Peringatan Keamanan

Data regarding acute overdose is not readily available.L9437 However, patients experiencing chronic overdose may present with mental symptoms, moon face, abnormal fat deposits, and fluid retention.L9437 Acute oral overdose may be treated with immediate gastric lavage or emesis followed by symptomatic and supportive treatment.L9437 Chronic overdosage can be managed by temporary dose reduction or alternate day treatment.L9437

Prednisolone phosphate

DB14631

small molecule approved vet_approved

Deskripsi

Prednisolone phosphate is a glucocorticoid similar to cortisol used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects.A187463

Prednisolone phosphate was granted FDA Approval on 19 December 1973.L14144

Struktur Molekul 2D

Berat 440.429
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) The half life of prednisolone is 2-4 hours.[L9437]
Volume Distribusi The volume of distribution of prednisolone phosphate has been reported as 0.22-0.7L/kg.[L9440]
Klirens (Clearance) -

Absorpsi

A 30mg prednisolone oral solution reaches a Cmax of 461.33±77.94ng/mL with an AUC of 2426.1±360.0ng\*h/mL.L9440 A 30mg prednisolone orally disintegrating tablet reaches a Cmax of 420.91±78.28ng/mL with an AUC of 2408.1±361.5ng\*h/mL.L9440

Metabolisme

Prednisolone phosphate undergoes ester hydrolysis to prednisolone.A187421 After this step, the drug undergoes the normal metabolism of prednisolone.

Rute Eliminasi

Prednisolone is predominantly eliminated in the urine as sulfate and glucuronide conjugate metabolites.L9437

Interaksi Makanan

1 Data
  • 1. Take with food. Food reduces GI irritation.

Interaksi Obat

1117 Data
Ranolazine The serum concentration of Prednisolone phosphate can be increased when it is combined with Ranolazine.
Ceritinib The risk or severity of hyperglycemia can be increased when Prednisolone phosphate is combined with Ceritinib.
Aldesleukin The therapeutic efficacy of Aldesleukin can be decreased when used in combination with Prednisolone phosphate.
Corticorelin ovine triflutate The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Prednisolone phosphate.
Deferasirox The risk or severity of gastrointestinal ulceration and gastrointestinal irritation can be increased when Prednisolone phosphate is combined with Deferasirox.
Afatinib The serum concentration of Afatinib can be decreased when it is combined with Prednisolone phosphate.
Brentuximab vedotin The serum concentration of Brentuximab vedotin can be decreased when it is combined with Prednisolone phosphate.
Dabigatran etexilate The serum concentration of Dabigatran etexilate can be decreased when it is combined with Prednisolone phosphate.
Linagliptin The serum concentration of Linagliptin can be decreased when it is combined with Prednisolone phosphate.
Paliperidone The serum concentration of Paliperidone can be decreased when it is combined with Prednisolone phosphate.
Sofosbuvir The serum concentration of Sofosbuvir can be decreased when it is combined with Prednisolone phosphate.
Amphotericin B The risk or severity of hypokalemia can be increased when Prednisolone phosphate is combined with Amphotericin B.
Isoetharine The risk or severity of hypokalemia can be increased when Prednisolone phosphate is combined with Isoetharine.
Norepinephrine The risk or severity of hypokalemia can be increased when Prednisolone phosphate is combined with Norepinephrine.
Phenylpropanolamine The risk or severity of hypokalemia can be increased when Prednisolone phosphate is combined with Phenylpropanolamine.
Epinephrine The risk or severity of hypokalemia can be increased when Prednisolone phosphate is combined with Epinephrine.
Orciprenaline The risk or severity of hypokalemia can be increased when Prednisolone phosphate is combined with Orciprenaline.
Dobutamine The risk or severity of hypokalemia can be increased when Prednisolone phosphate is combined with Dobutamine.
Ritodrine The risk or severity of hypokalemia can be increased when Prednisolone phosphate is combined with Ritodrine.
Bitolterol The risk or severity of hypokalemia can be increased when Prednisolone phosphate is combined with Bitolterol.
Salmeterol The risk or severity of hypokalemia can be increased when Prednisolone phosphate is combined with Salmeterol.
Formoterol The risk or severity of hypokalemia can be increased when Prednisolone phosphate is combined with Formoterol.
Albuterol The risk or severity of hypokalemia can be increased when Prednisolone phosphate is combined with Salbutamol.
Isoprenaline The therapeutic efficacy of Isoprenaline can be decreased when used in combination with Prednisolone phosphate.
Arbutamine The risk or severity of hypokalemia can be increased when Prednisolone phosphate is combined with Arbutamine.
Arformoterol The risk or severity of hypokalemia can be increased when Prednisolone phosphate is combined with Arformoterol.
Fenoterol The risk or severity of hypokalemia can be increased when Prednisolone phosphate is combined with Fenoterol.
Pirbuterol The risk or severity of hypokalemia can be increased when Prednisolone phosphate is combined with Pirbuterol.
Ephedra sinica root The risk or severity of hypokalemia can be increased when Prednisolone phosphate is combined with Ephedra sinica root.
Procaterol The risk or severity of hypokalemia can be increased when Prednisolone phosphate is combined with Procaterol.
Clenbuterol The risk or severity of hypokalemia can be increased when Prednisolone phosphate is combined with Clenbuterol.
Celiprolol The risk or severity of hypokalemia can be increased when Prednisolone phosphate is combined with Celiprolol.
Indacaterol The risk or severity of hypokalemia can be increased when Prednisolone phosphate is combined with Indacaterol.
Droxidopa The risk or severity of hypokalemia can be increased when Prednisolone phosphate is combined with Droxidopa.
Protokylol The risk or severity of hypokalemia can be increased when Prednisolone phosphate is combined with Protokylol.
Hexoprenaline The risk or severity of hypokalemia can be increased when Prednisolone phosphate is combined with Hexoprenaline.
Olodaterol The risk or severity of hypokalemia can be increased when Prednisolone phosphate is combined with Olodaterol.
Vilanterol The risk or severity of hypokalemia can be increased when Prednisolone phosphate is combined with Vilanterol.
Doxofylline The risk or severity of hypokalemia can be increased when Prednisolone phosphate is combined with Doxofylline.
Racepinephrine The risk or severity of hypokalemia can be increased when Prednisolone phosphate is combined with Racepinephrine.
Etafedrine The risk or severity of hypokalemia can be increased when Prednisolone phosphate is combined with Etafedrine.
PF-00610355 The risk or severity of hypokalemia can be increased when Prednisolone phosphate is combined with PF-00610355.
Abediterol The risk or severity of hypokalemia can be increased when Prednisolone phosphate is combined with Abediterol.
Batefenterol The risk or severity of hypokalemia can be increased when Prednisolone phosphate is combined with Batefenterol.
Levosalbutamol The risk or severity of hypokalemia can be increased when Prednisolone phosphate is combined with Levosalbutamol.
Mifepristone The therapeutic efficacy of Prednisolone phosphate can be decreased when used in combination with Mifepristone.
Mitotane The serum concentration of Prednisolone phosphate can be decreased when it is combined with Mitotane.
Dicoumarol Prednisolone phosphate may increase the anticoagulant activities of Dicoumarol.
Phenindione Prednisolone phosphate may increase the anticoagulant activities of Phenindione.
Warfarin Prednisolone phosphate may increase the anticoagulant activities of Warfarin.
Phenprocoumon Prednisolone phosphate may increase the anticoagulant activities of Phenprocoumon.
Acenocoumarol Prednisolone phosphate may increase the anticoagulant activities of Acenocoumarol.
4-hydroxycoumarin Prednisolone phosphate may increase the anticoagulant activities of 4-hydroxycoumarin.
Coumarin Prednisolone phosphate may increase the anticoagulant activities of Coumarin.
(R)-warfarin Prednisolone phosphate may increase the anticoagulant activities of (R)-warfarin.
Ethyl biscoumacetate Prednisolone phosphate may increase the anticoagulant activities of Ethyl biscoumacetate.
Fluindione Prednisolone phosphate may increase the anticoagulant activities of Fluindione.
Clorindione Prednisolone phosphate may increase the anticoagulant activities of Clorindione.
Diphenadione Prednisolone phosphate may increase the anticoagulant activities of Diphenadione.
Tioclomarol Prednisolone phosphate may increase the anticoagulant activities of Tioclomarol.
(S)-Warfarin Prednisolone phosphate may increase the anticoagulant activities of (S)-Warfarin.
Aspartame The excretion of Prednisolone phosphate can be decreased when combined with Aspartame.
Pravastatin The excretion of Prednisolone phosphate can be decreased when combined with Pravastatin.
Pantoprazole The excretion of Prednisolone phosphate can be decreased when combined with Pantoprazole.
Cefotiam The excretion of Prednisolone phosphate can be decreased when combined with Cefotiam.
Conjugated estrogens The excretion of Prednisolone phosphate can be decreased when combined with Conjugated estrogens.
Valproic acid The excretion of Prednisolone phosphate can be decreased when combined with Valproic acid.
Aminohippuric acid The excretion of Prednisolone phosphate can be decreased when combined with Aminohippuric acid.
Lansoprazole The excretion of Prednisolone phosphate can be decreased when combined with Lansoprazole.
Cefalotin The excretion of Prednisolone phosphate can be decreased when combined with Cefalotin.
Cefotaxime The excretion of Prednisolone phosphate can be decreased when combined with Cefotaxime.
Zidovudine The excretion of Prednisolone phosphate can be decreased when combined with Zidovudine.
Cimetidine The excretion of Prednisolone phosphate can be decreased when combined with Cimetidine.
Guanidine The excretion of Prednisolone phosphate can be decreased when combined with Guanidine.
Enalapril The excretion of Prednisolone phosphate can be decreased when combined with Enalapril.
Oxytetracycline The excretion of Prednisolone phosphate can be decreased when combined with Oxytetracycline.
Leucovorin The excretion of Prednisolone phosphate can be decreased when combined with Leucovorin.
Esomeprazole The excretion of Prednisolone phosphate can be decreased when combined with Esomeprazole.
Tetracycline The excretion of Prednisolone phosphate can be decreased when combined with Tetracycline.
Acyclovir The excretion of Prednisolone phosphate can be decreased when combined with Acyclovir.
Cefaclor The excretion of Prednisolone phosphate can be decreased when combined with Cefaclor.
Dinoprostone The excretion of Prednisolone phosphate can be decreased when combined with Dinoprostone.
Famotidine The excretion of Prednisolone phosphate can be decreased when combined with Famotidine.
Ganciclovir The excretion of Prednisolone phosphate can be decreased when combined with Ganciclovir.
Minocycline The excretion of Prednisolone phosphate can be decreased when combined with Minocycline.
Probenecid The excretion of Prednisolone phosphate can be decreased when combined with Probenecid.
Mercaptopurine The excretion of Prednisolone phosphate can be decreased when combined with Mercaptopurine.
Novobiocin The excretion of Prednisolone phosphate can be decreased when combined with Novobiocin.
Benzylpenicillin The excretion of Prednisolone phosphate can be decreased when combined with Benzylpenicillin.
Melatonin The excretion of Prednisolone phosphate can be decreased when combined with Melatonin.
Ouabain The excretion of Prednisolone phosphate can be decreased when combined with Ouabain.
Cefadroxil The excretion of Prednisolone phosphate can be decreased when combined with Cefadroxil.
Ceftriaxone The excretion of Prednisolone phosphate can be decreased when combined with Ceftriaxone.
Gemfibrozil The excretion of Prednisolone phosphate can be decreased when combined with Gemfibrozil.
Cefamandole The excretion of Prednisolone phosphate can be decreased when combined with Cefamandole.
Cefazolin The excretion of Prednisolone phosphate can be decreased when combined with Cefazolin.
Cefoperazone The excretion of Prednisolone phosphate can be decreased when combined with Cefoperazone.
Ceftizoxime The excretion of Prednisolone phosphate can be decreased when combined with Ceftizoxime.
Cefacetrile The excretion of Prednisolone phosphate can be decreased when combined with Cefacetrile.
Ceftibuten The excretion of Prednisolone phosphate can be decreased when combined with Ceftibuten.

Target Protein

Glucocorticoid receptor NR3C1
Annexin A1 ANXA1

Referensi & Sumber

Artikel (PubMed)
  • PMID: 1874907
    Musson DG, Bidgood AM, Olejnik O: Assay methodology for prednisolone, prednisolone acetate and prednisolone sodium phosphate in rabbit aqueous humor and ocular physiological solutions. J Chromatogr. 1991 Apr 19;565(1-2):89-102. doi: 10.1016/0378-4347(91)80373-k.
  • PMID: 30285357
    Yasir M, Sonthalia S: Corticosteroid Adverse Effects .
  • PMID: 15634032
    Czock D, Keller F, Rasche FM, Haussler U: Pharmacokinetics and pharmacodynamics of systemically administered glucocorticoids. Clin Pharmacokinet. 2005;44(1):61-98. doi: 10.2165/00003088-200544010-00003.
  • PMID: 23300763
    Gardill BR, Vogl MR, Lin HY, Hammond GL, Muller YA: Corticosteroid-binding globulin: structure-function implications from species differences. PLoS One. 2012;7(12):e52759. doi: 10.1371/journal.pone.0052759. Epub 2012 Dec 26.
  • PMID: 378499
    Pickup ME: Clinical pharmacokinetics of prednisone and prednisolone. Clin Pharmacokinet. 1979 Mar-Apr;4(2):111-28. doi: 10.2165/00003088-197904020-00004.

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