Viper antivenom

DB14114

biotech approved

Deskripsi

Viper antivenom consists of antibodies derived from horses immunized and subsequently developed antibodies against snake venoms. ANAVIP, an equine-derived antivenom made with venom from Bothrops asper and Crotalus durissus, was first approved by the FDA on October 1, 2015, for the management of North American rattlesnake envenomation.^A250795

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) Following intravenous administration in healthy subjects, the mean (SD) elimination half-life was 133 (53) L.[L42475]

Volume Distribusi Following intravenous administration in healthy subjects, the mean (SD) steady-state volume of distribution was 3.3 (0.9) L.[L42475]

Klirens (Clearance) Following intravenous administration in healthy subjects, the mean (SD) total clearance was 22 (7) mL/h.[L42475]

Absorpsi

Following intravenous administration in healthy subjects, the mean (SD) area under plasma concentration versus time curve 4144 (670) µgxh/mL.^L42475

Metabolisme

There is no information available.

Rute Eliminasi

There is no information available.

Interaksi Obat

0 Data

Tidak ada data.

Referensi & Sumber

Artikel (PubMed)

PMID: 33703984
Wilson BZ, Larsen J, Smelski G, Dudley S, Shirazi FM: Use of Crotalidae equine immune F(ab')2 antivenom for treatment of an Agkistrodon envenomation. Clin Toxicol (Phila). 2021 Nov;59(11):1023-1026. doi: 10.1080/15563650.2021.1892718. Epub 2021 Mar 11.

Link

FDA Approved Drug Products: ANAVIP [crotalidae immune F(ab’)2 (equine)] Lyophilized Powder for Solution for Injection For Intravenous Use Only

Contoh Produk & Brand

Produk: 1 • International brands: 0

Produk

Anavip

Injection, powder, lyophilized, for solution • 12 mg/1mL • Intravenous • US • Approved

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.

Peringatan Keamanan