Interferon Kappa

DB15749

biotech investigational

Deskripsi

Interferon kappa is a subclass of type I interferon mediating host defence which consists of 207 amino acids and has 30% homology with others of the same class as it consists of a series of cysteine and a 27-amino acid signal peptide conserved in type I interferons. This gene encoding for this interferon is expressed in human epidermal keratinocytes.

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

40 Data
Zidovudine The risk or severity of adverse effects can be increased when Interferon Kappa is combined with Zidovudine.
Caffeine The metabolism of Caffeine can be decreased when combined with Interferon Kappa.
Theophylline The metabolism of Theophylline can be decreased when combined with Interferon Kappa.
Dyphylline The metabolism of Dyphylline can be decreased when combined with Interferon Kappa.
Pentoxifylline The metabolism of Pentoxifylline can be decreased when combined with Interferon Kappa.
Mercaptopurine The metabolism of Mercaptopurine can be decreased when combined with Interferon Kappa.
Aminophylline The metabolism of Aminophylline can be decreased when combined with Interferon Kappa.
Oxtriphylline The metabolism of Oxtriphylline can be decreased when combined with Interferon Kappa.
Theobromine The metabolism of Theobromine can be decreased when combined with Interferon Kappa.
Fenethylline The metabolism of Fenethylline can be decreased when combined with Interferon Kappa.
8-azaguanine The metabolism of 8-azaguanine can be decreased when combined with Interferon Kappa.
7,9-Dimethylguanine The metabolism of 7,9-Dimethylguanine can be decreased when combined with Interferon Kappa.
Xanthine The metabolism of Xanthine can be decreased when combined with Interferon Kappa.
7-Deazaguanine The metabolism of 7-Deazaguanine can be decreased when combined with Interferon Kappa.
Guanine The metabolism of Guanine can be decreased when combined with Interferon Kappa.
9-Methylguanine The metabolism of 9-Methylguanine can be decreased when combined with Interferon Kappa.
Peldesine The metabolism of Peldesine can be decreased when combined with Interferon Kappa.
Hypoxanthine The metabolism of Hypoxanthine can be decreased when combined with Interferon Kappa.
9-Deazaguanine The metabolism of 9-Deazaguanine can be decreased when combined with Interferon Kappa.
Propentofylline The metabolism of Propentofylline can be decreased when combined with Interferon Kappa.
Valomaciclovir The metabolism of Valomaciclovir can be decreased when combined with Interferon Kappa.
3-isobutyl-1-methyl-7H-xanthine The metabolism of 3-isobutyl-1-methyl-7H-xanthine can be decreased when combined with Interferon Kappa.
Uric acid The metabolism of Uric acid can be decreased when combined with Interferon Kappa.
Doxofylline The metabolism of Doxofylline can be decreased when combined with Interferon Kappa.
6-O-benzylguanine The metabolism of 6-O-benzylguanine can be decreased when combined with Interferon Kappa.
Lisofylline The metabolism of Lisofylline can be decreased when combined with Interferon Kappa.
Lobucavir The metabolism of Lobucavir can be decreased when combined with Interferon Kappa.
Cafedrine The metabolism of Cafedrine can be decreased when combined with Interferon Kappa.
Theodrenaline The metabolism of Theodrenaline can be decreased when combined with Interferon Kappa.
Bamifylline The metabolism of Bamifylline can be decreased when combined with Interferon Kappa.
Proxyphylline The metabolism of Proxyphylline can be decreased when combined with Interferon Kappa.
Acefylline The metabolism of Acefylline can be decreased when combined with Interferon Kappa.
Etamiphylline The metabolism of Etamiphylline can be decreased when combined with Interferon Kappa.
Pentifylline The metabolism of Pentifylline can be decreased when combined with Interferon Kappa.
Bufylline The metabolism of Bufylline can be decreased when combined with Interferon Kappa.
Bromotheophylline The metabolism of Bromotheophylline can be decreased when combined with Interferon Kappa.
Furafylline The metabolism of Furafylline can be decreased when combined with Interferon Kappa.
8-chlorotheophylline The metabolism of 8-chlorotheophylline can be decreased when combined with Interferon Kappa.
PCS-499 The metabolism of PCS-499 can be decreased when combined with Interferon Kappa.
Lomifylline The metabolism of Lomifylline can be decreased when combined with Interferon Kappa.

Referensi & Sumber

Artikel (PubMed)
  • PMID: 11514542
    LaFleur DW, Nardelli B, Tsareva T, Mather D, Feng P, Semenuk M, Taylor K, Buergin M, Chinchilla D, Roshke V, Chen G, Ruben SM, Pitha PM, Coleman TA, Moore PA: Interferon-kappa, a novel type I interferon expressed in human keratinocytes. J Biol Chem. 2001 Oct 26;276(43):39765-71. doi: 10.1074/jbc.M102502200. Epub 2001 Aug 20.
  • PMID: 22410872
    de Weerd NA, Nguyen T: The interferons and their receptors--distribution and regulation. Immunol Cell Biol. 2012 May;90(5):483-91. doi: 10.1038/icb.2012.9. Epub 2012 Mar 13.

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