Peringatan Keamanan

There are no data regarding overdose of intravenously administered human plasminogen.

Plasminogen

DB16701

biotech approved

Deskripsi

Plasminogen is a pro-enzyme (i.e. a zymogen) which is cleaved to form plasmin - also known as fibrinolysin - as part of the fibrinolytic pathway that breaks down fibrin blood clots.^A236035 This pathway is activated when a clot is no longer needed or to prevent a clot from extending beyond the site of injury.^L34635

In June 2021, the FDA approved a plasma-derived plasminogen (Ryplazim, human plasminogen-tvmh)^L34620 for the treatment of type 1 plasminogen deficiency (hypoplasminogenemia).^L34615 It is the first and only FDA-approved treatment for this condition, which causes wood-like lesions to form on the mucous membranes of patients, providing an unmet medical need for patients with this rare congenital disease.

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) The mean half-life of Ryplazim at steady-state is approximately 39.2 hours.[L34620]

Volume Distribusi The mean steady-state volume of distribution of Ryplazim is approximately 49.3 mL/kg.[L34620]

Klirens (Clearance) The clearance of Ryplazim appears to slow with extended use. Following the first intravenous dose the mean clearance of Ryplazim was 1.4 mL/hr/kg, while following an intravenous dose at week 12 the mean clearance was 0.9 mL/hr/kg.[L34620]

Absorpsi

Following 12 weeks of intravenous administration every 2 to 4 days, the mean AUC_inf of Ryplazim was 5731.8 hr*% and its C_max was approximately 125% of the mean physiological level (normal: 70-130%).^L34620 After 12 weeks of therapy, physiological plasminogen levels were sustained for approximately 24 hours post-dose and patients maintained a 10% absolute increase in plasminogen concentration for up to 96 hours after administration.^L34620

Metabolisme

Plasminogen is a zymogen which is converted into the active fibrinolytic plasmin, or fibrinolysin, by tissue plasminogen activator (tPA) or urokinase-like plasminogen activator (uPA).L34635,A236035

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

0 Data

Tidak ada data.

Referensi & Sumber

Artikel (PubMed)

PMID: 30969567
Katz JM, Tadi P: Physiology, Plasminogen Activation .
PMID: 17900274
Schuster V, Hugle B, Tefs K: Plasminogen deficiency. J Thromb Haemost. 2007 Dec;5(12):2315-22. doi: 10.1111/j.1538-7836.2007.02776.x. Epub 2007 Sep 26.

Link

Contoh Produk & Brand

Produk: 1 • International brands: 1

Produk

Ryplazim

Injection, powder, lyophilized, for solution • 68.8 mg/1 • Intravenous • US • Approved

International Brands

Ryplazim — Liminal BioSciences Inc.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.