Edetate calcium disodium anhydrous

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) The half life of edetate calcium disodium is 20-60 minutes.[L12774]

Volume Distribusi The volume of distribution of edetate calcium disodium is 0.19±0.10L/kg.[A204122]

Klirens (Clearance) The mean clearance of edetate in 1 month olds is 54.6mL/min/1.73m<sup>2</sup>.[A204275] 2-17 year olds have a mean clearance of 113.9±24.4mL/min/1.73m<sup>2</sup>.[A204275]

Absorpsi

Calcium edetate disodium's C_max and AUC are dependant on renal function.^A204125 5% of an oral dose is absorbed from the gastrointestinal tract.^A204275

Metabolisme

Edetate calcium disodium is almost completely unmetabolized in vivo.A204275,L12774

Rute Eliminasi

Edetate calcium disodium is 95% eliminated in the urine within 24 hours.A204122,L12774 An oral dose in rats was 88.32% recovered in the feces and 10.30% recovered in the urine.^A204275

Interaksi Obat

1 Data

Technetium Tc-99m oxidronate

Edetate calcium disodium anhydrous may decrease effectiveness of Technetium Tc-99m oxidronate as a diagnostic agent.

Target Protein

Lead

Iron

Manganese cation

Referensi & Sumber

Artikel (PubMed)

PMID: 4961749
Hammond PB, Aronson AL, Olson WC: The mechanism of mobilization of lead by ethylenediaminetetraacetate. J Pharmacol Exp Ther. 1967 Jul;157(1):196-206.
PMID: 3121845
Cory-Slechta DA, Weiss B, Cox C: Mobilization and redistribution of lead over the course of calcium disodium ethylenediamine tetraacetate chelation therapy. J Pharmacol Exp Ther. 1987 Dec;243(3):804-13.
PMID: 19852620
Bradberry S, Vale A: A comparison of sodium calcium edetate (edetate calcium disodium) and succimer (DMSA) in the treatment of inorganic lead poisoning. Clin Toxicol (Phila). 2009 Nov;47(9):841-58. doi: 10.3109/15563650903321064.
PMID: 3096624
Osterloh J, Becker CE: Pharmacokinetics of CaNa2EDTA and chelation of lead in renal failure. Clin Pharmacol Ther. 1986 Dec;40(6):686-93. doi: 10.1038/clpt.1986.245.
PMID: 29889577
Sakthithasan K, Levy P, Poupon J, Garnier R: A comparative study of edetate calcium disodium and dimercaptosuccinic acid in the treatment of lead poisoning in adults. Clin Toxicol (Phila). 2018 Nov;56(11):1143-1149. doi: 10.1080/15563650.2018.1478424. Epub 2018 Jun 11.
PMID: 12396676
Lanigan RS, Yamarik TA: Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tripotassium EDTA, trisodium EDTA, HEDTA, and trisodium HEDTA. Int J Toxicol. 2002;21 Suppl 2:95-142. doi: 10.1080/10915810290096522.

Link

FDA Approved Drug Products: Edetate Calcium Disodium Intravenous or Intramuscular Injection

Contoh Produk & Brand

Produk: 8 • International brands: 0

Produk

Calcium Disodium Versenate

Injection • 200 mg/1mL • Intramuscular • US • Approved
Calcium Disodium Versenate

Injection • 200 mg/1mL • Intramuscular • US • Approved
Calcium Disodium Versenate

Injection • 200 mg/1mL • Intramuscular • US • Approved
Calcium Disodium Versenate

Injection • 200 mg/1mL • Intramuscular; Intravenous • US • Approved
Calcium Disodium Versenate Liq 200mg/ml

Liquid • 200 mg / mL • Intramuscular; Intravenous; Subcutaneous • Canada • Approved
Calcium Edetate de Sodium

Solution • 50 mg/1mL • Intravenous • US
Edetate Calcium Disodium

Injection • 200 mg/1mL • Intramuscular; Intravenous • US • Generic • Approved
Edetate Calcium Disodium

Injection • 200 mg/1mL • Intramuscular; Intravenous • US • Generic • Approved

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.

Peringatan Keamanan