Cinnamaldehyde

DB14184

small molecule approved experimental

Deskripsi

Cinnamaldehyde is a naturally occurring flavonoid that gives the spice cinnamon its flavour and odour. It occurs naturally in the bark of cinnamon trees and other species of the genus Cinnamomum such as camphor and cassia.

Sensitivity to cinnamaldehyde may be identified with a clinical patch test.

Struktur Molekul 2D

Berat 132.1592
Wujud -

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Cinnamaldehyde is 52% absorbed through the skin and shown to be rapidly absorbed from the gut A34266.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Cinnamaldehyde is metabolized and excreted primarily in the urine and, to a minor extent, in the feces A34266. After oral or intraperitoneal administration to rats and mice, 69–98% of the dose of cinnamaldehyde was recovered in the urine and feces within 24 h A34266.

Interaksi Obat

37 Data
Calcium carbimide The risk or severity of adverse effects can be increased when Calcium carbimide is combined with Cinnamaldehyde.
Disulfiram The risk or severity of adverse effects can be increased when Disulfiram is combined with Cinnamaldehyde.
Lidocaine The risk or severity of methemoglobinemia can be increased when Cinnamaldehyde is combined with Lidocaine.
Ropivacaine The risk or severity of methemoglobinemia can be increased when Cinnamaldehyde is combined with Ropivacaine.
Bupivacaine The risk or severity of methemoglobinemia can be increased when Cinnamaldehyde is combined with Bupivacaine.
Cinchocaine The risk or severity of methemoglobinemia can be increased when Cinnamaldehyde is combined with Cinchocaine.
Dyclonine The risk or severity of methemoglobinemia can be increased when Cinnamaldehyde is combined with Dyclonine.
Procaine The risk or severity of methemoglobinemia can be increased when Cinnamaldehyde is combined with Procaine.
Prilocaine The risk or severity of methemoglobinemia can be increased when Cinnamaldehyde is combined with Prilocaine.
Proparacaine The risk or severity of methemoglobinemia can be increased when Cinnamaldehyde is combined with Proparacaine.
Meloxicam The risk or severity of methemoglobinemia can be increased when Cinnamaldehyde is combined with Meloxicam.
Oxybuprocaine The risk or severity of methemoglobinemia can be increased when Cinnamaldehyde is combined with Oxybuprocaine.
Cocaine The risk or severity of methemoglobinemia can be increased when Cinnamaldehyde is combined with Cocaine.
Mepivacaine The risk or severity of methemoglobinemia can be increased when Cinnamaldehyde is combined with Mepivacaine.
Levobupivacaine The risk or severity of methemoglobinemia can be increased when Cinnamaldehyde is combined with Levobupivacaine.
Diphenhydramine The risk or severity of methemoglobinemia can be increased when Cinnamaldehyde is combined with Diphenhydramine.
Benzocaine The risk or severity of methemoglobinemia can be increased when Cinnamaldehyde is combined with Benzocaine.
Chloroprocaine The risk or severity of methemoglobinemia can be increased when Cinnamaldehyde is combined with Chloroprocaine.
Phenol The risk or severity of methemoglobinemia can be increased when Cinnamaldehyde is combined with Phenol.
Tetrodotoxin The risk or severity of methemoglobinemia can be increased when Cinnamaldehyde is combined with Tetrodotoxin.
Benzyl alcohol The risk or severity of methemoglobinemia can be increased when Cinnamaldehyde is combined with Benzyl alcohol.
Capsaicin The risk or severity of methemoglobinemia can be increased when Cinnamaldehyde is combined with Capsaicin.
Etidocaine The risk or severity of methemoglobinemia can be increased when Cinnamaldehyde is combined with Etidocaine.
Articaine The risk or severity of methemoglobinemia can be increased when Cinnamaldehyde is combined with Articaine.
Tetracaine The risk or severity of methemoglobinemia can be increased when Cinnamaldehyde is combined with Tetracaine.
Propoxycaine The risk or severity of methemoglobinemia can be increased when Cinnamaldehyde is combined with Propoxycaine.
Pramocaine The risk or severity of methemoglobinemia can be increased when Cinnamaldehyde is combined with Pramocaine.
Butamben The risk or severity of methemoglobinemia can be increased when Cinnamaldehyde is combined with Butamben.
Butacaine The risk or severity of methemoglobinemia can be increased when Cinnamaldehyde is combined with Butacaine.
Oxetacaine The risk or severity of methemoglobinemia can be increased when Cinnamaldehyde is combined with Oxetacaine.
Ethyl chloride The risk or severity of methemoglobinemia can be increased when Cinnamaldehyde is combined with Ethyl chloride.
Butanilicaine The risk or severity of methemoglobinemia can be increased when Cinnamaldehyde is combined with Butanilicaine.
Metabutethamine The risk or severity of methemoglobinemia can be increased when Cinnamaldehyde is combined with Metabutethamine.
Quinisocaine The risk or severity of methemoglobinemia can be increased when Cinnamaldehyde is combined with Quinisocaine.
Tenofovir alafenamide The serum concentration of Tenofovir alafenamide can be increased when it is combined with Cinnamaldehyde.
Ambroxol The risk or severity of methemoglobinemia can be increased when Cinnamaldehyde is combined with Ambroxol.
Etrasimod The risk or severity of immunosuppression can be increased when Cinnamaldehyde is combined with Etrasimod.

Target Protein

Transient receptor potential cation channel subfamily V member 3 TRPV3
Transient receptor potential cation channel subfamily A member 1 TRPA1

Referensi & Sumber

Artikel (PubMed)
  • PMID: 18035463
    Belsito D, Bickers D, Bruze M, Calow P, Greim H, Hanifin JM, Rogers AE, Saurat JH, Sipes IG, Tagami H: A toxicologic and dermatologic assessment of related esters and alcohols of cinnamic acid and cinnamyl alcohol when used as fragrance ingredients. Food Chem Toxicol. 2007;45 Suppl 1:S1-23. doi: 10.1016/j.fct.2007.09.087. Epub 2007 Sep 18.

Contoh Produk & Brand

Produk: 2 • International brands: 0
Produk
  • Dso Dressing
    Liquid • - • Dental • Canada • Approved
  • T.R.U.E. Test Thin-Layer Rapid Use Patch Test
    Kit • - • Cutaneous • US • Approved

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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