Interferon Gamma

DB15753

biotech investigational

Deskripsi

Interferon gamma is a Type 1 inflammatory cytokine and the only type II interferon. It has antitumor properties, antiviral activities, and important immunoregulatory functions. The interferon is primarily produced by activated T lymphocytes and natural killer cells.

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

40 Data
Zidovudine The risk or severity of adverse effects can be increased when Interferon Gamma is combined with Zidovudine.
Caffeine The metabolism of Caffeine can be decreased when combined with Interferon Gamma.
Theophylline The metabolism of Theophylline can be decreased when combined with Interferon Gamma.
Dyphylline The metabolism of Dyphylline can be decreased when combined with Interferon Gamma.
Pentoxifylline The metabolism of Pentoxifylline can be decreased when combined with Interferon Gamma.
Mercaptopurine The metabolism of Mercaptopurine can be decreased when combined with Interferon Gamma.
Aminophylline The metabolism of Aminophylline can be decreased when combined with Interferon Gamma.
Oxtriphylline The metabolism of Oxtriphylline can be decreased when combined with Interferon Gamma.
Theobromine The metabolism of Theobromine can be decreased when combined with Interferon Gamma.
Fenethylline The metabolism of Fenethylline can be decreased when combined with Interferon Gamma.
8-azaguanine The metabolism of 8-azaguanine can be decreased when combined with Interferon Gamma.
7,9-Dimethylguanine The metabolism of 7,9-Dimethylguanine can be decreased when combined with Interferon Gamma.
Xanthine The metabolism of Xanthine can be decreased when combined with Interferon Gamma.
7-Deazaguanine The metabolism of 7-Deazaguanine can be decreased when combined with Interferon Gamma.
Guanine The metabolism of Guanine can be decreased when combined with Interferon Gamma.
9-Methylguanine The metabolism of 9-Methylguanine can be decreased when combined with Interferon Gamma.
Peldesine The metabolism of Peldesine can be decreased when combined with Interferon Gamma.
Hypoxanthine The metabolism of Hypoxanthine can be decreased when combined with Interferon Gamma.
9-Deazaguanine The metabolism of 9-Deazaguanine can be decreased when combined with Interferon Gamma.
Propentofylline The metabolism of Propentofylline can be decreased when combined with Interferon Gamma.
Valomaciclovir The metabolism of Valomaciclovir can be decreased when combined with Interferon Gamma.
3-isobutyl-1-methyl-7H-xanthine The metabolism of 3-isobutyl-1-methyl-7H-xanthine can be decreased when combined with Interferon Gamma.
Uric acid The metabolism of Uric acid can be decreased when combined with Interferon Gamma.
Doxofylline The metabolism of Doxofylline can be decreased when combined with Interferon Gamma.
6-O-benzylguanine The metabolism of 6-O-benzylguanine can be decreased when combined with Interferon Gamma.
Lisofylline The metabolism of Lisofylline can be decreased when combined with Interferon Gamma.
Lobucavir The metabolism of Lobucavir can be decreased when combined with Interferon Gamma.
Cafedrine The metabolism of Cafedrine can be decreased when combined with Interferon Gamma.
Theodrenaline The metabolism of Theodrenaline can be decreased when combined with Interferon Gamma.
Bamifylline The metabolism of Bamifylline can be decreased when combined with Interferon Gamma.
Proxyphylline The metabolism of Proxyphylline can be decreased when combined with Interferon Gamma.
Acefylline The metabolism of Acefylline can be decreased when combined with Interferon Gamma.
Etamiphylline The metabolism of Etamiphylline can be decreased when combined with Interferon Gamma.
Pentifylline The metabolism of Pentifylline can be decreased when combined with Interferon Gamma.
Bufylline The metabolism of Bufylline can be decreased when combined with Interferon Gamma.
Bromotheophylline The metabolism of Bromotheophylline can be decreased when combined with Interferon Gamma.
Furafylline The metabolism of Furafylline can be decreased when combined with Interferon Gamma.
8-chlorotheophylline The metabolism of 8-chlorotheophylline can be decreased when combined with Interferon Gamma.
PCS-499 The metabolism of PCS-499 can be decreased when combined with Interferon Gamma.
Lomifylline The metabolism of Lomifylline can be decreased when combined with Interferon Gamma.

Referensi & Sumber

Artikel (PubMed)
  • PMID: 22410872
    de Weerd NA, Nguyen T: The interferons and their receptors--distribution and regulation. Immunol Cell Biol. 2012 May;90(5):483-91. doi: 10.1038/icb.2012.9. Epub 2012 Mar 13.
  • PMID: 22896633
    McBerry C, Egan CE, Rani R, Yang Y, Wu D, Boespflug N, Boon L, Butcher B, Mirpuri J, Hogan SP, Denkers EY, Aliberti J, Herbert DR: Trefoil factor 2 negatively regulates type 1 immunity against Toxoplasma gondii. J Immunol. 2012 Sep 15;189(6):3078-84. doi: 10.4049/jimmunol.1103374. Epub 2012 Aug 15.
  • PMID: 30318081
    Bello-Rivero I, Garcia-Vega Y, Duncan-Roberts Y, Vazquez-Blomquistc D, Santana-Milian H, Besada-Perez V, Rios-Cabrera M: HeberFERON, a new formulation of IFNs with improved pharmacodynamics: Perspective for cancer treatment. Semin Oncol. 2018 Jan;45(1-2):27-33. doi: 10.1053/j.seminoncol.2018.04.007. Epub 2018 May 4.
  • PMID: 10688427
    Tau G, Rothman P: Biologic functions of the IFN-gamma receptors. Allergy. 1999 Dec;54(12):1233-51. doi: 10.1034/j.1398-9995.1999.00099.x.

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