Peringatan Keamanan

Side effects include inhibition of bone formation, suppression of calcium absorption and delayed wound healing

Hydrocortisone acetate

DB14539

small molecule approved vet_approved

Deskripsi

Struktur Molekul 2D

Berat 404.4966
Wujud -

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 6-8 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin increase percutaneous absorption.

Metabolisme

Primarily hepatic via CYP3A4

Rute Eliminasi

Corticosteroids are metabolized primarily in the liver and are then excreted by the kidneys. Some of the topical corticosteroids and their metabolites are also excreted into the bile.

Interaksi Obat

1152 Data
Denosumab The risk or severity of adverse effects can be increased when Denosumab is combined with Hydrocortisone acetate.
Peginterferon alfa-2a The risk or severity of adverse effects can be increased when Peginterferon alfa-2a is combined with Hydrocortisone acetate.
Interferon alfa-n1 The risk or severity of adverse effects can be increased when Interferon alfa-n1 is combined with Hydrocortisone acetate.
Interferon alfa-n3 The risk or severity of adverse effects can be increased when Interferon alfa-n3 is combined with Hydrocortisone acetate.
Peginterferon alfa-2b The risk or severity of adverse effects can be increased when Peginterferon alfa-2b is combined with Hydrocortisone acetate.
Interferon gamma-1b The risk or severity of adverse effects can be increased when Interferon gamma-1b is combined with Hydrocortisone acetate.
Interferon alfa-2a The risk or severity of adverse effects can be increased when Interferon alfa-2a is combined with Hydrocortisone acetate.
Aldesleukin The risk or severity of adverse effects can be increased when Aldesleukin is combined with Hydrocortisone acetate.
Gemtuzumab ozogamicin The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Hydrocortisone acetate.
Pegaspargase The risk or severity of adverse effects can be increased when Pegaspargase is combined with Hydrocortisone acetate.
Interferon beta-1b The risk or severity of adverse effects can be increased when Interferon beta-1b is combined with Hydrocortisone acetate.
Interferon alfacon-1 The risk or severity of adverse effects can be increased when Interferon alfacon-1 is combined with Hydrocortisone acetate.
Rituximab The risk or severity of adverse effects can be increased when Rituximab is combined with Hydrocortisone acetate.
Basiliximab The risk or severity of adverse effects can be increased when Basiliximab is combined with Hydrocortisone acetate.
Muromonab The risk or severity of adverse effects can be increased when Muromonab is combined with Hydrocortisone acetate.
Ibritumomab tiuxetan The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Hydrocortisone acetate.
Tositumomab The risk or severity of adverse effects can be increased when Tositumomab is combined with Hydrocortisone acetate.
Alemtuzumab The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Hydrocortisone acetate.
Alefacept The risk or severity of adverse effects can be increased when Alefacept is combined with Hydrocortisone acetate.
Efalizumab The risk or severity of adverse effects can be increased when Efalizumab is combined with Hydrocortisone acetate.
Antithymocyte immunoglobulin (rabbit) The risk or severity of adverse effects can be increased when Antithymocyte immunoglobulin (rabbit) is combined with Hydrocortisone acetate.
Interferon alfa-2b The risk or severity of adverse effects can be increased when Interferon alfa-2b is combined with Hydrocortisone acetate.
Daclizumab The risk or severity of adverse effects can be increased when Daclizumab is combined with Hydrocortisone acetate.
Phenylalanine The risk or severity of adverse effects can be increased when Phenylalanine is combined with Hydrocortisone acetate.
Cladribine Hydrocortisone acetate may increase the immunosuppressive activities of Cladribine.
Carmustine The risk or severity of adverse effects can be increased when Carmustine is combined with Hydrocortisone acetate.
Amsacrine The risk or severity of adverse effects can be increased when Amsacrine is combined with Hydrocortisone acetate.
Bleomycin The risk or severity of adverse effects can be increased when Bleomycin is combined with Hydrocortisone acetate.
Chlorambucil The risk or severity of adverse effects can be increased when Chlorambucil is combined with Hydrocortisone acetate.
Raltitrexed The risk or severity of adverse effects can be increased when Raltitrexed is combined with Hydrocortisone acetate.
Mitomycin The risk or severity of adverse effects can be increased when Mitomycin is combined with Hydrocortisone acetate.
Bexarotene The risk or severity of adverse effects can be increased when Bexarotene is combined with Hydrocortisone acetate.
Floxuridine The risk or severity of adverse effects can be increased when Floxuridine is combined with Hydrocortisone acetate.
Tioguanine The risk or severity of adverse effects can be increased when Tioguanine is combined with Hydrocortisone acetate.
Dexrazoxane The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Hydrocortisone acetate.
Streptozocin The risk or severity of adverse effects can be increased when Streptozocin is combined with Hydrocortisone acetate.
Trifluridine The risk or severity of adverse effects can be increased when Trifluridine is combined with Hydrocortisone acetate.
Gemcitabine The risk or severity of adverse effects can be increased when Gemcitabine is combined with Hydrocortisone acetate.
Epirubicin The risk or severity of adverse effects can be increased when Epirubicin is combined with Hydrocortisone acetate.
Chloramphenicol The risk or severity of adverse effects can be increased when Chloramphenicol is combined with Hydrocortisone acetate.
Lenalidomide The risk or severity of adverse effects can be increased when Lenalidomide is combined with Hydrocortisone acetate.
Altretamine The risk or severity of adverse effects can be increased when Altretamine is combined with Hydrocortisone acetate.
Zidovudine The risk or severity of adverse effects can be increased when Zidovudine is combined with Hydrocortisone acetate.
Oxaliplatin The risk or severity of adverse effects can be increased when Oxaliplatin is combined with Hydrocortisone acetate.
Propylthiouracil The risk or severity of adverse effects can be increased when Propylthiouracil is combined with Hydrocortisone acetate.
Pentostatin The risk or severity of adverse effects can be increased when Pentostatin is combined with Hydrocortisone acetate.
Linezolid The risk or severity of adverse effects can be increased when Linezolid is combined with Hydrocortisone acetate.
Clofarabine The risk or severity of adverse effects can be increased when Clofarabine is combined with Hydrocortisone acetate.
Pemetrexed The risk or severity of adverse effects can be increased when Pemetrexed is combined with Hydrocortisone acetate.
Mycophenolate mofetil The risk or severity of adverse effects can be increased when Mycophenolate mofetil is combined with Hydrocortisone acetate.
Tretinoin The metabolism of Hydrocortisone acetate can be decreased when combined with Tretinoin.
Dacarbazine The risk or severity of adverse effects can be increased when Dacarbazine is combined with Hydrocortisone acetate.
Temozolomide The risk or severity of adverse effects can be increased when Temozolomide is combined with Hydrocortisone acetate.
Penicillamine The risk or severity of adverse effects can be increased when Penicillamine is combined with Hydrocortisone acetate.
Azacitidine The risk or severity of adverse effects can be increased when Azacitidine is combined with Hydrocortisone acetate.
Carboplatin The risk or severity of adverse effects can be increased when Carboplatin is combined with Hydrocortisone acetate.
Dactinomycin The risk or severity of adverse effects can be increased when Dactinomycin is combined with Hydrocortisone acetate.
Azathioprine The risk or severity of adverse effects can be increased when Azathioprine is combined with Hydrocortisone acetate.
Hydroxyurea The risk or severity of adverse effects can be increased when Hydroxyurea is combined with Hydrocortisone acetate.
Mycophenolic acid The risk or severity of adverse effects can be increased when Mycophenolic acid is combined with Hydrocortisone acetate.
Topotecan The risk or severity of adverse effects can be increased when Topotecan is combined with Hydrocortisone acetate.
Mercaptopurine The risk or severity of adverse effects can be increased when Mercaptopurine is combined with Hydrocortisone acetate.
Thalidomide The risk or severity of adverse effects can be increased when Thalidomide is combined with Hydrocortisone acetate.
Melphalan The risk or severity of adverse effects can be increased when Melphalan is combined with Hydrocortisone acetate.
Fludarabine The risk or severity of adverse effects can be increased when Fludarabine is combined with Hydrocortisone acetate.
Flucytosine The risk or severity of adverse effects can be increased when Flucytosine is combined with Hydrocortisone acetate.
Capecitabine The risk or severity of adverse effects can be increased when Capecitabine is combined with Hydrocortisone acetate.
Procarbazine The risk or severity of adverse effects can be increased when Procarbazine is combined with Hydrocortisone acetate.
Arsenic trioxide The risk or severity of adverse effects can be increased when Arsenic trioxide is combined with Hydrocortisone acetate.
Idarubicin The risk or severity of adverse effects can be increased when Idarubicin is combined with Hydrocortisone acetate.
Estramustine The risk or severity of adverse effects can be increased when Estramustine is combined with Hydrocortisone acetate.
Mitoxantrone The risk or severity of adverse effects can be increased when Mitoxantrone is combined with Hydrocortisone acetate.
Lomustine The risk or severity of adverse effects can be increased when Lomustine is combined with Hydrocortisone acetate.
Eculizumab The risk or severity of adverse effects can be increased when Eculizumab is combined with Hydrocortisone acetate.
Decitabine The risk or severity of adverse effects can be increased when Decitabine is combined with Hydrocortisone acetate.
Nelarabine The risk or severity of adverse effects can be increased when Nelarabine is combined with Hydrocortisone acetate.
Stepronin The risk or severity of adverse effects can be increased when Stepronin is combined with Hydrocortisone acetate.
Hydroxychloroquine The risk or severity of adverse effects can be increased when Hydroxychloroquine is combined with Hydrocortisone acetate.
Castanospermine The risk or severity of adverse effects can be increased when Castanospermine is combined with Hydrocortisone acetate.
Vorinostat The risk or severity of adverse effects can be increased when Vorinostat is combined with Hydrocortisone acetate.
2-Methoxyethanol The risk or severity of adverse effects can be increased when 2-Methoxyethanol is combined with Hydrocortisone acetate.
Brequinar The risk or severity of adverse effects can be increased when Brequinar is combined with Hydrocortisone acetate.
Pirfenidone The risk or severity of adverse effects can be increased when Pirfenidone is combined with Hydrocortisone acetate.
Interferon alfa The risk or severity of adverse effects can be increased when Interferon alfa is combined with Hydrocortisone acetate.
Glatiramer The risk or severity of adverse effects can be increased when Glatiramer is combined with Hydrocortisone acetate.
Briakinumab The risk or severity of adverse effects can be increased when Briakinumab is combined with Hydrocortisone acetate.
Human interferon omega-1 The risk or severity of adverse effects can be increased when Human interferon omega-1 is combined with Hydrocortisone acetate.
Mepolizumab The risk or severity of adverse effects can be increased when Mepolizumab is combined with Hydrocortisone acetate.
Abetimus The risk or severity of adverse effects can be increased when Abetimus is combined with Hydrocortisone acetate.
Belatacept The risk or severity of adverse effects can be increased when Belatacept is combined with Hydrocortisone acetate.
Bendamustine The risk or severity of adverse effects can be increased when Bendamustine is combined with Hydrocortisone acetate.
Pralatrexate The risk or severity of adverse effects can be increased when Pralatrexate is combined with Hydrocortisone acetate.
Wortmannin The risk or severity of adverse effects can be increased when Wortmannin is combined with Hydrocortisone acetate.
Eribulin The risk or severity of adverse effects can be increased when Eribulin is combined with Hydrocortisone acetate.
Belimumab The risk or severity of adverse effects can be increased when Belimumab is combined with Hydrocortisone acetate.
Teriflunomide The risk or severity of adverse effects can be increased when Teriflunomide is combined with Hydrocortisone acetate.
Carfilzomib The risk or severity of adverse effects can be increased when Carfilzomib is combined with Hydrocortisone acetate.
Dimethyl fumarate The risk or severity of adverse effects can be increased when Dimethyl fumarate is combined with Hydrocortisone acetate.
Obinutuzumab The risk or severity of adverse effects can be increased when Obinutuzumab is combined with Hydrocortisone acetate.
Vedolizumab The risk or severity of adverse effects can be increased when Vedolizumab is combined with Hydrocortisone acetate.

Target Protein

Annexin A1 ANXA1
Glucocorticoid receptor NR3C1
11-beta-hydroxysteroid dehydrogenase type 2 HSD11B2
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 HSD3B1

Referensi & Sumber

Artikel (PubMed)
  • PMID: 12932892
    de Weerth C, Zijl RH, Buitelaar JK: Development of cortisol circadian rhythm in infancy. Early Hum Dev. 2003 Aug;73(1-2):39-52.
  • PMID: 6461917
    Palacios R, Sugawara I: Hydrocortisone abrogates proliferation of T cells in autologous mixed lymphocyte reaction by rendering the interleukin-2 Producer T cells unresponsive to interleukin-1 and unable to synthesize the T-cell growth factor. Scand J Immunol. 1982 Jan;15(1):25-31.
  • PMID: 13233328
    KNIGHT RP Jr, KORNFELD DS, GLASER GH, BONDY PK: Effects of intravenous hydrocortisone on electrolytes of serum and urine in man. J Clin Endocrinol Metab. 1955 Feb;15(2):176-81.

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International Brands
  • Micort-HC

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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