Peringatan Keamanan

Patients experiencing an acute overdose of somapacitan may present with fluid retention.L15661 Chronic overdose may resemble gigantism or acromegaly.L15661 Treat patients with symptomatic and supportive measures to minimize the permanent effects.A219141

Somapacitan

DB15093

biotech approved investigational

Deskripsi

Somapacitan, also known as NNC0195-0092,A219136 is a growth hormone analog indicated to treat adults with growth hormone deficiency.A219126,L15661 This human growth hormone analog differs by the creation of an albumin binding site, and prolonging the effect so that it requires weekly dosing rather than daily.A219146

Somapacitan was granted FDA approval on 28 August 2020.L15666

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) The elimination half life of somapacitan is 2-3 days.[L15661]
Volume Distribusi The approximate volume of distribution of somapacitan is 14.6 L.[L15661]
Klirens (Clearance) The apparent maximum rate of saturable elimination is estimated to be 0.268 ± 0.03 mg/h.[A219126]

Absorpsi

A 0.02mg/kg single dose of somapacitan reaches a Cmax of 14.4 ng/mL, with a Tmax of 11.1 hours, and an AUC of 475 ng\*h/mL.A219136 A 0.04mg/kg single dose of somapacitan reaches a Cmax of 19.8 ng/mL, with a Tmax of 25.6 hours, and an AUC of 777 ng\*h/mL.A219136 A 0.08mg/kg single dose of somapacitan reaches a Cmax of 64.2 ng/mL, with a Tmax of 16.6 hours, and an AUC of 2753 ng\*h/mL.A219136 A 0.12mg/kg single dose of somapacitan reaches a Cmax of 142.5 ng/mL, with a Tmax of 22.5 hours, and an AUC of 6382 ng\*h/mL.A219136

Metabolisme

Studies in humans and rats show that somapacitan is metabolized through cleavage of the albumin-binding moiety and linker sidechain before further non-specific mechanisms.A219096,L15661

Rute Eliminasi

Somapacitan is approximately 81% eliminated in the urine and 13% in the feces.L15661

Interaksi Obat

407 Data
Cilostazol The serum concentration of Cilostazol can be increased when it is combined with Somapacitan.
Cortisone acetate The serum concentration of the active metabolites of Cortisone acetate can be reduced when Cortisone acetate is used in combination with Somapacitan resulting in a loss in efficacy.
Amitriptyline The metabolism of Amitriptyline can be decreased when combined with Somapacitan.
Zolpidem The metabolism of Zolpidem can be decreased when combined with Somapacitan.
Fluoxetine The metabolism of Fluoxetine can be decreased when combined with Somapacitan.
Albendazole The metabolism of Albendazole can be decreased when combined with Somapacitan.
Verapamil The metabolism of Verapamil can be increased when combined with Somapacitan.
Paroxetine The metabolism of Paroxetine can be decreased when combined with Somapacitan.
Clopidogrel The metabolism of Clopidogrel can be decreased when combined with Somapacitan.
Ramelteon The metabolism of Ramelteon can be decreased when combined with Somapacitan.
Praziquantel The metabolism of Praziquantel can be decreased when combined with Somapacitan.
Doxepin The metabolism of Doxepin can be decreased when combined with Somapacitan.
(R)-warfarin The metabolism of (R)-warfarin can be decreased when combined with Somapacitan.
Stiripentol The metabolism of Stiripentol can be decreased when combined with Somapacitan.
Methylene blue The metabolism of Methylene blue can be decreased when combined with Somapacitan.
Selumetinib The metabolism of Selumetinib can be decreased when combined with Somapacitan.
Triclabendazole The metabolism of Triclabendazole can be decreased when combined with Somapacitan.
Benzocaine The metabolism of Benzocaine can be decreased when combined with Somapacitan.
Ticlopidine The metabolism of Ticlopidine can be decreased when combined with Somapacitan.
Pantoprazole The metabolism of Pantoprazole can be decreased when combined with Somapacitan.
Pentobarbital The metabolism of Pentobarbital can be decreased when combined with Somapacitan.
Valproic acid The metabolism of Valproic acid can be decreased when combined with Somapacitan.
Methadone The metabolism of Methadone can be decreased when combined with Somapacitan.
Omeprazole The metabolism of Omeprazole can be decreased when combined with Somapacitan.
Trimethadione The metabolism of Trimethadione can be decreased when combined with Somapacitan.
Clobazam The metabolism of Clobazam can be decreased when combined with Somapacitan.
Timolol The metabolism of Timolol can be decreased when combined with Somapacitan.
Carisoprodol The metabolism of Carisoprodol can be decreased when combined with Somapacitan.
Progesterone The metabolism of Progesterone can be decreased when combined with Somapacitan.
Lansoprazole The metabolism of Lansoprazole can be decreased when combined with Somapacitan.
Voriconazole The metabolism of Voriconazole can be decreased when combined with Somapacitan.
Doxazosin The metabolism of Doxazosin can be decreased when combined with Somapacitan.
Labetalol The metabolism of Labetalol can be decreased when combined with Somapacitan.
Testosterone The metabolism of Testosterone can be decreased when combined with Somapacitan.
Nilutamide The metabolism of Nilutamide can be decreased when combined with Somapacitan.
Thioridazine The metabolism of Thioridazine can be decreased when combined with Somapacitan.
Esomeprazole The metabolism of Esomeprazole can be decreased when combined with Somapacitan.
Primidone The metabolism of Primidone can be decreased when combined with Somapacitan.
Diazepam The metabolism of Diazepam can be decreased when combined with Somapacitan.
Methylphenobarbital The metabolism of Methylphenobarbital can be decreased when combined with Somapacitan.
Zonisamide The metabolism of Zonisamide can be decreased when combined with Somapacitan.
Formoterol The metabolism of Formoterol can be decreased when combined with Somapacitan.
Sertraline The metabolism of Sertraline can be decreased when combined with Somapacitan.
Rabeprazole The metabolism of Rabeprazole can be decreased when combined with Somapacitan.
Proguanil The metabolism of Proguanil can be decreased when combined with Somapacitan.
Moclobemide The metabolism of Moclobemide can be decreased when combined with Somapacitan.
Escitalopram The metabolism of Escitalopram can be decreased when combined with Somapacitan.
Lapatinib The metabolism of Lapatinib can be decreased when combined with Somapacitan.
St. John's Wort The metabolism of St. John's Wort can be decreased when combined with Somapacitan.
Hexobarbital The metabolism of Hexobarbital can be decreased when combined with Somapacitan.
Barbital The metabolism of Barbital can be decreased when combined with Somapacitan.
Nebivolol The metabolism of Nebivolol can be decreased when combined with Somapacitan.
Methsuximide The metabolism of Methsuximide can be decreased when combined with Somapacitan.
Dexlansoprazole The metabolism of Dexlansoprazole can be decreased when combined with Somapacitan.
Cenobamate The metabolism of Cenobamate can be decreased when combined with Somapacitan.
Lacosamide The metabolism of Lacosamide can be decreased when combined with Somapacitan.
Etravirine The metabolism of Etravirine can be decreased when combined with Somapacitan.
Apixaban The metabolism of Apixaban can be decreased when combined with Somapacitan.
Vilazodone The metabolism of Vilazodone can be decreased when combined with Somapacitan.
Artemether The metabolism of Artemether can be decreased when combined with Somapacitan.
Seratrodast The metabolism of Seratrodast can be decreased when combined with Somapacitan.
Rilpivirine The metabolism of Rilpivirine can be decreased when combined with Somapacitan.
Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Somapacitan.
Etizolam The metabolism of Etizolam can be decreased when combined with Somapacitan.
Esketamine The metabolism of Esketamine can be decreased when combined with Somapacitan.
Lynestrenol The metabolism of Lynestrenol can be decreased when combined with Somapacitan.
Fedratinib The metabolism of Fedratinib can be decreased when combined with Somapacitan.
Dexrabeprazole The metabolism of Dexrabeprazole can be decreased when combined with Somapacitan.
(S)-Warfarin The metabolism of (S)-Warfarin can be decreased when combined with Somapacitan.
Voxelotor The metabolism of Voxelotor can be decreased when combined with Somapacitan.
Imipramine The metabolism of Imipramine can be decreased when combined with Somapacitan.
Tamoxifen The metabolism of Tamoxifen can be decreased when combined with Somapacitan.
Clomipramine The metabolism of Clomipramine can be decreased when combined with Somapacitan.
Acenocoumarol The metabolism of Acenocoumarol can be decreased when combined with Somapacitan.
Axitinib The metabolism of Axitinib can be decreased when combined with Somapacitan.
Phenytoin The metabolism of Phenytoin can be decreased when combined with Somapacitan.
Teniposide The metabolism of Teniposide can be decreased when combined with Somapacitan.
Cyclophosphamide The metabolism of Cyclophosphamide can be decreased when combined with Somapacitan.
Thiopental The metabolism of Thiopental can be decreased when combined with Somapacitan.
Phenobarbital The metabolism of Phenobarbital can be decreased when combined with Somapacitan.
Fosphenytoin The metabolism of Fosphenytoin can be decreased when combined with Somapacitan.
Trimipramine The metabolism of Trimipramine can be decreased when combined with Somapacitan.
Trabectedin The metabolism of Trabectedin can be decreased when combined with Somapacitan.
Fluvoxamine The metabolism of Fluvoxamine can be increased when combined with Somapacitan.
Bortezomib The metabolism of Bortezomib can be increased when combined with Somapacitan.
Betaxolol The metabolism of Betaxolol can be increased when combined with Somapacitan.
Caffeine The metabolism of Caffeine can be increased when combined with Somapacitan.
Carmustine The metabolism of Carmustine can be increased when combined with Somapacitan.
Lidocaine The metabolism of Lidocaine can be increased when combined with Somapacitan.
Ropivacaine The metabolism of Ropivacaine can be increased when combined with Somapacitan.
Penciclovir The metabolism of Penciclovir can be increased when combined with Somapacitan.
Zolmitriptan The metabolism of Zolmitriptan can be increased when combined with Somapacitan.
Acetaminophen The metabolism of Acetaminophen can be increased when combined with Somapacitan.
Olanzapine The metabolism of Olanzapine can be increased when combined with Somapacitan.
Chlorzoxazone The metabolism of Chlorzoxazone can be increased when combined with Somapacitan.
Clozapine The serum concentration of Clozapine can be decreased when it is combined with Somapacitan.
Grepafloxacin The metabolism of Grepafloxacin can be increased when combined with Somapacitan.
Mirtazapine The metabolism of Mirtazapine can be increased when combined with Somapacitan.
Mexiletine The metabolism of Mexiletine can be increased when combined with Somapacitan.
Tacrine The metabolism of Tacrine can be increased when combined with Somapacitan.

Target Protein

Growth hormone receptor GHR

Referensi & Sumber

Artikel (PubMed)
  • PMID: 32053994
    Petersen M, Gandhi PS, Buchardt J, Alanentalo T, Fels JJ, Johansen NL, Helding-Kvist P, Vad K, Thygesen P: Tissue Distribution and Receptor Activation by Somapacitan, a Long Acting Growth Hormone Derivative. Int J Mol Sci. 2020 Feb 11;21(4). pii: ijms21041181. doi: 10.3390/ijms21041181.
  • PMID: 29671202
    Juul RV, Rasmussen MH, Agerso H, Overgaard RV: Pharmacokinetics and Pharmacodynamics of Once-Weekly Somapacitan in Children and Adults: Supporting Dosing Rationales with a Model-Based Analysis of Three Phase I Trials. Clin Pharmacokinet. 2019 Jan;58(1):63-75. doi: 10.1007/s40262-018-0662-5.
  • PMID: 26727076
    Rasmussen MH, Janukonyte J, Klose M, Marina D, Tanvig M, Nielsen LF, Hoybye C, Andersen M, Feldt-Rasmussen U, Christiansen JS: Reversible Albumin-Binding GH Possesses a Potential Once-Weekly Treatment Profile in Adult Growth Hormone Deficiency. J Clin Endocrinol Metab. 2016 Mar;101(3):988-98. doi: 10.1210/jc.2015-1991. Epub 2016 Jan 4.
  • PMID: 23359786
    Adelman DT, Liebert KJ, Nachtigall LB, Lamerson M, Bakker B: Acromegaly: the disease, its impact on patients, and managing the burden of long-term treatment. Int J Gen Med. 2013;6:31-8. doi: 10.2147/IJGM.S38594. Epub 2013 Jan 18.
  • PMID: 25013997
    Rasmussen MH, Olsen MW, Alifrangis L, Klim S, Suntum M: A reversible albumin-binding growth hormone derivative is well tolerated and possesses a potential once-weekly treatment profile. J Clin Endocrinol Metab. 2014 Oct;99(10):E1819-29. doi: 10.1210/jc.2014-1702. Epub 2014 Jul 11.

Contoh Produk & Brand

Produk: 12 • International brands: 1
Produk
  • Sogroya
    Injection, solution • 10 mg/1.5ml • Subcutaneous • EU • Approved
  • Sogroya
    Injection, solution • 10 mg/1.5ml • Subcutaneous • EU • Approved
  • Sogroya
    Solution • 5 mg / 1.5 mL • Subcutaneous • Canada • Approved
  • Sogroya
    Solution • 10 mg / 1.5 mL • Subcutaneous • Canada • Approved
  • Sogroya
    Injection, solution • 15 mg/1.5ml • Subcutaneous • EU • Approved
  • Sogroya
    Solution • 15 mg / 1.5 mL • Subcutaneous • Canada • Approved
  • Sogroya
    Injection, solution • 15 mg/1.5ml • Subcutaneous • EU • Approved
  • Sogroya
    Injection, solution • 10 mg/1mL • Subcutaneous • US • Approved
Menampilkan 8 dari 12 produk.
International Brands
  • Sogroya — Novo Nordisk

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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