Peringatan Keamanan

The intraperitoneal LD₅₀ of triazavirin in mice is 1400±120mg/kg in mice and the intragastric LD₅₀ is 2200±96mg/kg.^A191706

Patients experiencing an overdose may present with nausea, vomiting, dyspepsia, and stomach pain.^L12165 Treat overdose with symptomatic and supportive treatment, which may include discontinuation of treatment.^L12165

Triazavirin

DB15622

small molecule experimental

Deskripsi

Triazavirin is a guanine nucleotide analog antiviral originally developed in Russia that has shown efficacy against influenza A and B, including the H5N1 strain.A191709,A191625,A191916 It appears that Triazavirin has shown promise in reducing influenza disease severity and associated complications.^L12087 Given the similarities between SARS-CoV-2 and H5N1, health officials are investigating Triazavirin as an option to combat SARS-CoV-2, the coronavirus responsible for COVID-19.^A191625

Struktur Molekul 2D

Berat 228.19

Wujud solid

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) In rabbits, intragastric triazavirin has a half life of 1.1±0.1h while intravenous triazavirin has a half life of 0.50±0.09h.[A191706] The half life of triazavirin is 1-1.5h.[L12165]

Volume Distribusi In rabbits, intragastric triazavirin has a volume of distribution of 83.5±19.2L/kg while intravenous triazavirin has a volume of distribution of 1.2±0.3L/kg.[A191706]

Klirens (Clearance) In rabbits, intragastric triazavirin has a clearance of 37.0±11.2L/h\*kg while intravenous triazavirin has a clearance of 14.0±3.7L/h\*kg.[A191706] The clearance of triazavirin is 246mL/min.[L12165]

Absorpsi

In rabbits, intragastric triazavirin reaches a C_max of 1.1±0.1mg/L, with a T_max of 0.40±0.16h, and an AUC of 3.10±0.8mg\*h/L.^A191706 In rabbits, intravenous triazavirin has an AUC of 1.2±0.3mg\*h/L.^A191706 In humans, triazavirin reaches a C_max of 4.8µg/mL, with a T_max of 1-1.5h, and an AUC of 12.8µgµg/h\*mL.^L12165

Metabolisme

Data regarding the metabolism of triazavirin is not readily available.

Rute Eliminasi

Data regarding the route of elimination of triazavirin is not readily available.

Interaksi Makanan

1 Data

1. Take with or without food.

Interaksi Obat

0 Data

Tidak ada data.

Referensi & Sumber

Artikel (PubMed)

PMID: 23477247
Kiselev OI, Deeva EG, Mel'nikova TI, Kozeletskaia KN, Kiselev AS, Rusinov VL, Charushin VN, Chupakhin ON: A new antiviral drug Triazavirin: results of phase II clinical trial. Vopr Virusol. 2012 Nov-Dec;57(6):9-12.
PMID: 16115318
Vincent MJ, Bergeron E, Benjannet S, Erickson BR, Rollin PE, Ksiazek TG, Seidah NG, Nichol ST: Chloroquine is a potent inhibitor of SARS coronavirus infection and spread. Virol J. 2005 Aug 22;2:69. doi: 10.1186/1743-422X-2-69.
PMID: 20194696
Karpenko I, Deev S, Kiselev O, Charushin V, Rusinov V, Ulomsky E, Deeva E, Yanvarev D, Ivanov A, Smirnova O, Kochetkov S, Chupakhin O, Kukhanova M: Antiviral properties, metabolism, and pharmacokinetics of a novel azolo-1,2,4-triazine-derived inhibitor of influenza A and B virus replication. Antimicrob Agents Chemother. 2010 May;54(5):2017-22. doi: 10.1128/AAC.01186-09. Epub 2010 Mar 1.
PMID: -
Shvetsov A, Zabrodskaya Y, Nekrasov P, Egorov V: Triazavirine supramolecular complexes as modifiers of the peptide oligomeric structure Journal of Biomolecular Structure and Dynamics. 2017 Sep 12;36(10):2694-2698.

Link

Contoh Produk & Brand

Produk: 0 • International brands: 0

Belum ada data produk/brand untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field produk/brand.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.