The recommended dietary allowance of magnesium ranges from 30 mg for infants to 420 mg for males between the age of 31 and 50.L2601 According to the institute of Medicine (IOM), the majority of adults can tolerate 350 mg of magnesium per day without experiencing adverse effects.A39559 Symptoms of magnesium toxicity include diarrhea and other gastrointestinal effects, thirst, muscle weakness, drowsiness, severe back and pelvic pain, hypotension, dizziness, confusion, difficulty breathing, lethargy, and deterioration of kidney function.A32810,A39559 Other more severe symptoms associated with magnesium overdose include loss of consciousness, respiratory arrest, cardiac arrhythmias and cardiac arrest.A39559
Regular use of laxatives containing magnesium may lead to severe and even fatal hypermagnesemia.A188081
Discontinuation of magnesium products including supplements, laxatives, and antacids is usually sufficient to manage mild cases of magnesium overdose; however, patients should also be screened for renal impairment.A39559
In severe cases of magnesium overdose, patients may require supportive care and interventions including intravenous fluids and furosemide, IV calcium chloride or calcium gluconate, renal dialysis and artificial respiratory support.A39559
Magnesium is classified as an alkaline earth metal and has 2 hydration shells.A19349 The element can be found in abundance in the hydrosphere and in mineral salts such as dolomite and magnesium carbonate.A19349
Common dietary sources of magnesium include nuts (cashews, peanuts, almonds), beans, bananas, apples, carrots, broccoli, and leafy greens.A188120,L2601 Magnesium is an important enzyme cofactor and is essential to several metabolic processes.A32810 Further, the mineral helps regulate blood pressure and is necessary for RNA, DNA and protein synthesis among several other functions.A32810
Despite the importance of magnesium and its availability via several food sources, an estimated 56 to 68% of adults who live in developed, western countries do not meet the recommended daily intake (RDI) of magnesium.A39559 Several factors and common behaviours reduce the availability of magnesium in the diet such as food processing and cooking vegetables (which are normally a rich source of magnesium).A39559
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Calcitriol | The serum concentration of Magnesium can be increased when it is combined with Calcitriol. |
| Calcifediol | The serum concentration of Magnesium can be increased when it is combined with Calcifediol. |
| Paricalcitol | The serum concentration of Magnesium can be increased when it is combined with Paricalcitol. |
| Dihydrotachysterol | The serum concentration of Magnesium can be increased when it is combined with Dihydrotachysterol. |
| Alfacalcidol | The serum concentration of Magnesium can be increased when it is combined with Alfacalcidol. |
| Seocalcitol | The serum concentration of Magnesium can be increased when it is combined with Seocalcitol. |
| Inecalcitol | The serum concentration of Magnesium can be increased when it is combined with Inecalcitol. |
| Becocalcidiol | The serum concentration of Magnesium can be increased when it is combined with Becocalcidiol. |
| Eldecalcitol | The serum concentration of Magnesium can be increased when it is combined with Eldecalcitol. |
| 1alpha,24S-Dihydroxyvitamin D2 | The serum concentration of Magnesium can be increased when it is combined with 1alpha,24S-Dihydroxyvitamin D2. |
| Elocalcitol | The serum concentration of Magnesium can be increased when it is combined with Elocalcitol. |
| Maxacalcitol | The serum concentration of Magnesium can be increased when it is combined with Maxacalcitol. |
| 1alpha-Hydroxyvitamin D5 | The serum concentration of Magnesium can be increased when it is combined with 1alpha-Hydroxyvitamin D5. |
| Previtamin D(3) | The serum concentration of Magnesium can be increased when it is combined with Previtamin D(3). |
| Deferiprone | Magnesium can cause a decrease in the absorption of Deferiprone resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Eltrombopag | Magnesium can cause a decrease in the absorption of Eltrombopag resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Raltegravir | Magnesium can cause a decrease in the absorption of Raltegravir resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Deferasirox | Magnesium can cause a decrease in the absorption of Deferasirox resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Halofantrine | Magnesium can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Misoprostol | The risk or severity of adverse effects can be increased when Magnesium is combined with Misoprostol. |
| Tramadol | The therapeutic efficacy of Magnesium can be decreased when used in combination with Tramadol. |
| Trospium | The therapeutic efficacy of Magnesium can be decreased when used in combination with Trospium. |
| Oxyphenonium | The therapeutic efficacy of Magnesium can be decreased when used in combination with Oxyphenonium. |
| Benzatropine | The therapeutic efficacy of Magnesium can be decreased when used in combination with Benzatropine. |
| Ziprasidone | The therapeutic efficacy of Magnesium can be decreased when used in combination with Ziprasidone. |
| Disopyramide | The therapeutic efficacy of Magnesium can be decreased when used in combination with Disopyramide. |
| Ipratropium | The therapeutic efficacy of Magnesium can be decreased when used in combination with Ipratropium. |
| Olanzapine | The therapeutic efficacy of Magnesium can be decreased when used in combination with Olanzapine. |
| Metixene | The therapeutic efficacy of Magnesium can be decreased when used in combination with Metixene. |
| Buclizine | The therapeutic efficacy of Magnesium can be decreased when used in combination with Buclizine. |
| Clozapine | The therapeutic efficacy of Magnesium can be decreased when used in combination with Clozapine. |
| Doxylamine | The therapeutic efficacy of Magnesium can be decreased when used in combination with Doxylamine. |
| Trihexyphenidyl | The therapeutic efficacy of Magnesium can be decreased when used in combination with Trihexyphenidyl. |
| Oxyphencyclimine | The therapeutic efficacy of Magnesium can be decreased when used in combination with Oxyphencyclimine. |
| Procyclidine | The therapeutic efficacy of Magnesium can be decreased when used in combination with Procyclidine. |
| Profenamine | The therapeutic efficacy of Magnesium can be decreased when used in combination with Profenamine. |
| Promazine | The therapeutic efficacy of Magnesium can be decreased when used in combination with Promazine. |
| Hyoscyamine | The therapeutic efficacy of Magnesium can be decreased when used in combination with Hyoscyamine. |
| Cyproheptadine | The therapeutic efficacy of Magnesium can be decreased when used in combination with Cyproheptadine. |
| Imipramine | The therapeutic efficacy of Magnesium can be decreased when used in combination with Imipramine. |
| Methscopolamine bromide | The therapeutic efficacy of Magnesium can be decreased when used in combination with Methscopolamine bromide. |
| Chlorpromazine | The therapeutic efficacy of Magnesium can be decreased when used in combination with Chlorpromazine. |
| Darifenacin | The therapeutic efficacy of Magnesium can be decreased when used in combination with Darifenacin. |
| Tridihexethyl | The therapeutic efficacy of Magnesium can be decreased when used in combination with Tridihexethyl. |
| Triflupromazine | The therapeutic efficacy of Magnesium can be decreased when used in combination with Triflupromazine. |
| Anisotropine methylbromide | The therapeutic efficacy of Magnesium can be decreased when used in combination with Anisotropine methylbromide. |
| Nortriptyline | The therapeutic efficacy of Magnesium can be decreased when used in combination with Nortriptyline. |
| Amoxapine | The therapeutic efficacy of Magnesium can be decreased when used in combination with Amoxapine. |
| Atropine | The therapeutic efficacy of Magnesium can be decreased when used in combination with Atropine. |
| Pirenzepine | The therapeutic efficacy of Magnesium can be decreased when used in combination with Pirenzepine. |
| Paroxetine | The therapeutic efficacy of Magnesium can be decreased when used in combination with Paroxetine. |
| Homatropine methylbromide | The therapeutic efficacy of Magnesium can be decreased when used in combination with Homatropine methylbromide. |
| Scopolamine | The therapeutic efficacy of Magnesium can be decreased when used in combination with Scopolamine. |
| Benzquinamide | The therapeutic efficacy of Magnesium can be decreased when used in combination with Benzquinamide. |
| Clidinium | The therapeutic efficacy of Magnesium can be decreased when used in combination with Clidinium. |
| Propiomazine | The therapeutic efficacy of Magnesium can be decreased when used in combination with Propiomazine. |
| Propantheline | The therapeutic efficacy of Magnesium can be decreased when used in combination with Propantheline. |
| Dicyclomine | The therapeutic efficacy of Magnesium can be decreased when used in combination with Dicyclomine. |
| Biperiden | The therapeutic efficacy of Magnesium can be decreased when used in combination with Biperiden. |
| Brompheniramine | The therapeutic efficacy of Magnesium can be decreased when used in combination with Brompheniramine. |
| Flupentixol | The therapeutic efficacy of Magnesium can be decreased when used in combination with Flupentixol. |
| Cocaine | The therapeutic efficacy of Magnesium can be decreased when used in combination with Cocaine. |
| Maprotiline | The therapeutic efficacy of Magnesium can be decreased when used in combination with Maprotiline. |
| Methantheline | The therapeutic efficacy of Magnesium can be decreased when used in combination with Methantheline. |
| Cycrimine | The therapeutic efficacy of Magnesium can be decreased when used in combination with Cycrimine. |
| Glycopyrronium | The therapeutic efficacy of Magnesium can be decreased when used in combination with Glycopyrronium. |
| Tolterodine | The therapeutic efficacy of Magnesium can be decreased when used in combination with Tolterodine. |
| Oxybutynin | The therapeutic efficacy of Magnesium can be decreased when used in combination with Oxybutynin. |
| Promethazine | The therapeutic efficacy of Magnesium can be decreased when used in combination with Promethazine. |
| Diphenhydramine | The therapeutic efficacy of Magnesium can be decreased when used in combination with Diphenhydramine. |
| Doxepin | The therapeutic efficacy of Magnesium can be decreased when used in combination with Doxepin. |
| Flavoxate | The therapeutic efficacy of Magnesium can be decreased when used in combination with Flavoxate. |
| Desipramine | The therapeutic efficacy of Magnesium can be decreased when used in combination with Desipramine. |
| Orphenadrine | The therapeutic efficacy of Magnesium can be decreased when used in combination with Orphenadrine. |
| Escitalopram | The therapeutic efficacy of Magnesium can be decreased when used in combination with Escitalopram. |
| Quetiapine | The therapeutic efficacy of Magnesium can be decreased when used in combination with Quetiapine. |
| Diphenidol | The therapeutic efficacy of Magnesium can be decreased when used in combination with Diphenidol. |
| Aripiprazole | The therapeutic efficacy of Magnesium can be decreased when used in combination with Aripiprazole. |
| Chlorprothixene | The therapeutic efficacy of Magnesium can be decreased when used in combination with Chlorprothixene. |
| Methotrimeprazine | The therapeutic efficacy of Magnesium can be decreased when used in combination with Methotrimeprazine. |
| Tiotropium | The therapeutic efficacy of Magnesium can be decreased when used in combination with Tiotropium. |
| Solifenacin | The therapeutic efficacy of Magnesium can be decreased when used in combination with Solifenacin. |
| Isopropamide | The therapeutic efficacy of Magnesium can be decreased when used in combination with Isopropamide. |
| Mepenzolate | The therapeutic efficacy of Magnesium can be decreased when used in combination with Mepenzolate. |
| Pizotifen | The therapeutic efficacy of Magnesium can be decreased when used in combination with Pizotifen. |
| Fesoterodine | The therapeutic efficacy of Magnesium can be decreased when used in combination with Fesoterodine. |
| Hexocyclium | The therapeutic efficacy of Magnesium can be decreased when used in combination with Hexocyclium. |
| Dimetindene | The therapeutic efficacy of Magnesium can be decreased when used in combination with Dimetindene. |
| Aclidinium | The therapeutic efficacy of Magnesium can be decreased when used in combination with Aclidinium. |
| Dexetimide | The therapeutic efficacy of Magnesium can be decreased when used in combination with Dexetimide. |
| Benactyzine | The therapeutic efficacy of Magnesium can be decreased when used in combination with Benactyzine. |
| Umeclidinium | The therapeutic efficacy of Magnesium can be decreased when used in combination with Umeclidinium. |
| Dosulepin | The therapeutic efficacy of Magnesium can be decreased when used in combination with Dosulepin. |
| Imidafenacin | The therapeutic efficacy of Magnesium can be decreased when used in combination with Imidafenacin. |
| Butylscopolamine | The therapeutic efficacy of Magnesium can be decreased when used in combination with Butylscopolamine. |
| Thonzylamine | The therapeutic efficacy of Magnesium can be decreased when used in combination with Thonzylamine. |
| Methscopolamine | The therapeutic efficacy of Magnesium can be decreased when used in combination with Methscopolamine. |
| Revefenacin | The therapeutic efficacy of Magnesium can be decreased when used in combination with Revefenacin. |
| Oxitropium | The therapeutic efficacy of Magnesium can be decreased when used in combination with Oxitropium. |
| Propiverine | The therapeutic efficacy of Magnesium can be decreased when used in combination with Propiverine. |