Inolimomab

DB15628

biotech investigational

Deskripsi

Inolimomab is under investigation as an agent to treat steroid-resistant graft vs host disease. It has thus far offered similar efficacy to other monoclonal antibody options, though it may carry a higher risk of infections.A241385

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

669 Data
Denosumab The risk or severity of adverse effects can be increased when Denosumab is combined with Inolimomab.
Adalimumab The risk or severity of adverse effects can be increased when Adalimumab is combined with Inolimomab.
Gemtuzumab ozogamicin The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Inolimomab.
Infliximab The risk or severity of adverse effects can be increased when Infliximab is combined with Inolimomab.
Rituximab The risk or severity of adverse effects can be increased when Rituximab is combined with Inolimomab.
Basiliximab The risk or severity of adverse effects can be increased when Basiliximab is combined with Inolimomab.
Muromonab The risk or severity of adverse effects can be increased when Muromonab is combined with Inolimomab.
Ibritumomab tiuxetan The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Inolimomab.
Tositumomab The risk or severity of adverse effects can be increased when Tositumomab is combined with Inolimomab.
Alemtuzumab The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Inolimomab.
Efalizumab The risk or severity of adverse effects can be increased when Efalizumab is combined with Inolimomab.
Antithymocyte immunoglobulin (rabbit) The risk or severity of adverse effects can be increased when Antithymocyte immunoglobulin (rabbit) is combined with Inolimomab.
Daclizumab The risk or severity of adverse effects can be increased when Daclizumab is combined with Inolimomab.
Eculizumab The risk or severity of adverse effects can be increased when Eculizumab is combined with Inolimomab.
Afelimomab The risk or severity of adverse effects can be increased when Afelimomab is combined with Inolimomab.
Briakinumab The risk or severity of adverse effects can be increased when Briakinumab is combined with Inolimomab.
Trastuzumab emtansine The risk or severity of adverse effects can be increased when Trastuzumab emtansine is combined with Inolimomab.
Canakinumab The risk or severity of adverse effects can be increased when Canakinumab is combined with Inolimomab.
Tocilizumab The risk or severity of adverse effects can be increased when Tocilizumab is combined with Inolimomab.
Mepolizumab The risk or severity of adverse effects can be increased when Mepolizumab is combined with Inolimomab.
Golimumab The risk or severity of adverse effects can be increased when Golimumab is combined with Inolimomab.
Brentuximab vedotin The risk or severity of adverse effects can be increased when Brentuximab vedotin is combined with Inolimomab.
Belimumab The risk or severity of adverse effects can be increased when Belimumab is combined with Inolimomab.
Certolizumab pegol The risk or severity of adverse effects can be increased when Certolizumab pegol is combined with Inolimomab.
Obinutuzumab The risk or severity of adverse effects can be increased when Obinutuzumab is combined with Inolimomab.
Secukinumab The risk or severity of adverse effects can be increased when Secukinumab is combined with Inolimomab.
Vedolizumab The risk or severity of adverse effects can be increased when Vedolizumab is combined with Inolimomab.
Siltuximab The risk or severity of adverse effects can be increased when Siltuximab is combined with Inolimomab.
Blinatumomab The risk or severity of adverse effects can be increased when Blinatumomab is combined with Inolimomab.
Dinutuximab The risk or severity of adverse effects can be increased when Dinutuximab is combined with Inolimomab.
Antilymphocyte immunoglobulin (horse) The risk or severity of adverse effects can be increased when Antilymphocyte immunoglobulin (horse) is combined with Inolimomab.
Ixekizumab The risk or severity of adverse effects can be increased when Ixekizumab is combined with Inolimomab.
Ravulizumab The risk or severity of adverse effects can be increased when Ravulizumab is combined with Inolimomab.
Sarilumab The risk or severity of adverse effects can be increased when Sarilumab is combined with Inolimomab.
Brodalumab The risk or severity of adverse effects can be increased when Brodalumab is combined with Inolimomab.
Sirukumab The risk or severity of adverse effects can be increased when Sirukumab is combined with Inolimomab.
Guselkumab The risk or severity of adverse effects can be increased when Guselkumab is combined with Inolimomab.
Emapalumab The risk or severity of adverse effects can be increased when Emapalumab is combined with Inolimomab.
Risankizumab The risk or severity of adverse effects can be increased when Risankizumab is combined with Inolimomab.
Rozanolixizumab The risk or severity of adverse effects can be increased when Rozanolixizumab is combined with Inolimomab.
Bleselumab The risk or severity of adverse effects can be increased when Bleselumab is combined with Inolimomab.
Etanercept The risk or severity of adverse effects can be increased when Etanercept is combined with Inolimomab.
Peginterferon alfa-2a The risk or severity of adverse effects can be increased when Peginterferon alfa-2a is combined with Inolimomab.
Interferon alfa-n1 The risk or severity of adverse effects can be increased when Interferon alfa-n1 is combined with Inolimomab.
Interferon alfa-n3 The risk or severity of adverse effects can be increased when Interferon alfa-n3 is combined with Inolimomab.
Peginterferon alfa-2b The risk or severity of adverse effects can be increased when Peginterferon alfa-2b is combined with Inolimomab.
Anakinra The risk or severity of adverse effects can be increased when Anakinra is combined with Inolimomab.
Interferon gamma-1b The risk or severity of adverse effects can be increased when Interferon gamma-1b is combined with Inolimomab.
Interferon alfa-2a The risk or severity of adverse effects can be increased when Interferon alfa-2a is combined with Inolimomab.
Aldesleukin The risk or severity of adverse effects can be increased when Aldesleukin is combined with Inolimomab.
Pegaspargase The risk or severity of adverse effects can be increased when Pegaspargase is combined with Inolimomab.
Interferon beta-1b The risk or severity of adverse effects can be increased when Interferon beta-1b is combined with Inolimomab.
Interferon alfacon-1 The risk or severity of adverse effects can be increased when Interferon alfacon-1 is combined with Inolimomab.
Alefacept The risk or severity of adverse effects can be increased when Alefacept is combined with Inolimomab.
Interferon alfa-2b The risk or severity of adverse effects can be increased when Interferon alfa-2b is combined with Inolimomab.
Phenylalanine The risk or severity of adverse effects can be increased when Phenylalanine is combined with Inolimomab.
Flunisolide The risk or severity of adverse effects can be increased when Flunisolide is combined with Inolimomab.
Bortezomib The risk or severity of adverse effects can be increased when Bortezomib is combined with Inolimomab.
Cladribine Inolimomab may increase the immunosuppressive activities of Cladribine.
Carmustine The risk or severity of adverse effects can be increased when Carmustine is combined with Inolimomab.
Amsacrine The risk or severity of adverse effects can be increased when Amsacrine is combined with Inolimomab.
Bleomycin The risk or severity of adverse effects can be increased when Bleomycin is combined with Inolimomab.
Chlorambucil The risk or severity of adverse effects can be increased when Chlorambucil is combined with Inolimomab.
Raltitrexed The risk or severity of adverse effects can be increased when Raltitrexed is combined with Inolimomab.
Mitomycin The risk or severity of adverse effects can be increased when Mitomycin is combined with Inolimomab.
Bexarotene The risk or severity of adverse effects can be increased when Bexarotene is combined with Inolimomab.
Vindesine The risk or severity of adverse effects can be increased when Vindesine is combined with Inolimomab.
Floxuridine The risk or severity of adverse effects can be increased when Floxuridine is combined with Inolimomab.
Fluorometholone The risk or severity of adverse effects can be increased when Fluorometholone is combined with Inolimomab.
Indomethacin The risk or severity of adverse effects can be increased when Indomethacin is combined with Inolimomab.
Tioguanine The risk or severity of adverse effects can be increased when Tioguanine is combined with Inolimomab.
Vinorelbine The risk or severity of adverse effects can be increased when Vinorelbine is combined with Inolimomab.
Dexrazoxane The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Inolimomab.
Beclomethasone dipropionate The risk or severity of adverse effects can be increased when Beclomethasone dipropionate is combined with Inolimomab.
Sorafenib The risk or severity of adverse effects can be increased when Sorafenib is combined with Inolimomab.
Streptozocin The risk or severity of adverse effects can be increased when Streptozocin is combined with Inolimomab.
Trifluridine The risk or severity of adverse effects can be increased when Trifluridine is combined with Inolimomab.
Gemcitabine The risk or severity of adverse effects can be increased when Gemcitabine is combined with Inolimomab.
Betamethasone The risk or severity of adverse effects can be increased when Betamethasone is combined with Inolimomab.
Teniposide The risk or severity of adverse effects can be increased when Teniposide is combined with Inolimomab.
Epirubicin The risk or severity of adverse effects can be increased when Epirubicin is combined with Inolimomab.
Chloramphenicol The risk or severity of adverse effects can be increased when Chloramphenicol is combined with Inolimomab.
Lenalidomide The risk or severity of adverse effects can be increased when Lenalidomide is combined with Inolimomab.
Altretamine The risk or severity of adverse effects can be increased when Altretamine is combined with Inolimomab.
Zidovudine The risk or severity of adverse effects can be increased when Zidovudine is combined with Inolimomab.
Cisplatin The risk or severity of adverse effects can be increased when Cisplatin is combined with Inolimomab.
Oxaliplatin The risk or severity of adverse effects can be increased when Oxaliplatin is combined with Inolimomab.
Cyclophosphamide The risk or severity of adverse effects can be increased when Cyclophosphamide is combined with Inolimomab.
Vincristine The risk or severity of adverse effects can be increased when Vincristine is combined with Inolimomab.
Fluorouracil The risk or severity of adverse effects can be increased when Fluorouracil is combined with Inolimomab.
Desoximetasone The risk or severity of adverse effects can be increased when Desoximetasone is combined with Inolimomab.
Propylthiouracil The risk or severity of adverse effects can be increased when Propylthiouracil is combined with Inolimomab.
Pentostatin The risk or severity of adverse effects can be increased when Pentostatin is combined with Inolimomab.
Methotrexate The risk or severity of adverse effects can be increased when Methotrexate is combined with Inolimomab.
Carbamazepine The risk or severity of adverse effects can be increased when Carbamazepine is combined with Inolimomab.
Vinblastine The risk or severity of adverse effects can be increased when Vinblastine is combined with Inolimomab.
Fluticasone propionate The risk or severity of adverse effects can be increased when Fluticasone propionate is combined with Inolimomab.
Fluocinolone acetonide The risk or severity of adverse effects can be increased when Fluocinolone acetonide is combined with Inolimomab.
Linezolid The risk or severity of adverse effects can be increased when Linezolid is combined with Inolimomab.
Imatinib The risk or severity of adverse effects can be increased when Imatinib is combined with Inolimomab.

Target Protein

Interleukin-2 receptor subunit alpha IL2RA

Referensi & Sumber

Artikel (PubMed)
  • PMID: 34621279
    Shen MZ, Li JX, Zhang XH, Xu LP, Wang Y, Liu KY, Huang XJ, Hong SD, Mo XD: Meta-Analysis of Interleukin-2 Receptor Antagonists as the Treatment for Steroid-Refractory Acute Graft-Versus-Host Disease. Front Immunol. 2021 Sep 21;12:749266. doi: 10.3389/fimmu.2021.749266. eCollection 2021.
  • PMID: 27899357
    Socie G, Vigouroux S, Yakoub-Agha I, Bay JO, Furst S, Bilger K, Suarez F, Michallet M, Bron D, Gard P, Medeghri Z, Lehert P, Lai C, Corn T, Vernant JP: A phase 3 randomized trial comparing inolimomab vs usual care in steroid-resistant acute GVHD. Blood. 2017 Feb 2;129(5):643-649. doi: 10.1182/blood-2016-09-738625. Epub 2016 Nov 29.

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