Mexazolam

DB15489

small molecule experimental

Deskripsi

Mexazolam (CS-386) is a benzodiazepine indicated for the treatment of anxiety with or without psychoneurotic conditions.^A184910 Mexazolam's structure is similar to that of other benzodiazepines such as oxazolam and cloxazolam.^A184910 The use of benzodiazepines in the treatment of anxiety is generally a second line measure.^A184910

Struktur Molekul 2D

Berat 363.238

Wujud -

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) Mexazolam follows a 2 compartment model with a first half life of 1.4h and a second half life of 76h.[A184910]

Volume Distribusi -

Klirens (Clearance) -

Absorpsi

The active metabolite chloronordiazepam has a T_max of 1-2h.^A184910

Metabolisme

Mexazolam is rapidly metabolized to the active metabolites chloronordiazepam and chloroxazepam.^A184910

Rute Eliminasi

Mexazolam is mainly eliminated in the bile and feces, with <10% eliminated as metabolites in the urine.^A184910 >50% of a dose of mexazolam is eliminated as the metabolite chloroxazepam.^A184910

Interaksi Obat

2 Data

Yohimbine	The therapeutic efficacy of Mexazolam can be increased when used in combination with Yohimbine.
Naphazoline	The risk or severity of CNS depression can be increased when Naphazoline is combined with Mexazolam.

Target Protein

GABA(A) Receptor Benzodiazepine Binding Site GABRA1

GABA(A) Receptor GABRA1

Referensi & Sumber

Artikel (PubMed)

PMID: 26000220
Fernandes H, Moreira R: Mexazolam: clinical efficacy and tolerability in the treatment of anxiety. Neurol Ther. 2014 Mar 29;3(1):1-14. doi: 10.1007/s40120-014-0016-7. eCollection 2014 Jun.

Link

INVIMA Product Information: SEDOXIL (mexazolam) oral tablet

Contoh Produk & Brand

Produk: 0 • International brands: 1

International Brands

Melex

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.