Janssen COVID-19 Vaccine

DB15857

biotech approved investigational

Deskripsi

The Janssen COVID-19 vaccine (Ad26.COV2.S) is a recombinant vaccine that contains an adenovirus serotype 26 (Ad26) vector expressing a stabilized SARS-CoV-2 spike protein. The vaccine was created in collaboration with Johnson and Johnson (J&J), Janssen Pharmaceutical, and the Beth Israel Deaconess Medical Center. A preclinical study in hamsters infected with SARS-COV-2 infection^A220053 showed a single immunization with the vaccine-elicited neutralizing responses and protected against SARS-CoV-2 induced pneumonia and mortality, providing protection against the disease progression. Follow-up preclinical studies in rhesus monkeys^A220058 showed that the Ad26 vaccine produced a robust response and provided near perfect protection in nasal swabs and bronchoalveolar lavage following SARS-COV-2 challenge. As of June 2020, a Phase 1/2 clinical trial in adult humans was announced to evaluate the safety, immunogenicity, and efficacy of the ad26.COV.S vaccine in 1045 healthy adults between the ages of 18-55 (NCT04436276). The Janssen COVID-19 vaccine is available under an Emergency Use Authorization (EUA) in the US.^L41745

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) -

Volume Distribusi -

Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

285 Data

Etanercept	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Etanercept.
Peginterferon alfa-2a	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Peginterferon alfa-2a.
Interferon alfa-n1	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Interferon alfa-n1.
Interferon alfa-n3	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Interferon alfa-n3.
Peginterferon alfa-2b	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Peginterferon alfa-2b.
Anakinra	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Anakinra.
Interferon gamma-1b	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Interferon gamma-1b.
Interferon alfa-2a	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Interferon alfa-2a.
Aldesleukin	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Aldesleukin.
Adalimumab	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Adalimumab.
Gemtuzumab ozogamicin	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Gemtuzumab ozogamicin.
Pegaspargase	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Pegaspargase.
Infliximab	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Infliximab.
Interferon beta-1b	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Interferon beta-1b.
Interferon alfacon-1	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Interferon alfacon-1.
Trastuzumab	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Trastuzumab.
Rituximab	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Rituximab.
Basiliximab	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Basiliximab.
Muromonab	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Muromonab.
Ibritumomab tiuxetan	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Ibritumomab tiuxetan.
Tositumomab	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Tositumomab.
Alemtuzumab	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Alemtuzumab.
Cyclosporine	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Cyclosporine.
Alefacept	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Alefacept.
Efalizumab	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Efalizumab.
Antithymocyte immunoglobulin (rabbit)	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Antithymocyte immunoglobulin (rabbit).
Interferon alfa-2b	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Interferon alfa-2b.
Natalizumab	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Natalizumab.
Daclizumab	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Daclizumab.
Phenylalanine	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Phenylalanine.
Flunisolide	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Flunisolide.
Bortezomib	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Bortezomib.
Cladribine	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Cladribine.
Carmustine	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Carmustine.
Amsacrine	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Amsacrine.
Bleomycin	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Bleomycin.
Chlorambucil	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Chlorambucil.
Raltitrexed	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Raltitrexed.
Mitomycin	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Mitomycin.
Bexarotene	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Bexarotene.
Vindesine	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Vindesine.
Floxuridine	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Floxuridine.
Fluorometholone	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Fluorometholone.
Indomethacin	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Indomethacin.
Tioguanine	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Tioguanine.
Vinorelbine	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Vinorelbine.
Dexrazoxane	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Dexrazoxane.
Beclomethasone dipropionate	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Beclomethasone dipropionate.
Sorafenib	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Sorafenib.
Streptozocin	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Streptozocin.
Trifluridine	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Trifluridine.
Gemcitabine	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Gemcitabine.
Betamethasone	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Betamethasone.
Teniposide	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Teniposide.
Epirubicin	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Epirubicin.
Chloramphenicol	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Chloramphenicol.
Lenalidomide	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Lenalidomide.
Altretamine	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Altretamine.
Zidovudine	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Zidovudine.
Cisplatin	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Cisplatin.
Oxaliplatin	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Oxaliplatin.
Cyclophosphamide	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Cyclophosphamide.
Vincristine	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Vincristine.
Fluorouracil	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Fluorouracil.
Desoximetasone	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Desoximetasone.
Propylthiouracil	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Propylthiouracil.
Pentostatin	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Pentostatin.
Methotrexate	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Methotrexate.
Carbamazepine	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Carbamazepine.
Vinblastine	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Vinblastine.
Fluticasone propionate	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Fluticasone propionate.
Fluocinolone acetonide	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Fluocinolone acetonide.
Linezolid	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Linezolid.
Imatinib	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Imatinib.
Triamcinolone	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Triamcinolone.
Clofarabine	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Clofarabine.
Prednisone	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Prednisone.
Pemetrexed	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Pemetrexed.
Flumethasone	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Flumethasone.
Fludrocortisone	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Fludrocortisone.
Mycophenolate mofetil	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Mycophenolate mofetil.
Daunorubicin	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Daunorubicin.
Hydrocortisone	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Hydrocortisone.
Irinotecan	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Irinotecan.
Methimazole	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Methimazole.
Mometasone	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Mometasone.
Etoposide	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Etoposide.
Sulfasalazine	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Sulfasalazine.
Dacarbazine	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Dacarbazine.
Temozolomide	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Temozolomide.
Penicillamine	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Penicillamine.
Prednisolone	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Prednisolone.
Tacrolimus	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Tacrolimus.
Sirolimus	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Sirolimus.
Mechlorethamine	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Mechlorethamine.
Azacitidine	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Azacitidine.
Carboplatin	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Carboplatin.
Methylprednisolone	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Methylprednisolone.
Dactinomycin	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Dactinomycin.
Azathioprine	The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Azathioprine.

Referensi & Sumber

Artikel (PubMed)

PMID: 32884153
Tostanoski LH, Wegmann F, Martinot AJ, Loos C, McMahan K, Mercado NB, Yu J, Chan CN, Bondoc S, Starke CE, Nekorchuk M, Busman-Sahay K, Piedra-Mora C, Wrijil LM, Ducat S, Custers J, Atyeo C, Fischinger S, Burke JS, Feldman J, Hauser BM, Caradonna TM, Bondzie EA, Dagotto G, Gebre MS, Jacob-Dolan C, Lin Z, Mahrokhian SH, Nampanya F, Nityanandam R, Pessaint L, Porto M, Ali V, Benetiene D, Tevi K, Andersen H, Lewis MG, Schmidt AG, Lauffenburger DA, Alter G, Estes JD, Schuitemaker H, Zahn R, Barouch DH: Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters. Nat Med. 2020 Sep 3. pii: 10.1038/s41591-020-1070-6. doi: 10.1038/s41591-020-1070-6.
PMID: 32731257
Mercado NB, Zahn R, Wegmann F, Loos C, Chandrashekar A, Yu J, Liu J, Peter L, McMahan K, Tostanoski LH, He X, Martinez DR, Rutten L, Bos R, van Manen D, Vellinga J, Custers J, Langedijk JP, Kwaks T, Bakkers MJG, Zuijdgeest D, Rosendahl Huber SK, Atyeo C, Fischinger S, Burke JS, Feldman J, Hauser BM, Caradonna TM, Bondzie EA, Dagotto G, Gebre MS, Hoffman E, Jacob-Dolan C, Kirilova M, Li Z, Lin Z, Mahrokhian SH, Maxfield LF, Nampanya F, Nityanandam R, Nkolola JP, Patel S, Ventura JD, Verrington K, Wan H, Pessaint L, Van Ry A, Blade K, Strasbaugh A, Cabus M, Brown R, Cook A, Zouantchangadou S, Teow E, Andersen H, Lewis MG, Cai Y, Chen B, Schmidt AG, Reeves RK, Baric RS, Lauffenburger DA, Alter G, Stoffels P, Mammen M, Van Hoof J, Schuitemaker H, Barouch DH: Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques. Nature. 2020 Jul 30. pii: 10.1038/s41586-020-2607-z. doi: 10.1038/s41586-020-2607-z.

Link

Contoh Produk & Brand

Produk: 4 • International brands: 0

Produk

Covid-19 Vaccine Janssen

Injection, suspension • 8.92 log₁₀ Inf. U • Intramuscular • EU
Covid-19 Vaccine Janssen

Injection, suspension • 8.92 log₁₀ Inf. U • Intramuscular • EU
Janssen COVID-19 Vaccine

Injection, suspension • 50000000000 {VP}/0.5mL • Intramuscular • US
Jcovden

Suspension • 50000000000 vp / 0.5 mL • Intramuscular • Canada • Approved

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.