Peringatan Keamanan

Intamuscular LD50 of 250mg/kg and oral LD50 of 8290 mg/kg reported in rats L799. Phosphate toxicity is likely due to the disturbance of other electrolytes when phosphate levels are high, producing symptoms including tetany, dehydration, hypotension, tachycardia, hyperpyrexia, cardiac arrest and coma A19449. Risk of raising phosphate levels through use of sodium phosphate appears to be higher in smaller patients A19448.

Sodium phosphate, dibasic

DB14502

small molecule approved

Deskripsi

Struktur Molekul 2D

Berat 141.9588
Wujud -

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Tmax for phosphate absorption with orally administered liquid sodium phosphate is 1-3h A19448.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

2 Data
  • 1. Take with a full glass of water.
  • 2. Take with food.

Interaksi Obat

427 Data
Chlorpropamide Sodium phosphate, dibasic may decrease the excretion rate of Chlorpropamide which could result in a higher serum level.
Mecamylamine Sodium phosphate, dibasic may increase the excretion rate of Mecamylamine which could result in a lower serum level and potentially a reduction in efficacy.
Tramadol The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Tramadol.
Trospium The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Trospium.
Oxyphenonium The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Oxyphenonium.
Benzatropine The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Benzatropine.
Ziprasidone The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Ziprasidone.
Disopyramide The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Disopyramide.
Amitriptyline The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Amitriptyline.
Ipratropium The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Ipratropium.
Olanzapine The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Olanzapine.
Metixene The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Metixene.
Terfenadine The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Terfenadine.
Buclizine The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Buclizine.
Clozapine The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Clozapine.
Doxylamine The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Doxylamine.
Trihexyphenidyl The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Trihexyphenidyl.
Oxyphencyclimine The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Oxyphencyclimine.
Procyclidine The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Procyclidine.
Profenamine The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Profenamine.
Promazine The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Promazine.
Hyoscyamine The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Hyoscyamine.
Cyproheptadine The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Cyproheptadine.
Imipramine The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Imipramine.
Methscopolamine bromide The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Methscopolamine bromide.
Chlorpromazine The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Chlorpromazine.
Gallamine triethiodide The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Gallamine triethiodide.
Darifenacin The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Darifenacin.
Tridihexethyl The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Tridihexethyl.
Triflupromazine The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Triflupromazine.
Anisotropine methylbromide The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Anisotropine methylbromide.
Nortriptyline The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Nortriptyline.
Amoxapine The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Amoxapine.
Atropine The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Atropine.
Nicardipine The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Nicardipine.
Pirenzepine The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Pirenzepine.
Paroxetine The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Paroxetine.
Homatropine methylbromide The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Homatropine methylbromide.
Rocuronium The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Rocuronium.
Scopolamine The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Scopolamine.
Benzquinamide The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Benzquinamide.
Clidinium The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Clidinium.
Propiomazine The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Propiomazine.
Propantheline The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Propantheline.
Dicyclomine The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Dicyclomine.
Biperiden The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Biperiden.
Brompheniramine The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Brompheniramine.
Flupentixol The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Flupentixol.
Cocaine The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Cocaine.
Quinidine The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Quinidine.
Maprotiline The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Maprotiline.
Methantheline The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Methantheline.
Cycrimine The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Cycrimine.
Glycopyrronium The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Glycopyrronium.
Tolterodine The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Tolterodine.
Oxybutynin The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Oxybutynin.
Promethazine The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Promethazine.
Diphenhydramine The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Diphenhydramine.
Doxacurium The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Doxacurium.
Doxepin The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Doxepin.
Flavoxate The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Flavoxate.
Desipramine The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Desipramine.
Orphenadrine The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Orphenadrine.
Escitalopram The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Escitalopram.
Quetiapine The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Quetiapine.
Mivacurium The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Mivacurium.
Diphenidol The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Diphenidol.
Aripiprazole The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Aripiprazole.
Chlorprothixene The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Chlorprothixene.
Metocurine The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Metocurine.
Pancuronium The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Pancuronium.
Pipecuronium The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Pipecuronium.
Methotrimeprazine The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Methotrimeprazine.
Tiotropium The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Tiotropium.
Solifenacin The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Solifenacin.
Isopropamide The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Isopropamide.
Rapacuronium The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Rapacuronium.
Mepenzolate The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Mepenzolate.
Pizotifen The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Pizotifen.
Fesoterodine The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Fesoterodine.
Hexocyclium The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Hexocyclium.
Dimetindene The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Dimetindene.
Aclidinium The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Aclidinium.
Dexetimide The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Dexetimide.
Benactyzine The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Benactyzine.
Umeclidinium The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Umeclidinium.
Trimebutine The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Trimebutine.
Dosulepin The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Dosulepin.
Imidafenacin The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Imidafenacin.
Butylscopolamine The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Butylscopolamine.
Thonzylamine The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Thonzylamine.
Methscopolamine The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Methscopolamine.
Revefenacin The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Revefenacin.
Oxitropium The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Oxitropium.
Propiverine The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Propiverine.
Batefenterol The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Batefenterol.
Mebeverine The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Mebeverine.
Tropatepine The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Tropatepine.
Prifinium The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Prifinium.
Piperidolate The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Piperidolate.

Target Protein

Carbonic anhydrase 4 CA4

Referensi & Sumber

Artikel (PubMed)
  • PMID: 17652123
    Rex DK: Dosing considerations in the use of sodium phosphate bowel preparations for colonoscopy. Ann Pharmacother. 2007 Sep;41(9):1466-75. Epub 2007 Jul 24.
  • PMID: 18645612
    Schanz S, Kruis W, Mickisch O, Kuppers B, Berg P, Frick B, Heiland G, Huppe D, Schenck B, Horstkotte H, Winkler A: Bowel Preparation for Colonoscopy with Sodium Phosphate Solution versus Polyethylene Glycol-Based Lavage: A Multicenter Trial. Diagn Ther Endosc. 2008;2008:713521. doi: 10.1155/2008/713521.
  • PMID: 19298584
    Ehrenpreis ED: Increased serum phosphate levels and calcium fluxes are seen in smaller individuals after a single dose of sodium phosphate colon cleansing solution: a pharmacokinetic analysis. Aliment Pharmacol Ther. 2009 Jun 1;29(11):1202-11. doi: 10.1111/j.1365-2036.2009.03987.x. Epub 2009 Feb 27.
  • PMID: 20958267
    Razzaque MS: Phosphate toxicity: new insights into an old problem. Clin Sci (Lond). 2011 Feb;120(3):91-7. doi: 10.1042/CS20100377.
  • PMID: 23398154
    Biber J, Hernando N, Forster I: Phosphate transporters and their function. Annu Rev Physiol. 2013;75:535-50. doi: 10.1146/annurev-physiol-030212-183748.

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