Peringatan Keamanan

There is no information regarding the acute toxicity (LD₅₀) and overdose of pemivibart.

Pemivibart

DB18720

biotech investigational

Deskripsi

Pemivibart (Pemgarda) is a human IgG1 monoclonal antibody targeting the SARS-CoV-2 spike protein receptor binding domain.^L50326 It received emergency use authorization (EUA) from the FDA in March 2024 for pre-exposure prophylaxis (PrEP) of COVID-19 in certain high-risk patient populations.^L51733 Due to the amino acid substitutions in the Fc region (M435L/N441A), pemivibart has an extended serum half-life.^L51728

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) Pemivibart has an extended serum half-life. The half-life was 44.8 days in adults who received a single 4500 IV dose of pemivibart.[L51728]

Volume Distribusi Following the administration of a single 4500 IV dose of pemivibart in adults, the volume of distribution at steady-state was 5.54 (17.0) L.[L51728]

Klirens (Clearance) Following the administration of a single 4500 IV dose of pemivibart in adults, the volume of distribution at steady-state was 0.0909 L/d.[L51728]

Absorpsi

Following the administration of a single 4500 IV dose of pemivibart in adults, the C_max and AUC_{0-3 months} were 1750 ?g/mL and 36600 days × ?g/mL, respectively.^L51728

Metabolisme

Pemivibart is expected to undergo catabolic pathways, in the same manner as endogenous IgG.^L51728

Rute Eliminasi

While no information is available, pemivibart is unlikely to undergo renal excretion.^L51728

Interaksi Obat

1 Data

Imlifidase

The therapeutic efficacy of Pemivibart can be decreased when used in combination with Imlifidase.

Target Protein

Spike glycoprotein S

Referensi & Sumber

Artikel (PubMed)

PMID: 39471458
Bhimraj A, Falck-Ytter Y, Kim AY, Li JZ, Baden LR, Johnson S, Shafer RW, Shoham S, Tebas P, Bedimo R, Cheng VC, Chew KW, Chiotos K, Daar ES, Dzierba AL, Glidden DV, Hardy EJ, Martin GS, MacBrayne C, Nadig N, Nakamura MM, Shumaker AH, Tien P, Loveless J, Morgan RL, Gandhi RT: 2024 Clinical Practice Guideline Update by the Infectious Diseases Society of America on the Management of COVID-19: Anti-SARS-CoV-2 Neutralizing Antibody Pemivibart for Pre-exposure Prophylaxis. Clin Infect Dis. 2024 Oct 29:ciae435. doi: 10.1093/cid/ciae435.
PMID: 32762417
Dehury B, Raina V, Misra N, Suar M: Effect of mutation on structure, function and dynamics of receptor binding domain of human SARS-CoV-2 with host cell receptor ACE2: a molecular dynamics simulations study. J Biomol Struct Dyn. 2021 Nov;39(18):7231-7245. doi: 10.1080/07391102.2020.1802348. Epub 2020 Aug 7.
PMID: 35787481
Verma S, Patil VM, Gupta MK: Mutation informatics: SARS-CoV-2 receptor-binding domain of the spike protein. Drug Discov Today. 2022 Oct;27(10):103312. doi: 10.1016/j.drudis.2022.06.012. Epub 2022 Jul 3.

Link

Contoh Produk & Brand

Produk: 1 • International brands: 0

Produk

Pemgarda

Injection • 125 mg/1mL • Intravenous • US

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.