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16

Total database: 17430
Struktur (SMILES)
16 (100.0%)
Target
12 (75.0%)
Genomik
0 (0%)
Referensi
16 (100.0%)

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Hasil Pencarian (16)

Bismuth subsalicylate Approved DB01294
small molecule | CAS: 14882-18-9

Bismuth subsalicylate is an antacid and anti-diarrheal agent. Exhibiting antibacterial and gastroprotective properties, bismuth subsalicylate is an insoluble salt of [salicylic acid] linked to trivalent [bismuth cation]. Each molecule of bismuth subsalicylate…

Kategori:
Acids, CarbocyclicAntacids and AdsorbentsAntidiarrheals +16
Waktu ParuhThe terminal half-l…
Vol. DistribusiThere is no informa…
KlirensThe renal clearance…
Genetik -
Chlortetracycline Approved DB09093
small molecule | CAS: 57-62-5

Chlortetracycline is a _tetracycline_ antibiotic, and historically the first member of this class to be identified. It was discovered in 1945 by the scientist, Benjamin Minge Duggar, working at Lederle Laboratories under the supervision of Yellapragada Subbar…

Kategori:
Agents that produce neuromuscular block (indirect)Alimentary Tract and MetabolismAnti-Bacterial Agents +15
Target Protein:
16S ribosomal RNA30S ribosomal protein S330S ribosomal protein S8 +8
Waktu ParuhThe half-life of Ch…
Vol. DistribusiChlortetracycline h…
Klirens-
Genetik -
Clomocycline DB00453
small molecule | CAS: 1181-54-0

Clomocycline is a tetracycline used to treat bacterial infections.

Kategori:
Agents that produce neuromuscular block (indirect)Anti-Bacterial AgentsAntibacterials for Systemic Use +3
Target Protein:
30S ribosomal protein S430S ribosomal protein S916S ribosomal RNA
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Demeclocycline Approved DB00618
small molecule | CAS: 127-33-3

A tetracycline analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.

Kategori:
Agents that produce neuromuscular block (indirect)Anti-Bacterial AgentsAnti-Infective Agents +8
Target Protein:
30S ribosomal proteinVasopressin V2 receptor
Waktu Paruh10-17 hours
Vol. Distribusi-
Klirens* Renal cl=35 mL/mi…
Genetik -
Doxycycline Approved DB00254
small molecule | CAS: 564-25-0

Doxycycline is a broad-spectrum antibiotic synthetically derived from [oxytetracycline].[L42880] It is a second-generation tetracycline that was first discovered in 1967.[A19429] Second-generation tetracyclines exhibit lesser toxicity than first-generation te…

Kategori:
Agents that produce neuromuscular block (indirect)Alimentary Tract and MetabolismAnti-Bacterial Agents +17
Target Protein:
30S ribosomal protein
Waktu ParuhThere is limited in…
Vol. DistribusiThere is limited in…
KlirensPopulation pharmaco…
Genetik -
Eravacycline Approved DB12329
small molecule | CAS: 1207283-85-9

Eravacycline, known as _Xerava_ by Tetraphase Pharmaceuticals, is a fully synthetic fluorocycline antibiotic of the tetracycline class with activity against clinically significant gram-negative, gram-positive aerobic, and facultative bacteria. This includes m…

Kategori:
Anti-Bacterial AgentsAntibacterials for Systemic UseAntiinfectives for Systemic Use +6
Target Protein:
30S ribosomal protein S4
Waktu ParuhThe mean eliminatio…
Vol. DistribusiThe volume of distr…
Klirens17.82 L/min (standa…
Genetik -
Lymecycline Approved DB00256
small molecule | CAS: 992-21-2

Lymecycline is a broad-spectrum second-generation tetracycline antibiotic used for the treatment of acne and other susceptible bacterial infections.[L13880,L13883] It has been proven a cost-effective alternative to treatment with [minocycline] with comparable…

Kategori:
Agents that produce neuromuscular block (indirect)Anti-Bacterial AgentsAnti-Infective Agents +4
Target Protein:
30S ribosomal protein S4
Waktu ParuhThe half-life of ly…
Vol. DistribusiLymecycline is lipo…
KlirensLymecycline is part…
Genetik -
Metacycline Approved DB00931
small molecule | CAS: 914-00-1

A broad-spectrum semisynthetic antibiotic related to tetracycline but excreted more slowly and maintaining effective blood levels for a more extended period.

Kategori:
Agents that produce neuromuscular block (indirect)Anti-Bacterial AgentsAnti-Infective Agents +4
Target Protein:
16S ribosomal RNA
Waktu Paruh14 hours
Vol. Distribusi-
Klirens-
Genetik -
Minocycline Approved DB01017
small molecule | CAS: 10118-90-8

Minocycline was first described in the literacture in 1966.[A190681] It is a second generation tetracycline antibiotic that is active against gram-negative and gram-positive bacteria.[A190723] Like other semisynthetic tetracyclines, minocycline has modificati…

Kategori:
Agents Causing Muscle ToxicityAgents that produce neuromuscular block (indirect)Alimentary Tract and Metabolism +16
Target Protein:
30S ribosomal protein S930S ribosomal protein S416S ribosomal RNA +9
Waktu ParuhThe half life of mi…
Vol. DistribusiThe volume of distr…
KlirensIntravenous minocyc…
Genetik -
Omadacycline Approved DB12455
small molecule | CAS: 389139-89-3

Omadacycline has been used in trials studying the treatment of Bacterial Pneumonia, Bacterial Infections, Community-Acquired Infections, and Skin Structures and Soft Tissue Infections. Omadacycline represents a significant advance over the well-known tetracyc…

Kategori:
Anti-Bacterial AgentsAntibacterials for Systemic UseAntiinfectives for Systemic Use +3
Target Protein:
30S ribosomal protein S330S ribosomal protein S730S ribosomal protein S8 +3
Waktu ParuhOmadacycline has a …
Vol. DistribusiOmadacycline has a …
KlirensOmadacycline has a …
Genetik -
Oxytetracycline Approved DB00595
small molecule | CAS: 79-57-2

A tetracycline analog isolated from the actinomycete streptomyces rimosus and used in a wide variety of clinical conditions.

Kategori:
Agents that produce neuromuscular block (indirect)Alimentary Tract and MetabolismAnti-Bacterial Agents +16
Target Protein:
30S ribosomal protein S930S ribosomal protein S416S ribosomal RNA
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Penimepicycline DB13264
small molecule | CAS: 4599-60-4

Penimepicycline is a tetracycline-class antibiotic. It is mentioned on List A produced by the Government of Canada, which is a list of antimicrobial active pharmaceutical ingredients [L2791]. In the classification of the active ingredients included on this li…

Kategori:
Agents that produce neuromuscular block (indirect)AmidesAnti-Bacterial Agents +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Rolitetracycline Approved DB01301
small molecule | CAS: 751-97-3

A pyrrolidinylmethyl tetracycline.

Kategori:
Agents that produce neuromuscular block (indirect)Anti-Bacterial AgentsAnti-Infective Agents +4
Target Protein:
30S ribosomal protein S916S ribosomal RNA
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sarecycline Approved DB12035
small molecule | CAS: 1035654-66-0

Sarecycline is a semi-synthetic derivative of tetracycline that was initially discovered by Paratek Pharmaceuticals from Boston, MA but then licensed to Warner Chilcott of Rockaway, NJ in July of 2007 [A40005]. After completing various phase-II and phase-III …

Kategori:
Anti-Acne PreparationsAnti-Acne Preparations for Systemic UseAnti-Bacterial Agents +7
Waktu ParuhThe mean eliminatio…
Vol. DistribusiThe mean apparent v…
KlirensThe mean apparent o…
Genetik -
Tetracycline Approved DB00759
small molecule | CAS: 60-54-8

Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from b…

Kategori:
Agents that produce neuromuscular block (indirect)Alimentary Tract and MetabolismAnti-Bacterial Agents +32
Target Protein:
30S ribosomal protein S730S ribosomal protein S1430S ribosomal protein S3 +6
Waktu Paruh6-12 hours
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 1336-20-5

Deskripsi belum tersedia.

Kategori:
Anti-Bacterial Agents
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -