Peringatan Keamanan

The intraperitoneal TDLO in rats is 100 mg/kg.^L10839 No overdose information is available at this time.^L10830 When compared to other ophthalmological dyes, brilliant blue G appears to have a comparable safety profile.^A188880 Ensure to remove the dye immediately after staining.^L10830

Brilliant blue G

DB15594

small molecule approved

Deskripsi

Brilliant Blue G is used in an ophthalmic solution for staining the internal limiting membrane (ILM) of the eye during ophthalmic procedures.A188841,A188844 This membrane is thin and translucent, making it difficult to identify during eye surgeries that require high levels of visual accuracy. Brilliant blue G, like its name, imparts a vibrant blue color, facilitating identification of the ILM. It was approved by the FDA for ophthalmic use on December 20, 2019.^L10830

Struktur Molekul 2D

Berat 854.02

Wujud liquid

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) -

Volume Distribusi This drug is administered via intravitreal injection and likely distributes only to parts of the eye.[L10830]

Klirens (Clearance) -

Absorpsi

Due to the fact that this drug is administered by intravitreal injection and subsequently removed after staining, it is not expected to be significantly absorbed systemically.^L10830

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

This dye is removed in a clinical setting after the surgical procedure in which it was used.^L10830

Interaksi Obat

0 Data

Tidak ada data.

Target Protein

Internal limiting membrane (ILM)

Referensi & Sumber

Artikel (PubMed)

PMID: 14660466
Gandorfer A, Haritoglou C, Kampik A: Staining of the ILM in macular surgery. Br J Ophthalmol. 2003 Dec;87(12):1530; author reply 1530. doi: 10.1136/bjo.87.12.1530.
PMID: 26425352
Semeraro F, Morescalchi F, Duse S, Gambicorti E, Russo A, Costagliola C: Current Trends about Inner Limiting Membrane Peeling in Surgery for Epiretinal Membranes. J Ophthalmol. 2015;2015:671905. doi: 10.1155/2015/671905. Epub 2015 Sep 3.
PMID: 16829804
Enaida H, Hisatomi T, Hata Y, Ueno A, Goto Y, Yamada T, Kubota T, Ishibashi T: Brilliant blue G selectively stains the internal limiting membrane/brilliant blue G-assisted membrane peeling. Retina. 2006 Jul-Aug;26(6):631-6. doi: 10.1097/01.iae.0000236469.71443.aa.
PMID: 31004281
Guber J, Pereni I, Scholl HPN, Guber I, Haynes RJ: Outcomes after Epiretinal Membrane Surgery with or Without Internal Limiting Membrane Peeling. Ophthalmol Ther. 2019 Jun;8(2):297-303. doi: 10.1007/s40123-019-0185-7. Epub 2019 Apr 19.
PMID: 12799245
Sheard RM, Sethi C, Gregor Z: Acute macular pucker. Ophthalmology. 2003 Jun;110(6):1178-84. doi: 10.1016/S0161-6420(03)00266-5.
PMID: 19561782
Konidaris V, Androudi S, Brazitikos P: Myopic traction maculopathy: study with spectral domain optical coherence tomography and review of the literature. Hippokratia. 2009 Apr;13(2):110-3.
PMID: 21372016
Awad D, Schrader I, Bartok M, Mohr A, Gabel D: Comparative toxicology of trypan blue, brilliant blue G, and their combination together with polyethylene glycol on human pigment epithelial cells. Invest Ophthalmol Vis Sci. 2011 Jun 9;52(7):4085-90. doi: 10.1167/iovs.10-6336.

Link

Contoh Produk & Brand

Produk: 2 • International brands: 0

Produk

Tissueblue

Injection, solution • 0.0125 mg/0.5mL • Intraocular; Ophthalmic • US • Approved
Tissueblue

Solution • 0.25 mg / mL • Intravitreal • Canada • Approved

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.