Peringatan Keamanan

In an acute oral toxicity study in mouse, LD50 was >2000 mg/kg MSDS. Single oral doses of curcumin at 1-5 g/kg bw induced no toxic effects in rats L34044. There has been no cases of overdose reported L34044.

Curcumin sulfate

DB14635

small molecule experimental

Deskripsi

Struktur Molekul 2D

Berat 448.44
Wujud -

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) No pharmacokinetic data available.
Volume Distribusi Following oral administration of radio-labelled curcumin to rats, radioactivity was detected in the liver and kidneys [L34044].
Klirens (Clearance) No pharmacokinetic data available.

Absorpsi

Curcumin displays poor absorption into the gastrointestinal tract. In a rat study, oral administration of a single dose of 2 g of curcumin resulted in a plasma concentration of less than 5 ?g/mL, indicating poor absorption from the gut L34044.

Metabolisme

Initially, curcumin undergoes rapid intestinal metabolism to form curcumin glucuronide and curcumin sulfate via O-conjugation. Other metabolites formed include tetrahydrocurcumin, hexahydrocurcumin, and hexahydrocurcuminol via reduction L34044. Curcumin may also undergo intensive second metabolism in the liver where the major metabolites were glucuronides of tetrahydrocurcumin and hexahydrocurcumin, with dihydroferulic acid and traces of ferulic acid as further metabolites L34044. Hepatic metabolites are expected to be excreted in the bile L34044. Certain curcumin metabolites, such as tetrahydrocurcumin, retain anti-inflammatory and antioxidant properties L34044.

Rute Eliminasi

Following oral administration of curcumin to rats at a dose of 1 g/kg bw, about 75% of dose was excreted in the faeces and only traces of the compound was detected in the urine L34044. When a single 400 mg dose of curcumin was administered orally to rats, about 60% was absorbed and 40% was excreted unchanged in the faeces over an period of 5 days L34044. Intraperitoneal administration resulted in fecal excretion of 73% and biliary excretion of 11% L34044.

Interaksi Obat

631 Data
Cilostazol The serum concentration of Cilostazol can be increased when it is combined with Curcumin sulfate.
Zolmitriptan The metabolism of Zolmitriptan can be decreased when combined with Curcumin sulfate.
Atomoxetine The metabolism of Atomoxetine can be decreased when combined with Curcumin sulfate.
Bupropion The serum concentration of Bupropion can be increased when it is combined with Curcumin sulfate.
Aripiprazole The metabolism of Aripiprazole can be decreased when combined with Curcumin sulfate.
Aripiprazole lauroxil The metabolism of Aripiprazole lauroxil can be decreased when combined with Curcumin sulfate.
Azithromycin The metabolism of Azithromycin can be decreased when combined with Curcumin sulfate.
Ziprasidone The metabolism of Ziprasidone can be decreased when combined with Curcumin sulfate.
Chlorpromazine The metabolism of Chlorpromazine can be decreased when combined with Curcumin sulfate.
Albendazole The metabolism of Albendazole can be decreased when combined with Curcumin sulfate.
Cephalexin The metabolism of Cephalexin can be decreased when combined with Curcumin sulfate.
Doxazosin The metabolism of Doxazosin can be decreased when combined with Curcumin sulfate.
Norethisterone The metabolism of Norethisterone can be decreased when combined with Curcumin sulfate.
Fenofibrate The metabolism of Fenofibrate can be decreased when combined with Curcumin sulfate.
Atazanavir The metabolism of Atazanavir can be decreased when combined with Curcumin sulfate.
Rosuvastatin The metabolism of Rosuvastatin can be decreased when combined with Curcumin sulfate.
Drospirenone The metabolism of Drospirenone can be decreased when combined with Curcumin sulfate.
Allylestrenol The metabolism of Allylestrenol can be decreased when combined with Curcumin sulfate.
Zuclopenthixol The metabolism of Zuclopenthixol can be decreased when combined with Curcumin sulfate.
Roflumilast The serum concentration of Roflumilast can be increased when it is combined with Curcumin sulfate.
Lacosamide The metabolism of Lacosamide can be decreased when combined with Curcumin sulfate.
Linagliptin The metabolism of Linagliptin can be decreased when combined with Curcumin sulfate.
Vorapaxar The metabolism of Vorapaxar can be decreased when combined with Curcumin sulfate.
Suvorexant The metabolism of Suvorexant can be decreased when combined with Curcumin sulfate.
Netupitant The metabolism of Netupitant can be decreased when combined with Curcumin sulfate.
Tasimelteon The metabolism of Tasimelteon can be decreased when combined with Curcumin sulfate.
Nintedanib The metabolism of Nintedanib can be decreased when combined with Curcumin sulfate.
Tenofovir alafenamide The metabolism of Tenofovir alafenamide can be decreased when combined with Curcumin sulfate.
Dihydroergocornine The metabolism of Dihydroergocornine can be decreased when combined with Curcumin sulfate.
Duvelisib The metabolism of Duvelisib can be decreased when combined with Curcumin sulfate.
Gilteritinib The metabolism of Gilteritinib can be decreased when combined with Curcumin sulfate.
9-aminocamptothecin The metabolism of 9-aminocamptothecin can be decreased when combined with Curcumin sulfate.
Methylprednisone The metabolism of Methylprednisone can be decreased when combined with Curcumin sulfate.
Dihydroergocristine The metabolism of Dihydroergocristine can be decreased when combined with Curcumin sulfate.
Dihydroergocryptine The metabolism of Dihydroergocryptine can be decreased when combined with Curcumin sulfate.
Medical Cannabis The metabolism of Medical Cannabis can be decreased when combined with Curcumin sulfate.
Elexacaftor The metabolism of Elexacaftor can be decreased when combined with Curcumin sulfate.
Tazemetostat The metabolism of Tazemetostat can be decreased when combined with Curcumin sulfate.
Fosaprepitant The metabolism of Fosaprepitant can be decreased when combined with Curcumin sulfate.
Lefamulin The metabolism of Lefamulin can be decreased when combined with Curcumin sulfate.
Methysergide The metabolism of Methysergide can be decreased when combined with Curcumin sulfate.
Meperidine The metabolism of Meperidine can be decreased when combined with Curcumin sulfate.
Ebastine The metabolism of Ebastine can be decreased when combined with Curcumin sulfate.
Terfenadine The metabolism of Terfenadine can be decreased when combined with Curcumin sulfate.
Cisapride The metabolism of Cisapride can be decreased when combined with Curcumin sulfate.
Isavuconazole The metabolism of Isavuconazole can be decreased when combined with Curcumin sulfate.
Pretomanid The metabolism of Pretomanid can be decreased when combined with Curcumin sulfate.
Pimavanserin The metabolism of Pimavanserin can be decreased when combined with Curcumin sulfate.
Estetrol The metabolism of Estetrol can be decreased when combined with Curcumin sulfate.
Infigratinib The metabolism of Infigratinib can be decreased when combined with Curcumin sulfate.
Cyclosporine The serum concentration of Cyclosporine can be increased when it is combined with Curcumin sulfate.
Dofetilide The serum concentration of Dofetilide can be increased when it is combined with Curcumin sulfate.
Theophylline The serum concentration of Theophylline can be increased when it is combined with Curcumin sulfate.
Carbamazepine The serum concentration of Carbamazepine can be increased when it is combined with Curcumin sulfate.
Warfarin The serum concentration of Warfarin can be increased when it is combined with Curcumin sulfate.
Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Curcumin sulfate.
Sirolimus The serum concentration of Sirolimus can be increased when it is combined with Curcumin sulfate.
Quinidine The serum concentration of Quinidine can be increased when it is combined with Curcumin sulfate.
Phenprocoumon The serum concentration of Phenprocoumon can be increased when it is combined with Curcumin sulfate.
Busulfan The serum concentration of Busulfan can be increased when it is combined with Curcumin sulfate.
Pimozide The serum concentration of Pimozide can be increased when it is combined with Curcumin sulfate.
Amiodarone The serum concentration of Amiodarone can be increased when it is combined with Curcumin sulfate.
Aminophylline The serum concentration of Aminophylline can be increased when it is combined with Curcumin sulfate.
Paclitaxel The serum concentration of Paclitaxel can be increased when it is combined with Curcumin sulfate.
Dasatinib The serum concentration of Dasatinib can be increased when it is combined with Curcumin sulfate.
Fosphenytoin The serum concentration of Fosphenytoin can be increased when it is combined with Curcumin sulfate.
Digitoxin The serum concentration of Digitoxin can be increased when it is combined with Curcumin sulfate.
Acenocoumarol The serum concentration of Acenocoumarol can be increased when it is combined with Curcumin sulfate.
Everolimus The serum concentration of Everolimus can be increased when it is combined with Curcumin sulfate.
Dronedarone The serum concentration of Dronedarone can be increased when it is combined with Curcumin sulfate.
Cobimetinib The serum concentration of Cobimetinib can be increased when it is combined with Curcumin sulfate.
Temsirolimus The serum concentration of Temsirolimus can be increased when it is combined with Curcumin sulfate.
Idelalisib The serum concentration of Idelalisib can be increased when it is combined with Curcumin sulfate.
Ceritinib The serum concentration of Ceritinib can be increased when it is combined with Curcumin sulfate.
Tianeptine The serum concentration of Tianeptine can be increased when it is combined with Curcumin sulfate.
Osimertinib The serum concentration of Osimertinib can be increased when it is combined with Curcumin sulfate.
Ribociclib The serum concentration of Ribociclib can be increased when it is combined with Curcumin sulfate.
Dacomitinib The serum concentration of Dacomitinib can be increased when it is combined with Curcumin sulfate.
Alpelisib The serum concentration of Alpelisib can be increased when it is combined with Curcumin sulfate.
Sorafenib The serum concentration of Sorafenib can be increased when it is combined with Curcumin sulfate.
Teniposide The serum concentration of Teniposide can be increased when it is combined with Curcumin sulfate.
Erlotinib The serum concentration of Erlotinib can be increased when it is combined with Curcumin sulfate.
Cyclophosphamide The serum concentration of Cyclophosphamide can be increased when it is combined with Curcumin sulfate.
Vincristine The serum concentration of Vincristine can be increased when it is combined with Curcumin sulfate.
Tamoxifen The serum concentration of Tamoxifen can be increased when it is combined with Curcumin sulfate.
Irinotecan The serum concentration of Irinotecan can be increased when it is combined with Curcumin sulfate.
Etoposide The serum concentration of Etoposide can be increased when it is combined with Curcumin sulfate.
Ifosfamide The serum concentration of Ifosfamide can be increased when it is combined with Curcumin sulfate.
Docetaxel The serum concentration of Docetaxel can be increased when it is combined with Curcumin sulfate.
Sunitinib The serum concentration of Sunitinib can be increased when it is combined with Curcumin sulfate.
Trastuzumab emtansine The serum concentration of Trastuzumab emtansine can be increased when it is combined with Curcumin sulfate.
Romidepsin The serum concentration of Romidepsin can be increased when it is combined with Curcumin sulfate.
Axitinib The serum concentration of Axitinib can be increased when it is combined with Curcumin sulfate.
Cabazitaxel The serum concentration of Cabazitaxel can be increased when it is combined with Curcumin sulfate.
Crizotinib The serum concentration of Crizotinib can be increased when it is combined with Curcumin sulfate.
Ponatinib The serum concentration of Ponatinib can be increased when it is combined with Curcumin sulfate.
Olaparib The serum concentration of Olaparib can be increased when it is combined with Curcumin sulfate.
Copanlisib The serum concentration of Copanlisib can be increased when it is combined with Curcumin sulfate.
Bortezomib The serum concentration of Bortezomib can be increased when it is combined with Curcumin sulfate.
Trabectedin The serum concentration of Trabectedin can be increased when it is combined with Curcumin sulfate.

Target Protein

Peroxisome proliferator-activated receptor gamma PPARG
Vitamin D3 receptor VDR
ATP-binding cassette sub-family C member 5 ABCC5
Carbonyl reductase [NADPH] 1 CBR1
Glutathione S-transferase P GSTP1

Referensi & Sumber

Artikel (PubMed)
  • PMID: 23143785
    Gupta SC, Patchva S, Aggarwal BB: Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS J. 2013 Jan;15(1):195-218. doi: 10.1208/s12248-012-9432-8. Epub 2012 Nov 10.

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