Lifileucel

DB17107

biotech approved investigational

Deskripsi

Lifileucel is a tumour-derived autologous T cell immunotherapy composed of a suspension of tumour-derived T cells from the patient L50171 which undergo isolation, ex vivo expansion, and activationA263341 Lifileucel was granted accelerated approval by the FDA on February 16, 2024, for the treatment of unresectable or metastatic melanoma.L50176

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

38 Data
Darbepoetin alfa The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Lifileucel.
Erythropoietin The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Lifileucel.
Peginesatide The risk or severity of Thrombosis can be increased when Peginesatide is combined with Lifileucel.
Methoxy polyethylene glycol-epoetin beta The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Lifileucel.
Lidocaine The risk or severity of methemoglobinemia can be increased when Lifileucel is combined with Lidocaine.
Ropivacaine The risk or severity of methemoglobinemia can be increased when Lifileucel is combined with Ropivacaine.
Bupivacaine The risk or severity of methemoglobinemia can be increased when Lifileucel is combined with Bupivacaine.
Cinchocaine The risk or severity of methemoglobinemia can be increased when Lifileucel is combined with Cinchocaine.
Dyclonine The risk or severity of methemoglobinemia can be increased when Lifileucel is combined with Dyclonine.
Procaine The risk or severity of methemoglobinemia can be increased when Lifileucel is combined with Procaine.
Prilocaine The risk or severity of methemoglobinemia can be increased when Lifileucel is combined with Prilocaine.
Proparacaine The risk or severity of methemoglobinemia can be increased when Lifileucel is combined with Proparacaine.
Meloxicam The risk or severity of methemoglobinemia can be increased when Lifileucel is combined with Meloxicam.
Oxybuprocaine The risk or severity of methemoglobinemia can be increased when Lifileucel is combined with Oxybuprocaine.
Cocaine The risk or severity of methemoglobinemia can be increased when Lifileucel is combined with Cocaine.
Mepivacaine The risk or severity of methemoglobinemia can be increased when Lifileucel is combined with Mepivacaine.
Levobupivacaine The risk or severity of methemoglobinemia can be increased when Lifileucel is combined with Levobupivacaine.
Diphenhydramine The risk or severity of methemoglobinemia can be increased when Lifileucel is combined with Diphenhydramine.
Benzocaine The risk or severity of methemoglobinemia can be increased when Lifileucel is combined with Benzocaine.
Chloroprocaine The risk or severity of methemoglobinemia can be increased when Lifileucel is combined with Chloroprocaine.
Phenol The risk or severity of methemoglobinemia can be increased when Lifileucel is combined with Phenol.
Tetrodotoxin The risk or severity of methemoglobinemia can be increased when Lifileucel is combined with Tetrodotoxin.
Ambroxol The risk or severity of methemoglobinemia can be increased when Lifileucel is combined with Ambroxol.
Benzyl alcohol The risk or severity of methemoglobinemia can be increased when Lifileucel is combined with Benzyl alcohol.
Capsaicin The risk or severity of methemoglobinemia can be increased when Lifileucel is combined with Capsaicin.
Etidocaine The risk or severity of methemoglobinemia can be increased when Lifileucel is combined with Etidocaine.
Articaine The risk or severity of methemoglobinemia can be increased when Lifileucel is combined with Articaine.
Tetracaine The risk or severity of methemoglobinemia can be increased when Lifileucel is combined with Tetracaine.
Propoxycaine The risk or severity of methemoglobinemia can be increased when Lifileucel is combined with Propoxycaine.
Pramocaine The risk or severity of methemoglobinemia can be increased when Lifileucel is combined with Pramocaine.
Butamben The risk or severity of methemoglobinemia can be increased when Lifileucel is combined with Butamben.
Butacaine The risk or severity of methemoglobinemia can be increased when Lifileucel is combined with Butacaine.
Oxetacaine The risk or severity of methemoglobinemia can be increased when Lifileucel is combined with Oxetacaine.
Ethyl chloride The risk or severity of methemoglobinemia can be increased when Lifileucel is combined with Ethyl chloride.
Butanilicaine The risk or severity of methemoglobinemia can be increased when Lifileucel is combined with Butanilicaine.
Metabutethamine The risk or severity of methemoglobinemia can be increased when Lifileucel is combined with Metabutethamine.
Quinisocaine The risk or severity of methemoglobinemia can be increased when Lifileucel is combined with Quinisocaine.
Etrasimod The risk or severity of immunosuppression can be increased when Lifileucel is combined with Etrasimod.

Referensi & Sumber

Artikel (PubMed)
  • PMID: 33979178
    Sarnaik AA, Hamid O, Khushalani NI, Lewis KD, Medina T, Kluger HM, Thomas SS, Domingo-Musibay E, Pavlick AC, Whitman ED, Martin-Algarra S, Corrie P, Curti BD, Olah J, Lutzky J, Weber JS, Larkin JMG, Shi W, Takamura T, Jagasia M, Qin H, Wu X, Chartier C, Graf Finckenstein F, Fardis M, Kirkwood JM, Chesney JA: Lifileucel, a Tumor-Infiltrating Lymphocyte Therapy, in Metastatic Melanoma. J Clin Oncol. 2021 Aug 20;39(24):2656-2666. doi: 10.1200/JCO.21.00612. Epub 2021 May 12.
  • PMID: 36600653
    Chesney J, Lewis KD, Kluger H, Hamid O, Whitman E, Thomas S, Wermke M, Cusnir M, Domingo-Musibay E, Phan GQ, Kirkwood JM, Hassel JC, Orloff M, Larkin J, Weber J, Furness AJS, Khushalani NI, Medina T, Egger ME, Graf Finckenstein F, Jagasia M, Hari P, Sulur G, Shi W, Wu X, Sarnaik A: Efficacy and safety of lifileucel, a one-time autologous tumor-infiltrating lymphocyte (TIL) cell therapy, in patients with advanced melanoma after progression on immune checkpoint inhibitors and targeted therapies: pooled analysis of consecutive cohorts of the C-144-01 study. J Immunother Cancer. 2022 Dec;10(12):e005755. doi: 10.1136/jitc-2022-005755.

Contoh Produk & Brand

Produk: 1 • International brands: 0
Produk
  • Amtagvi
    Suspension • 72000000000 1/500mL • Intravenous • US • Approved

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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