Peringatan Keamanan

Side effects include inhibition of bone formation, suppression of calcium absorption and delayed wound healing

Hydrocortisone phosphate

DB14542

small molecule approved vet_approved

Deskripsi

Struktur Molekul 2D

Berat 442.445
Wujud -

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 6-8 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin increase percutaneous absorption.

Metabolisme

Primarily hepatic via CYP3A4

Rute Eliminasi

Corticosteroids are metabolized primarily in the liver and are then excreted by the kidneys. Some of the topical corticosteroids and their metabolites are also excreted into the bile.

Interaksi Obat

332 Data
Pitolisant The serum concentration of Hydrocortisone phosphate can be decreased when it is combined with Pitolisant.
Metreleptin The metabolism of Hydrocortisone phosphate can be increased when combined with Metreleptin.
Cimetidine The metabolism of Hydrocortisone phosphate can be decreased when combined with Cimetidine.
Ciprofloxacin The metabolism of Hydrocortisone phosphate can be decreased when combined with Ciprofloxacin.
Verapamil The metabolism of Hydrocortisone phosphate can be decreased when combined with Verapamil.
Isavuconazole The metabolism of Hydrocortisone phosphate can be decreased when combined with Isavuconazole.
Erythromycin The serum concentration of Hydrocortisone phosphate can be increased when it is combined with Erythromycin.
Troglitazone The metabolism of Hydrocortisone phosphate can be decreased when combined with Troglitazone.
Chloramphenicol The metabolism of Hydrocortisone phosphate can be decreased when combined with Chloramphenicol.
Fluticasone propionate The metabolism of Hydrocortisone phosphate can be decreased when combined with Fluticasone propionate.
Imatinib The metabolism of Hydrocortisone phosphate can be decreased when combined with Imatinib.
Aprepitant The metabolism of Hydrocortisone phosphate can be decreased when combined with Aprepitant.
Clofazimine The metabolism of Hydrocortisone phosphate can be decreased when combined with Clofazimine.
Mibefradil The metabolism of Hydrocortisone phosphate can be decreased when combined with Mibefradil.
Gestodene The metabolism of Hydrocortisone phosphate can be decreased when combined with Gestodene.
Seproxetine The metabolism of Hydrocortisone phosphate can be decreased when combined with Seproxetine.
Fluticasone furoate The metabolism of Hydrocortisone phosphate can be decreased when combined with Fluticasone furoate.
Methylene blue The metabolism of Hydrocortisone phosphate can be decreased when combined with Methylene blue.
Letermovir The metabolism of Hydrocortisone phosphate can be decreased when combined with Letermovir.
Rucaparib The metabolism of Hydrocortisone phosphate can be decreased when combined with Rucaparib.
Fluticasone The metabolism of Hydrocortisone phosphate can be decreased when combined with Fluticasone.
Medical Cannabis The metabolism of Hydrocortisone phosphate can be decreased when combined with Medical Cannabis.
Nabiximols The metabolism of Hydrocortisone phosphate can be decreased when combined with Nabiximols.
Curcumin sulfate The metabolism of Hydrocortisone phosphate can be decreased when combined with Curcumin sulfate.
Pralsetinib The metabolism of Hydrocortisone phosphate can be decreased when combined with Pralsetinib.
Levoketoconazole The metabolism of Hydrocortisone phosphate can be decreased when combined with Levoketoconazole.
Acalabrutinib The metabolism of Hydrocortisone phosphate can be decreased when combined with Acalabrutinib.
Osilodrostat The metabolism of Hydrocortisone phosphate can be decreased when combined with Osilodrostat.
Modafinil The metabolism of Hydrocortisone phosphate can be increased when combined with Modafinil.
Budesonide The metabolism of Hydrocortisone phosphate can be increased when combined with Budesonide.
Icotinib The metabolism of Hydrocortisone phosphate can be increased when combined with Icotinib.
Dexamethasone acetate The metabolism of Hydrocortisone phosphate can be increased when combined with Dexamethasone acetate.
Reserpine The metabolism of Hydrocortisone phosphate can be increased when combined with Reserpine.
Beclomethasone dipropionate The metabolism of Hydrocortisone phosphate can be increased when combined with Beclomethasone dipropionate.
Triamcinolone The metabolism of Hydrocortisone phosphate can be increased when combined with Triamcinolone.
Daunorubicin The metabolism of Hydrocortisone phosphate can be increased when combined with Daunorubicin.
Mometasone The metabolism of Hydrocortisone phosphate can be increased when combined with Mometasone.
Oxcarbazepine The metabolism of Hydrocortisone phosphate can be increased when combined with Oxcarbazepine.
Clobetasol propionate The metabolism of Hydrocortisone phosphate can be increased when combined with Clobetasol propionate.
Thalidomide The metabolism of Hydrocortisone phosphate can be increased when combined with Thalidomide.
Fluocinonide The metabolism of Hydrocortisone phosphate can be increased when combined with Fluocinonide.
Cortisone acetate The metabolism of Hydrocortisone phosphate can be increased when combined with Cortisone acetate.
Paramethasone The metabolism of Hydrocortisone phosphate can be increased when combined with Paramethasone.
Armodafinil The metabolism of Hydrocortisone phosphate can be increased when combined with Armodafinil.
Fluprednidene The metabolism of Hydrocortisone phosphate can be increased when combined with Fluprednidene.
Fluocortolone The metabolism of Hydrocortisone phosphate can be increased when combined with Fluocortolone.
Difluocortolone The metabolism of Hydrocortisone phosphate can be increased when combined with Difluocortolone.
Meprednisone The metabolism of Hydrocortisone phosphate can be increased when combined with Meprednisone.
Dexamethasone isonicotinate The metabolism of Hydrocortisone phosphate can be increased when combined with Dexamethasone isonicotinate.
Cortivazol The metabolism of Hydrocortisone phosphate can be increased when combined with Cortivazol.
Prednylidene The metabolism of Hydrocortisone phosphate can be increased when combined with Prednylidene.
Cloprednol The metabolism of Hydrocortisone phosphate can be increased when combined with Cloprednol.
Mometasone furoate The metabolism of Hydrocortisone phosphate can be increased when combined with Mometasone furoate.
Prednisolone phosphate The metabolism of Hydrocortisone phosphate can be increased when combined with Prednisolone phosphate.
Prednisolone hemisuccinate The metabolism of Hydrocortisone phosphate can be increased when combined with Prednisolone hemisuccinate.
Prednisone acetate The metabolism of Hydrocortisone phosphate can be increased when combined with Prednisone acetate.
Clocortolone acetate The metabolism of Hydrocortisone phosphate can be increased when combined with Clocortolone acetate.
Melengestrol acetate The metabolism of Hydrocortisone phosphate can be increased when combined with Melengestrol acetate.
Betamethasone phosphate The metabolism of Hydrocortisone phosphate can be increased when combined with Betamethasone phosphate.
Cortisone The metabolism of Hydrocortisone phosphate can be increased when combined with Cortisone.
Betamethasone The metabolism of Hydrocortisone phosphate can be increased when combined with Betamethasone.
Sildenafil The metabolism of Hydrocortisone phosphate can be decreased when combined with Sildenafil.
Nevirapine The metabolism of Hydrocortisone phosphate can be decreased when combined with Nevirapine.
Lidocaine The metabolism of Hydrocortisone phosphate can be decreased when combined with Lidocaine.
Gefitinib The metabolism of Hydrocortisone phosphate can be decreased when combined with Gefitinib.
Levonorgestrel The metabolism of Hydrocortisone phosphate can be decreased when combined with Levonorgestrel.
Nisoldipine The metabolism of Hydrocortisone phosphate can be decreased when combined with Nisoldipine.
Alprazolam The metabolism of Hydrocortisone phosphate can be decreased when combined with Alprazolam.
Buspirone The metabolism of Hydrocortisone phosphate can be decreased when combined with Buspirone.
Oxycodone The metabolism of Hydrocortisone phosphate can be decreased when combined with Oxycodone.
Flutamide The metabolism of Hydrocortisone phosphate can be decreased when combined with Flutamide.
Dextromethorphan The metabolism of Hydrocortisone phosphate can be decreased when combined with Dextromethorphan.
Lercanidipine The metabolism of Hydrocortisone phosphate can be decreased when combined with Lercanidipine.
Hydroxyzine The metabolism of Hydrocortisone phosphate can be decreased when combined with Hydroxyzine.
Propranolol The metabolism of Hydrocortisone phosphate can be decreased when combined with Propranolol.
Testosterone The metabolism of Hydrocortisone phosphate can be decreased when combined with Testosterone.
Trazodone The metabolism of Hydrocortisone phosphate can be decreased when combined with Trazodone.
Midazolam The metabolism of Hydrocortisone phosphate can be decreased when combined with Midazolam.
Eplerenone The metabolism of Hydrocortisone phosphate can be decreased when combined with Eplerenone.
Norethisterone The metabolism of Hydrocortisone phosphate can be decreased when combined with Norethisterone.
Nateglinide The metabolism of Hydrocortisone phosphate can be decreased when combined with Nateglinide.
Risperidone The metabolism of Hydrocortisone phosphate can be decreased when combined with Risperidone.
Pentamidine The metabolism of Hydrocortisone phosphate can be decreased when combined with Pentamidine.
Hydrocortisone The metabolism of Hydrocortisone phosphate can be decreased when combined with Hydrocortisone.
Clopidogrel The metabolism of Hydrocortisone phosphate can be decreased when combined with Clopidogrel.
Irinotecan The metabolism of Hydrocortisone phosphate can be decreased when combined with Irinotecan.
Alfentanil The metabolism of Hydrocortisone phosphate can be decreased when combined with Alfentanil.
Disulfiram The metabolism of Hydrocortisone phosphate can be decreased when combined with Disulfiram.
Diazepam The metabolism of Hydrocortisone phosphate can be decreased when combined with Diazepam.
Vardenafil The metabolism of Hydrocortisone phosphate can be decreased when combined with Vardenafil.
Triazolam The metabolism of Hydrocortisone phosphate can be decreased when combined with Triazolam.
Ondansetron The metabolism of Hydrocortisone phosphate can be decreased when combined with Ondansetron.
Zonisamide The metabolism of Hydrocortisone phosphate can be decreased when combined with Zonisamide.
Metronidazole The metabolism of Hydrocortisone phosphate can be decreased when combined with Metronidazole.
Salmeterol The metabolism of Hydrocortisone phosphate can be decreased when combined with Salmeterol.
Zaleplon The metabolism of Hydrocortisone phosphate can be decreased when combined with Zaleplon.
Glyburide The metabolism of Hydrocortisone phosphate can be decreased when combined with Glyburide.
Felodipine The metabolism of Hydrocortisone phosphate can be decreased when combined with Felodipine.
Nitrendipine The metabolism of Hydrocortisone phosphate can be decreased when combined with Nitrendipine.
Praziquantel The metabolism of Hydrocortisone phosphate can be decreased when combined with Praziquantel.

Target Protein

Annexin A1 ANXA1
Glucocorticoid receptor NR3C1
11-beta-hydroxysteroid dehydrogenase type 2 HSD11B2
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 HSD3B1

Referensi & Sumber

Artikel (PubMed)
  • PMID: 12932892
    de Weerth C, Zijl RH, Buitelaar JK: Development of cortisol circadian rhythm in infancy. Early Hum Dev. 2003 Aug;73(1-2):39-52.
  • PMID: 6461917
    Palacios R, Sugawara I: Hydrocortisone abrogates proliferation of T cells in autologous mixed lymphocyte reaction by rendering the interleukin-2 Producer T cells unresponsive to interleukin-1 and unable to synthesize the T-cell growth factor. Scand J Immunol. 1982 Jan;15(1):25-31.
  • PMID: 13233328
    KNIGHT RP Jr, KORNFELD DS, GLASER GH, BONDY PK: Effects of intravenous hydrocortisone on electrolytes of serum and urine in man. J Clin Endocrinol Metab. 1955 Feb;15(2):176-81.

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