Peringatan Keamanan

Side effects include inhibition of bone formation, suppression of calcium absorption and delayed wound healing

Hydrocortisone cypionate

DB14541

small molecule approved investigational vet_approved

Deskripsi

Struktur Molekul 2D

Berat 486.649
Wujud -

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 6-8 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin increase percutaneous absorption.

Metabolisme

Primarily hepatic via CYP3A4

Rute Eliminasi

Corticosteroids are metabolized primarily in the liver and are then excreted by the kidneys. Some of the topical corticosteroids and their metabolites are also excreted into the bile.

Interaksi Obat

834 Data
Ceritinib The risk or severity of hyperglycemia can be increased when Hydrocortisone cypionate is combined with Ceritinib.
Corticorelin ovine triflutate The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Hydrocortisone cypionate.
Deferasirox The risk or severity of gastrointestinal ulceration and gastrointestinal irritation can be increased when Hydrocortisone cypionate is combined with Deferasirox.
Amphotericin B The risk or severity of hypokalemia can be increased when Hydrocortisone cypionate is combined with Amphotericin B.
Isoetharine The risk or severity of hypokalemia can be increased when Hydrocortisone cypionate is combined with Isoetharine.
Norepinephrine The risk or severity of hypokalemia can be increased when Hydrocortisone cypionate is combined with Norepinephrine.
Phenylpropanolamine The risk or severity of hypokalemia can be increased when Hydrocortisone cypionate is combined with Phenylpropanolamine.
Epinephrine The risk or severity of hypokalemia can be increased when Hydrocortisone cypionate is combined with Epinephrine.
Orciprenaline The risk or severity of hypokalemia can be increased when Hydrocortisone cypionate is combined with Orciprenaline.
Dobutamine The risk or severity of hypokalemia can be increased when Hydrocortisone cypionate is combined with Dobutamine.
Ritodrine The risk or severity of hypokalemia can be increased when Hydrocortisone cypionate is combined with Ritodrine.
Bitolterol The risk or severity of hypokalemia can be increased when Hydrocortisone cypionate is combined with Bitolterol.
Salmeterol The risk or severity of hypokalemia can be increased when Hydrocortisone cypionate is combined with Salmeterol.
Formoterol The risk or severity of hypokalemia can be increased when Hydrocortisone cypionate is combined with Formoterol.
Albuterol The risk or severity of hypokalemia can be increased when Hydrocortisone cypionate is combined with Salbutamol.
Isoprenaline The therapeutic efficacy of Isoprenaline can be decreased when used in combination with Hydrocortisone cypionate.
Arbutamine The risk or severity of hypokalemia can be increased when Hydrocortisone cypionate is combined with Arbutamine.
Arformoterol The risk or severity of hypokalemia can be increased when Hydrocortisone cypionate is combined with Arformoterol.
Fenoterol The risk or severity of hypokalemia can be increased when Hydrocortisone cypionate is combined with Fenoterol.
Pirbuterol The risk or severity of hypokalemia can be increased when Hydrocortisone cypionate is combined with Pirbuterol.
Ephedra sinica root The risk or severity of hypokalemia can be increased when Hydrocortisone cypionate is combined with Ephedra sinica root.
Procaterol The risk or severity of hypokalemia can be increased when Hydrocortisone cypionate is combined with Procaterol.
Clenbuterol The risk or severity of hypokalemia can be increased when Hydrocortisone cypionate is combined with Clenbuterol.
Celiprolol The risk or severity of hypokalemia can be increased when Hydrocortisone cypionate is combined with Celiprolol.
Indacaterol The risk or severity of hypokalemia can be increased when Hydrocortisone cypionate is combined with Indacaterol.
Droxidopa The risk or severity of hypokalemia can be increased when Hydrocortisone cypionate is combined with Droxidopa.
Protokylol The risk or severity of hypokalemia can be increased when Hydrocortisone cypionate is combined with Protokylol.
Hexoprenaline The risk or severity of hypokalemia can be increased when Hydrocortisone cypionate is combined with Hexoprenaline.
Olodaterol The risk or severity of hypokalemia can be increased when Hydrocortisone cypionate is combined with Olodaterol.
Vilanterol The risk or severity of hypokalemia can be increased when Hydrocortisone cypionate is combined with Vilanterol.
Doxofylline The risk or severity of hypokalemia can be increased when Hydrocortisone cypionate is combined with Doxofylline.
Racepinephrine The risk or severity of hypokalemia can be increased when Hydrocortisone cypionate is combined with Racepinephrine.
Etafedrine The risk or severity of hypokalemia can be increased when Hydrocortisone cypionate is combined with Etafedrine.
PF-00610355 The risk or severity of hypokalemia can be increased when Hydrocortisone cypionate is combined with PF-00610355.
Abediterol The risk or severity of hypokalemia can be increased when Hydrocortisone cypionate is combined with Abediterol.
Batefenterol The risk or severity of hypokalemia can be increased when Hydrocortisone cypionate is combined with Batefenterol.
Levosalbutamol The risk or severity of hypokalemia can be increased when Hydrocortisone cypionate is combined with Levosalbutamol.
Mitotane The serum concentration of Hydrocortisone cypionate can be decreased when it is combined with Mitotane.
Dicoumarol Hydrocortisone cypionate may increase the anticoagulant activities of Dicoumarol.
Phenindione Hydrocortisone cypionate may increase the anticoagulant activities of Phenindione.
Warfarin Hydrocortisone cypionate may increase the anticoagulant activities of Warfarin.
Phenprocoumon Hydrocortisone cypionate may increase the anticoagulant activities of Phenprocoumon.
Acenocoumarol Hydrocortisone cypionate may increase the anticoagulant activities of Acenocoumarol.
4-hydroxycoumarin Hydrocortisone cypionate may increase the anticoagulant activities of 4-hydroxycoumarin.
Coumarin Hydrocortisone cypionate may increase the anticoagulant activities of Coumarin.
(R)-warfarin Hydrocortisone cypionate may increase the anticoagulant activities of (R)-warfarin.
Ethyl biscoumacetate Hydrocortisone cypionate may increase the anticoagulant activities of Ethyl biscoumacetate.
Fluindione Hydrocortisone cypionate may increase the anticoagulant activities of Fluindione.
Clorindione Hydrocortisone cypionate may increase the anticoagulant activities of Clorindione.
Diphenadione Hydrocortisone cypionate may increase the anticoagulant activities of Diphenadione.
Tioclomarol Hydrocortisone cypionate may increase the anticoagulant activities of Tioclomarol.
(S)-Warfarin Hydrocortisone cypionate may increase the anticoagulant activities of (S)-Warfarin.
Nicorandil The risk or severity of ulceration can be increased when Hydrocortisone cypionate is combined with Nicorandil.
Calcifediol The therapeutic efficacy of Calcifediol can be decreased when used in combination with Hydrocortisone cypionate.
Ergocalciferol The therapeutic efficacy of Ergocalciferol can be decreased when used in combination with Hydrocortisone cypionate.
Dihydrotachysterol The therapeutic efficacy of Dihydrotachysterol can be decreased when used in combination with Hydrocortisone cypionate.
Alfacalcidol The therapeutic efficacy of Alfacalcidol can be decreased when used in combination with Hydrocortisone cypionate.
Seocalcitol The therapeutic efficacy of Seocalcitol can be decreased when used in combination with Hydrocortisone cypionate.
Inecalcitol The therapeutic efficacy of Inecalcitol can be decreased when used in combination with Hydrocortisone cypionate.
Becocalcidiol The therapeutic efficacy of Becocalcidiol can be decreased when used in combination with Hydrocortisone cypionate.
Eldecalcitol The therapeutic efficacy of Eldecalcitol can be decreased when used in combination with Hydrocortisone cypionate.
1alpha,24S-Dihydroxyvitamin D2 The therapeutic efficacy of 1alpha,24S-Dihydroxyvitamin D2 can be decreased when used in combination with Hydrocortisone cypionate.
Elocalcitol The therapeutic efficacy of Elocalcitol can be decreased when used in combination with Hydrocortisone cypionate.
Maxacalcitol The therapeutic efficacy of Maxacalcitol can be decreased when used in combination with Hydrocortisone cypionate.
Doxercalciferol The therapeutic efficacy of Doxercalciferol can be decreased when used in combination with Hydrocortisone cypionate.
1alpha-Hydroxyvitamin D5 The therapeutic efficacy of 1alpha-Hydroxyvitamin D5 can be decreased when used in combination with Hydrocortisone cypionate.
Calcitriol The therapeutic efficacy of Calcitriol can be decreased when used in combination with Hydrocortisone cypionate.
Cholecalciferol The therapeutic efficacy of Cholecalciferol can be decreased when used in combination with Hydrocortisone cypionate.
Paricalcitol The therapeutic efficacy of Paricalcitol can be decreased when used in combination with Hydrocortisone cypionate.
Vitamin D The therapeutic efficacy of Vitamin D can be decreased when used in combination with Hydrocortisone cypionate.
Previtamin D(3) The therapeutic efficacy of Previtamin D(3) can be decreased when used in combination with Hydrocortisone cypionate.
Octylphenoxy polyethoxyethanol The serum concentration of Hydrocortisone cypionate can be increased when it is combined with Octylphenoxy polyethoxyethanol.
Cloprostenol The serum concentration of Hydrocortisone cypionate can be increased when it is combined with Cloprostenol.
Gossypol The serum concentration of Hydrocortisone cypionate can be increased when it is combined with Gossypol.
Ormeloxifene The serum concentration of Hydrocortisone cypionate can be increased when it is combined with Ormeloxifene.
Norgestrienone The serum concentration of Hydrocortisone cypionate can be increased when it is combined with Norgestrienone.
Norethindrone enanthate The serum concentration of Hydrocortisone cypionate can be increased when it is combined with Norethindrone enanthate.
Mifepristone The serum concentration of Hydrocortisone cypionate can be increased when it is combined with Mifepristone.
Gestodene The serum concentration of Hydrocortisone cypionate can be increased when it is combined with Gestodene.
Levonorgestrel The serum concentration of Hydrocortisone cypionate can be increased when it is combined with Levonorgestrel.
Progesterone The serum concentration of Hydrocortisone cypionate can be increased when it is combined with Progesterone.
Norethisterone The serum concentration of Hydrocortisone cypionate can be increased when it is combined with Norethisterone.
Estradiol The serum concentration of Hydrocortisone cypionate can be increased when it is combined with Estradiol.
Hydroxyprogesterone caproate The serum concentration of Hydrocortisone cypionate can be increased when it is combined with Hydroxyprogesterone caproate.
Estradiol benzoate The serum concentration of Hydrocortisone cypionate can be increased when it is combined with Estradiol benzoate.
Estradiol cypionate The serum concentration of Hydrocortisone cypionate can be increased when it is combined with Estradiol cypionate.
Estradiol valerate The serum concentration of Hydrocortisone cypionate can be increased when it is combined with Estradiol valerate.
Diethylstilbestrol The serum concentration of Hydrocortisone cypionate can be increased when it is combined with Diethylstilbestrol.
Etonogestrel The serum concentration of Hydrocortisone cypionate can be increased when it is combined with Etonogestrel.
Desogestrel The serum concentration of Hydrocortisone cypionate can be increased when it is combined with Desogestrel.
Megestrol acetate The serum concentration of Hydrocortisone cypionate can be increased when it is combined with Megestrol acetate.
Medroxyprogesterone acetate The serum concentration of Hydrocortisone cypionate can be increased when it is combined with Medroxyprogesterone acetate.
Ethynodiol diacetate The serum concentration of Hydrocortisone cypionate can be increased when it is combined with Ethynodiol diacetate.
Norgestimate The serum concentration of Hydrocortisone cypionate can be increased when it is combined with Norgestimate.
Ethinylestradiol The serum concentration of Hydrocortisone cypionate can be increased when it is combined with Ethinylestradiol.
Mestranol The serum concentration of Hydrocortisone cypionate can be increased when it is combined with Mestranol.
Drospirenone The serum concentration of Hydrocortisone cypionate can be increased when it is combined with Drospirenone.
Estrone sulfate The serum concentration of Hydrocortisone cypionate can be increased when it is combined with Estrone sulfate.
Cyproterone acetate The serum concentration of Hydrocortisone cypionate can be increased when it is combined with Cyproterone acetate.
Norelgestromin The serum concentration of Hydrocortisone cypionate can be increased when it is combined with Norelgestromin.

Target Protein

Annexin A1 ANXA1
Glucocorticoid receptor NR3C1
11-beta-hydroxysteroid dehydrogenase type 2 HSD11B2
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 HSD3B1

Referensi & Sumber

Artikel (PubMed)
  • PMID: 12932892
    de Weerth C, Zijl RH, Buitelaar JK: Development of cortisol circadian rhythm in infancy. Early Hum Dev. 2003 Aug;73(1-2):39-52.
  • PMID: 6461917
    Palacios R, Sugawara I: Hydrocortisone abrogates proliferation of T cells in autologous mixed lymphocyte reaction by rendering the interleukin-2 Producer T cells unresponsive to interleukin-1 and unable to synthesize the T-cell growth factor. Scand J Immunol. 1982 Jan;15(1):25-31.
  • PMID: 13233328
    KNIGHT RP Jr, KORNFELD DS, GLASER GH, BONDY PK: Effects of intravenous hydrocortisone on electrolytes of serum and urine in man. J Clin Endocrinol Metab. 1955 Feb;15(2):176-81.

Contoh Produk & Brand

Produk: 1 • International brands: 0
Produk
  • Cortef
    Suspension • 10 mg/5mL • Oral • US • Approved

Sekuens Gen/Protein (FASTA)

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