Peringatan Keamanan

Side effects include inhibition of bone formation, suppression of calcium absorption and delayed wound healing

Hydrocortisone butyrate

DB14540

small molecule approved vet_approved

Deskripsi

Struktur Molekul 2D

Berat 432.557
Wujud -

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 6-8 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin increase percutaneous absorption.

Metabolisme

Primarily hepatic via CYP3A4

Rute Eliminasi

Corticosteroids are metabolized primarily in the liver and are then excreted by the kidneys. Some of the topical corticosteroids and their metabolites are also excreted into the bile.

Interaksi Obat

1185 Data
Denosumab The risk or severity of adverse effects can be increased when Denosumab is combined with Hydrocortisone butyrate.
Peginterferon alfa-2a The risk or severity of adverse effects can be increased when Peginterferon alfa-2a is combined with Hydrocortisone butyrate.
Interferon alfa-n1 The risk or severity of adverse effects can be increased when Interferon alfa-n1 is combined with Hydrocortisone butyrate.
Interferon alfa-n3 The risk or severity of adverse effects can be increased when Interferon alfa-n3 is combined with Hydrocortisone butyrate.
Peginterferon alfa-2b The risk or severity of adverse effects can be increased when Peginterferon alfa-2b is combined with Hydrocortisone butyrate.
Interferon gamma-1b The risk or severity of adverse effects can be increased when Interferon gamma-1b is combined with Hydrocortisone butyrate.
Interferon alfa-2a The risk or severity of adverse effects can be increased when Interferon alfa-2a is combined with Hydrocortisone butyrate.
Aldesleukin The risk or severity of adverse effects can be increased when Aldesleukin is combined with Hydrocortisone butyrate.
Gemtuzumab ozogamicin The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Hydrocortisone butyrate.
Pegaspargase The risk or severity of adverse effects can be increased when Pegaspargase is combined with Hydrocortisone butyrate.
Interferon beta-1b The risk or severity of adverse effects can be increased when Interferon beta-1b is combined with Hydrocortisone butyrate.
Interferon alfacon-1 The risk or severity of adverse effects can be increased when Interferon alfacon-1 is combined with Hydrocortisone butyrate.
Rituximab The risk or severity of adverse effects can be increased when Rituximab is combined with Hydrocortisone butyrate.
Basiliximab The risk or severity of adverse effects can be increased when Basiliximab is combined with Hydrocortisone butyrate.
Muromonab The risk or severity of adverse effects can be increased when Muromonab is combined with Hydrocortisone butyrate.
Ibritumomab tiuxetan The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Hydrocortisone butyrate.
Tositumomab The risk or severity of adverse effects can be increased when Tositumomab is combined with Hydrocortisone butyrate.
Alemtuzumab The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Hydrocortisone butyrate.
Alefacept The risk or severity of adverse effects can be increased when Alefacept is combined with Hydrocortisone butyrate.
Efalizumab The risk or severity of adverse effects can be increased when Efalizumab is combined with Hydrocortisone butyrate.
Antithymocyte immunoglobulin (rabbit) The risk or severity of adverse effects can be increased when Antithymocyte immunoglobulin (rabbit) is combined with Hydrocortisone butyrate.
Interferon alfa-2b The risk or severity of adverse effects can be increased when Interferon alfa-2b is combined with Hydrocortisone butyrate.
Daclizumab The risk or severity of adverse effects can be increased when Daclizumab is combined with Hydrocortisone butyrate.
Phenylalanine The risk or severity of adverse effects can be increased when Phenylalanine is combined with Hydrocortisone butyrate.
Flunisolide The risk or severity of adverse effects can be increased when Flunisolide is combined with Hydrocortisone butyrate.
Cladribine Hydrocortisone butyrate may increase the immunosuppressive activities of Cladribine.
Carmustine The risk or severity of adverse effects can be increased when Carmustine is combined with Hydrocortisone butyrate.
Amsacrine The risk or severity of adverse effects can be increased when Amsacrine is combined with Hydrocortisone butyrate.
Bleomycin The risk or severity of adverse effects can be increased when Bleomycin is combined with Hydrocortisone butyrate.
Chlorambucil The risk or severity of adverse effects can be increased when Chlorambucil is combined with Hydrocortisone butyrate.
Raltitrexed The risk or severity of adverse effects can be increased when Raltitrexed is combined with Hydrocortisone butyrate.
Mitomycin The risk or severity of adverse effects can be increased when Mitomycin is combined with Hydrocortisone butyrate.
Bexarotene The risk or severity of adverse effects can be increased when Bexarotene is combined with Hydrocortisone butyrate.
Floxuridine The risk or severity of adverse effects can be increased when Floxuridine is combined with Hydrocortisone butyrate.
Tioguanine The risk or severity of adverse effects can be increased when Tioguanine is combined with Hydrocortisone butyrate.
Dexrazoxane The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Hydrocortisone butyrate.
Beclomethasone dipropionate The risk or severity of adverse effects can be increased when Beclomethasone dipropionate is combined with Hydrocortisone butyrate.
Streptozocin The risk or severity of adverse effects can be increased when Streptozocin is combined with Hydrocortisone butyrate.
Trifluridine The risk or severity of adverse effects can be increased when Trifluridine is combined with Hydrocortisone butyrate.
Gemcitabine The risk or severity of adverse effects can be increased when Gemcitabine is combined with Hydrocortisone butyrate.
Betamethasone The risk or severity of adverse effects can be increased when Betamethasone is combined with Hydrocortisone butyrate.
Epirubicin The risk or severity of adverse effects can be increased when Epirubicin is combined with Hydrocortisone butyrate.
Chloramphenicol The risk or severity of adverse effects can be increased when Chloramphenicol is combined with Hydrocortisone butyrate.
Lenalidomide The risk or severity of adverse effects can be increased when Lenalidomide is combined with Hydrocortisone butyrate.
Altretamine The risk or severity of adverse effects can be increased when Altretamine is combined with Hydrocortisone butyrate.
Zidovudine The risk or severity of adverse effects can be increased when Zidovudine is combined with Hydrocortisone butyrate.
Oxaliplatin The risk or severity of adverse effects can be increased when Oxaliplatin is combined with Hydrocortisone butyrate.
Propylthiouracil The risk or severity of adverse effects can be increased when Propylthiouracil is combined with Hydrocortisone butyrate.
Pentostatin The risk or severity of adverse effects can be increased when Pentostatin is combined with Hydrocortisone butyrate.
Fluticasone propionate The risk or severity of adverse effects can be increased when Fluticasone propionate is combined with Hydrocortisone butyrate.
Fluocinolone acetonide The risk or severity of adverse effects can be increased when Fluocinolone acetonide is combined with Hydrocortisone butyrate.
Linezolid The risk or severity of adverse effects can be increased when Linezolid is combined with Hydrocortisone butyrate.
Triamcinolone The risk or severity of adverse effects can be increased when Triamcinolone is combined with Hydrocortisone butyrate.
Clofarabine The risk or severity of adverse effects can be increased when Clofarabine is combined with Hydrocortisone butyrate.
Prednisone The risk or severity of adverse effects can be increased when Prednisone is combined with Hydrocortisone butyrate.
Pemetrexed The risk or severity of adverse effects can be increased when Pemetrexed is combined with Hydrocortisone butyrate.
Fludrocortisone The risk or severity of adverse effects can be increased when Fludrocortisone is combined with Hydrocortisone butyrate.
Mycophenolate mofetil The risk or severity of adverse effects can be increased when Mycophenolate mofetil is combined with Hydrocortisone butyrate.
Daunorubicin The risk or severity of adverse effects can be increased when Daunorubicin is combined with Hydrocortisone butyrate.
Tretinoin The metabolism of Hydrocortisone butyrate can be decreased when combined with Tretinoin.
Dacarbazine The risk or severity of adverse effects can be increased when Dacarbazine is combined with Hydrocortisone butyrate.
Temozolomide The risk or severity of adverse effects can be increased when Temozolomide is combined with Hydrocortisone butyrate.
Penicillamine The risk or severity of adverse effects can be increased when Penicillamine is combined with Hydrocortisone butyrate.
Prednisolone The risk or severity of adverse effects can be increased when Prednisolone is combined with Hydrocortisone butyrate.
Azacitidine The risk or severity of adverse effects can be increased when Azacitidine is combined with Hydrocortisone butyrate.
Carboplatin The risk or severity of adverse effects can be increased when Carboplatin is combined with Hydrocortisone butyrate.
Methylprednisolone The risk or severity of adverse effects can be increased when Methylprednisolone is combined with Hydrocortisone butyrate.
Dactinomycin The risk or severity of adverse effects can be increased when Dactinomycin is combined with Hydrocortisone butyrate.
Cytarabine The risk or severity of adverse effects can be increased when Cytarabine is combined with Hydrocortisone butyrate.
Azathioprine The risk or severity of adverse effects can be increased when Azathioprine is combined with Hydrocortisone butyrate.
Hydroxyurea The risk or severity of adverse effects can be increased when Hydroxyurea is combined with Hydrocortisone butyrate.
Clobetasol propionate The risk or severity of adverse effects can be increased when Clobetasol propionate is combined with Hydrocortisone butyrate.
Mycophenolic acid The risk or severity of adverse effects can be increased when Mycophenolic acid is combined with Hydrocortisone butyrate.
Topotecan The risk or severity of adverse effects can be increased when Topotecan is combined with Hydrocortisone butyrate.
Mercaptopurine The risk or severity of adverse effects can be increased when Mercaptopurine is combined with Hydrocortisone butyrate.
Thalidomide The risk or severity of adverse effects can be increased when Thalidomide is combined with Hydrocortisone butyrate.
Melphalan The risk or severity of adverse effects can be increased when Melphalan is combined with Hydrocortisone butyrate.
Fluocinonide The risk or severity of adverse effects can be increased when Fluocinonide is combined with Hydrocortisone butyrate.
Fludarabine The risk or severity of adverse effects can be increased when Fludarabine is combined with Hydrocortisone butyrate.
Flucytosine The risk or severity of adverse effects can be increased when Flucytosine is combined with Hydrocortisone butyrate.
Capecitabine The risk or severity of adverse effects can be increased when Capecitabine is combined with Hydrocortisone butyrate.
Procarbazine The risk or severity of adverse effects can be increased when Procarbazine is combined with Hydrocortisone butyrate.
Arsenic trioxide The risk or severity of adverse effects can be increased when Arsenic trioxide is combined with Hydrocortisone butyrate.
Idarubicin The risk or severity of adverse effects can be increased when Idarubicin is combined with Hydrocortisone butyrate.
Estramustine The risk or severity of adverse effects can be increased when Estramustine is combined with Hydrocortisone butyrate.
Mitoxantrone The risk or severity of adverse effects can be increased when Mitoxantrone is combined with Hydrocortisone butyrate.
Lomustine The risk or severity of adverse effects can be increased when Lomustine is combined with Hydrocortisone butyrate.
Budesonide The risk or severity of adverse effects can be increased when Budesonide is combined with Hydrocortisone butyrate.
Dexamethasone The risk or severity of adverse effects can be increased when Dexamethasone is combined with Hydrocortisone butyrate.
Eculizumab The risk or severity of adverse effects can be increased when Eculizumab is combined with Hydrocortisone butyrate.
Decitabine The risk or severity of adverse effects can be increased when Decitabine is combined with Hydrocortisone butyrate.
Nelarabine The risk or severity of adverse effects can be increased when Nelarabine is combined with Hydrocortisone butyrate.
Corticotropin The risk or severity of adverse effects can be increased when Corticotropin is combined with Hydrocortisone butyrate.
Cortisone acetate The risk or severity of adverse effects can be increased when Cortisone acetate is combined with Hydrocortisone butyrate.
Paramethasone The risk or severity of adverse effects can be increased when Paramethasone is combined with Hydrocortisone butyrate.
Ciclesonide The risk or severity of adverse effects can be increased when Ciclesonide is combined with Hydrocortisone butyrate.
Stepronin The risk or severity of adverse effects can be increased when Stepronin is combined with Hydrocortisone butyrate.
Hydroxychloroquine The risk or severity of adverse effects can be increased when Hydroxychloroquine is combined with Hydrocortisone butyrate.
Castanospermine The risk or severity of adverse effects can be increased when Castanospermine is combined with Hydrocortisone butyrate.
Vorinostat The risk or severity of adverse effects can be increased when Vorinostat is combined with Hydrocortisone butyrate.

Target Protein

Annexin A1 ANXA1
Glucocorticoid receptor NR3C1
11-beta-hydroxysteroid dehydrogenase type 2 HSD11B2
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 HSD3B1

Referensi & Sumber

Artikel (PubMed)
  • PMID: 12932892
    de Weerth C, Zijl RH, Buitelaar JK: Development of cortisol circadian rhythm in infancy. Early Hum Dev. 2003 Aug;73(1-2):39-52.
  • PMID: 6461917
    Palacios R, Sugawara I: Hydrocortisone abrogates proliferation of T cells in autologous mixed lymphocyte reaction by rendering the interleukin-2 Producer T cells unresponsive to interleukin-1 and unable to synthesize the T-cell growth factor. Scand J Immunol. 1982 Jan;15(1):25-31.
  • PMID: 13233328
    KNIGHT RP Jr, KORNFELD DS, GLASER GH, BONDY PK: Effects of intravenous hydrocortisone on electrolytes of serum and urine in man. J Clin Endocrinol Metab. 1955 Feb;15(2):176-81.

Contoh Produk & Brand

Produk: 36 • International brands: 0
Produk
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    Cream • 30 mg/30g • Topical • US
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    Cream • 1.0 mg/1g • Topical • US • Approved
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