Peringatan Keamanan

Data regarding the toxicity of brolucizumab is not readily available.L9089

Brolucizumab

DB14864

biotech approved investigational

Deskripsi

Brolucizumab, also known as RTH258 or ESBA1008,A187211 is a monoclonal antibody indicated to treat neovascular age related macular degeneration.L9089

Brolucizumab was granted FDA approval in October 2019.L9089

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) The systemic half life of bolucizumab is 4.4±2.0 days.[L9089] The elimination half life is 108h for a 3mg dose and 103h for a 6mg dose.[L9104]
Volume Distribusi Data regarding the volume of distribution is not readily available.[L9089]
Klirens (Clearance) Data regarding the clearance of brolucizumab is not readily available.[L9089]

Absorpsi

A 3mg dose of brolucizumab reaches a Cmax of 20.7ng/mL with a Tmax of 20.3h and an AUC of 2480ng\*h/mL.L9104 A 6mg dose of brolucizumab reaches a Cmax of 77.6ng/mL with a Tmax of 17.4h and an AUC of 9169ng\*h/mL.L9104

Metabolisme

Monoclonal antibodies are expected to undergo proteolysis to smaller peptides and amino acids.A31470

Rute Eliminasi

Data regarding the route of elimination is not readily available.L9089 Monoclonal antibodies are generally not eliminated in the urine, and only a small amount is excreted in bile.A40006

Interaksi Obat

382 Data
Diethylstilbestrol Diethylstilbestrol may increase the thrombogenic activities of Brolucizumab.
Chlorotrianisene Chlorotrianisene may increase the thrombogenic activities of Brolucizumab.
Conjugated estrogens Conjugated estrogens may increase the thrombogenic activities of Brolucizumab.
Estrone Estrone may increase the thrombogenic activities of Brolucizumab.
Estradiol Estradiol may increase the thrombogenic activities of Brolucizumab.
Dienestrol Dienestrol may increase the thrombogenic activities of Brolucizumab.
Ethinylestradiol Ethinylestradiol may increase the thrombogenic activities of Brolucizumab.
Mestranol Mestranol may increase the thrombogenic activities of Brolucizumab.
Estriol Estriol may increase the thrombogenic activities of Brolucizumab.
Estrone sulfate Estrone sulfate may increase the thrombogenic activities of Brolucizumab.
Quinestrol Quinestrol may increase the thrombogenic activities of Brolucizumab.
Hexestrol Hexestrol may increase the thrombogenic activities of Brolucizumab.
Tibolone Tibolone may increase the thrombogenic activities of Brolucizumab.
Synthetic Conjugated Estrogens, A Synthetic Conjugated Estrogens, A may increase the thrombogenic activities of Brolucizumab.
Synthetic Conjugated Estrogens, B Synthetic Conjugated Estrogens, B may increase the thrombogenic activities of Brolucizumab.
Polyestradiol phosphate Polyestradiol phosphate may increase the thrombogenic activities of Brolucizumab.
Esterified estrogens Esterified estrogens may increase the thrombogenic activities of Brolucizumab.
Zeranol Zeranol may increase the thrombogenic activities of Brolucizumab.
Equol Equol may increase the thrombogenic activities of Brolucizumab.
Promestriene Promestriene may increase the thrombogenic activities of Brolucizumab.
Methallenestril Methallenestril may increase the thrombogenic activities of Brolucizumab.
Epimestrol Epimestrol may increase the thrombogenic activities of Brolucizumab.
Moxestrol Moxestrol may increase the thrombogenic activities of Brolucizumab.
Estradiol acetate Estradiol acetate may increase the thrombogenic activities of Brolucizumab.
Estradiol benzoate Estradiol benzoate may increase the thrombogenic activities of Brolucizumab.
Estradiol cypionate Estradiol cypionate may increase the thrombogenic activities of Brolucizumab.
Estradiol valerate Estradiol valerate may increase the thrombogenic activities of Brolucizumab.
Biochanin A Biochanin A may increase the thrombogenic activities of Brolucizumab.
Formononetin Formononetin may increase the thrombogenic activities of Brolucizumab.
Estetrol Estetrol may increase the thrombogenic activities of Brolucizumab.
Pamidronic acid The risk or severity of jaw osteonecrosis and anti-angiogenesis can be increased when Brolucizumab is combined with Pamidronic acid.
Zoledronic acid The risk or severity of jaw osteonecrosis and anti-angiogenesis can be increased when Brolucizumab is combined with Zoledronic acid.
Alendronic acid The risk or severity of jaw osteonecrosis and anti-angiogenesis can be increased when Brolucizumab is combined with Alendronic acid.
Ibandronate The risk or severity of jaw osteonecrosis and anti-angiogenesis can be increased when Brolucizumab is combined with Ibandronate.
Clodronic acid The risk or severity of jaw osteonecrosis and anti-angiogenesis can be increased when Brolucizumab is combined with Clodronic acid.
Risedronic acid The risk or severity of jaw osteonecrosis and anti-angiogenesis can be increased when Brolucizumab is combined with Risedronic acid.
Etidronic acid The risk or severity of jaw osteonecrosis and anti-angiogenesis can be increased when Brolucizumab is combined with Etidronic acid.
Tiludronic acid The risk or severity of jaw osteonecrosis and anti-angiogenesis can be increased when Brolucizumab is combined with Tiludronic acid.
Incadronic acid The risk or severity of jaw osteonecrosis and anti-angiogenesis can be increased when Brolucizumab is combined with Incadronic acid.
Cetuximab The risk or severity of adverse effects can be increased when Cetuximab is combined with Brolucizumab.
Human immunoglobulin G The risk or severity of adverse effects can be increased when Human immunoglobulin G is combined with Brolucizumab.
Omalizumab The risk or severity of adverse effects can be increased when Omalizumab is combined with Brolucizumab.
Adalimumab The risk or severity of adverse effects can be increased when Adalimumab is combined with Brolucizumab.
Abciximab The risk or severity of adverse effects can be increased when Abciximab is combined with Brolucizumab.
Gemtuzumab ozogamicin The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Brolucizumab.
Indium In-111 satumomab pendetide The risk or severity of adverse effects can be increased when Indium In-111 satumomab pendetide is combined with Brolucizumab.
Infliximab The risk or severity of adverse effects can be increased when Infliximab is combined with Brolucizumab.
Trastuzumab The risk or severity of adverse effects can be increased when Trastuzumab is combined with Brolucizumab.
Rituximab The risk or severity of adverse effects can be increased when Rituximab is combined with Brolucizumab.
Basiliximab The risk or severity of adverse effects can be increased when Basiliximab is combined with Brolucizumab.
Muromonab The risk or severity of adverse effects can be increased when Muromonab is combined with Brolucizumab.
Digoxin Immune Fab (Ovine) The risk or severity of adverse effects can be increased when Digoxin Immune Fab (Ovine) is combined with Brolucizumab.
Ibritumomab tiuxetan The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Brolucizumab.
Tositumomab The risk or severity of adverse effects can be increased when Tositumomab is combined with Brolucizumab.
Alemtuzumab The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Brolucizumab.
Capromab pendetide The risk or severity of adverse effects can be increased when Capromab pendetide is combined with Brolucizumab.
Efalizumab The risk or severity of adverse effects can be increased when Efalizumab is combined with Brolucizumab.
Antithymocyte immunoglobulin (rabbit) The risk or severity of adverse effects can be increased when Antithymocyte immunoglobulin (rabbit) is combined with Brolucizumab.
Natalizumab The risk or severity of adverse effects can be increased when Natalizumab is combined with Brolucizumab.
Palivizumab The risk or severity of adverse effects can be increased when Palivizumab is combined with Brolucizumab.
Daclizumab The risk or severity of adverse effects can be increased when Daclizumab is combined with Brolucizumab.
Bevacizumab The risk or severity of adverse effects can be increased when Bevacizumab is combined with Brolucizumab.
Technetium Tc-99m arcitumomab The risk or severity of adverse effects can be increased when Technetium Tc-99m arcitumomab is combined with Brolucizumab.
Eculizumab The risk or severity of adverse effects can be increased when Eculizumab is combined with Brolucizumab.
Panitumumab The risk or severity of adverse effects can be increased when Panitumumab is combined with Brolucizumab.
Ranibizumab The risk or severity of adverse effects can be increased when Ranibizumab is combined with Brolucizumab.
Galiximab The risk or severity of adverse effects can be increased when Galiximab is combined with Brolucizumab.
Pexelizumab The risk or severity of adverse effects can be increased when Pexelizumab is combined with Brolucizumab.
Afelimomab The risk or severity of adverse effects can be increased when Afelimomab is combined with Brolucizumab.
Epratuzumab The risk or severity of adverse effects can be increased when Epratuzumab is combined with Brolucizumab.
Bectumomab The risk or severity of adverse effects can be increased when Bectumomab is combined with Brolucizumab.
Oregovomab The risk or severity of adverse effects can be increased when Oregovomab is combined with Brolucizumab.
IGN311 The risk or severity of adverse effects can be increased when IGN311 is combined with Brolucizumab.
Adecatumumab The risk or severity of adverse effects can be increased when Adecatumumab is combined with Brolucizumab.
Labetuzumab The risk or severity of adverse effects can be increased when Labetuzumab is combined with Brolucizumab.
Matuzumab The risk or severity of adverse effects can be increased when Matuzumab is combined with Brolucizumab.
Fontolizumab The risk or severity of adverse effects can be increased when Fontolizumab is combined with Brolucizumab.
Bavituximab The risk or severity of adverse effects can be increased when Bavituximab is combined with Brolucizumab.
CR002 The risk or severity of adverse effects can be increased when CR002 is combined with Brolucizumab.
Rozrolimupab The risk or severity of adverse effects can be increased when Rozrolimupab is combined with Brolucizumab.
Girentuximab The risk or severity of adverse effects can be increased when Girentuximab is combined with Brolucizumab.
Obiltoxaximab The risk or severity of adverse effects can be increased when Obiltoxaximab is combined with Brolucizumab.
XTL-001 The risk or severity of adverse effects can be increased when XTL-001 is combined with Brolucizumab.
NAV 1800 The risk or severity of adverse effects can be increased when NAV 1800 is combined with Brolucizumab.
Briakinumab The risk or severity of adverse effects can be increased when Briakinumab is combined with Brolucizumab.
Otelixizumab The risk or severity of adverse effects can be increased when Otelixizumab is combined with Brolucizumab.
AMG 108 The risk or severity of adverse effects can be increased when AMG 108 is combined with Brolucizumab.
Iratumumab The risk or severity of adverse effects can be increased when Iratumumab is combined with Brolucizumab.
Enokizumab The risk or severity of adverse effects can be increased when Enokizumab is combined with Brolucizumab.
Ramucirumab The risk or severity of adverse effects can be increased when Ramucirumab is combined with Brolucizumab.
Farletuzumab The risk or severity of adverse effects can be increased when Farletuzumab is combined with Brolucizumab.
Veltuzumab The risk or severity of adverse effects can be increased when Veltuzumab is combined with Brolucizumab.
Ustekinumab The risk or severity of adverse effects can be increased when Ustekinumab is combined with Brolucizumab.
Trastuzumab emtansine The risk or severity of adverse effects can be increased when Trastuzumab emtansine is combined with Brolucizumab.
PRO-542 The risk or severity of adverse effects can be increased when PRO-542 is combined with Brolucizumab.
TNX-901 The risk or severity of adverse effects can be increased when TNX-901 is combined with Brolucizumab.
Inotuzumab ozogamicin The risk or severity of adverse effects can be increased when Inotuzumab ozogamicin is combined with Brolucizumab.
RI 624 The risk or severity of adverse effects can be increased when RI 624 is combined with Brolucizumab.
Stamulumab The risk or severity of adverse effects can be increased when MYO-029 is combined with Brolucizumab.
CT-011 The risk or severity of adverse effects can be increased when CT-011 is combined with Brolucizumab.

Target Protein

Vascular endothelial growth factor A, long form VEGFA

Referensi & Sumber

Artikel (PubMed)
  • PMID: 23257829
    Perrot-Applanat M: VEGF isoforms. Cell Adh Migr. 2012 Nov-Dec;6(6):526-7. doi: 10.4161/cam.23256. Epub 2012 Nov 1.
  • PMID: 16478695
    Tabrizi MA, Tseng CM, Roskos LK: Elimination mechanisms of therapeutic monoclonal antibodies. Drug Discov Today. 2006 Jan;11(1-2):81-8. doi: 10.1016/S1359-6446(05)03638-X.
  • PMID: 28551167
    Dugel PU, Jaffe GJ, Sallstig P, Warburton J, Weichselberger A, Wieland M, Singerman L: Brolucizumab Versus Aflibercept in Participants with Neovascular Age-Related Macular Degeneration: A Randomized Trial. Ophthalmology. 2017 Sep;124(9):1296-1304. doi: 10.1016/j.ophtha.2017.03.057. Epub 2017 May 24.
  • PMID: 31413539
    Yannuzzi NA, Freund KB: Brolucizumab: evidence to date in the treatment of neovascular age-related macular degeneration. Clin Ophthalmol. 2019 Jul 24;13:1323-1329. doi: 10.2147/OPTH.S184706. eCollection 2019.
  • PMID: 28653357
    Ryman JT, Meibohm B: Pharmacokinetics of Monoclonal Antibodies. CPT Pharmacometrics Syst Pharmacol. 2017 Sep;6(9):576-588. doi: 10.1002/psp4.12224. Epub 2017 Jul 29.

Contoh Produk & Brand

Produk: 5 • International brands: 0
Produk
  • Beovu
    Solution • 6 mg / 0.05 mL • Intravitreal • Canada • Approved
  • Beovu
    Solution • 6 mg / 0.05 mL • Intravitreal • Canada • Approved
  • Beovu
    Injection, solution • 6 mg/0.05mL • Intravitreal • US • Approved
  • Beovu
    Injection, solution • 120 mg/ml • Intravitreal • EU • Approved
  • Beovu
    Injection, solution • 120 mg/ml • Intravitreal • EU • Approved

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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