Toxicity information regarding anacaulase is not readily available. Patients experiencing an overdose are at an increased risk of severe adverse effects such as pain and coagulation abnormalities. Symptomatic and supportive measures are recommended. The carcinogenic effects of anacaulase have not been evaluated, and fertility studies have not been performed. A bacterial reverse mutation assay and an in vitro mammalian chromosome aberration assay showed that anacaulase was not genotoxic.L44717
Anacaulase (anacaulase-bcdb) is a mixture of proteolytic enzymes extracted from the stems of pineapple plants (Ananas comosus L. Merr.). It is mostly composed (80-95% w/w) of proteins such as stem bromelain, ananain, jacalin-like lectin, bromelain inhibitors, and phytocystatin inhibitor, as well as saccharides, as both free monosaccharides and the N-linked glycan of stem bromelain and small molecule metabolites.L44717 Anacaulase is indicated for eschar removal in patients with deep partial thickness and/or full-thickness thermal burns. Removing eschar (a process also known as debridement) through surgical procedures can lead to significant trauma, major blood and heat loss and adjacent tissue damage. They also require specialized surgical personnel and facilities, and autologous skin grafting may be needed. Therefore, enzymatic alternatives such as anacaulase can lead to better clinical outcomes.A256047,A256052,A256057 The EMA approved the use of anacaulase in 2013,A256047,A256052 and in January 2023, anacaulase received FDA approval.L44717
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.