Echinacoside

DB15488

small molecule experimental

Deskripsi

Echinacoside is a phenylethanoid glycoside isolated from Echinacea angustifolia in 1950, and currently being investigated for the treatment of Parkinson's, Alzheimer's, atherosclerosis, osteoporosis, acute colitis, wound treatment, and hepatitis.^A184577 Echinacoside has demonstrated inhibition of apoptosis in neural cell lines, demonstrating potential for use in the treatment of neurological conditions.^A184592

Struktur Molekul 2D

Berat 786.733

Wujud solid

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) -

Volume Distribusi -

Klirens (Clearance) -

Absorpsi

Animal studies suggest an oral bioavailability of 0.83%.^A184577

Metabolisme

The metabolism of echinacoside has been investigated in rats and is thought to involve catechol O-methyltransferase as well as unspecified UDP-gluc- uronosyltransferases and sulfotransferases.^A184595 A study of echinacoside's metabolism by human intestinal flora identified 13 metabolites which are produced independantly of human metabolism.^A184598

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

6 Data

Tolcapone	The metabolism of Echinacoside can be decreased when combined with Tolcapone.
Entacapone	The metabolism of Echinacoside can be decreased when combined with Entacapone.
Testosterone propionate	The metabolism of Echinacoside can be decreased when combined with Testosterone propionate.
3,5-Dinitrocatechol	The metabolism of Echinacoside can be decreased when combined with 3,5-Dinitrocatechol.
Quercetin	The metabolism of Echinacoside can be decreased when combined with Quercetin.
Opicapone	The metabolism of Echinacoside can be decreased when combined with Opicapone.

Target Protein

Growth hormone secretagogue receptor type 1 GHSR

Androgen receptor AR

Referensi & Sumber

Artikel (PubMed)

PMID: 29783690
Liu J, Yang L, Dong Y, Zhang B, Ma X: Echinacoside, an Inestimable Natural Product in Treatment of Neurological and other Disorders. Molecules. 2018 May 18;23(5). pii: molecules23051213. doi: 10.3390/molecules23051213.
PMID: 15556132
Deng M, Zhao JY, Tu PF, Jiang Y, Li ZB, Wang YH: Echinacoside rescues the SHSY5Y neuronal cells from TNFalpha-induced apoptosis. Eur J Pharmacol. 2004 Nov 28;505(1-3):11-8. doi: 10.1016/j.ejphar.2004.09.059.
PMID: 19022941
Jia C, Shi H, Jin W, Zhang K, Jiang Y, Zhao M, Tu P: Metabolism of echinacoside, a good antioxidant, in rats: isolation and identification of its biliary metabolites. Drug Metab Dispos. 2009 Feb;37(2):431-8. doi: 10.1124/dmd.108.023697. Epub 2008 Nov 20.
PMID: 26186273
Li Y, Zhou G, Xing S, Tu P, Li X: Identification of Echinacoside Metabolites Produced by Human Intestinal Bacteria Using Ultraperformance Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry. J Agric Food Chem. 2015 Aug 5;63(30):6764-71. doi: 10.1021/acs.jafc.5b02881. Epub 2015 Jul 24.
PMID: 23591053
Zhou J, Zeng P, Sun JB, Wang FQ, Zhang Q: Application of two-phase hollow fiber liquid phase microextraction coupled with high-performance liquid chromatography for the study of the echinacoside pharmacokinetics in Parkinson's disease rat plasma. J Pharm Biomed Anal. 2013 Jul-Aug;81-82:27-33. doi: 10.1016/j.jpba.2013.03.020. Epub 2013 Apr 3.

Contoh Produk & Brand

Produk: 0 • International brands: 0

Belum ada data produk/brand untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field produk/brand.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.