillin The therapeutic efficacy of Sulbenicillin can be decreased when used in combination with Lymecycline.
Penamecillin The therapeutic efficacy of Penamecillin can be decreased when used in combination with Lymecycline.
Talampicillin The therapeutic efficacy of Talampicillin can be decreased when used in combination with Lymecycline.
Aspoxicillin The therapeutic efficacy of Aspoxicillin can be decreased when used in combination with Lymecycline.
Metampicillin The therapeutic efficacy of Metampicillin can be decreased when used in combination with Lymecycline.
Picosulfuric acid The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Lymecycline.
Bismuth subcitrate potassium The serum concentration of Lymecycline can be decreased when it is combined with Bismuth subcitrate potassium.
Strontium ranelate The serum concentration of Lymecycline can be decreased when it is combined with Strontium ranelate.
Calcium glucoheptonate The serum concentration of Lymecycline can be decreased when it is combined with Calcium glucoheptonate.
Calcium glubionate anhydrous The serum concentration of Lymecycline can be decreased when it is combined with Calcium glubionate anhydrous.
Calcium gluconate The serum concentration of Lymecycline can be decreased when it is combined with Calcium gluconate.
Calcium citrate The serum concentration of Lymecycline can be decreased when it is combined with Calcium citrate.
Calcium Phosphate The serum concentration of Lymecycline can be decreased when it is combined with Calcium Phosphate.
Calcium lactate The serum concentration of Lymecycline can be decreased when it is combined with Calcium lactate.
Calcium lactate gluconate The serum concentration of Lymecycline can be decreased when it is combined with Calcium lactate gluconate.
Calcium pangamate The serum concentration of Lymecycline can be decreased when it is combined with Calcium pangamate.
Calcium levulinate The serum concentration of Lymecycline can be decreased when it is combined with Calcium levulinate.
Calcium acetate The serum concentration of Lymecycline can be decreased when it is combined with Calcium acetate.
Calcium chloride The serum concentration of Lymecycline can be decreased when it is combined with Calcium chloride.
Calcium The serum concentration of Lymecycline can be decreased when it is combined with Calcium.
Calcium cation The serum concentration of Lymecycline can be decreased when it is combined with Calcium cation.
Calcium polycarbophil The serum concentration of Lymecycline can be decreased when it is combined with Calcium polycarbophil.
Colestipol Colestipol can cause a decrease in the absorption of Lymecycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Colesevelam Colesevelam can cause a decrease in the absorption of Lymecycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cholestyramine Cholestyramine can cause a decrease in the absorption of Lymecycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sevelamer Sevelamer can cause a decrease in the absorption of Lymecycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium sulfate Magnesium sulfate can cause a decrease in the absorption of Lymecycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium salicylate Magnesium salicylate can cause a decrease in the absorption of Lymecycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium chloride Magnesium chloride can cause a decrease in the absorption of Lymecycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium citrate Magnesium citrate can cause a decrease in the absorption of Lymecycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium aspartate Magnesium aspartate can cause a decrease in the absorption of Lymecycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium gluconate Magnesium gluconate can cause a decrease in the absorption of Lymecycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium orotate Magnesium orotate can cause a decrease in the absorption of Lymecycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium levulinate Magnesium levulinate can cause a decrease in the absorption of Lymecycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium lactate Magnesium lactate can cause a decrease in the absorption of Lymecycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcium carbonate Calcium carbonate can cause a decrease in the absorption of Lymecycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium oxide Magnesium oxide can cause a decrease in the absorption of Lymecycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magaldrate Magaldrate can cause a decrease in the absorption of Lymecycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium hydroxide Magnesium hydroxide can cause a decrease in the absorption of Lymecycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium trisilicate Magnesium trisilicate can cause a decrease in the absorption of Lymecycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium carbonate Magnesium carbonate can cause a decrease in the absorption of Lymecycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium silicate Magnesium silicate can cause a decrease in the absorption of Lymecycline resulting in a reduced serum concentration and potentially a decrease in efficacy.

Target Protein

30S ribosomal protein S4 rpsD

Referensi & Sumber

Synthesis reference: Willis L. Winstrom, "Process and apparatus for the preparation of chlortetracycline-containing animal feed compositions." U.S. Patent US06844006, issued January 18, 2005.
Artikel (PubMed)
  • PMID: 12609781
    Dubertret L, Alirezai M, Rostain G, Lahfa M, Forsea D, Niculae BD, Simola M, Horvath A, Mizzi F: The use of lymecycline in the treatment of moderate to severe acne vulgaris: a comparison of the efficacy and safety of two dosing regimens. Eur J Dermatol. 2003 Jan-Feb;13(1):44-8.
  • PMID: 12695127
    Bossuyt L, Bosschaert J, Richert B, Cromphaut P, Mitchell T, Al Abadie M, Henry I, Bewley A, Poyner T, Mann N, Czernielewski J: Lymecycline in the treatment of acne: an efficacious, safe and cost-effective alternative to minocycline. Eur J Dermatol. 2003 Mar-Apr;13(2):130-5.
  • PMID: 16816396
    Agwuh KN, MacGowan A: Pharmacokinetics and pharmacodynamics of the tetracyclines including glycylcyclines. J Antimicrob Chemother. 2006 Aug;58(2):256-65. Epub 2006 Jul 1.
  • PMID: 6487493
    Sjolin-Forsberg G, Hermansson J: Comparative bioavailability of tetracycline and lymecycline. Br J Clin Pharmacol. 1984 Oct;18(4):529-33. doi: 10.1111/j.1365-2125.1984.tb02500.x.
  • PMID: 11381101
    Chopra I, Roberts M: Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance. Microbiol Mol Biol Rev. 2001 Jun;65(2):232-60 ; second page, table of contents.
  • PMID: 27246781
    Chukwudi CU: rRNA Binding Sites and the Molecular Mechanism of Action of the Tetracyclines. Antimicrob Agents Chemother. 2016 Jul 22;60(8):4433-41. doi: 10.1128/AAC.00594-16. Print 2016 Aug.
  • PMID: 19399726
    Vojtova V, Urbanek K: Pharmacokinetics of tetracyclines and glycylcyclines. Klin Mikrobiol Infekc Lek. 2009 Feb;15(1):17-21.

Contoh Produk & Brand

Produk: 0 • International brands: 3
International Brands
  • Eficiclina
  • Tetralisal
  • Tetralysal

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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