Peringatan Keamanan

The oral LD50 of prednisolone acetate in mice is 1680 mg/kg.L9476 Patients experiencing an overdose of oral prednisolone acetate may experience an increased severity in the adverse effects of corticosteroids.L9449 Overdose of oral prednisolone acetate may be treated by gastric lavage or inducing vomiting if the overdose was recent, as well as supportive and symptomatic therapy.L9449 Chronic overdosage may be treated by dose reduction or treating patients on alternate days.L9449 An overdose by the ophthalmic route is not expected to cause problems.L9449

Prednisolone acetate

DB15566

small molecule approved vet_approved

Deskripsi

Prednisolone acetate is a prednisolone molecule bound to an acetate functional group by an ester bond.L9449

Prednisolone acetate was granted FDA approval in 1955.L9449

Struktur Molekul 2D

Berat 402.4807
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Oral prednisolone acetate has a plasma half life of 2-3 hours.[L9449]
Volume Distribusi The volume of distribution of the active metabolite, prednisolone, is 0.22/0.7L/kg.[L9449]
Klirens (Clearance) Data regarding the clearance of prednisolone acetate is not readily available.[L9452,L9455,L9476]

Absorpsi

Prednisolone acetate oral suspension given at a dose equivalent to 15mg prednisolone has a Cmax of 321.1ng/hr, a Tmaxof 1-2 hours, and an AUC of 1999.4ng\*hr/mL.L9449 The absorption pharmacokinetics of prednisolone acetate are not significantly different from a comparable dose of prednisolone.L9449

Metabolisme

Prednisolone acetate undergoes ester hydrolysis to prednisolone.A187421 After this step, the drug undergoes the normal metabolism of prednisolone. Prednisolone can be reversibly metabolized to prednisone which is then metabolized to 17?,21-dihydroxy-pregnan-1,4,6-trien-3,11,30-trione (M-XVII), 20?-dihydro-prednisone (M-V), 6?hydroxy-prednisone (M-XII), 6?-hydroxy-prednisone (M-XIII), or 20?-dihydro-prednisone (M-IV).A187403 20?-dihydro-prednisone is metabolized to 17?,20?,21-trihydroxy-5?-pregn-1-en-3,11-dione(M-XVIII).A187403 Prednisolone is metabolized to ?6-prednisolone (M-XI), 20?-dihydro-prednisolone (M-III), 20?-dihydro-prednisolone (M-II), 6?hydroxy-prednisolone (M-VII), or 6?hydroxy-prednisolone(M-VI).A187403 6?hydroxy-prednisolone is metabolized to 6?,11?,17?,20?,21-pentahydroxypregnan-1,4-diene-3-one (M-X).A187403 6?hydroxy-prednisolone is metabolized to 6?,11?,17?,20?,21-pentahydroxypregnan-1,4-diene-3-one (M-VIII), 6?,11?,17?,20?,21-pentahydroxypregnan-1,4-diene-3-one (M-IX), and 6?,11?,17?,21-tetrahydroxy-5?-pregn-1-en-3,20-dione (M-XIV).A187403 MVIII is metabolized to 6?,11?,17?,20?,21-pentahydroxy-5?-pregn-1-en-3-one (M-XV) and then to MXIV, while MIX is metabolized to 6?,11?,17?,20?,21-pentahydroxy-5?-pregn-1-en-3-one (M-XVI) and then to MXIV.A187403 These metabolites and their glucuronide conjugates are excreted predominantly in the urine.A187403,L9449

Rute Eliminasi

Prednisolone acetate is predominantly excreted in the urine.L9449

Interaksi Makanan

2 Data
  • 1. Avoid excessive or chronic alcohol consumption. Alcohol may cause gastric irritation.
  • 2. Take with food. Food reduces gastrointestinal irritation.

Interaksi Obat

764 Data
Aripiprazole The metabolism of Aripiprazole can be increased when combined with Prednisolone acetate.
Aripiprazole lauroxil The metabolism of Aripiprazole lauroxil can be increased when combined with Prednisolone acetate.
Ceritinib The risk or severity of hyperglycemia can be increased when Prednisolone acetate is combined with Ceritinib.
Corticorelin ovine triflutate The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Prednisolone acetate.
Deferasirox The risk or severity of gastrointestinal ulceration and gastrointestinal irritation can be increased when Prednisolone acetate is combined with Deferasirox.
Hyaluronidase (ovine) The therapeutic efficacy of Hyaluronidase (ovine) can be decreased when used in combination with Prednisolone acetate.
Hyaluronidase (human recombinant) The therapeutic efficacy of Hyaluronidase (human recombinant) can be decreased when used in combination with Prednisolone acetate.
Hyaluronidase The therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Prednisolone acetate.
Amphotericin B The risk or severity of hypokalemia can be increased when Prednisolone acetate is combined with Amphotericin B.
Isoetharine The risk or severity of hypokalemia can be increased when Prednisolone acetate is combined with Isoetharine.
Norepinephrine The risk or severity of hypokalemia can be increased when Prednisolone acetate is combined with Norepinephrine.
Phenylpropanolamine The risk or severity of hypokalemia can be increased when Prednisolone acetate is combined with Phenylpropanolamine.
Epinephrine The risk or severity of hypokalemia can be increased when Prednisolone acetate is combined with Epinephrine.
Orciprenaline The risk or severity of hypokalemia can be increased when Prednisolone acetate is combined with Orciprenaline.
Dobutamine The risk or severity of hypokalemia can be increased when Prednisolone acetate is combined with Dobutamine.
Ritodrine The risk or severity of hypokalemia can be increased when Prednisolone acetate is combined with Ritodrine.
Bitolterol The risk or severity of hypokalemia can be increased when Prednisolone acetate is combined with Bitolterol.
Salmeterol The risk or severity of hypokalemia can be increased when Prednisolone acetate is combined with Salmeterol.
Formoterol The risk or severity of hypokalemia can be increased when Prednisolone acetate is combined with Formoterol.
Albuterol The risk or severity of hypokalemia can be increased when Prednisolone acetate is combined with Salbutamol.
Isoprenaline The therapeutic efficacy of Isoprenaline can be decreased when used in combination with Prednisolone acetate.
Arbutamine The risk or severity of hypokalemia can be increased when Prednisolone acetate is combined with Arbutamine.
Arformoterol The risk or severity of hypokalemia can be increased when Prednisolone acetate is combined with Arformoterol.
Fenoterol The risk or severity of hypokalemia can be increased when Prednisolone acetate is combined with Fenoterol.
Pirbuterol The risk or severity of hypokalemia can be increased when Prednisolone acetate is combined with Pirbuterol.
Ephedra sinica root The risk or severity of hypokalemia can be increased when Prednisolone acetate is combined with Ephedra sinica root.
Procaterol The risk or severity of hypokalemia can be increased when Prednisolone acetate is combined with Procaterol.
Clenbuterol The risk or severity of hypokalemia can be increased when Prednisolone acetate is combined with Clenbuterol.
Celiprolol The risk or severity of hypokalemia can be increased when Prednisolone acetate is combined with Celiprolol.
Indacaterol The risk or severity of hypokalemia can be increased when Prednisolone acetate is combined with Indacaterol.
Droxidopa The risk or severity of hypokalemia can be increased when Prednisolone acetate is combined with Droxidopa.
Protokylol The risk or severity of hypokalemia can be increased when Prednisolone acetate is combined with Protokylol.
Hexoprenaline The risk or severity of hypokalemia can be increased when Prednisolone acetate is combined with Hexoprenaline.
Olodaterol The risk or severity of hypokalemia can be increased when Prednisolone acetate is combined with Olodaterol.
Vilanterol The risk or severity of hypokalemia can be increased when Prednisolone acetate is combined with Vilanterol.
Doxofylline The risk or severity of hypokalemia can be increased when Prednisolone acetate is combined with Doxofylline.
Racepinephrine The risk or severity of hypokalemia can be increased when Prednisolone acetate is combined with Racepinephrine.
Etafedrine The risk or severity of hypokalemia can be increased when Prednisolone acetate is combined with Etafedrine.
PF-00610355 The risk or severity of hypokalemia can be increased when Prednisolone acetate is combined with PF-00610355.
Abediterol The risk or severity of hypokalemia can be increased when Prednisolone acetate is combined with Abediterol.
Batefenterol The risk or severity of hypokalemia can be increased when Prednisolone acetate is combined with Batefenterol.
Levosalbutamol The risk or severity of hypokalemia can be increased when Prednisolone acetate is combined with Levosalbutamol.
Mitotane The serum concentration of Prednisolone acetate can be decreased when it is combined with Mitotane.
Dicoumarol Prednisolone acetate may increase the anticoagulant activities of Dicoumarol.
Phenindione Prednisolone acetate may increase the anticoagulant activities of Phenindione.
Warfarin Prednisolone acetate may increase the anticoagulant activities of Warfarin.
Phenprocoumon Prednisolone acetate may increase the anticoagulant activities of Phenprocoumon.
Acenocoumarol Prednisolone acetate may increase the anticoagulant activities of Acenocoumarol.
4-hydroxycoumarin Prednisolone acetate may increase the anticoagulant activities of 4-hydroxycoumarin.
Coumarin Prednisolone acetate may increase the anticoagulant activities of Coumarin.
(R)-warfarin Prednisolone acetate may increase the anticoagulant activities of (R)-warfarin.
Ethyl biscoumacetate Prednisolone acetate may increase the anticoagulant activities of Ethyl biscoumacetate.
Fluindione Prednisolone acetate may increase the anticoagulant activities of Fluindione.
Clorindione Prednisolone acetate may increase the anticoagulant activities of Clorindione.
Diphenadione Prednisolone acetate may increase the anticoagulant activities of Diphenadione.
Tioclomarol Prednisolone acetate may increase the anticoagulant activities of Tioclomarol.
(S)-Warfarin Prednisolone acetate may increase the anticoagulant activities of (S)-Warfarin.
Ifosfamide The metabolism of Ifosfamide can be increased when combined with Prednisolone acetate.
Perampanel The metabolism of Perampanel can be increased when combined with Prednisolone acetate.
R,S-Warfarin alcohol The metabolism of R,S-Warfarin alcohol can be increased when combined with Prednisolone acetate.
S,R-Warfarin alcohol The metabolism of S,R-Warfarin alcohol can be increased when combined with Prednisolone acetate.
Nicorandil The risk or severity of ulceration can be increased when Prednisolone acetate is combined with Nicorandil.
Calcitriol The therapeutic efficacy of Calcitriol can be decreased when used in combination with Prednisolone acetate.
Calcifediol The therapeutic efficacy of Calcifediol can be decreased when used in combination with Prednisolone acetate.
Ergocalciferol The therapeutic efficacy of Ergocalciferol can be decreased when used in combination with Prednisolone acetate.
Cholecalciferol The therapeutic efficacy of Cholecalciferol can be decreased when used in combination with Prednisolone acetate.
Paricalcitol The therapeutic efficacy of Paricalcitol can be decreased when used in combination with Prednisolone acetate.
Dihydrotachysterol The therapeutic efficacy of Dihydrotachysterol can be decreased when used in combination with Prednisolone acetate.
Alfacalcidol The therapeutic efficacy of Alfacalcidol can be decreased when used in combination with Prednisolone acetate.
Seocalcitol The therapeutic efficacy of Seocalcitol can be decreased when used in combination with Prednisolone acetate.
Inecalcitol The therapeutic efficacy of Inecalcitol can be decreased when used in combination with Prednisolone acetate.
Becocalcidiol The therapeutic efficacy of Becocalcidiol can be decreased when used in combination with Prednisolone acetate.
Eldecalcitol The therapeutic efficacy of Eldecalcitol can be decreased when used in combination with Prednisolone acetate.
1alpha,24S-Dihydroxyvitamin D2 The therapeutic efficacy of 1alpha,24S-Dihydroxyvitamin D2 can be decreased when used in combination with Prednisolone acetate.
Elocalcitol The therapeutic efficacy of Elocalcitol can be decreased when used in combination with Prednisolone acetate.
Maxacalcitol The therapeutic efficacy of Maxacalcitol can be decreased when used in combination with Prednisolone acetate.
Doxercalciferol The therapeutic efficacy of Doxercalciferol can be decreased when used in combination with Prednisolone acetate.
Vitamin D The therapeutic efficacy of Vitamin D can be decreased when used in combination with Prednisolone acetate.
1alpha-Hydroxyvitamin D5 The therapeutic efficacy of 1alpha-Hydroxyvitamin D5 can be decreased when used in combination with Prednisolone acetate.
Previtamin D(3) The therapeutic efficacy of Previtamin D(3) can be decreased when used in combination with Prednisolone acetate.
Mifepristone The serum concentration of Prednisolone acetate can be increased when it is combined with Mifepristone.
Diethylstilbestrol The serum concentration of Prednisolone acetate can be increased when it is combined with Diethylstilbestrol.
Etonogestrel The serum concentration of Prednisolone acetate can be increased when it is combined with Etonogestrel.
Desogestrel The serum concentration of Prednisolone acetate can be increased when it is combined with Desogestrel.
Megestrol acetate The serum concentration of Prednisolone acetate can be increased when it is combined with Megestrol acetate.
Levonorgestrel The serum concentration of Prednisolone acetate can be increased when it is combined with Levonorgestrel.
Progesterone The serum concentration of Prednisolone acetate can be increased when it is combined with Progesterone.
Medroxyprogesterone acetate The serum concentration of Prednisolone acetate can be increased when it is combined with Medroxyprogesterone acetate.
Norethisterone The serum concentration of Prednisolone acetate can be increased when it is combined with Norethisterone.
Estradiol The serum concentration of Prednisolone acetate can be increased when it is combined with Estradiol.
Ethynodiol diacetate The serum concentration of Prednisolone acetate can be increased when it is combined with Ethynodiol diacetate.
Norgestimate The serum concentration of Prednisolone acetate can be increased when it is combined with Norgestimate.
Ethinylestradiol The serum concentration of Prednisolone acetate can be increased when it is combined with Ethinylestradiol.
Mestranol The serum concentration of Prednisolone acetate can be increased when it is combined with Mestranol.
Drospirenone The serum concentration of Prednisolone acetate can be increased when it is combined with Drospirenone.
Estrone sulfate The serum concentration of Prednisolone acetate can be increased when it is combined with Estrone sulfate.
Octylphenoxy polyethoxyethanol The serum concentration of Prednisolone acetate can be increased when it is combined with Octylphenoxy polyethoxyethanol.
Cyproterone acetate The serum concentration of Prednisolone acetate can be increased when it is combined with Cyproterone acetate.
Trestolone The serum concentration of Prednisolone acetate can be increased when it is combined with Trestolone.
Norelgestromin The serum concentration of Prednisolone acetate can be increased when it is combined with Norelgestromin.

Target Protein

Glucocorticoid receptor NR3C1

Referensi & Sumber

Artikel (PubMed)
  • PMID: 1874907
    Musson DG, Bidgood AM, Olejnik O: Assay methodology for prednisolone, prednisolone acetate and prednisolone sodium phosphate in rabbit aqueous humor and ocular physiological solutions. J Chromatogr. 1991 Apr 19;565(1-2):89-102. doi: 10.1016/0378-4347(91)80373-k.
  • PMID: 25800201
    Matabosch X, Pozo OJ, Perez-Mana C, Papaseit E, Segura J, Ventura R: Detection and characterization of prednisolone metabolites in human urine by LC-MS/MS. J Mass Spectrom. 2015 Mar;50(3):633-42. doi: 10.1002/jms.3571.
  • PMID: 8788152
    Doppenschmitt SA, Scheidel B, Harrison F, Surmann JP: Simultaneous determination of prednisolone, prednisolone acetate and hydrocortisone in human serum by high-performance liquid chromatography. J Chromatogr B Biomed Appl. 1995 Dec 15;674(2):237-46. doi: 10.1016/0378-4347(95)00317-7.
  • PMID: 30285357
    Yasir M, Sonthalia S: Corticosteroid Adverse Effects .

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