Peringatan Keamanan

Patients experiencing and overdose may present with hypotension, pulmonary edema, diarrhea, vomiting, jaundice, and oligouria.L14186 Overdose can be managed through symptomatic and supportive treatment which may include sodium calcium edetate and analgesics.L14186

The oral LD50 in mice is 329 mg/kg and in rats is 350 mg/kg.L14183

Zinc chloride

DB14533

small molecule approved investigational

Deskripsi

Zinc chloride is a solution of ions indicated for use in total parenteral nutrition to maintain zinc levels and prevent deficiency syndromes.L14189

Zinc chloride was granted FDA approval before 26 June 1986.L14189

Struktur Molekul 2D

Berat 136.315
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Using a two compartment model, zinc has once half life of 4.5-26 days and a second half life of 387-478 days.[A204095]
Volume Distribusi -
Klirens (Clearance) In one study of healthy patients, the clearance of zinc was found to be 0.63 ± 0.39 ?g/min.[A204092]

Absorpsi

Zinc is approximately 33% orally bioavailable in humans but bioavailability can vary between patients and depending on current zinc levels.A204089 Further data regarding the pharmacokinetics of zinc chloride are not readily available.

Metabolisme

Zinc chloride dissociates into ions in vivo and does not undergo further metabolism.

Rute Eliminasi

Zinc is predominantly eliminated in the feces.A204089,L14186 Gastrointestinal elimination of zinc is responsible for approximately half of all zinc elimination.A204089

Interaksi Obat

61 Data
Eltrombopag Zinc chloride can cause a decrease in the absorption of Eltrombopag resulting in a reduced serum concentration and potentially a decrease in efficacy.
Raltegravir Zinc chloride can cause a decrease in the absorption of Raltegravir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ceftibuten Zinc chloride can cause a decrease in the absorption of Ceftibuten resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cephalexin Zinc chloride can cause a decrease in the absorption of Cephalexin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Deferiprone Zinc chloride can cause a decrease in the absorption of Deferiprone resulting in a reduced serum concentration and potentially a decrease in efficacy.
Dolutegravir Zinc chloride can cause a decrease in the absorption of Dolutegravir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Deferasirox Zinc chloride can cause a decrease in the absorption of Deferasirox resulting in a reduced serum concentration and potentially a decrease in efficacy.
Halofantrine Zinc chloride can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Triethylenetetramine The serum concentration of Triethylenetetramine can be decreased when it is combined with Zinc chloride.
Moxifloxacin Zinc chloride can cause a decrease in the absorption of Moxifloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Grepafloxacin Zinc chloride can cause a decrease in the absorption of Grepafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Enoxacin Zinc chloride can cause a decrease in the absorption of Enoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Pefloxacin Zinc chloride can cause a decrease in the absorption of Pefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ciprofloxacin Zinc chloride can cause a decrease in the absorption of Ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Trovafloxacin Zinc chloride can cause a decrease in the absorption of Trovafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Nalidixic acid Zinc chloride can cause a decrease in the absorption of Nalidixic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Rosoxacin Zinc chloride can cause a decrease in the absorption of Rosoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cinoxacin Zinc chloride can cause a decrease in the absorption of Cinoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Lomefloxacin Zinc chloride can cause a decrease in the absorption of Lomefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Gatifloxacin Zinc chloride can cause a decrease in the absorption of Gatifloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Norfloxacin Zinc chloride can cause a decrease in the absorption of Norfloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Levofloxacin Zinc chloride can cause a decrease in the absorption of Levofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Gemifloxacin Zinc chloride can cause a decrease in the absorption of Gemifloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ofloxacin Zinc chloride can cause a decrease in the absorption of Ofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sparfloxacin Zinc chloride can cause a decrease in the absorption of Sparfloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Temafloxacin Zinc chloride can cause a decrease in the absorption of Temafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Fleroxacin Zinc chloride can cause a decrease in the absorption of Fleroxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Technetium Tc-99m ciprofloxacin Zinc chloride can cause a decrease in the absorption of Technetium Tc-99m ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Garenoxacin Zinc chloride can cause a decrease in the absorption of Garenoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Nemonoxacin Zinc chloride can cause a decrease in the absorption of Nemonoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Flumequine Zinc chloride can cause a decrease in the absorption of Flumequine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Enrofloxacin Zinc chloride can cause a decrease in the absorption of Enrofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Orbifloxacin Zinc chloride can cause a decrease in the absorption of Orbifloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sarafloxacin Zinc chloride can cause a decrease in the absorption of Sarafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Difloxacin Zinc chloride can cause a decrease in the absorption of Difloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Pazufloxacin Zinc chloride can cause a decrease in the absorption of Pazufloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Prulifloxacin Zinc chloride can cause a decrease in the absorption of Prulifloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Delafloxacin Zinc chloride can cause a decrease in the absorption of Delafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sitafloxacin Zinc chloride can cause a decrease in the absorption of Sitafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Oxolinic acid Zinc chloride can cause a decrease in the absorption of Oxolinic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Rufloxacin Zinc chloride can cause a decrease in the absorption of Rufloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Pipemidic acid Zinc chloride can cause a decrease in the absorption of Pipemidic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Lymecycline Zinc chloride can cause a decrease in the absorption of Lymecycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Clomocycline Zinc chloride can cause a decrease in the absorption of Clomocycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Tigecycline Zinc chloride can cause a decrease in the absorption of Tigecycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Oxytetracycline Zinc chloride can cause a decrease in the absorption of Oxytetracycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Demeclocycline Zinc chloride can cause a decrease in the absorption of Demeclocycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Tetracycline Zinc chloride can cause a decrease in the absorption of Tetracycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Metacycline Zinc chloride can cause a decrease in the absorption of Metacycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Minocycline Zinc chloride can cause a decrease in the absorption of Minocycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Rolitetracycline Zinc chloride can cause a decrease in the absorption of Rolitetracycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sarecycline Zinc chloride can cause a decrease in the absorption of Sarecycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Eravacycline Zinc chloride can cause a decrease in the absorption of Eravacycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Omadacycline Zinc chloride can cause a decrease in the absorption of Omadacycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Penimepicycline Zinc chloride can cause a decrease in the absorption of Penimepicycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Phenytoin Zinc chloride can cause a decrease in the absorption of Phenytoin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Mephenytoin Zinc chloride can cause a decrease in the absorption of Mephenytoin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Carbamazepine Zinc chloride can cause a decrease in the absorption of Carbamazepine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Methylphenobarbital Zinc chloride can cause a decrease in the absorption of Methylphenobarbital resulting in a reduced serum concentration and potentially a decrease in efficacy.
Phenobarbital Zinc chloride can cause a decrease in the absorption of Phenobarbital resulting in a reduced serum concentration and potentially a decrease in efficacy.
Roxadustat Zinc chloride can cause a decrease in the absorption of Roxadustat resulting in a reduced serum concentration and potentially a decrease in efficacy.

Target Protein

B1 bradykinin receptor BDKRB1
Methylated-DNA--protein-cysteine methyltransferase MGMT
Fructose-bisphosphate aldolase A ALDOA
Elongation factor 1-alpha 1 EEF1A1
Alpha-enolase ENO1
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS
Nucleoside diphosphate kinase A NME1
Protein disulfide-isomerase P4HB
Protein disulfide-isomerase A3 PDIA3
Peroxiredoxin-1 PRDX1
Phosphoserine phosphatase PSPH
Triosephosphate isomerase TPI1
Elongation factor Tu, mitochondrial TUFM
Estrogen receptor ESR1
Interleukin-3 IL3
Metallothionein-2 MT2A
Copper chaperone for superoxide dismutase CCS
Histone deacetylase 1 HDAC1
Histone deacetylase 4 HDAC4
DNA-3-methyladenine glycosylase MPG
Semenogelin-1 SEMG1
Superoxide dismutase [Cu-Zn] SOD1
Histone deacetylase 8 HDAC8
Apoptosis regulatory protein Siva SIVA1
Glycine receptor subunit alpha-1 GLRA1
E3 ubiquitin-protein ligase Mdm2 MDM2
Insulin INS
Utrophin UTRN
Aspartoacylase ASPA
Protein S100-A8 S100A8
Protein S100-A9 S100A9
Matrix metalloproteinase-9 MMP9
Tumor protein p73 TP73
Protein S100-A2 S100A2
Cellular tumor antigen p53 TP53
Metallothionein-3 MT3
Metallothionein-1A MT1A
Alpha-2-macroglobulin A2M
Alpha-2-HS-glycoprotein AHSG
Apolipoprotein A-I APOA1
Apolipoprotein B receptor APOBR
Apolipoprotein E APOE
Apolipoprotein L1 APOL1
Complement C1q subcomponent subunit B C1QB
Complement C1q subcomponent subunit C C1QC
Complement C1r subcomponent C1R
Complement C1s subcomponent C1S
Complement C3 C3
Complement C4-B C4B
C4b-binding protein alpha chain C4BPA
C4b-binding protein beta chain C4BPB
Complement C5 C5
Lys-63-specific deubiquitinase BRCC36 BRCC3
Complement factor H CFH
Clusterin CLU
Ceruloplasmin CP
Carboxypeptidase N catalytic chain CPN1
Carboxypeptidase N subunit 2 CPN2
Dermcidin DCD
Fibrinogen alpha chain FGA
Fibronectin FN1
Hemoglobin subunit alpha HBA1
Hemoglobin subunit beta HBB
Haptoglobin HP
Insulin-like growth factor-binding protein complex acid labile subunit IGFALS
Inter-alpha-trypsin inhibitor heavy chain H1 ITIH1
Inter-alpha-trypsin inhibitor heavy chain H2 ITIH2
Inter-alpha-trypsin inhibitor heavy chain H3 ITIH3
Inter-alpha-trypsin inhibitor heavy chain H4 ITIH4
Immunoglobulin J chain JCHAIN
Plasma kallikrein KLKB1
Kininogen-1 KNG1
Keratin, type I cytoskeletal 9 KRT9
Alpha-1-acid glycoprotein 2 ORM2
N-acetylmuramoyl-L-alanine amidase PGLYRP2
Serum paraoxonase/arylesterase 1 PON1
Pregnancy zone protein PZP
Protein S100-A7 S100A7
Selenoprotein P SELENOP
Alpha-1-antitrypsin SERPINA1
Alpha-1-antichymotrypsin SERPINA3
Corticosteroid-binding globulin SERPINA6
Heparin cofactor 2 SERPIND1
Sex hormone-binding globulin SHBG
Serotransferrin TF
Transthyretin TTR
Vitronectin VTN
Amyloid beta precursor like protein 1 APLP1
Amyloid beta precursor like protein 2 APLP2
Amyloid-beta precursor protein APP
Poly [ADP-ribose] polymerase 1 PARP1
Apolipoprotein B-100 APOB
Hemopexin HPX
Histidine-rich glycoprotein HRG
Coagulation factor XI F11
C->U-editing enzyme APOBEC-1 APOBEC1
Semenogelin-2 SEMG2

Referensi & Sumber

Artikel (PubMed)
  • PMID: 18385818
    Prasad AS: Zinc in human health: effect of zinc on immune cells. Mol Med. 2008 May-Jun;14(5-6):353-7. doi: 10.2119/2008-00033.Prasad.
  • PMID: 23914218
    Roohani N, Hurrell R, Kelishadi R, Schulin R: Zinc and its importance for human health: An integrative review. J Res Med Sci. 2013 Feb;18(2):144-57.
  • PMID: 2735321
    Yuzbasiyan-Gurkan VA, Brewer GJ, Vander AJ, Guenther MJ, Prasad AS: Net renal tubular reabsorption of zinc in healthy man and impaired handling in sickle cell anemia. Am J Hematol. 1989 Jun;31(2):87-90. doi: 10.1002/ajh.2830310203.
  • PMID: -
    Unknown Author: Metabolic data for zinc . 1980 Jul 1;4(3-4):21-23.
  • PMID: 27996088
    Lazzerini M, Wanzira H: Oral zinc for treating diarrhoea in children. Cochrane Database Syst Rev. 2016 Dec 20;12:CD005436. doi: 10.1002/14651858.CD005436.pub5.
  • PMID: 23304467
    Myers SA, Nield A, Myers M: Zinc transporters, mechanisms of action and therapeutic utility: implications for type 2 diabetes mellitus. J Nutr Metab. 2012;2012:173712. doi: 10.1155/2012/173712. Epub 2012 Dec 12.
  • PMID: 12142956
    Dardenne M: Zinc and immune function. Eur J Clin Nutr. 2002 Aug;56 Suppl 3:S20-3. doi: 10.1038/sj.ejcn.1601479.
  • PMID: 17244314
    Lansdown AB, Mirastschijski U, Stubbs N, Scanlon E, Agren MS: Zinc in wound healing: theoretical, experimental, and clinical aspects. Wound Repair Regen. 2007 Jan-Feb;15(1):2-16. doi: 10.1111/j.1524-475X.2006.00179.x.

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Sekuens Gen/Protein (FASTA)

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